CN104337919A - Internal medicine for treating nasosinusitis and preparation method thereof - Google Patents

Internal medicine for treating nasosinusitis and preparation method thereof Download PDF

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Publication number
CN104337919A
CN104337919A CN201410542835.XA CN201410542835A CN104337919A CN 104337919 A CN104337919 A CN 104337919A CN 201410542835 A CN201410542835 A CN 201410542835A CN 104337919 A CN104337919 A CN 104337919A
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medicine
parts
herba
sinusitis
grams
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夏瑜
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Sichuan Jintang Haina Biomedical Technology Institute
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Sichuan Jintang Haina Biomedical Technology Institute
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00Medicinal preparations containing inorganic active ingredients
    • A61K33/06Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185Magnoliopsida (dicotyledons)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288Taraxacum (dandelion)
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/31Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
    • A61K36/315Isatis, e.g. Dyer's woad
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/35Caprifoliaceae (Honeysuckle family)
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539Scutellaria (skullcap)
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    • A61K36/57Magnoliaceae (Magnolia family)
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/70Polygonaceae (Buckwheat family), e.g. spineflower or dock
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    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

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Abstract

The invention discloses an internal medicine for treating nasosinusitis and a preparation method thereof. The medicine comprises the following components in parts by mass: 1-3 parts of dandelion, 1-3 parts of honeysuckle flower, 1-3 parts of scutellaria baicalensis, 1-3 parts of folium isatidis, 1-3 parts of cordate houttuynia, 1-3 parts of cocklebur fruit, 1-3 parts of asarum, 1-3 parts of gypsum, 1-3 parts of magnolia denudata desr. and 1-3 parts of radix angelicae. The preparation method of the medicine comprises the following steps: purchasing high-quality and clean dandelion, honeysuckle flower, scutellaria baicalensis, folium isatidis, cordate houttuynia, cocklebur fruit, asarum, gypsum, magnolia denudata desr. and radix angelicae, and grinding the purchased materials into granules for later use; storing the granular materials in a cloth bag and tying up; soaking the cloth bag in cold boiled water for 20min, putting the soaked medicines and clear liquid for soaking the medicines in an earthen pot, adding proper amount of cold boiled water, decocting for 50min by heavy fire and slow fire sequentially, filtering and reserving 600ml of medicinal decoction, and sealing.

Description

A kind of endo-medicine for the treatment of sinusitis and preparation method thereof
Technical field
The present invention relates to field of Chinese herbal medicine technology, be specifically related to a kind of endo-medicine for the treatment of sinusitis, particularly for the field of the endo-medicine and preparation method thereof of sinusitis in patients.
Background technology
Sinusitis is the nonspecific inflammation of sinus mucosa, for a kind of nose section common frdquently encountered disease, so-called nasal sinuses is the gassiness cavity of bones of facial cranium around nasal cavity, it is 4 right that left and right has: claim sinus frontalis, maxillary sinus, sieve hole and sphenoid sinus, because each hole of its anatomical features can be fallen ill separately, also polysinusitis or pansinusitis can be formed.Primary disease is generally divided into acute and chronic 2 classes, and its reason is a lot, and more complicated, acute sinusitis is many to be caused by acute rhinitis, and chronic sinusitis is often because acute sinusitis fails thoroughly to cure or recurrent exerbation and being formed.In addition: sewage enters nasal sinuses, adjacent organs infects diffusion, and rhino tumor hinders nasal sinuses drain, and wound etc. all can cause sinusitis.
So, just how finding a kind of medicine effectively can treating above-mentioned sinusitis, is our current problem in urgent need to solve.
Summary of the invention
The object of this invention is to provide a kind of endo-medicine for the treatment of sinusitis and preparation method thereof, to solve sinusitis in patients's restorative problem early.This medicine is that have meticulous allotment, compatibility is investigated, and the efficacy of a drug is powerful, hit pathogenesis with common Chinese herbal medicine for raw material, has fully demonstrated lung heat clearing and has rushed down harmonization of the stomach removing toxic substances and to dispel dirty Therapeutic Principle.
For reaching the object of foregoing invention, the technical solution adopted in the present invention is: provide a kind of endo-medicine for the treatment of sinusitis and preparation method thereof, it is characterized in that, each component of described medicine and mass parts thereof are than as follows:
Herba Taraxaci 1-3 part;
Flos Lonicerae 1-3 part;
Radix Scutellariae 1-3 part;
Folium Isatidis 1-3 part;
Herba Houttuyniae 1-3 part;
Fructus Xanthii 1-3 part;
Herba Asari 1-3 part;
Gypsum Fibrosum 1-3 part;
Flos Magnoliae 1-3 part;
Radix Angelicae Dahuricae 1-3 part.
According to the endo-medicine for the treatment of sinusitis provided by the present invention, it is characterized in that, each component of described medicine and mass parts thereof are than as follows:
Herba Taraxaci 1 part;
Flos Lonicerae 1 part;
Radix Scutellariae 1 part;
Folium Isatidis 1 part;
Herba Houttuyniae 1 part;
Fructus Xanthii 1 part;
Herba Asari 1 part;
Gypsum Fibrosum 1 part;
Flos Magnoliae 1 part;
The Radix Angelicae Dahuricae 1 part.
A kind of endo-medicine for the treatment of sinusitis and preparation method thereof, is characterized in that, described method comprises the steps:
A, choose the clean Herba Taraxaci of high-quality 1 part, Flos Lonicerae 1 part, Radix Scutellariae 1 part, Folium Isatidis 1 part, Herba Houttuyniae 1 part, Fructus Xanthii 1 part, Herba Asari 1 part, Gypsum Fibrosum 1 part, Flos Magnoliae 1 part, the Radix Angelicae Dahuricae 1 part, be ground into graininess altogether for subsequent use;
B, by after tying in granular medicament splendid attire to cloth bag, soak 20 minutes in cold boiled water, and then the clear liquor of soaked medicine and soak medicine is put in sand tank in the lump, insert appropriate cold boiled water, slow fire boiling 50 minutes after first intense fire, after drug decocting is good, leaching herb liquid 600 milliliters seals.
A kind of endo-medicine for the treatment of sinusitis and preparation method thereof, is characterized in that, described instructions of taking is: will decoct well-done herb liquid potion every day, the morning, noon and afternoon service once, dosage 200 milliliters/time, taking medicine before meal.Take medicine after 5-9 agent, disease obtains recovery from illness.
Medicine provided by the present invention is oral traditional Chinese medicine composition, and it for raw material, gives full play to the property of medicine of each component with common Chinese herbal medicine:
Herba Taraxaci, nature and flavor: cold in nature, bitter in the mouth, sweet, have effect of heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome, are used for the treatment of acute mastitis, scrofula, furuncle swelling toxin, pharyngalgia, lung abscess, acute appendicitis, conjunctival congestion, jaundice due to damp-heat, the puckery pain of pyretic stranguria;
Flos Lonicerae, nature and flavor: sweet in the mouth, cold in nature, have heat-clearing and toxic substances removing, dispelling wind and heat pathogens, dredge effect of throat, relieving restlessness of relieving summer heat, be used for the treatment of the diseases such as febrile disease due to summer-heat pathogen, dysentery, influenza, furuncle toxic swelling, acute and chronic tonsillitis, periodontitis;
Radix Scutellariae, nature and flavor: bitter, cold, have heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive effect, be used for the treatment of hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tell nosebleed, carbuncle sore tumefacting virus, frequent fetal movement;
Folium Isatidis, nature and flavor: bitter, salty, Great Cold, have the function of clearing away heat and cooling blood, Xie Xin, gastric heat poison, are used for the treatment of influenza, calentura sends out speckle, pharyngolaryngitis, tonsillitis, parotitis, epidemic encephalitis, enteritis, bacillary dysentery;
Herba Houttuyniae, nature and flavor: pungent, cold, there is effect of heat-clearing and toxic substances removing, removing pus and relieving carbuncle, inducing diuresis for treating stranguria syndrome, be used for the treatment of lung abscess vomiting pus, expectorant dyspnea of heat type is coughed, larynx Oh, hematodiarrhoea, carbuncle sore tumefacting virus, pyretic stranguria;
Fructus Xanthii, nature and flavor: sweetness and bitterness temperature, slightly poisonous, there is diaphoresis, loose wind, the effect of drying, be used for the treatment of headche due to wind-cold, nasal sinusitis, arthralgia pain contracture;
Herba Asari, nature and flavor: pungent, warm, have dispel the wind, cold expelling, Hang Shui, the effect of having one's ideas straightened out, be used for the treatment of anemofrigid cold, air-cooled headache, nasal obstruction nasal sinusitis, toothache, phlegm retention cough with dyspnea, rheumatic arthralgia, phlegm retention breath with cough;
Gypsum Fibrosum, nature and flavor: acrid in the mouth, sweet, cold in nature, there is expelling pathogenic factors from muscles for clearing heat, relieving restlessness is quenched the thirst, heat-clearing and toxic substances removing, rush down effect of fire, be used for the treatment of that calentura high fever does not move back, vexed coma, delirium are gone mad, the headache of thirsty and dry pharynx, lung-heat dyspnea with rapid respiration, heatstroke spontaneous perspiration, stomach-fire, toothache, hyperactivity of toxic heat, send out speckle dermexanthesis, aphtha of the mouth and tongue, forge deposited promoting tissue regeneration and ulcer healing;
Flos Magnoliae, nature and flavor: pungent, warm, have effect of dispersing wind and cold, clearing the nasal passage, are used for the treatment of headche due to wind-cold, nasal obstruction, nasal sinusitis, turbid nasal discharge;
The Radix Angelicae Dahuricae, nature and flavor: acrid in the mouth, warm in nature, have dispel the wind, effect of cold relieving, dampness, understand things pain-stopping, detumescence and apocenosis, be used for the treatment of anemofrigid cold headache, eyebrow shuttle osteodynia, nasal obstruction, toothache, leucorrhea, skin infection swell and ache.
When taking, will decoct well-done herb liquid potion every day, the morning, noon and afternoon service once, dosage 200 milliliters/time, taking medicine before meal.Take medicine after 5-9 agent, disease obtains recovery from illness.This medicine is that have meticulous allotment, compatibility is investigated, and the efficacy of a drug is powerful, hit pathogenesis with common Chinese herbal medicine for raw material, has fully demonstrated lung heat clearing and has rushed down harmonization of the stomach removing toxic substances and to dispel dirty Therapeutic Principle.
Detailed description of the invention
Below embodiments of the present invention are described in detail
Sinusitis is the nonspecific inflammation of sinus mucosa, for a kind of nose section common frdquently encountered disease, so-called nasal sinuses is the gassiness cavity of bones of facial cranium around nasal cavity, it is 4 right that left and right has: claim sinus frontalis, maxillary sinus, sieve hole and sphenoid sinus, because each hole of its anatomical features can be fallen ill separately, also polysinusitis or pansinusitis can be formed.Primary disease is generally divided into acute and chronic 2 classes, and its reason is a lot, and more complicated, acute sinusitis is many to be caused by acute rhinitis, and chronic sinusitis is often because acute sinusitis fails thoroughly to cure or recurrent exerbation and being formed.In addition: sewage enters nasal sinuses, adjacent organs infects diffusion, and rhino tumor hinders nasal sinuses drain, and wound etc. all can cause sinusitis.
The present invention is exactly treatment for above-mentioned sinusitis and a kind of Chinese herbal medicine formula proposed, and the medicine effect adopting this formula to prepare is good, instant effect, and toxic and side effects is little, effectively can treat sinusitis.Below specific embodiment provided by the present invention is described in detail.
Embodiment 1:
Choose the clean Herba Taraxaci of high-quality 31 grams, Flos Lonicerae 31 grams, Radix Scutellariae 13 grams, Folium Isatidis 16 grams, Herba Houttuyniae 31 grams, Fructus Xanthii 15 grams, Herba Asari 4 grams, Gypsum Fibrosum 31 grams, Flos Magnoliae 10 grams, the Radix Angelicae Dahuricae 13 grams, be ground into graininess altogether for subsequent use; After tying in granular medicament splendid attire to cloth bag, soak 20 minutes in cold boiled water, and then the clear liquor of soaked medicine and soak medicine is put in sand tank in the lump, insert appropriate cold boiled water, slow fire boiling 50 minutes after first intense fire, after drug decocting is good, leaching herb liquid 600 milliliters seals.When taking, will decoct well-done herb liquid potion every day, the morning, noon and afternoon service once, dosage 200 milliliters/time, taking medicine before meal.Take medicine after 5-9 agent, disease obtains recovery from illness.
Embodiment 2:
Choose the clean Herba Taraxaci of high-quality 37 grams, Flos Lonicerae 37 grams, Radix Scutellariae 15 grams, Folium Isatidis 19 grams, Herba Houttuyniae 37 grams, Fructus Xanthii 16 grams, Herba Asari 4.5 grams, Gypsum Fibrosum 37 grams, Flos Magnoliae 12 grams, the Radix Angelicae Dahuricae 15 grams, be ground into graininess altogether for subsequent use; After tying in granular medicament splendid attire to cloth bag, soak 20 minutes in cold boiled water, and then the clear liquor of soaked medicine and soak medicine is put in sand tank in the lump, insert appropriate cold boiled water, slow fire boiling 50 minutes after first intense fire, after drug decocting is good, leaching herb liquid 600 milliliters seals.When taking, will decoct well-done herb liquid potion every day, the morning, noon and afternoon service once, dosage 200 milliliters/time, taking medicine before meal.Take medicine after 5-7 agent, disease obtains recovery from illness.
Embodiment 3:
Choose the clean Herba Taraxaci of high-quality 31 grams, Flos Lonicerae 31 grams, Radix Scutellariae 13 grams, Folium Isatidis 16 grams, Herba Houttuyniae 31 grams, Fructus Xanthii 15 grams, Herba Asari 4 grams, Gypsum Fibrosum 31 grams, Flos Magnoliae 10 grams, the Radix Angelicae Dahuricae 13 grams, be ground into graininess altogether for subsequent use; After tying in granular medicament splendid attire to cloth bag, soak 20 minutes in cold boiled water, and then the clear liquor of soaked medicine and soak medicine is put in sand tank in the lump, insert appropriate cold boiled water, slow fire boiling 50 minutes after first intense fire, after drug decocting is good, leaching herb liquid 600 milliliters seals.When taking, will decoct well-done herb liquid potion every day, the morning, noon and afternoon service once, dosage 200 milliliters/time, taking medicine before meal.Take medicine after 5-8 agent, disease obtains recovery from illness.
Embodiment 4:
Choose the clean Herba Taraxaci of high-quality 37 grams, Flos Lonicerae 37 grams, Radix Scutellariae 15 grams, Folium Isatidis 19 grams, Herba Houttuyniae 37 grams, Fructus Xanthii 16 grams, Herba Asari 4.5 grams, Gypsum Fibrosum 37 grams, Flos Magnoliae 12 grams, the Radix Angelicae Dahuricae 15 grams, be ground into graininess altogether for subsequent use; After tying in granular medicament splendid attire to cloth bag, soak 20 minutes in cold boiled water, and then the clear liquor of soaked medicine and soak medicine is put in sand tank in the lump, insert appropriate cold boiled water, slow fire boiling 50 minutes after first intense fire, after drug decocting is good, leaching herb liquid 600 milliliters seals.When taking, will decoct well-done herb liquid potion every day, the morning, noon and afternoon service once, dosage 200 milliliters/time, taking medicine before meal.Take medicine after 5-7 agent, disease obtains recovery from illness.
The present invention is through the treatment of the routine patient of logarithm one hundred, and therapeutic effect is remarkable, and toxic and side effects is little, and part allusion quotation shape case is as follows.
1, patient: Peng XX, female, 57 years old, address: Chengdu, Sichuan Province
Illness symptom: Chengdu, Sichuan Province state-owned enterprise cadre, first visit on May 13 in 2003.Patient flows in left nostril more than yellow pus sample turbid tears January, breathes also to feel its abnormal smells from the patient and smell as of rotten fish time serious, and eyebrow volume and eye socket pain, mouth breathing is slept, and body of the tongue is purple, and yellow and thin fur, moderate pulse is large.
Treatment: throw top treatment, every day potion, take medicine after four doses, turbid tears are thinning, but still have a small amount of pus sample thing, play bad smell morning and alleviate, advise it to renew and take three doses, and nasal mucus is normal, without bad smell, all disease disappearances, and fully recovering.Follow up a case by regular visits to 2 years, all are normal.
2, patient: Liu XX, man, 49 years old, address: Wu Hou district, Chengdu
Illness symptom: in first visit on May 21 in 2010.Patient feels that right nose is uncomfortable, and the yellow pus sample turbid tears several months is flowed out in nostril, and breathe also sense abnormal smells from the patient time serious and smell as of rotten fish, eyebrow volume, eye socket pain, mouth breathing during sleep, is diagnosed as sinusitis.
Treatment: throw top treatment, every day potion, take medicine after five doses, symptom disappears substantially, and advise it to consolidate again and take medicine three doses, symptom all disappears, and disease obtains recovery from illness.Within 1 year, follow up a case by regular visits to twice, no abnormality seen.
3, patient: neat XX, female, 51 years old, address: Jinniu District, Chengdu
Illness symptom: Sichuan Province Ziyang City county government functionary, on July 1st, 2011 goes to a doctor.The turbid tears of yellow pus sample are flowed more than three month in the left nostril of readme, also feel abnormal smells from the patient and smell as of rotten fish, eyebrow volume, eye socket pain during breathing, and sleep of dehiscing, body of the tongue is purple, yellow and thin fur.
Treatment: throw top treatment, every day potion, check after three doses of taking medicine, turbid tears are slightly thinning, but still have pus sample thing, and playing stench alleviating morning, advising it to renew and take three doses, all diseases disappear and fully recover.Follow up a case by regular visits to 3 year, all are normal.
4, patient: thank XX, man, 63 years old, address: Jintang County, Chengdu
Illness symptom: patient feels that right nose is uncomfortable, and the turbid tears of yellow pus sample are flowed out many months in nostril, time serious, breathe also sense abnormal smells from the patient and smell as of rotten fish, eyebrow volume, eye socket pain, mouth breathing during sleep, is " sinusitis " after diagnosing.
Treatment: throw top treatment, every day, potion, took medicine after five doses, and transference cure is obvious, and advise it to consolidate again and take medicine three doses, symptom all disappears, and fully recovers.Within 1 year, follow up a case by regular visits to three time, no abnormality seen.

Claims (3)

1. treat an endo-medicine for sinusitis, it is characterized in that, each component of described medicine and mass parts thereof are than as follows:
Herba Taraxaci 1-3 part;
Flos Lonicerae 1-3 part;
Radix Scutellariae 1-3 part;
Folium Isatidis 1-3 part;
Herba Houttuyniae 1-3 part;
Fructus Xanthii 1-3 part;
Herba Asari 1-3 part;
Gypsum Fibrosum 1-3 part;
Flos Magnoliae 1-3 part;
Radix Angelicae Dahuricae 1-3 part.
2. the endo-medicine for the treatment of sinusitis according to claim 1, is characterized in that, each component of described medicine and mass parts thereof are than as follows:
Herba Taraxaci 1 part;
Flos Lonicerae 1 part;
Radix Scutellariae 1 part;
Folium Isatidis 1 part;
Herba Houttuyniae 1 part;
Fructus Xanthii 1 part;
Herba Asari 1 part;
Gypsum Fibrosum 1 part;
Flos Magnoliae 1 part;
The Radix Angelicae Dahuricae 1 part.
3. endo-medicine of the treatment sinusitis described in a claim 1 or 2 and preparation method thereof, is characterized in that, described method comprises the steps:
A, according to mass parts than choosing the clean Herba Taraxaci of high-quality, Flos Lonicerae, Radix Scutellariae, Folium Isatidis, Herba Houttuyniae, Fructus Xanthii, Herba Asari, Gypsum Fibrosum, Flos Magnoliae, the Radix Angelicae Dahuricae, be ground into graininess altogether for subsequent use;
B, by after tying in granular medicament splendid attire to cloth bag, soak 20 minutes in cold boiled water, and then the clear liquor of soaked medicine and soak medicine is put in sand tank in the lump, insert appropriate cold boiled water, slow fire boiling 50 minutes after first intense fire, after drug decocting is good, leaching herb liquid 600 milliliters seals.
CN201410542835.XA 2014-10-15 2014-10-15 Internal medicine for treating nasosinusitis and preparation method thereof Pending CN104337919A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104825626A (en) * 2015-05-26 2015-08-12 王德合 Medicine for treating frontal sinusitis
CN109172698A (en) * 2018-03-05 2019-01-11 张顺礼 A kind of drug and preparation method thereof for treating rhinitis

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006007758A1 (en) * 2004-07-16 2006-01-26 Zhiquan Zhao Traditional chinese medicine composition for treating acute and chronic nasosinusitis and preparation thereof
CN1943738A (en) * 2006-10-23 2007-04-11 杨磊 A medicine for treatment of chronic nasosinusitis

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Publication number Priority date Publication date Assignee Title
WO2006007758A1 (en) * 2004-07-16 2006-01-26 Zhiquan Zhao Traditional chinese medicine composition for treating acute and chronic nasosinusitis and preparation thereof
CN1943738A (en) * 2006-10-23 2007-04-11 杨磊 A medicine for treatment of chronic nasosinusitis

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104825626A (en) * 2015-05-26 2015-08-12 王德合 Medicine for treating frontal sinusitis
CN109172698A (en) * 2018-03-05 2019-01-11 张顺礼 A kind of drug and preparation method thereof for treating rhinitis

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Application publication date: 20150211