CN114099569A - Traditional Chinese medicine composition for treating rhinitis and preventing cold, medicine bag and sachet - Google Patents

Traditional Chinese medicine composition for treating rhinitis and preventing cold, medicine bag and sachet Download PDF

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CN114099569A
CN114099569A CN202010893110.0A CN202010893110A CN114099569A CN 114099569 A CN114099569 A CN 114099569A CN 202010893110 A CN202010893110 A CN 202010893110A CN 114099569 A CN114099569 A CN 114099569A
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陈静
曹海宏
韦劲
金芸
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Shanghai Jiading Nanxiang Hospital
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/532—Agastache, e.g. giant hyssop
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/57—Magnoliaceae (Magnolia family)
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    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/009—Sachets, pouches characterised by the material or function of the envelope
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants

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Abstract

The invention discloses a traditional Chinese medicine composition for treating rhinitis and preventing cold, a medicine bag and a sachet, wherein the traditional Chinese medicine composition comprises the following components in parts by weight: 3-8 parts of wrinkled gianthyssop herb, 3-7 parts of fortune eupatorium herb, 8-15 parts of folium artemisiae argyi, 4-8 parts of radix angelicae, 7-13 parts of biond magnolia flower, 1-3 parts of fried cocklebur fruit, 4-6 parts of mint and 4-8 parts of atractylodes macrocephala; the traditional Chinese medicine composition is filled into a composite fiber bag with a single side having an adhesive effect and good air permeability to prepare a medicine bag, the medicine bag is directly attached to the inner sides of a collar, a shirt pocket and a mask, or the medicine bag is filled into a jute bag to prepare a sachet, oral administration is not required, rhinitis is treated and cold is prevented by adopting a mode of external treatment by sniffing, and long-term use and stable release of the traditional Chinese medicine composition can be ensured by long-term wearing, so that the rhinitis is not easy to relapse after being cured, the treatment effect is improved, and the medical cost is saved.

Description

Traditional Chinese medicine composition for treating rhinitis and preventing cold, medicine bag and sachet
Technical Field
The invention relates to the field of traditional Chinese medicine compositions, in particular to a traditional Chinese medicine composition for treating rhinitis and preventing cold, a medicine bag and a sachet.
Background
Rhinitis refers to inflammation of the nasal mucosa and submucosal tissues; rhinitis is caused by acute or chronic nasal mucosal infections, such as viruses, germs, or irritants. The symptoms of rhinitis are mainly manifested as: nasosinusitis is not easy to blow out due to hypertrophy, mucus or pus; tinnitus and hearing loss can occur; chronic pharyngitis or cough is easy to occur; headache, dizziness, insomnia and listlessness occur; acute rhinitis is an acute inflammatory disease of the nasal mucosa caused by viral infection, also known as cold and common cold, and symptoms comprise nasal obstruction, watery nasal discharge, fever and the like. Chronic allergic rhinitis, also known as allergic rhinitis, is an allergic disease of the nasal mucosa and can cause various complications; sneezing, rhinocnesmus, watery nasal discharge and nasal obstruction are the four most common symptoms; the nasal inflammation cannot be treated in time, not only affects the smell of a patient and the physiological function of a nasal cavity, but also spreads to adjacent organs or tissues, so that the patient is more uncomfortable, and the life and the work of the patient are seriously affected; the existing methods for treating the rhinoinflammation comprise oral medicines, nasal medicines and operations, but the methods have the problems of great side effect and pain of patients in the treatment process; although the existing methods for treating rhinitis also comprise rhinitis patches directly attached to the nose, the way causes poor body feeling of patients and does not fundamentally solve the problem of breathing.
The cold is an acute inflammatory disease of nasal mucosa caused by virus infection, and symptoms of the cold comprise fever, headache, nasal obstruction and the like, which seriously affect the work, study or rest of a patient; in addition, the main symptoms of the pneumonia epidemic situation caused by the novel coronavirus infection from the end of 2019 are cold and fever, so that people are particularly sensitive to cold symptoms, and relevant preventive measures can be taken to prevent the cold symptoms from occurring; however, at present, the method for preventing cold mainly comprises the steps of orally taking isatis root, honeysuckle and antipyretic and the like, but the granular substance with slightly sweet taste is a challenge for some people to take orally, and the effect is single.
In view of the above, there is a need to develop a drug for treating rhinitis and preventing cold, which is not required to be orally taken and is convenient to carry.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide a traditional Chinese medicine composition for treating rhinitis and preventing cold, a medicine bag and a sachet, wherein the traditional Chinese medicine composition is prepared by grinding agastache rugosus, eupatorium fortunei, folium artemisiae argyi, radix angelicae, biond magnolia flower, fried cocklebur fruit, mint, atractylodes macrocephala and the like into powder, the traditional Chinese medicine composition is filled into a composite fiber bag with a single surface having an adhesive effect and good air permeability to prepare the medicine bag, the rhinitis and the cold are treated and prevented by smelling and inhaling in an external treatment mode, the medicine bag is not required to be orally taken and can be directly attached to the inner sides of a collar, a shirt pocket and a mask, or the medicine bag is filled into a hemp bag to prepare the sachet, so that the traditional Chinese medicine composition can be used for a long time and released stably, the rhinitis is not easy to relapse after being cured, the treatment effect is improved, and the medical cost is saved.
In order to achieve the purpose, the invention adopts the following technical scheme:
the invention provides a traditional Chinese medicine composition for treating rhinitis and preventing cold, which comprises the following components in parts by weight: 3-8 parts of wrinkled gianthyssop herb, 3-7 parts of fortune eupatorium herb, 8-15 parts of folium artemisiae argyi, 4-8 parts of radix angelicae, 7-13 parts of biond magnolia flower, 1-3 parts of fried cocklebur fruit, 4-6 parts of mint and 4-8 parts of rhizoma atractylodis.
Preferably, the composition comprises the following components in parts by weight: 5-8 parts of wrinkled gianthyssop herb, 5-6 parts of fortune eupatorium herb, 10-15 parts of folium artemisiae argyi, 5-8 parts of radix angelicae, 8-10 parts of biond magnolia flower, 1-3 parts of fried cocklebur fruit, 4-6 parts of mint and 4-5 parts of rhizoma atractylodis.
Preferably, the composition comprises the following components in parts by weight: 5 parts of wrinkled gianthyssop herb, 5 parts of fortune eupatorium herb, 10 parts of Chinese mugwort leaf, 5 parts of dahurian angelica root, 10 parts of biond magnolia flower, 2 parts of fried cocklebur fruit, 5 parts of mint and 5 parts of swordlike atractylodes rhizome.
Preferably, the traditional Chinese medicine composition is prepared by adopting the following method: firstly putting two hard medicinal materials of rhizoma atractylodis and angelica dahurica into a powder grinding machine for grinding, then putting two dry whole herb medicinal materials of magnolia flower and fried cocklebur fruit and wrinkled gianthyssop and eupatorium into the powder grinding machine for grinding, then respectively putting two dry leaves of folium artemisiae argyi and mint into the powder grinding machine for grinding, and then uniformly mixing the coarse powder and sieving the mixture by a 50-mesh sieve to obtain the traditional Chinese medicine composition.
The second aspect of the invention provides a medicine bag for treating rhinitis and preventing cold, which is prepared by filling the traditional Chinese medicine composition in the first aspect of the invention into a composite fiber bag, compressing and flattening the composite fiber bag, and then sealing the bag opening;
one side of the composite fiber bag is provided with a water-soluble adhesive layer, and the water-soluble adhesive layer is provided with stripping paper.
Preferably, the specification of the composite fiber bag is 1.5-2.5 cm by 1.5-2.5 cm.
Preferably, the mass of the traditional Chinese medicine composition is 10-15 g.
In a third aspect of the invention there is provided a sachet for the treatment of rhinitis and prophylaxis of the common cold, the sachet being prepared by filling a sachet of the second aspect of the invention into a hop-pocket.
The traditional Chinese medicine composition for treating rhinitis and preventing cold has the following effects:
agastache rugosus: pungent in nature and slightly warm in taste; entering lung, spleen and stomach meridians; for nasosinusitis, it is often combined with pig bile; disperse wind-heat, clear head and eyes; antibacterial, antiinflammatory, and skin absorption promoting effects; it can be used for treating neuralgia, skin pruritus, erythra, eczema, etc.
Herba Eupatorii: the eupatorium fortunei has the effects of resolving dampness and relieving summer-heat, and dispelling damp-heat in summer and pestilence qi in influenza in four seasons; huoxiang and Eupatorium fortunei are used in combination to dispel turbidity with aromatics and activate spleen and harmonize stomach.
Folium artemisiae argyi: bitter and pungent in flavor and warm in nature. The folium artemisiae argyi has strong fragrance containing a large amount of phytoncide, can effectively repel mosquitoes and sterilize, treat and prevent influenza and plague, and is a natural bactericide.
Radix angelicae: dispel wind, dispel cold, dry dampness, disperse lung qi, raise yang to clear qi, dredge nasal orifices to alleviate pain.
And (3) magnolia flower: entering lung and stomach channels, moving fragrance, floating body, floating air, specially walking head and eye, and has effects of dispelling pathogenic wind, dispelling cold, dredging obstruction and orifice, and warming and dredging collaterals; main symptoms are headache, nasosinusitis, stuffy nose obstruction and toothache, and the nasal obstruction, watery nasal discharge, bad smell and headache and the like are well treated, and the magnolia flower has the function of astringing to protect nasal mucosa, can promote the absorption of mucosal secretion, relieve inflammation and even ensure that the nasal cavity is unobstructed.
And (3) frying the cocklebur fruit: fructus Xanthii dispels wind-cold, clears nasal orifice, receives qi and stops sneeze; pungent, bitter and warm, entering lung meridian, "dispelling wind and dampness, dredging nasal orifice", obstructed nasal orifice, and obstructed thick nasal discharge, and can be used for treating headache, nasosinusitis, headache, and thick nasal discharge; the whole cocklebur fruit is toxic, the fruit is the most toxic, the young leaf is toxic to the old leaf, the medicine has to be fried for use and can not be used for raw use according to the regulation of pharmacopoeia, and the toxicity can be destroyed by high-temperature treatment or charcoal frying; it is often combined with Yi Xiang, Bai Zhi and Bo He.
Mint: pungent and cool with fragrant smell, light and loose, fragrant and depression relieving, treating exogenous wind-heat pathogen, early epidemic febrile disease, fever and aversion to cold, and is characterized by dispelling wind-heat and clearing head and eyes.
Rhizoma atractylodis: pungent and bitter taste, warm nature; spleen, stomach and liver meridians entered; has the effects of eliminating dampness, strengthening spleen, dispelling wind and cold, improving eyesight and the like; it is combined with Bai Zhi to treat wind-cold exterior syndrome with dampness.
The invention has the beneficial effects that:
1. the traditional Chinese medicine composition for treating rhinitis and preventing cold is prepared by grinding wrinkled gianthyssop herb, fortune eupatorium herb, Chinese mugwort leaf, dahurian angelica root, biond magnolia flower, fried cocklebur fruit, mint, swordlike atractylodes rhizome and the like into powder, has low price and convenient sources of raw materials of the traditional Chinese medicine, helps to treat the rhinitis by absorbing the medicine property of the medicine powder through a nasal cavity, plays roles of clearing away heat and toxic materials, eliminating dampness by fragrance and promoting resuscitation, and has the advantages of lasting medicine property of the traditional Chinese medicine, difficult relapse after the rhinitis is cured, prevention of the cold and alleviation of nasal discomfort caused by the cold after long-term wearing, certain treatment effect on chronic pharyngitis and effects of clearing head and eyes and refreshing brain;
2. the traditional Chinese medicine composition is filled into the composite fiber bag with the single side having the sticking effect and good air permeability to prepare the medicine bag, and the medicine bag can be directly stuck to the inner sides of a collar, a shirt pocket and a mask when being worn, or the medicine bag is filled into a hemp bag to prepare the wearable sachet, so that the medicine bag and the sachet for treating rhinitis and preventing cold have the advantages of simple manufacturing process, low cost, small size and convenience for carrying; the traditional Chinese medicine composition can be used for treating rhinitis and preventing cold by means of external treatment by sniffing, and long-term wearing can ensure long-term use and stable release of the traditional Chinese medicine composition, so that the rhinitis is not easy to relapse after being cured, the treatment effect is improved, and the medical cost is saved.
Detailed Description
The present invention will be described in detail with reference to specific examples. The following examples will assist those skilled in the art in further understanding the invention, but are not intended to limit the invention in any way.
The traditional Chinese medicine composition for treating rhinitis and preventing cold provided by the invention comprises the following components in parts by weight: 3-8 parts of wrinkled gianthyssop herb, 3-7 parts of fortune eupatorium herb, 8-15 parts of folium artemisiae argyi, 4-8 parts of radix angelicae, 7-13 parts of biond magnolia flower, 1-3 parts of fried cocklebur fruit, 4-6 parts of mint and 4-8 parts of rhizoma atractylodis. Further, the traditional Chinese medicine composition for treating rhinitis and preventing cold comprises the following components in parts by weight: 5-8 parts of wrinkled gianthyssop herb, 5-6 parts of fortune eupatorium herb, 10-15 parts of folium artemisiae argyi, 5-8 parts of radix angelicae, 8-10 parts of biond magnolia flower, 1-3 parts of fried cocklebur fruit, 4-6 parts of mint and 4-5 parts of rhizoma atractylodis.
After the materials are mixed according to the proportion, firstly putting two hard medicinal materials of the rhizoma atractylodis and the angelica dahurica into a powder grinding machine for grinding, then putting two dry flower buds of the magnolia flower and the fried cocklebur fruit and two dry whole herb medicinal materials of the wrinkled gianthyssop herb and the eupatorium into the powder grinding machine for grinding, then respectively putting two dry leaves of the folium artemisiae argyi and the mint into the powder grinding machine for grinding, and then uniformly mixing the coarse powder and sieving the mixture by a 50-mesh sieve to obtain the traditional Chinese medicine composition; then weighing 10-15 g of the traditional Chinese medicine composition, filling the traditional Chinese medicine composition into a composite fiber bag with good air permeability and a sticking effect on one side, compressing and flattening the composite fiber bag, and sealing the bag opening to prepare the traditional Chinese medicine composition; the specification of the composite fiber bag is 1.5-2.5 cm x 1.5-2.5 cm, a water-soluble adhesive layer is coated on one surface of the composite fiber bag with good air permeability, then a piece of release paper is pasted on the water-soluble adhesive layer to prevent the composite fiber bag from being pasted on other articles or packages, the release paper is torn off when the composite fiber bag is used, and the composite fiber bag is pasted on a use position to treat rhinitis and prevent cold in an external treatment mode by smelling and inhaling, for example, the composite fiber bag is pasted on the inner sides of collars, shirt pockets and masks (usable in epidemic situations such as flu) or a medicine bag is filled into a hemp bag with good air permeability to prepare a wearable sachet.
The following further describes the traditional Chinese medicine composition, the medicine bag and the sachet for treating rhinitis and preventing cold according to the invention by specific examples;
example 1
The traditional Chinese medicine composition for treating rhinitis and preventing cold comprises the following components in parts by weight: 3 parts of wrinkled gianthyssop herb, 4 parts of fortune eupatorium herb, 8 parts of Chinese mugwort leaf, 6 parts of dahurian angelica root, 7 parts of biond magnolia flower, 3 parts of fried cocklebur fruit, 4 parts of mint and 7 parts of swordlike atractylodes rhizome.
Mixing the materials according to the proportion, and preparing the traditional Chinese medicine composition, the medicine bags and the sachets according to the method, wherein 10-15 g of the traditional Chinese medicine composition is filled in each medicine bag;
example 2
The traditional Chinese medicine composition for treating rhinitis and preventing cold comprises the following components in parts by weight: 8 parts of wrinkled gianthyssop herb, 6 parts of fortune eupatorium herb, 15 parts of Chinese mugwort leaf, 8 parts of dahurian angelica root, 10 parts of biond magnolia flower, 2 parts of fried cocklebur fruit, 5 parts of mint and 4 parts of swordlike atractylodes rhizome.
Mixing the materials according to the proportion, and preparing the traditional Chinese medicine composition, the medicine bags and the sachets according to the method, wherein 10-15 g of the traditional Chinese medicine composition is filled in each medicine bag;
example 3
The traditional Chinese medicine composition for treating rhinitis and preventing cold comprises the following components in parts by weight: 5 parts of wrinkled gianthyssop herb, 5 parts of fortune eupatorium herb, 10 parts of Chinese mugwort leaf, 5 parts of dahurian angelica root, 10 parts of biond magnolia flower, 2 parts of fried cocklebur fruit, 5 parts of mint and 5 parts of swordlike atractylodes rhizome.
Mixing the materials according to the proportion, and preparing the traditional Chinese medicine composition, the medicine bags and the sachets according to the method, wherein 10-15 g of the traditional Chinese medicine composition is filled in each medicine bag;
example 4
The traditional Chinese medicine composition for treating rhinitis and preventing cold comprises the following components in parts by weight: 6 parts of wrinkled gianthyssop herb, 7 parts of fortune eupatorium herb, 14 parts of Chinese mugwort leaf, 7 parts of dahurian angelica root, 13 parts of biond magnolia flower, 3 parts of fried cocklebur fruit, 6 parts of mint and 5 parts of swordlike atractylodes rhizome.
Mixing the materials according to the proportion, and preparing the traditional Chinese medicine composition, the medicine bags and the sachets according to the method, wherein 10-15 g of the traditional Chinese medicine composition is filled in each medicine bag;
example 5
The traditional Chinese medicine composition for treating rhinitis and preventing cold comprises the following components in parts by weight: 5 parts of wrinkled gianthyssop herb, 5 parts of fortune eupatorium herb, 10 parts of Chinese mugwort leaf, 5 parts of dahurian angelica root, 7 parts of biond magnolia flower, 2 parts of fried cocklebur fruit, 5 parts of mint and 5 parts of swordlike atractylodes rhizome.
Mixing the materials according to the proportion, and preparing the traditional Chinese medicine composition, the medicine bags and the sachets according to the method, wherein 10-15 g of the traditional Chinese medicine composition is filled in each medicine bag;
example 6
The traditional Chinese medicine composition for treating rhinitis and preventing cold in the comparative example is the same as other components in example 3, and 9 parts of magnolia flower is weighed and comprises the following components in parts by weight: 5 parts of wrinkled gianthyssop herb, 5 parts of fortune eupatorium herb, 10 parts of Chinese mugwort leaf, 5 parts of dahurian angelica root, 9 parts of biond magnolia flower, 2 parts of fried cocklebur fruit, 5 parts of mint and 5 parts of swordlike atractylodes rhizome.
Mixing the materials according to the proportion, and preparing the traditional Chinese medicine composition, the medicine bags and the sachets according to the method, wherein 10-15 g of the traditional Chinese medicine composition is filled in each medicine bag;
example 7:
the traditional Chinese medicine composition for treating rhinitis and preventing cold comprises the following components in parts by weight: 5 parts of wrinkled gianthyssop herb, 5 parts of fortune eupatorium herb, 10 parts of Chinese mugwort leaf, 5 parts of dahurian angelica root, 13 parts of biond magnolia flower, 2 parts of fried cocklebur fruit, 5 parts of mint and 5 parts of swordlike atractylodes rhizome.
Mixing the materials according to the proportion, and preparing the traditional Chinese medicine composition, the medicine bags and the sachets according to the method, wherein 10-15 g of the traditional Chinese medicine composition is filled in each medicine bag;
comparative example:
the traditional Chinese medicine composition for treating rhinitis and preventing cold in the comparative example is the same as other components in example 3, omits magnolia flower and comprises the following components in parts by weight: 5 parts of wrinkled gianthyssop herb, 5 parts of fortune eupatorium herb, 10 parts of Chinese mugwort leaf, 5 parts of dahurian angelica root, 2 parts of fried siberian cocklebur fruit, 5 parts of mint and 5 parts of swordlike atractylodes rhizome.
Mixing the materials according to the proportion, and preparing the traditional Chinese medicine composition, the medicine bags and the sachets according to the method, wherein 10-15 g of the traditional Chinese medicine composition is filled in each medicine bag;
the effects of examples 1-4 and comparative examples were examined in combination with clinical trial data as follows:
therapeutic effect on rhinitis
1.1, 400 outpatients of rhinitis are collected from general materials within 6 months of 2017 to 2020 and within 6 months of 2020, wherein the age range of the patients is 12-65 years, 200 men and 200 women have the disease course of 0.5-5 years. The traditional Chinese medicine composition is divided into 8 groups according to a completely random principle, wherein each group comprises 50 cases which are respectively marked as a first treatment group, a second treatment group, a third treatment group, a fourth treatment group, a fifth treatment group, a sixth treatment group, a seventh treatment group and a control group, and the age, the sex, the main symptoms, the disease course and the like of 8 groups of patients have no significant difference and are comparable.
1.2 case grouping criteria
Inclusion: according to the clinical manifestations and pathological characteristics of rhinitis patients, but the gender and age are not limited, excluding: patients in pregnancy and lactation period stop taking various other medicines and treatment modes for treating rhinitis before treatment.
1.3, test method: the first treatment group was wearing the drug bag prepared in example 1; the second treatment group was wearing the drug bag prepared in example 2; the third treatment group was worn with the drug bag prepared in example 3; the fourth treatment group was worn with the drug bag prepared in example 4; the fifth treatment group was wearing the drug bag prepared in example 5; the sixth treatment group was fitted with the drug bag prepared in example 6; the seventh treatment group was fitted with the drug bag prepared in example 7; the fourth control group was worn with the drug pouch prepared in the comparative example; the total wearing time of each group of people is not less than 3 hours/day, the change is carried out every 2-3 days, 7 days are 1 course of treatment, and 4 courses of treatment are observed.
1.4, standard of therapeutic effect
And (3) healing: the rhinitis symptom disappears, and no relapse occurs within half a year of follow-up visit;
improvement: the rhinitis symptom is obviously relieved;
and (4) invalidation: the change before and after treatment is not large;
poor: the symptoms of rhinitis worsen after treatment;
the total effective rate (%). the proportion of the cured and improved cases in each group accounts for all cases;
recurrence rate (%): the proportion of the relapsing cases in each group after recovery is the proportion of the recovery cases.
1.5 therapeutic results
TABLE 1 treatment statistics
Figure BDA0002657607060000071
Figure BDA0002657607060000081
The results in table 1 show that more than 56% of patients in the treatment group can be effectively treated, which indicates that the effect of the traditional Chinese medicine composition prepared into portable sachets or scented tablets for treating rhinitis is obvious. It is known from the third treatment group, the fifth treatment group, the sixth treatment group, the seventh treatment group and the control group that the treatment effect of rhinitis can be improved by adding magnolia flower under the condition that other components are not changed, but the total effective rate of treatment is affected by too little or too much content of the magnolia flower, wherein under the condition that other components are not changed, when the content of the magnolia flower is 10 parts, the total effective rate of treatment is far higher than the condition that the magnolia flower is not added or a large amount of the magnolia flower is added, because the magnolia flower has the functions of convergence and protection on nasal mucosa, can reduce secretion, expand local microvessels, promote absorption of nasal secretion and resolution of inflammation, has the functions of anti-inflammation, analgesia and anti-allergy, and is more favorable for exerting the treatment effect.
Second, Cold prevention Effect
2.1, 400 outpatients with the cold of more than 4 times per year are collected in 6 months to 2020 in 2017 of general materials, wherein the age range of the patients is 12-65 years, and 200 men and 200 women are in the age range. The patients were divided into 8 groups according to the completely random principle, and each group was divided into 50 cases, which were respectively recorded as observation 1 group, observation 2 group, observation 3 group, observation 4 group, observation 5 group, observation 6 group, observation 7 group and control group, and the age, sex and symptoms of cold of the 8 patients were comparable without significant difference.
2.2 case grouping criteria
Inclusion criteria were: the diagnosis of common cold is based on the diagnosis standard of clinical research guiding principle of new Chinese medicine for treating common cold; the main symptoms are: marked fever, slight aversion to wind, obstructed sweating, dry throat, or red, swollen and painful tonsillitis in throat, nasal obstruction, yellow and turbid nasal discharge, and superficial and rapid pulse. The secondary symptoms are as follows: distending pain in the head, cough, sticky or yellow sputum, thirst with desire for water, thin and yellowish tongue coating, and red tongue edge and tip.
Exclusion criteria: (1) pregnant and lactating women; (2) psychotic patients; (3) those with severe primary disease involving heart, liver, kidney function and hematopoietic system; (4) those who have used other therapeutic drugs; (5) allergic constitution or people allergic to various drugs.
2.3, test method: observation 1 group was worn with the drug bag prepared in example 1; observe 2 groups wearing the drug bags prepared in example 2; observe 3 groups wearing the drug bags prepared in example 3; observe 4 groups wearing the drug bags prepared in example 4; observation of 5 groups wearing the drug bags prepared in example 5; observe 6 groups wearing the drug bags prepared in example 6; observation of 7 groups wearing the drug bags prepared in example 7; the control group was worn with the drug pouch prepared in the comparative example; the total wearing time of each group of people is not less than 3 hours/day, 1 month is 1 course of treatment, each course of treatment is replaced once, and the observation period is 12 courses of treatment.
2.4 therapeutic criteria
The method is completely effective: no cold symptoms occur in the observation period;
the effect is remarkable: cold is caused for 1-2 times in an observation period;
and (4) invalidation: the number of cold in the observation period is basically the same as that before wearing;
poor: the number of cold increases during the observation period;
total effective rate (%): significant and effective cases in each group account for the proportion of all cases.
2.4, prevention of outcome
TABLE 2 preventive statistics
Figure BDA0002657607060000091
The results in table 2 show that after patients who have a cold more than 4 times per year in the observation group wear the medicine bag of the present invention for a long time, the cold frequency of more than 78% of the patients is obviously reduced, and by combining the observation of 3 groups, the observation of 5 groups, the observation of 6 groups, the observation of 7 groups and the comparison group, it is obvious that magnolia flower plays a key role in preventing the cold, under the condition that other components are not changed, the effect of preventing the cold can be improved by adding magnolia flower, but the total effective rate of preventing the cold is affected by too little or too much magnolia flower, wherein under the condition that other components are not changed, when the content of the magnolia flower is 10 parts, the total effective rate of preventing the cold is far higher than that of preventing the cold when the content of the magnolia flower is too high or too low, because the magnolia flower has the effects of dispelling wind cold and relieving stuffy nose, has the anti-inflammatory, analgesic and antiallergic effects, and is beneficial to the improvement of cold symptoms.
Although the present invention has been described in detail with reference to the preferred embodiments, it will be understood by those skilled in the art that various changes may be made and equivalents may be substituted without departing from the spirit and scope of the invention as defined in the appended claims.

Claims (8)

1. The traditional Chinese medicine composition for treating rhinitis and preventing cold is characterized by comprising the following components in parts by weight: 3-8 parts of wrinkled gianthyssop herb, 3-7 parts of fortune eupatorium herb, 8-15 parts of folium artemisiae argyi, 4-8 parts of radix angelicae, 7-13 parts of biond magnolia flower, 1-3 parts of fried cocklebur fruit, 4-6 parts of mint and 4-8 parts of atractylodes macrocephala.
2. The traditional Chinese medicine composition of claim 1, which comprises the following components in parts by weight: 5-8 parts of wrinkled gianthyssop herb, 5-6 parts of fortune eupatorium herb, 10-15 parts of folium artemisiae argyi, 5-8 parts of radix angelicae, 8-10 parts of biond magnolia flower, 1-3 parts of fried cocklebur fruit, 4-6 parts of mint and 4-5 parts of atractylodes macrocephala.
3. The traditional Chinese medicine composition of claim 2, which comprises the following components in parts by weight: 5 parts of wrinkled gianthyssop herb, 5 parts of fortune eupatorium herb, 10 parts of Chinese mugwort leaf, 5 parts of dahurian angelica root, 10 parts of biond magnolia flower, 2 parts of fried cocklebur fruit, 5 parts of mint and 5 parts of atractylodes macrocephala.
4. The traditional Chinese medicine composition of claim 1, which is prepared by the following method: firstly putting two hard medicinal materials of atractylodes rhizome and angelica dahurica into a powder grinding machine for grinding, then putting two dry whole herb medicinal materials of magnolia flower and fried cocklebur fruit and wrinkled giant hyssop and eupatorium into the powder grinding machine for grinding, then respectively putting two dry leaves of Chinese mugwort leaf and mint into the powder grinding machine for grinding, and then uniformly mixing the coarse powder and sieving by a 50-mesh sieve to obtain the traditional Chinese medicine composition.
5. A medicine bag for treating rhinitis and preventing cold is characterized in that the medicine bag is prepared by filling the traditional Chinese medicine composition as claimed in any one of claims 1 to 4 into a composite fiber bag, compressing and flattening the composite fiber bag, and then sealing the bag opening;
one side of the composite fiber bag is provided with a water-soluble adhesive layer, and the water-soluble adhesive layer is provided with stripping paper.
6. The drug pouch of claim 5, wherein the composite fiber pouch has a gauge of 1.5 to 2.5cm by 1.5 to 2.5 cm.
7. The drug bag according to claim 5, wherein the mass of the traditional Chinese medicine composition is 10-15 g.
8. A sachet for the treatment of rhinitis and prevention of cold, wherein the sachet is prepared by filling the drug bag of claim 5 into a hop-pocket.
CN202010893110.0A 2020-08-31 2020-08-31 Traditional Chinese medicine composition for treating rhinitis and preventing cold, medicine bag and sachet Pending CN114099569A (en)

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Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
张建文: "香花汤闻吸治疗过敏性鼻炎", 《山西中医》 *
方敏: "中药气雾治疗鼻咽喉疾病", 《中国中西医结合耳鼻咽喉科杂志》 *

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