CN109071488B - 取代的1,2,3-三唑作为nr2b-选择性nmda调节剂 - Google Patents

取代的1,2,3-三唑作为nr2b-选择性nmda调节剂 Download PDF

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CN109071488B
CN109071488B CN201780022887.6A CN201780022887A CN109071488B CN 109071488 B CN109071488 B CN 109071488B CN 201780022887 A CN201780022887 A CN 201780022887A CN 109071488 B CN109071488 B CN 109071488B
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triazol
methoxy
phenyl
pyrimidine
methyl
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CN109071488A (zh
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陈钢
C.C.克罗维安
H.R.寇特
C.A.德沃拉克
C.F.格林
A.希斯克斯
M.A.勒塔维克
J.C.瑞克
A.索由德-约翰逊
B.斯坦
J.L.沃尔
张炜
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Janssen Pharmaceutica NV
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201780022887.6A 2016-02-10 2017-02-09 取代的1,2,3-三唑作为nr2b-选择性nmda调节剂 Expired - Fee Related CN109071488B (zh)

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Application Number Priority Date Filing Date Title
US201662293680P 2016-02-10 2016-02-10
US62/293680 2016-02-10
PCT/US2017/017093 WO2017139428A1 (en) 2016-02-10 2017-02-09 Substituted 1,2,3-triazoles as nr2b-selective nmda modulators

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CN109071488A CN109071488A (zh) 2018-12-21
CN109071488B true CN109071488B (zh) 2021-08-13

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US (3) US10071988B2 (https=)
EP (1) EP3414233A1 (https=)
JP (1) JP6923543B2 (https=)
KR (1) KR20180108822A (https=)
CN (1) CN109071488B (https=)
AU (1) AU2017217542B2 (https=)
BR (1) BR112018016329A2 (https=)
CA (1) CA3014314A1 (https=)
EA (1) EA201891799A1 (https=)
IL (1) IL261046B (https=)
MA (1) MA44008A (https=)
MX (1) MX2018009752A (https=)
SG (1) SG11201806750WA (https=)
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MX2018009752A (es) 2019-02-07
US20170226089A1 (en) 2017-08-10
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BR112018016329A2 (pt) 2018-12-18
AU2017217542A1 (en) 2018-08-23
JP2019504854A (ja) 2019-02-21
US20180334451A1 (en) 2018-11-22
US20190135791A1 (en) 2019-05-09
EA201891799A1 (ru) 2019-02-28
SG11201806750WA (en) 2018-09-27
US10071988B2 (en) 2018-09-11
WO2017139428A1 (en) 2017-08-17
JP6923543B2 (ja) 2021-08-18
IL261046B (en) 2021-09-30
US10233173B2 (en) 2019-03-19
CA3014314A1 (en) 2017-08-17
IL261046A (en) 2019-02-28
KR20180108822A (ko) 2018-10-04
US10766880B2 (en) 2020-09-08
EP3414233A1 (en) 2018-12-19
CN109071488A (zh) 2018-12-21

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