KR20180135460A - 면역치료제를 표적으로 하는 다중-특이적 항원-결합 작제물 - Google Patents
면역치료제를 표적으로 하는 다중-특이적 항원-결합 작제물 Download PDFInfo
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| US10752653B2 (en) | 2016-05-06 | 2020-08-25 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| IL268554B2 (en) | 2017-02-08 | 2025-03-01 | Dragonfly Therapeutics Inc | Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer |
| CA3235295C (en) | 2017-02-20 | 2024-11-19 | Dragonfly Therapeutics, Inc. | Proteins binding her2, nkg2d and cd16 |
| US20210130494A1 (en) * | 2017-02-22 | 2021-05-06 | Aleta Biotherapeutics Inc. | Compositions and methods for treatment of cancer |
| AU2018225153A1 (en) * | 2017-02-22 | 2019-09-19 | Aleta Biotherapeutics Inc. | Compositions and methods for tumor transduction |
| KR20230008254A (ko) | 2017-11-08 | 2023-01-13 | 바이오엔테크 유에스 인크. | T 세포 제조 조성물 및 방법 |
| MX2020004801A (es) * | 2017-11-09 | 2020-08-13 | Medimmune Llc | Polipeptidos de fusion biespecificos y sus metodos de uso. |
| US12384847B2 (en) | 2018-02-08 | 2025-08-12 | Dragonfly Therapeutics, Inc. | Cancer therapy involving an anti-PD1 antibody and a multi-specific binding protein that binds NKG2D, CD16, and a tumor-associated antigen |
| US11884733B2 (en) | 2018-02-08 | 2024-01-30 | Dragonfly Therapeutics, Inc. | Antibody variable domains targeting the NKG2D receptor |
| US12215157B2 (en) | 2018-02-20 | 2025-02-04 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins that bind CD33, NKG2D, and CD16, and methods of use |
| WO2019162043A1 (en) * | 2018-02-26 | 2019-08-29 | Medigene Immunotherapies Gmbh | Nyeso tcr |
| CN112437672A (zh) * | 2018-05-07 | 2021-03-02 | 蜻蜓疗法股份有限公司 | 结合nkg2d、cd16和肿瘤相关抗原的蛋白质 |
| CN110507824A (zh) * | 2018-05-21 | 2019-11-29 | 荣昌生物制药(烟台)有限公司 | 一种抗间皮素抗体及其抗体药物缀合物 |
| JP7398396B2 (ja) | 2018-06-01 | 2023-12-14 | ノバルティス アーゲー | Bcmaに対する結合分子及びその使用 |
| MA53284A (fr) | 2018-08-08 | 2022-01-26 | Dragonfly Therapeutics Inc | Protéines de liaison à nkg2d, à cd16 et à un antigène associé à une tumeur |
| EA202091888A1 (ru) | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| EP3833392A4 (en) | 2018-08-08 | 2022-05-18 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins that bind bcma, nkg2d and cd16, and methods of use |
| WO2020084608A1 (en) * | 2018-10-22 | 2020-04-30 | Explore Bio 1 Ltd | Precursor bispecific antibody constructs and methods of use thereof |
| EP3877417A4 (en) * | 2018-10-30 | 2022-08-03 | Peter MacCallum Cancer Institute | Bispecific polypeptides for engagement of car expressing immune cells with antigen presenting cells and uses thereof |
| WO2020088631A1 (en) * | 2018-11-01 | 2020-05-07 | Gracell Biotechnologies (Shanghai) Co., Ltd. | Compositions and methods for t cell engineering |
| US20220089719A1 (en) * | 2019-01-08 | 2022-03-24 | Labyrx Immunologic Therapeutics (Usa) Limited | Constructs targeting labyrinthin or a portion thereof and uses thereof |
| US20220257760A1 (en) * | 2019-02-20 | 2022-08-18 | Research Institute At Nationwide Children's Hospital | Cancer-targeted, virus-encoded, regulatable t (catvert) or nk cell (catvern) linkers |
| EP3972998A1 (en) | 2019-05-21 | 2022-03-30 | Novartis AG | Cd19 binding molecules and uses thereof |
| US20220396631A1 (en) * | 2019-05-21 | 2022-12-15 | Lu HUANG | Trispecific binding molecules against bcma and uses thereof |
| SMT202400527T1 (it) | 2019-07-01 | 2025-01-14 | Tonix Pharma Ltd | Anticorpi anti-cd154 e loro usi |
| WO2021057906A1 (zh) * | 2019-09-25 | 2021-04-01 | 科济生物医药(上海)有限公司 | 表达il-15的免疫效应细胞 |
| CN111235113A (zh) * | 2020-01-21 | 2020-06-05 | 南京北恒生物科技有限公司 | 包含嵌合抗原受体的免疫细胞及其用途 |
| TW202208428A (zh) | 2020-05-06 | 2022-03-01 | 美商蜻蜓醫療公司 | 結合nkg2d、cd16及clec12a之蛋白質 |
| GB202008688D0 (en) * | 2020-06-09 | 2020-07-22 | Cancer Research Tech Ltd | Chimeric antigen receptor cell |
| WO2022064397A1 (en) * | 2020-09-22 | 2022-03-31 | World Biotech Regenerative Medical Group Limited | Methods and compositions of car-expressing natural killer cells with bispecific antigen-binding molecules as cancer therapeutic agents |
| EP4274587A1 (en) | 2021-01-06 | 2023-11-15 | Tonix Pharma Limited | Methods of inducing immune tolerance with modified anti-cd154 antibodies |
| EP4301774A4 (en) | 2021-03-03 | 2025-08-13 | Dragonfly Therapeutics Inc | METHODS OF TREATING CANCER USING MULTI-SPECIFIC BINDING PROTEINS THAT BIND TO NKG2D, CD16, AND A TUMOR-ASSOCIATED ANTIGEN |
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| WO2023011338A1 (zh) * | 2021-08-02 | 2023-02-09 | 信达生物制药(苏州)有限公司 | 抗CD79b×CD3双特异性抗体及其用途 |
| JP2024532709A (ja) * | 2021-08-12 | 2024-09-10 | サンシャイン・レイク・ファーマ・カンパニー・リミテッド | Il-11ヒト化抗体及びその用途 |
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| CN115368446B (zh) * | 2022-07-19 | 2025-08-08 | 合肥天港免疫药物有限公司 | 双特异性抗体及其应用 |
| AU2023367039A1 (en) | 2022-10-25 | 2025-05-15 | Ablexis, Llc | Anti-cd3 antibodies |
| WO2024107731A2 (en) | 2022-11-14 | 2024-05-23 | Ablexis, Llc | Anti-pd-l1 antibodies |
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| PL2825553T3 (pl) * | 2012-03-14 | 2018-12-31 | Regeneron Pharmaceuticals, Inc. | Wieloswoiste cząsteczki wiążące antygen i ich zastosowanie |
| JP6849868B2 (ja) * | 2012-05-10 | 2021-03-31 | ザイムワークス,インコーポレイテッド | シングルアーム一価抗体構築物およびその用途 |
| DK3473707T3 (da) * | 2012-05-25 | 2025-03-17 | Cellectis | Fremgangsmåder til engineering af allogen og immunsuppressiv resistent t-celle til immunoterapi |
| EP2872170A4 (en) * | 2012-07-13 | 2016-06-22 | Zymeworks Inc | ASYMMETRIC BISPECIFIC HETERODIMERS WITH ANTI-CD3 CONSTRUCTS |
| CN104968364A (zh) * | 2012-12-03 | 2015-10-07 | 百时美施贵宝公司 | 强化免疫调变性Fc融合蛋白的抗癌活性 |
| WO2014190273A1 (en) * | 2013-05-24 | 2014-11-27 | Board Of Regents, The University Of Texas System | Chimeric antigen receptor-targeting monoclonal antibodies |
| MX386422B (es) * | 2013-12-20 | 2025-03-18 | Fred Hutchinson Cancer Center | Moléculas efectoras químericas etiquetadas y receptores de las mismas. |
| EP3105317B1 (en) * | 2014-02-14 | 2018-09-19 | Cellectis | Cells for immunotherapy engineered for targeting antigen present both on immune cells and pathological cells |
| JP7372728B2 (ja) * | 2014-10-31 | 2023-11-01 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 改変t細胞に関する方法および組成物 |
| US10617720B2 (en) * | 2016-10-20 | 2020-04-14 | Miltenyi Biotech, GmbH | Chimeric antigen receptor specific for tumor cells |
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