CN109153727A - 靶向免疫治疗剂的多特异性抗原结合构建体 - Google Patents

靶向免疫治疗剂的多特异性抗原结合构建体 Download PDF

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CN109153727A
CN109153727A CN201780027726.6A CN201780027726A CN109153727A CN 109153727 A CN109153727 A CN 109153727A CN 201780027726 A CN201780027726 A CN 201780027726A CN 109153727 A CN109153727 A CN 109153727A
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antigen
cell
binding
polyspecific
binding constructs
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D·M·米尔斯
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ZYMEWORKS Inc
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ZYMEWORKS Inc
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CN201780027726.6A 2016-04-15 2017-04-13 靶向免疫治疗剂的多特异性抗原结合构建体 Pending CN109153727A (zh)

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US201662323432P 2016-04-15 2016-04-15
US62/323,432 2016-04-15
PCT/CA2017/050463 WO2017177337A1 (en) 2016-04-15 2017-04-13 Multi-specific antigen-binding constructs targeting immunotherapeutics

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US (1) US20190111079A1 (enExample)
EP (1) EP3443014A4 (enExample)
JP (1) JP2019513777A (enExample)
KR (1) KR20180135460A (enExample)
CN (1) CN109153727A (enExample)
AU (1) AU2017251116A1 (enExample)
BR (1) BR112018070676A2 (enExample)
CA (1) CA3021634A1 (enExample)
MX (1) MX2018012468A (enExample)
RU (1) RU2018139811A (enExample)
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Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111235113A (zh) * 2020-01-21 2020-06-05 南京北恒生物科技有限公司 包含嵌合抗原受体的免疫细胞及其用途
CN113646334A (zh) * 2019-02-20 2021-11-12 国家儿童医院研究所 癌症靶向的、病毒编码的、可调节的t细胞（catvert）或nk细胞（catvern）接头
CN115368446A (zh) * 2022-07-19 2022-11-22 合肥天港免疫药物有限公司 双特异性抗体及其应用
CN115975027A (zh) * 2021-08-12 2023-04-18 广东东阳光药业有限公司 Il-11人源化抗体及其应用
CN117965633A (zh) * 2024-04-01 2024-05-03 北京双赢科创生物科技有限公司 一种IFNγ受体敲除的CAR-T细胞的制备方法与应用

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10752653B2 (en) 2016-05-06 2020-08-25 Sage Therapeutics, Inc. Oxysterols and methods of use thereof
IL268554B2 (en) 2017-02-08 2025-03-01 Dragonfly Therapeutics Inc Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer
CA3235295C (en) 2017-02-20 2024-11-19 Dragonfly Therapeutics, Inc. Proteins binding her2, nkg2d and cd16
US20210130494A1 (en) * 2017-02-22 2021-05-06 Aleta Biotherapeutics Inc. Compositions and methods for treatment of cancer
AU2018225153A1 (en) * 2017-02-22 2019-09-19 Aleta Biotherapeutics Inc. Compositions and methods for tumor transduction
KR20230008254A (ko) 2017-11-08 2023-01-13 바이오엔테크 유에스 인크. T 세포 제조 조성물 및 방법
MX2020004801A (es) * 2017-11-09 2020-08-13 Medimmune Llc Polipeptidos de fusion biespecificos y sus metodos de uso.
US12384847B2 (en) 2018-02-08 2025-08-12 Dragonfly Therapeutics, Inc. Cancer therapy involving an anti-PD1 antibody and a multi-specific binding protein that binds NKG2D, CD16, and a tumor-associated antigen
US11884733B2 (en) 2018-02-08 2024-01-30 Dragonfly Therapeutics, Inc. Antibody variable domains targeting the NKG2D receptor
US12215157B2 (en) 2018-02-20 2025-02-04 Dragonfly Therapeutics, Inc. Multi-specific binding proteins that bind CD33, NKG2D, and CD16, and methods of use
WO2019162043A1 (en) * 2018-02-26 2019-08-29 Medigene Immunotherapies Gmbh Nyeso tcr
CN112437672A (zh) * 2018-05-07 2021-03-02 蜻蜓疗法股份有限公司 结合nkg2d、cd16和肿瘤相关抗原的蛋白质
CN110507824A (zh) * 2018-05-21 2019-11-29 荣昌生物制药（烟台）有限公司 一种抗间皮素抗体及其抗体药物缀合物
JP7398396B2 (ja) 2018-06-01 2023-12-14 ノバルティス アーゲー Ｂｃｍａに対する結合分子及びその使用
MA53284A (fr) 2018-08-08 2022-01-26 Dragonfly Therapeutics Inc Protéines de liaison à nkg2d, à cd16 et à un antigène associé à une tumeur
EA202091888A1 (ru) 2018-08-08 2020-10-23 Драгонфлай Терапьютикс, Инк. Вариабельные домены антител, нацеленные на рецептор nkg2d
EP3833392A4 (en) 2018-08-08 2022-05-18 Dragonfly Therapeutics, Inc. Multi-specific binding proteins that bind bcma, nkg2d and cd16, and methods of use
WO2020084608A1 (en) * 2018-10-22 2020-04-30 Explore Bio 1 Ltd Precursor bispecific antibody constructs and methods of use thereof
EP3877417A4 (en) * 2018-10-30 2022-08-03 Peter MacCallum Cancer Institute Bispecific polypeptides for engagement of car expressing immune cells with antigen presenting cells and uses thereof
WO2020088631A1 (en) * 2018-11-01 2020-05-07 Gracell Biotechnologies (Shanghai) Co., Ltd. Compositions and methods for t cell engineering
US20220089719A1 (en) * 2019-01-08 2022-03-24 Labyrx Immunologic Therapeutics (Usa) Limited Constructs targeting labyrinthin or a portion thereof and uses thereof
EP3972998A1 (en) 2019-05-21 2022-03-30 Novartis AG Cd19 binding molecules and uses thereof
US20220396631A1 (en) * 2019-05-21 2022-12-15 Lu HUANG Trispecific binding molecules against bcma and uses thereof
SMT202400527T1 (it) 2019-07-01 2025-01-14 Tonix Pharma Ltd Anticorpi anti-cd154 e loro usi
WO2021057906A1 (zh) * 2019-09-25 2021-04-01 科济生物医药（上海）有限公司 表达il-15的免疫效应细胞
TW202208428A (zh) 2020-05-06 2022-03-01 美商蜻蜓醫療公司 結合ｎｋｇ２ｄ、ｃｄ１６及ｃｌｅｃ１２ａ之蛋白質
GB202008688D0 (en) * 2020-06-09 2020-07-22 Cancer Research Tech Ltd Chimeric antigen receptor cell
WO2022064397A1 (en) * 2020-09-22 2022-03-31 World Biotech Regenerative Medical Group Limited Methods and compositions of car-expressing natural killer cells with bispecific antigen-binding molecules as cancer therapeutic agents
EP4274587A1 (en) 2021-01-06 2023-11-15 Tonix Pharma Limited Methods of inducing immune tolerance with modified anti-cd154 antibodies
EP4301774A4 (en) 2021-03-03 2025-08-13 Dragonfly Therapeutics Inc METHODS OF TREATING CANCER USING MULTI-SPECIFIC BINDING PROTEINS THAT BIND TO NKG2D, CD16, AND A TUMOR-ASSOCIATED ANTIGEN
CA3223179A1 (en) 2021-06-11 2022-12-15 Sage Therapeutics, Inc. Neuroactive steroid for the treatment of alzheimer's disease
WO2023011338A1 (zh) * 2021-08-02 2023-02-09 信达生物制药(苏州)有限公司 抗CD79b×CD3双特异性抗体及其用途
AU2022353119A1 (en) * 2021-09-24 2024-04-11 Synergy Imt, Inc. Composition of recombinant antigen binding molecules and method of making and using thereof
TW202340474A (zh) * 2022-01-11 2023-10-16 大陸商深圳市珈鈺生物科技有限公司 樹突細胞腫瘤疫苗和其用途
AU2023367039A1 (en) 2022-10-25 2025-05-15 Ablexis, Llc Anti-cd3 antibodies
WO2024107731A2 (en) 2022-11-14 2024-05-23 Ablexis, Llc Anti-pd-l1 antibodies
AU2024230609A1 (en) * 2023-02-28 2025-09-04 Juno Therapeutics, Inc. Cell therapy for treating systemic autoimmune diseases
WO2025194123A1 (en) * 2024-03-15 2025-09-18 Aarvik Therapeutics, Inc. Muc16/napi-2b antibodies and methods of use
WO2025248134A1 (en) 2024-05-31 2025-12-04 Tonix Pharma Limited Treatment methods comprising administration of modified cd154 antibodies

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104520327A (zh) * 2012-05-10 2015-04-15 酵活有限公司 单臂单价抗体构建体及其用途
CN104640562A (zh) * 2012-07-13 2015-05-20 酵活有限公司 包含抗-cd3构建体的双特异性不对称异二聚体
WO2015121454A1 (en) * 2014-02-14 2015-08-20 Cellectis Cells for immunotherapy engineered for targeting antigen present both on immune cells and pathological cells
CN104968364A (zh) * 2012-12-03 2015-10-07 百时美施贵宝公司 强化免疫调变性Fc融合蛋白的抗癌活性

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2825553T3 (pl) * 2012-03-14 2018-12-31 Regeneron Pharmaceuticals, Inc. Wieloswoiste cząsteczki wiążące antygen i ich zastosowanie
DK3473707T3 (da) * 2012-05-25 2025-03-17 Cellectis Fremgangsmåder til engineering af allogen og immunsuppressiv resistent t-celle til immunoterapi
WO2014190273A1 (en) * 2013-05-24 2014-11-27 Board Of Regents, The University Of Texas System Chimeric antigen receptor-targeting monoclonal antibodies
MX386422B (es) * 2013-12-20 2025-03-18 Fred Hutchinson Cancer Center Moléculas efectoras químericas etiquetadas y receptores de las mismas.
JP7372728B2 (ja) * 2014-10-31 2023-11-01 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア 改変ｔ細胞に関する方法および組成物
US10617720B2 (en) * 2016-10-20 2020-04-14 Miltenyi Biotech, GmbH Chimeric antigen receptor specific for tumor cells

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104520327A (zh) * 2012-05-10 2015-04-15 酵活有限公司 单臂单价抗体构建体及其用途
CN104640562A (zh) * 2012-07-13 2015-05-20 酵活有限公司 包含抗-cd3构建体的双特异性不对称异二聚体
CN104968364A (zh) * 2012-12-03 2015-10-07 百时美施贵宝公司 强化免疫调变性Fc融合蛋白的抗癌活性
WO2015121454A1 (en) * 2014-02-14 2015-08-20 Cellectis Cells for immunotherapy engineered for targeting antigen present both on immune cells and pathological cells

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHRISTOPH PIESS等: "《Alternative molecular formats and therapeutic applications for bispecific antibodies》", 《MOLECULAR IMMUNOLOGY》 *

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113646334A (zh) * 2019-02-20 2021-11-12 国家儿童医院研究所 癌症靶向的、病毒编码的、可调节的t细胞（catvert）或nk细胞（catvern）接头
CN111235113A (zh) * 2020-01-21 2020-06-05 南京北恒生物科技有限公司 包含嵌合抗原受体的免疫细胞及其用途
WO2021147928A1 (zh) * 2020-01-21 2021-07-29 南京北恒生物科技有限公司 包含嵌合抗原受体的免疫细胞及其用途
CN113993992A (zh) * 2020-01-21 2022-01-28 南京北恒生物科技有限公司 包含嵌合抗原受体的免疫细胞及其用途
CN115975027A (zh) * 2021-08-12 2023-04-18 广东东阳光药业有限公司 Il-11人源化抗体及其应用
CN115975027B (zh) * 2021-08-12 2023-10-20 广东东阳光药业股份有限公司 Il-11人源化抗体及其应用
CN115368446A (zh) * 2022-07-19 2022-11-22 合肥天港免疫药物有限公司 双特异性抗体及其应用
CN115368446B (zh) * 2022-07-19 2025-08-08 合肥天港免疫药物有限公司 双特异性抗体及其应用
CN117965633A (zh) * 2024-04-01 2024-05-03 北京双赢科创生物科技有限公司 一种IFNγ受体敲除的CAR-T细胞的制备方法与应用

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