CN109172698A - A kind of drug and preparation method thereof for treating rhinitis - Google Patents
A kind of drug and preparation method thereof for treating rhinitis Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
The present invention relates to a kind of drugs and preparation method thereof for treating rhinitis, the treatment rhinitis drug uses folium isatidis, dandelion, peppermint, honeysuckle flower, radix scutellariae, raw Radix Astragali, the root of Dahurain angelica, asarum, hairyvein agrimony, radix pseudostellariae is raw material and carries out suitable weight proportion, according to the nature and flavor of each medicine, channel tropism, function, cure mainly and respectively open up it can monarch, minister, assistant, history, it supplements and complements each other, it plays jointly clearing heat and detoxicating, analgesia, it is anti-inflammatory, antiallergy, it is antiviral, improve immunity, enhance the effect of antiviral functions, treating both manifestation and root cause of disease, strengthening vital QI to eliminate pathogenic factors, all kinds of rhinitis are cured jointly, and modern Western medicine is added in traditional Chinese medicine prescription, make the drug for the treatment of rhinitis of the present invention, administration time is short, therapeutic effect is good and stablizes, it is not recurred after drug withdrawal, it has no toxic side effect, it is scorching suitable for treatment nasosinusitis, pharyngitis, acute and chronic rhinitis, anaphylaxis nasal cavity Prolong inflammation before hypertrophic rhinit's, atrophic rhinitis, chronic purulent rhinitis, nasosinusitis, nose, the diseases such as nosebleed epistaxis blood, nasal obstruction, nose capsule are itched.
Description
Technical field
The invention belongs to technical field of pharmaceuticals, and in particular to a kind of drug and preparation method thereof for treating rhinitis.
Background technique
Rhinitis is the inflammation of nasal membrane and submucous tissue, shows as congested or oedema.Patient often has a stuffy nose, stream
Clear nasal discharge, rhiocnesmus, throat is uncomfortable, the symptoms such as sneeze, cough.It is because acute or chronic schneiderian membrane such as virus, germ infection, or
The effect of stimulant is impaired and causes.Rhinitis not only influences nose, throat and eyes, also will affect sleep, hearing, or even have a headache,
Giddy, loss of appetite, easily tired, failure of memory etc..When influencing the physiological function of nasal cavity, it may appear that respiratory disorder causes
Lowered blood oxygen influences the function and metabolism of other tissues and organ.Rhinitis etiology and pathogenesis is mostly to experience wind-heat or chill, enters innerization
Heat, the turbid tears of heat toxin block nose key and form.Chronic person is mostly because of spleen and lung weakness, insufficiency of lung-QI,deficiency of lung-QI to weakened defensive QI, susceptible exopathogen.Spleen deficiency is then
Transformation failure of spleen, phlegm wet are detained, and knot nose key is stranded, and contamination sinus mucosa forms nasosinusitis.Therefore rhinitis chronic answers clearing lung-heat benefit spleen.Rhinitis is first
First due to Lung Qi deficiency, instability of surface, chill is taken advantage of a weak point, and criminal and nose key, pathogen conflicting with vital QI, lung qi is obstructed, and body fluid stops gathering, sneeze stream
Tears；Enriching for lung qi, depends on the defeated cloth of temper, Spleen-Qi Deficiency then Lung Qi deficiency, and the root of gas is in kidney, and kidney deficiency, which is then taken the photograph, receives inability, gas
Do not return member, yang-energy is easy to dissipate, invades and cause a disease in ailment said due to cold or exposure.Therefore, it is wind-cold affecting lung or lung channel intrinsic heat etc. that early stage is often dialectical
Real example, with disease progression, different degrees of deficient of internal organs is often dialectical for Lung Qi deficiency or lung spleen or deficiency of both the lung and kidney, even lung
The dirty all void of spleen kidney three.Caused by nearly ninety percent nasopharyngeal carcinoma is because of rhinitis obstinate.Some patients with rhinitis's hypertrophic inferior turbinates, oxygen when sleep
Unsaturated vapor, it is serious to cause cerebral infarction, hypertension, heart attack etc., or even sudden death.
Summary of the invention
In order to solve the above problems existing in the present technology, the present invention provides a kind of good effect, cure rate are high, at low cost
Treatment rhinitis drug and preparation method thereof.
The technical scheme adopted by the invention is as follows:
A kind of drug for treating rhinitis, raw material components include:
Folium isatidis 5-15 parts by weight, dandelion 5-15 parts by weight, peppermint 5-15 parts by weight, honeysuckle flower 5-15 parts by weight, radix scutellariae
5-15 parts by weight, raw Radix Astragali 10-30 parts by weight, root of Dahurain angelica 5-15 parts by weight, asarum 1-3 parts by weight, hairyvein agrimony 10-30 parts by weight,
Radix pseudostellariae 10-30 parts by weight.
The raw material components of the drug of the further preferably described treatment rhinitis include:
Folium isatidis 8-12 parts by weight, dandelion 8-12 parts by weight, peppermint 8-12 parts by weight, honeysuckle flower 8-12 parts by weight, radix scutellariae
8-12 parts by weight, raw Radix Astragali 15-25 parts by weight, root of Dahurain angelica 8-12 parts by weight, asarum 1.5-2.5 parts by weight, hairyvein agrimony 15-25 weight
Part, radix pseudostellariae 15-25 parts by weight.
The raw material components of the drug of the further preferably described treatment rhinitis include:
10 parts by weight of folium isatidis, 10 parts by weight of dandelion, 10 parts by weight of peppermint, 10 parts by weight of honeysuckle flower, 10 parts by weight of radix scutellariae,
Raw 20 parts by weight of Radix Astragali, 10 parts by weight of the root of Dahurain angelica, 2 parts by weight of asarum, 20 parts by weight of hairyvein agrimony, 20 parts by weight of radix pseudostellariae.
The raw material components of the further preferably drug of the treatment rhinitis further include the antiallergic of 0.1-2 parts by weight,
The antiallergic is chlorpheniramine, cyproheptadine or dexamethasone.
A method of the drug preparing the treatment rhinitis includes the following steps:
Folium isatidis, dandelion, peppermint, honeysuckle flower, radix scutellariae, raw Radix Astragali, the root of Dahurain angelica, asarum, hairyvein agrimony, radix pseudostellariae are weighed respectively,
After being separately dried, being crushed, each raw material fine powder is obtained, each raw material fine powder is sufficiently mixed, obtains mixed powder i.e.
For the drug of the treatment rhinitis.
A method of the drug preparing the treatment rhinitis includes the following steps:
Folium isatidis, dandelion, peppermint, honeysuckle flower, radix scutellariae, raw Radix Astragali, the root of Dahurain angelica, asarum, hairyvein agrimony, radix pseudostellariae are weighed respectively,
After being separately dried, being crushed, each raw material fine powder is obtained, each raw material fine powder is sufficiently mixed, mixed powder is obtained；It will
The mixed powder is mixed with chlorpheniramine to get the drug of the treatment rhinitis.
The temperature for carrying out the drying is 60-90 DEG C, and the time for carrying out the drying is 1-6h.
The temperature for carrying out the drying is 75 DEG C, and the time for carrying out the drying is 3.5h.
The partial size of each raw material fine powder is 300-500 mesh.
The partial size of each raw material fine powder is 400 mesh.
To facilitate the understanding of the present invention, below in the present invention raw material and drug effect be further elaborated.
Folium isatidis, cold in nature, bitter.Clearing heat and detoxicating, the clear spot of cool blood.With control warm disease, blood-head macular eruption, high fever do not move back, mumps, larynx
Numbness, erysipelas and the top of blood-heat bleeding haemorrhage etc..
Dandelion, it is cold in nature, it is bitter, sweet.It is clearing heat and detoxicating, diuresis dissipating bind.Treat acute mastitis, adenolymphitis, scrofula, malignant boil
Carbuncle toxin, acute conjunctivitis, cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, urinary tract sense
Dye.
Peppermint, cool in nature, acrid flavour.Dispelling wind-heat, refresh oneself, promoting eruption.With the wind-heat that cures cold, headache, hot eyes, pharyngitis pain
Bitterly, pruitus, measles without adequate eruption etc..
Honeysuckle, it is cold in nature, it is sweet in flavor.Clearing heat and detoxicating, wind-heat dissipating.With controlling carbuncle swells furunculosis, sore throat, erysipelas, toxic-heat and blood stasis, wind
Thermal sensation emits, warm disease heating.
Radix scutellariae, cold in nature, bitter.Heat-clearing and damp-drying drug, purging fire for removing toxin, hemostasis, miscarriage prevention.With controlling damp-warm syndrome, heat temperature chest tightness and emesis, damp and hot
Feeling of fullness, dysentery, jaundice, cough with lung heat, hyperpyrexia polydipsia, blood-head tells nosebleed, carbuncle sore tumefacting virus, threatened abortion.
Radix Astragali, slightly warm in nature are sweet in flavor.Invigorating qi for strengthening superficies, diuresis, pus draining and toxin expelling, myogenic.Treat shortness of breath and palpitation, it is out of strength, collapse,
Spontaneous perspiration, night sweat, physically weak edema, chronic nephritis, chronic diarrhea, rectal prolapse, uterine prolapse, ulcer is difficult to burst, the long disunion of the open sore part, children's branch gas
Pipe asthma, chronic hepatitis B, chronic nephritis and vital myocarditis.
The root of Dahurain angelica, warm-natured, acrid flavour.Relieve heat dehumidifying, sensible analgesic, detumescence and apocenosis.With the headache that cures cold, pain in the supra-orbital bone, nasal obstruction,
Nasosinusitis, toothache, leukorrhea, sore swell and ache curative.There is preferable analgesic effect, especially has good effect to headache etc., and have removing toxic substances, disappear
Inflammation effect.
Asarum, warm-natured, acrid flavour.Wind-dispelling, cold dispelling, sensible analgesic, warm lung eliminating the phlegm.With anemofrigid cold is controlled, have a headache, toothache nasal obstruction
Nasosinusitis, rheumatic arthralgia, sputum cough.
Hairyvein agrimony, it is mild-natured, it is bitter, puckery.Astringing to arrest bleeding, preventing malaria, stop dysentery, removing toxic substances.With controlling hemoptysis, haematemesis, metrostaxis, malaria
Disease, bloody flux, de-power internal lesion caused by overexertion, carbuncle sore tumefacting virus, pruritus vulvae leukorrhagia.
Radix pseudostellariae, mild-natured, sweet in flavor, slight bitter.It replenishes qi to invigorate the spleen, is promoting production of body fluid and nourishing the lung.With controlling tired spleen deficiency body, loss of appetite, empty after being ill
Weak, deficiency of both vital energy and Yin, spontaneous perspiration and thirst, dryness of the lung dry cough.
The drug for the treatment of rhinitis of the present invention, is the famous Traditional Chinese Medicine experts Zhang Shun of Changji curry favour Sheng Tang Chinese herbalist clinic
The Chen Zhao unicorn of gift and Bao Rentang Chinese herbalist clinic of Changji city pays chief physician and is added according to the tcm clinical practice experience in more than 50 years
Receive in ancestors' case distinguished unique prescription composed by unique diagnosis and treatment theory, have its " harmony between man and nature and heresy are played,
Its gas must be empty " big data guidance under Overall View, have its " treating both manifestation and root cause of disease " drug combination Dialectics, having it, " righting is dispelled
Heresy, high and level tone sun is close, life activities being normally maintained " balance growth and decline see.In specific medication, screened from the Chinese herbal medicine of over one hundred kind for the treatment of rhinitis
More than ten special efficacy medicinal material out, according to the nature and flavor of each medicine, channel tropism, function, cure mainly and respectively open up its can monarch, minister, assistant, history, it is mutually auxiliary
Xiang Cheng, treating both manifestation and root cause of disease, strengthening vital QI to eliminate pathogenic factors cure rhinitis jointly.
Open for many years, Chen Liangwei expert is in the diagnosis and treatment of a clinical line, to all kinds of acute and chronic rhinitis, allergic rhinitis, nose
Chamber hyperemia, oedema, impotence contracting, the rhinitis suppurated etc., nasosinusitis, the clinical efficacy also all ten that the preceding court of a feudal ruler inflammation of nose, sinus frontalis, jaw sinusitis are treated
Divide satisfaction.Over the past two years, there is partial data, the medical record with statistical significance there are 413, wherein rhinitis chronic 229, allergy
Property rhinitis 167, other Combination rhinitis 17.Treatment results: rhinitis chronic effective percentage 89.1%, allergic rhinitis are efficient
87.4%, chronic nasosinusitis effective percentage 79.4%, total effective rate 87.6%.
Modern antianaphylactic Western medicine (one of chlorpheniramine or cyproheptadine or dexamethasone etc.) is dissolved in Chinese herbal medicine
In, at Chinese and Western medicine combination, curative effect is obviously increased.
The invention has the benefit that
The drug for the treatment of rhinitis of the present invention, by using folium isatidis, dandelion, peppermint, honeysuckle flower, radix scutellariae, raw Huang
Stilbene, the root of Dahurain angelica, asarum, hairyvein agrimony, radix pseudostellariae are raw material and carry out suitable weight proportion, according to the nature and flavor of each medicine, channel tropism, function
Can, cure mainly and respectively open up its can energy monarch, minister, assistant, history, supplement and complement each other, play jointly clearing heat and detoxicating, analgesia, anti-inflammatory, antiallergy,
Effect that is antiviral, improving immunity, enhance antiviral functions, treating both manifestation and root cause of disease, strengthening vital QI to eliminate pathogenic factors cure all kinds of rhinitis jointly, and
Modern Western medicine is added in traditional traditional Chinese medicine recipe, makes the drug for the treatment of rhinitis of the present invention, administration time is short, treatment effect
Fruit is good and stablizes, and does not recur, has no toxic side effect after drug withdrawal, can be suitable for treatment nasosinusitis inflammation, pharyngitis, acute and chronic rhinitis, mistake
Prolong inflammation, nosebleed epistaxis blood, nasal obstruction, nose capsule before quick property nasal cavity hypertrophic rhinit's, atrophic rhinitis, chronic purulent rhinitis, nasosinusitis, nose
It itches and waits diseases.
Specific embodiment
Below with reference to embodiment, the invention will be further described.
1g is represented in following example with 1 parts by weight.
Embodiment 1
The present embodiment provides a kind of drug for treating rhinitis, raw material components include:
5 parts by weight of folium isatidis, 15 parts by weight of dandelion, 5 parts by weight of peppermint, 15 parts by weight of honeysuckle flower, 5 parts by weight of radix scutellariae, life
30 parts by weight of Radix Astragali, 5 parts by weight of the root of Dahurain angelica, 3 parts by weight of asarum, 10 parts by weight of hairyvein agrimony, 30 parts by weight of radix pseudostellariae.
Further, the present invention provides a kind of preparation method of the drug for the treatment of rhinitis, includes the following steps:
Folium isatidis, dandelion, peppermint, honeysuckle flower, radix scutellariae, raw Radix Astragali, the root of Dahurain angelica, asarum, hairyvein agrimony, radix pseudostellariae are weighed respectively,
Through after 60 DEG C of dry 6h, crushing, obtaining partial size is each raw material fine powder of 300 mesh, and each raw material fine powder is filled respectively
Divide mixing, obtains the drug that mixed powder is the treatment rhinitis.
Embodiment 2
The present embodiment provides a kind of drug for treating rhinitis, raw material components include:
15 parts by weight of folium isatidis, 5 parts by weight of dandelion, 15 parts by weight of peppermint, 5 parts by weight of honeysuckle flower, 15 parts by weight of radix scutellariae, life
10 parts by weight of Radix Astragali, 15 parts by weight of the root of Dahurain angelica, 1 parts by weight of asarum, 30 parts by weight of hairyvein agrimony, 10 parts by weight of radix pseudostellariae.
Further, the present invention provides a kind of preparation method of the drug for the treatment of rhinitis, includes the following steps:
Folium isatidis, dandelion, peppermint, honeysuckle flower, radix scutellariae, raw Radix Astragali, the root of Dahurain angelica, asarum, hairyvein agrimony, radix pseudostellariae are weighed respectively,
Through after 90 DEG C of dry 1h, crushing, obtaining partial size is each raw material fine powder of 500 mesh, and each raw material fine powder is filled respectively
Divide mixing, obtains the drug that mixed powder is the treatment rhinitis.
Embodiment 3
The present embodiment provides a kind of drug for treating rhinitis, raw material components include:
8 parts by weight of folium isatidis, 12 parts by weight of dandelion, 8 parts by weight of peppermint, 12 parts by weight of honeysuckle flower, 8 parts by weight of radix scutellariae, life
25 parts by weight of Radix Astragali, 8 parts by weight of the root of Dahurain angelica, 2.5 parts by weight of asarum, 15 parts by weight of hairyvein agrimony, 25 parts by weight of radix pseudostellariae, 0.12 weight
The chlorpheniramine of part (being equivalent to 120mg, ten days dosages are no more than 12mg daily).
Further, the present invention provides a kind of preparation method of the drug for the treatment of rhinitis, includes the following steps:
Folium isatidis, dandelion, peppermint, honeysuckle flower, radix scutellariae, raw Radix Astragali, the root of Dahurain angelica, asarum, hairyvein agrimony, radix pseudostellariae are weighed respectively,
Through after 75 DEG C of dry 3.5h, crushing respectively, obtaining partial size is each raw material fine powder of 400 mesh, and each raw material fine powder is carried out
It is sufficiently mixed, obtains mixed powder；The mixed powder is mixed with chlorpheniramine to get the drug of the treatment rhinitis.
Embodiment 4
The present embodiment provides a kind of drug for treating rhinitis, raw material components include:
12 parts by weight of folium isatidis, 8 parts by weight of dandelion, 12 parts by weight of peppermint, 8 parts by weight of honeysuckle flower, 12 parts by weight of radix scutellariae, life
15 parts by weight of Radix Astragali, 12 parts by weight of the root of Dahurain angelica, 1.5 parts by weight of asarum, 25 parts by weight of hairyvein agrimony, 15 parts by weight of radix pseudostellariae, 0.2 weight
The cyproheptadine (being equivalent to 200mg, ten days dosages are no more than 20mg daily) of part.
Further, the present invention provides a kind of preparation method of the drug for the treatment of rhinitis, includes the following steps:
Folium isatidis, dandelion, peppermint, honeysuckle flower, radix scutellariae, raw Radix Astragali, the root of Dahurain angelica, asarum, hairyvein agrimony, radix pseudostellariae are weighed respectively,
Through after 75 DEG C of dry 4h, crushing, obtaining partial size is each raw material fine powder of 400 mesh, and each raw material fine powder is filled respectively
Divide mixing, obtains mixed powder；The mixed powder is mixed with cyproheptadine to get the drug of the treatment rhinitis.
Embodiment 5
The present embodiment provides a kind of drug for treating rhinitis, raw material components include:
10 parts by weight of folium isatidis, 10 parts by weight of dandelion, 10 parts by weight of peppermint, 10 parts by weight of honeysuckle flower, 10 parts by weight of radix scutellariae,
Raw 20 parts by weight of Radix Astragali, 10 parts by weight of the root of Dahurain angelica, 2 parts by weight of asarum, 20 parts by weight of hairyvein agrimony, 20 parts by weight of radix pseudostellariae, 0.12 weight
The dexamethasone of amount part (being equivalent to 120mg, ten days dosages are no more than 12mg daily).
Further, the present invention provides a kind of preparation method of the drug for the treatment of rhinitis, includes the following steps:
Folium isatidis, dandelion, peppermint, honeysuckle flower, radix scutellariae, raw Radix Astragali, the root of Dahurain angelica, asarum, hairyvein agrimony, radix pseudostellariae are weighed respectively,
Through after 75 DEG C of dry 3.5h, crushing respectively, obtaining partial size is each raw material fine powder of 400 mesh, and each raw material fine powder is carried out
It is sufficiently mixed, obtains mixed powder；The mixed powder is mixed with dexamethasone to get the drug of the treatment rhinitis.
Experimental example
1, pharmacological evaluation is carried out such as to the clearing heat and detoxicating analgesia effect for the treatment of rhinitis drug described in the embodiment of the present invention 5
Under:
According to the dosage of 0.609g/kg to rats gavaged drug of the present invention, body temperature caused by fresh yeast can obviously reduce
It increases, there are antipyretic and antidote functions.
Mouse writhing method and hot plate method experiment show: drug of the present invention can be such that mouse writhing number caused by acetic acid obviously subtracts
Few, administration group is 16.2 ± 8 beats/min, and control group is then 32.4 ± 4.5 times/20 minutes, and is remarkably improved the pain of mouse
Valve has clearing heat and detoxicating analgesic effect.
2, pharmacology reality is carried out to the anti-inflammatory for the treatment of rhinitis drug, antiallergy described in the embodiment of the present invention 5, antiviral drug effect
It tests as follows:
Drug of the present invention is gavaged to gland mouse, display oozes out inflammation to non-specificity caused by carrageenan, there is apparent suppression
Production is used, and caused Experimental Asthma In Guinea-pigs spraying to histamine and acetylcholine have inhibiting effect.
Guinea-pig isolated trachea experiment shows: in the case that the tracheae elastic force caused by histamine and acetylcholine is significantly raised
Drug of the present invention is added, can fight its effect is decreased obviously tracheae tension, until to the normal level before histamine or acetylcholine,
Show that drug of the present invention can fight the effect of the pathergy rhinitis as caused by histamine.
3, immune to the raising for the treatment of rhinitis drug described in the embodiment of the present invention 5 to increase antiviral drug effect progress pharmacology reality
It tests as follows:
According to the dosage of 20g/kg to mouse gavaging drug of the present invention, control group is poured water, and continuous 13 days, as a result two groups of mouse
1gG content is respectively 24.6 ± 28.4mg/ml and 22.2 ± 2.6mg/ml in serum, and thymus gland is respectively 33.4 ± 7.1mg/10g
With 26.4 ± 7.33mg/10g, difference highly significant.Drug of the present invention can effectively enhance the immune function of mouse, make mouse thymus
1gG content dramatically increases in weight and serum.
The present invention is not limited to above-mentioned preferred forms, anyone can show that other are various under the inspiration of the present invention
The product of form, however, make any variation in its shape or structure, it is all that there is skill identical or similar to the present application
Art scheme, is within the scope of the present invention.
Claims (10)
1. a kind of drug for treating rhinitis, which is characterized in that raw material components include:
Folium isatidis 5-15 parts by weight, dandelion 5-15 parts by weight, peppermint 5-15 parts by weight, honeysuckle flower 5-15 parts by weight, radix scutellariae 5-15
Parts by weight, raw Radix Astragali 10-30 parts by weight, root of Dahurain angelica 5-15 parts by weight, asarum 1-3 parts by weight, hairyvein agrimony 10-30 parts by weight, crown prince
Join 10-30 parts by weight.
2. the drug for the treatment of rhinitis according to claim 1, which is characterized in that raw material components include:
Folium isatidis 8-12 parts by weight, dandelion 8-12 parts by weight, peppermint 8-12 parts by weight, honeysuckle flower 8-12 parts by weight, radix scutellariae 8-12
Parts by weight, raw Radix Astragali 15-25 parts by weight, root of Dahurain angelica 8-12 parts by weight, asarum 1.5-2.5 parts by weight, hairyvein agrimony 15-25 parts by weight,
Radix pseudostellariae 15-25 parts by weight.
3. the drug for the treatment of rhinitis according to claim 1, which is characterized in that raw material components include:
10 parts by weight of folium isatidis, 10 parts by weight of dandelion, 10 parts by weight of peppermint, 10 parts by weight of honeysuckle flower, 10 parts by weight of radix scutellariae, raw Huang
20 parts by weight of stilbene, 10 parts by weight of the root of Dahurain angelica, 2 parts by weight of asarum, 20 parts by weight of hairyvein agrimony, 20 parts by weight of radix pseudostellariae.
4. the drug for the treatment of rhinitis according to claim 1, which is characterized in that raw material components further include 0.1-2 parts by weight
Antiallergic, the antiallergic be chlorpheniramine, cyproheptadine or dexamethasone.
5. a kind of method for the drug for preparing the described in any item treatment rhinitis of claim 1-3, which is characterized in that including as follows
Step:
Folium isatidis, dandelion, peppermint, honeysuckle flower, radix scutellariae, raw Radix Astragali, the root of Dahurain angelica, asarum, hairyvein agrimony, radix pseudostellariae are weighed respectively, through dividing
After Gan Zao, not crushing, each raw material fine powder is obtained, each raw material fine powder is sufficiently mixed, obtaining mixed powder is institute
State the drug for the treatment of rhinitis.
6. a kind of method for the drug for preparing treatment rhinitis as claimed in claim 4, which comprises the steps of:
Folium isatidis, dandelion, peppermint, honeysuckle flower, radix scutellariae, raw Radix Astragali, the root of Dahurain angelica, asarum, hairyvein agrimony, radix pseudostellariae are weighed respectively, through dividing
After Gan Zao, not crushing, each raw material fine powder is obtained, each raw material fine powder is sufficiently mixed, mixed powder is obtained；It will be described
Mixed powder is mixed with the antiallergic to get the drug of the treatment rhinitis.
7. preparation method according to claim 5 or 6, which is characterized in that the temperature for carrying out the drying is 60-90 DEG C,
The time for carrying out the drying is 1-6h.
8. the preparation method of the drug for the treatment of rhinitis according to claim 7, which is characterized in that carry out the temperature of the drying
Degree is 75 DEG C, and the time for carrying out the drying is 3.5h.
9. the preparation method of the drug for the treatment of rhinitis according to claim 5 or 6, which is characterized in that each raw material is thin
The partial size of powder is 300-500 mesh.
10. the preparation method of the drug for the treatment of rhinitis according to claim 9, which is characterized in that each raw material fine powder
Partial size be 400 mesh.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104337919A (en) * | 2014-10-15 | 2015-02-11 | 四川金堂海纳生物医药技术研究所 | Internal medicine for treating nasosinusitis and preparation method thereof |
| CN106074883A (en) * | 2016-08-05 | 2016-11-09 | 王豪鹏 | Ginseng stilbene antiallergic rhinitis particle and preparation method thereof |
| CN106214859A (en) * | 2016-08-29 | 2016-12-14 | 凯里市新元药店 | A kind of Chinese medicine formula treating allergic rhinitis |
| CN107375513A (en) * | 2017-09-02 | 2017-11-24 | 桐乡市仟茼家居设计有限公司 | A kind of sachet of home therapy nasosinusitis |
-
2018
- 2018-10-19 CN CN201811219797.9A patent/CN109172698A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104337919A (en) * | 2014-10-15 | 2015-02-11 | 四川金堂海纳生物医药技术研究所 | Internal medicine for treating nasosinusitis and preparation method thereof |
| CN106074883A (en) * | 2016-08-05 | 2016-11-09 | 王豪鹏 | Ginseng stilbene antiallergic rhinitis particle and preparation method thereof |
| CN106214859A (en) * | 2016-08-29 | 2016-12-14 | 凯里市新元药店 | A kind of Chinese medicine formula treating allergic rhinitis |
| CN107375513A (en) * | 2017-09-02 | 2017-11-24 | 桐乡市仟茼家居设计有限公司 | A kind of sachet of home therapy nasosinusitis |
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