CN109096199B - 二羧酸双酰胺衍生物、其用途和基于其的药物组合物 - Google Patents

二羧酸双酰胺衍生物、其用途和基于其的药物组合物 Download PDF

Info

Publication number
CN109096199B
CN109096199B CN201811167688.7A CN201811167688A CN109096199B CN 109096199 B CN109096199 B CN 109096199B CN 201811167688 A CN201811167688 A CN 201811167688A CN 109096199 B CN109096199 B CN 109096199B
Authority
CN
China
Prior art keywords
general formula
disease
following general
compound
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201811167688.7A
Other languages
English (en)
Chinese (zh)
Other versions
CN109096199A (zh
Inventor
弗拉迪米尔·叶夫根尼耶维奇·涅博利辛
塔季扬娜·亚历山德罗芙娜·克罗莫瓦
加林娜·亚历山德罗芙娜·热尔图希纳
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Treamid Therapeutics GmbH
Original Assignee
Treamid Therapeutics GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Treamid Therapeutics GmbH filed Critical Treamid Therapeutics GmbH
Publication of CN109096199A publication Critical patent/CN109096199A/zh
Application granted granted Critical
Publication of CN109096199B publication Critical patent/CN109096199B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/18—Antioxidants, e.g. antiradicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/04—Chelating agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/64—Benzothiazoles with only hydrocarbon or substituted hydrocarbon radicals attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Toxicology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Molecular Biology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Addiction (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Vascular Medicine (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Biochemistry (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Hospice & Palliative Care (AREA)
  • AIDS & HIV (AREA)
CN201811167688.7A 2013-04-12 2014-04-10 二羧酸双酰胺衍生物、其用途和基于其的药物组合物 Active CN109096199B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
RU2013116822 2013-04-12
RU2013116822A RU2665688C2 (ru) 2013-04-12 2013-04-12 Производные бисамидов дикарбоновых кислот, их применение, фармацевтическая композиция на их основе, способы их получения
CN201480027307.9A CN105358548A (zh) 2013-04-12 2014-04-10 二羧酸双酰胺衍生物、其用途、基于其的药物组合物和用于生产二羧酸双酰胺衍生物的方法
PCT/RU2014/000265 WO2014168523A1 (ru) 2013-04-12 2014-04-10 Производные бисамидов дикарбоновых кислот, их применение, фармацевтическая композиция на их основе, способы их получения

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201480027307.9A Division CN105358548A (zh) 2013-04-12 2014-04-10 二羧酸双酰胺衍生物、其用途、基于其的药物组合物和用于生产二羧酸双酰胺衍生物的方法

Publications (2)

Publication Number Publication Date
CN109096199A CN109096199A (zh) 2018-12-28
CN109096199B true CN109096199B (zh) 2022-05-10

Family

ID=51689820

Family Applications (6)

Application Number Title Priority Date Filing Date
CN201811167688.7A Active CN109096199B (zh) 2013-04-12 2014-04-10 二羧酸双酰胺衍生物、其用途和基于其的药物组合物
CN201811168167.3A Active CN109134378B (zh) 2013-04-12 2014-04-10 二羧酸双酰胺衍生物、其用途和基于其的药物组合物
CN201480027307.9A Pending CN105358548A (zh) 2013-04-12 2014-04-10 二羧酸双酰胺衍生物、其用途、基于其的药物组合物和用于生产二羧酸双酰胺衍生物的方法
CN201811167650.XA Active CN109336819B (zh) 2013-04-12 2014-04-10 二羧酸双酰胺衍生物、其用途和基于其的药物组合物
CN201811167661.8A Active CN109096198B (zh) 2013-04-12 2014-04-10 二羧酸双酰胺衍生物、其用途和基于其的药物组合物
CN201811167690.4A Active CN109096200B (zh) 2013-04-12 2014-04-10 二羧酸双酰胺衍生物、其用途和基于其的药物组合物

Family Applications After (5)

Application Number Title Priority Date Filing Date
CN201811168167.3A Active CN109134378B (zh) 2013-04-12 2014-04-10 二羧酸双酰胺衍生物、其用途和基于其的药物组合物
CN201480027307.9A Pending CN105358548A (zh) 2013-04-12 2014-04-10 二羧酸双酰胺衍生物、其用途、基于其的药物组合物和用于生产二羧酸双酰胺衍生物的方法
CN201811167650.XA Active CN109336819B (zh) 2013-04-12 2014-04-10 二羧酸双酰胺衍生物、其用途和基于其的药物组合物
CN201811167661.8A Active CN109096198B (zh) 2013-04-12 2014-04-10 二羧酸双酰胺衍生物、其用途和基于其的药物组合物
CN201811167690.4A Active CN109096200B (zh) 2013-04-12 2014-04-10 二羧酸双酰胺衍生物、其用途和基于其的药物组合物

Country Status (27)

Country Link
US (3) US20160031858A1 (enExample)
EP (1) EP2985284B1 (enExample)
JP (1) JP6760837B2 (enExample)
KR (1) KR102218134B1 (enExample)
CN (6) CN109096199B (enExample)
AU (1) AU2014251443C1 (enExample)
BR (1) BR112015025675B1 (enExample)
CA (1) CA2909411C (enExample)
CY (1) CY1125062T1 (enExample)
DK (1) DK2985284T3 (enExample)
EA (6) EA202190775A1 (enExample)
ES (1) ES2904568T3 (enExample)
HK (1) HK1221223A1 (enExample)
HR (1) HRP20220103T1 (enExample)
HU (1) HUE057209T2 (enExample)
IL (1) IL242029B (enExample)
LT (1) LT2985284T (enExample)
MX (2) MX379205B (enExample)
PL (1) PL2985284T3 (enExample)
PT (1) PT2985284T (enExample)
RS (1) RS62889B1 (enExample)
RU (1) RU2665688C2 (enExample)
SG (2) SG10202008505VA (enExample)
SI (1) SI2985284T1 (enExample)
SM (1) SMT202200064T1 (enExample)
UA (1) UA119748C2 (enExample)
WO (1) WO2014168523A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2909057C (en) * 2013-04-12 2022-03-22 Obschestvo S Ogranichennoi Otvetstvennostiyu "Pharmenterprises" Glutarimide derivatives, use thereof, pharmaceutical composition based thereon and methods for producing glutarimide derivatives
RU2665688C2 (ru) * 2013-04-12 2018-09-04 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" Производные бисамидов дикарбоновых кислот, их применение, фармацевтическая композиция на их основе, способы их получения
RU2647438C2 (ru) * 2015-05-27 2018-03-15 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" Бисамидное производное дикарбоновой кислоты в качестве средства, стимулирующего регенерацию тканей и восстановление сниженных функций тканей
RU2665633C1 (ru) * 2017-05-26 2018-09-03 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" Новый ингибитор глутаминилциклаз и его применение
RU2662559C1 (ru) * 2017-10-27 2018-07-26 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" Новый ингибитор глутаминилциклаз и его применение для лечения заболеваний легких и дыхательных путей
KR102714537B1 (ko) * 2017-05-26 2024-10-11 엘티디 "발렌타-인텔렉트" 신규한 글루타미닐 고리화효소 억제제 및 다양한 질환의 치료에서의 이의 용도
WO2018237163A1 (en) * 2017-06-23 2018-12-27 Roman Manetsch 5-aminolevulinate synthase inhibitors and methods of use thereof
RU2685277C1 (ru) * 2018-05-24 2019-04-17 Общество с ограниченной ответственностью "Фарминтерпрайсез Аллерджи" Применение бисамидного производного малоновой кислоты для лечения аллергических и других заболеваний человека и животных
RU2679636C1 (ru) * 2018-10-29 2019-02-12 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" Новый способ получения n,n'-бис[2-(1н-имидазол-4-ил)этил]малонамида
RU2745265C2 (ru) * 2019-09-12 2021-03-22 Общество С Ограниченной Ответственностью "Валента - Интеллект" Новые составы 2-(имидазол-4-ил)-этанамида пентандиовой-1,5 кислоты для лечения и профилактики вирусных заболеваний
WO2021049980A1 (ru) * 2019-09-12 2021-03-18 Общество С Ограниченной Ответственностью "Валента-Интеллект" Новые составы для лечения и профилактики вирусных заболеваний
RU2746692C1 (ru) * 2020-04-14 2021-04-19 Общество С Ограниченной Ответственностью "Валента - Интеллект" Новые составы 2-(имидазол-4-ил)-этанамида пентандиовой-1,5 кислоты для лечения и профилактики вирусных заболеваний
WO2023177328A1 (en) 2022-03-17 2023-09-21 Treamid Therapeutics Gmbh Bisamide derivative of dicarboxylic acid for use in restoring the external respiratory function after coronavirus infection
WO2025095813A1 (ru) * 2023-11-03 2025-05-08 Общество С Ограниченной Ответственностью "Валента-Интеллект" Новые соединения

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6169759A (ja) * 1984-09-14 1986-04-10 Agency Of Ind Science & Technol タンパク質の架橋反応用修飾剤及びそれを用いる方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6344567A (ja) * 1986-08-08 1988-02-25 Shikoku Chem Corp 新規なイミダゾール系ジアミド化合物、該化合物の合成方法および該化合物を有効成分とするポリエポキシ樹脂硬化剤
IL86131A0 (en) * 1987-04-24 1988-11-15 Boehringer Ingelheim Kg Benzo-and thieno-3,4-dihydropyridine derivatives,their preparation and pharmaceutical compositions containing them
WO2002013843A2 (en) * 2000-08-17 2002-02-21 University Of British Columbia Chemotherapeutic agents conjugated to p97 and their methods of use in treating neurological tumours
RU2287524C1 (ru) * 2005-03-31 2006-11-20 ООО "Фарминтерпрайсез" Аспартильные производные гистамина, способ их получения, фармацевтическая композиция и их применение в качестве модуляторов активности ферментов антиоксидантной защиты
RU2335495C2 (ru) * 2005-06-15 2008-10-10 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" N-ацильные производные аминокислот, их фармацевтически приемлевые соли, фармацевтическая композиция и применение в качестве гиполипидемических средств
CN1919884A (zh) * 2005-08-26 2007-02-28 建筑技术研究有限公司 基于氧化烯二醇烯基醚和不饱和二羧酸衍生物的共聚物
JP5225857B2 (ja) * 2005-11-14 2013-07-03 ジェネンテック，インコーポレイティド ヘッジホッグシグナル伝達のビスアミド阻害剤
EP1884515A1 (en) * 2006-07-31 2008-02-06 Laboratorios del Dr. Esteve S.A. Substituted indanyl sulfonamide compounds, their preparation and use as medicaments
JP6079148B2 (ja) * 2012-11-07 2017-02-15 Jsr株式会社 液晶配向剤、液晶配向膜及び液晶表示素子
RU2665688C2 (ru) * 2013-04-12 2018-09-04 Общество С Ограниченной Ответственностью "Фарминтерпрайсез" Производные бисамидов дикарбоновых кислот, их применение, фармацевтическая композиция на их основе, способы их получения

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6169759A (ja) * 1984-09-14 1986-04-10 Agency Of Ind Science & Technol タンパク質の架橋反応用修飾剤及びそれを用いる方法

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
A zinc chelator inhibiting gelatinases exerts potent in vitro anti-invasive effects;Gilles Ferry et al.;《European Journal of Pharmacology》;19980731;第351卷(第2期);第225-233页 *
Bis[platinum(II)] and Bis[palladium(II)] Complexes of α,ω-Dicarboxylic Acid Bis(l,2,4-triaminobutane-N4) Amides;Elfriede Schuhmann et al.;《Inorg. Chem.》;19950430;第34卷(第9期);第2316-2322页 *
Lipophilic complexones. Part 6. Synthesis of di- and tri-armed ligands containing pyridine and imidazole moieties;Anil Gupta and Jacek skarzewski;《J.Chem. Research，Synopses》;19941231(第6期);第206-207页 *
Metal complexes with disubstituted oxamidic ligands;U. Casellato et al.;《Inorganica Chimica Acta》;19970731;第260卷;第1-9页 *
Preparation of an Imidazole-Conjugated Oligonucleotide;Marc Beban and Paul S. Miller;《Bioconjugate Chem.》;20000613;第11卷(第4期);第599-603页 *
Preparation of certain bis-compounds derived from β-(2-thienyl)ethylamine and β-(2-thienyl)isopropylamine;Tadeusz Juliusz Burakowski et al.;《Acta Poloniae Pharmaceutica》;19781231;第35卷(第2期);第175-179页 *
Synthetic RNA-cleaving molecules mimicking ribonuclease A active center. Design and cleavage of tRNA transcripts;Mikhail A.Podyminogin et al.;《Nucleic Acids Research》;19931231;第21卷(第25期);第5950-5956页 *
The study of steric effect on the magnetic interaction between two metal ions in a binuclear complex;WEN-JWU WANG;《J. Chinese Chem. Soc.》;19820630;第29卷;第87-92页 *

Also Published As

Publication number Publication date
DK2985284T3 (da) 2022-02-07
US20230203016A1 (en) 2023-06-29
JP6760837B2 (ja) 2020-09-23
CN109096198A (zh) 2018-12-28
RS62889B1 (sr) 2022-03-31
SMT202200064T1 (it) 2022-03-21
EA036961B1 (ru) 2021-01-20
MX379205B (es) 2025-03-10
AU2014251443A1 (en) 2015-11-19
MX2020013371A (es) 2021-03-09
AU2014251443C1 (en) 2019-05-30
EA039440B1 (ru) 2022-01-27
EP2985284B1 (en) 2021-11-03
CN109096198B (zh) 2022-03-08
PT2985284T (pt) 2022-01-28
PL2985284T3 (pl) 2022-02-28
US20160031858A1 (en) 2016-02-04
BR112015025675A2 (pt) 2017-07-18
KR102218134B1 (ko) 2021-02-19
EA202190775A1 (ru) 2021-06-24
CN105358548A (zh) 2016-02-24
EA202190774A2 (ru) 2021-07-30
SG10202008505VA (en) 2020-10-29
CN109134378A (zh) 2019-01-04
LT2985284T (lt) 2022-01-25
CA2909411C (en) 2018-05-22
CN109336819A (zh) 2019-02-15
EA202092452A3 (ru) 2021-06-30
EA201992275A2 (ru) 2020-01-16
IL242029B (en) 2020-01-30
HUE057209T2 (hu) 2022-04-28
WO2014168523A4 (ru) 2015-01-08
HRP20220103T1 (hr) 2022-04-29
WO2014168523A1 (ru) 2014-10-16
SG11201508342RA (en) 2015-11-27
BR112015025675B1 (pt) 2024-01-02
EA202092453A3 (ru) 2021-06-30
CA2909411A1 (en) 2014-10-16
CN109096200B (zh) 2022-04-08
EP2985284A1 (en) 2016-02-17
RU2665688C2 (ru) 2018-09-04
BR112015025675A8 (pt) 2023-04-18
ES2904568T3 (es) 2022-04-05
HK1221223A1 (zh) 2017-05-26
KR20150142034A (ko) 2015-12-21
EA201992275A3 (ru) 2020-04-30
CN109336819B (zh) 2022-05-10
EA202092452A2 (ru) 2021-02-26
EA202092453A2 (ru) 2021-02-26
JP2016516767A (ja) 2016-06-09
EA201501014A1 (ru) 2016-02-29
MX2015014213A (es) 2016-06-02
RU2013116822A (ru) 2014-10-20
CN109096200A (zh) 2018-12-28
AU2014251443B2 (en) 2018-10-04
UA119748C2 (uk) 2019-08-12
CN109134378B (zh) 2022-09-20
CY1125062T1 (el) 2023-06-09
US20220324843A1 (en) 2022-10-13
SI2985284T1 (sl) 2022-04-29
EP2985284A4 (en) 2016-12-07
EA202190774A3 (ru) 2021-10-29
CN109096199A (zh) 2018-12-28

Similar Documents

Publication Publication Date Title
CN109096199B (zh) 二羧酸双酰胺衍生物、其用途和基于其的药物组合物
HK40012041B (en) Dicarboxylic acid bisamide derivatives, use thereof, pharmaceutical composition based thereon
HK40012041A (en) Dicarboxylic acid bisamide derivatives, use thereof, pharmaceutical composition based thereon
HK40002625A (en) Dicarboxylic acid bisamide derivatives, use thereof, pharmaceutical composition based thereon
HK40002625B (en) Dicarboxylic acid bisamide derivatives, use thereof, pharmaceutical composition based thereon
HK40002912B (en) Dicarboxylic acid bisamide derivatives, use thereof, pharmaceutical composition based thereon
HK40002912A (en) Dicarboxylic acid bisamide derivatives, use thereof, pharmaceutical composition based thereon
HK40002626A (en) Dicarboxylic acid bisamide derivatives, use thereof, pharmaceutical composition based thereon
HK40002626B (en) Dicarboxylic acid bisamide derivatives, use thereof, pharmaceutical composition based thereon
HK40012042B (en) Dicarboxylic acid bisamide derivatives, use thereof, pharmaceutical composition based thereon
HK40012042A (en) Dicarboxylic acid bisamide derivatives, use thereof, pharmaceutical composition based thereon
RU2840866C2 (ru) Производное бисамидов дикарбоновых кислот, его применение, фармацевтическая композиция на его основе, способы его получения
RU2719464C2 (ru) Производное бисамидов дикарбоновых кислот, его применение, фармацевтическая композиция на его основе, способы его получения
RU2709529C1 (ru) Производные бисамидов дикарбоновых кислот, их применение, фармацевтическая композиция на их основе, способы их получения
RU2721421C2 (ru) Производное бисамидов дикарбоновых кислот, его применение, фармацевтическая композиция на его основе, способы его получения
RU2725770C2 (ru) Производное бисамидов дикарбоновых кислот, его применение, фармацевтическая композиция на его основе, способы его получения
RU2725881C2 (ru) Производное бисамидов дикарбоновых кислот, его применение, фармацевтическая композиция на его основе, способы его получения
RU2815401C2 (ru) Производное бисамидов дикарбоновых кислот, его применение, фармацевтическая композиция на его основе, способы его получения
EA043024B1 (ru) Производное бисамидов дикарбоновых кислот и способы его получения
EA045515B1 (ru) Производные бисамидов дикарбоновых кислот, их применение, фармацевтическая композиция на их основе, способы их получения
EA045675B1 (ru) Способы получения бисамида дикарбоновой кислоты
EA043680B1 (ru) Производное бисамидов дикарбоновых кислот, его применение, фармацевтическая композиция на его основе
EA043025B1 (ru) Производное бисамида дикарбоновой кислоты и способы его получения

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40012041

Country of ref document: HK

GR01 Patent grant
GR01 Patent grant