AU2017217542B2 - Substituted 1,2,3-triazoles as NR2B-selective NMDA modulators - Google Patents

Substituted 1,2,3-triazoles as NR2B-selective NMDA modulators Download PDF

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Publication number
AU2017217542B2
AU2017217542B2 AU2017217542A AU2017217542A AU2017217542B2 AU 2017217542 B2 AU2017217542 B2 AU 2017217542B2 AU 2017217542 A AU2017217542 A AU 2017217542A AU 2017217542 A AU2017217542 A AU 2017217542A AU 2017217542 B2 AU2017217542 B2 AU 2017217542B2
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triazol
methoxy
phenyl
pyrimidine
fluoro
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AU2017217542A1 (en
Inventor
Gang Chen
Christa C. Chrovian
Heather R. COATE
Curt A. Dvorak
Christine F. GELIN
Afton HISCOX
Michael A. Letavic
Jason C. Rech
Akinola Soyode-Johnson
Brice Stenne
Jessica L. WALL
Wei Zhang
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Janssen Pharmaceutica NV
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
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  • Health & Medical Sciences (AREA)
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  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Vascular Medicine (AREA)
  • Addiction (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AU2017217542A 2016-02-10 2017-02-09 Substituted 1,2,3-triazoles as NR2B-selective NMDA modulators Ceased AU2017217542B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662293680P 2016-02-10 2016-02-10
US62/293,680 2016-02-10
PCT/US2017/017093 WO2017139428A1 (en) 2016-02-10 2017-02-09 Substituted 1,2,3-triazoles as nr2b-selective nmda modulators

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AU2017217542A1 AU2017217542A1 (en) 2018-08-23
AU2017217542B2 true AU2017217542B2 (en) 2021-06-03

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US (3) US10071988B2 (https=)
EP (1) EP3414233A1 (https=)
JP (1) JP6923543B2 (https=)
KR (1) KR20180108822A (https=)
CN (1) CN109071488B (https=)
AU (1) AU2017217542B2 (https=)
BR (1) BR112018016329A2 (https=)
CA (1) CA3014314A1 (https=)
EA (1) EA201891799A1 (https=)
IL (1) IL261046B (https=)
MA (1) MA44008A (https=)
MX (1) MX2018009752A (https=)
SG (1) SG11201806750WA (https=)
WO (1) WO2017139428A1 (https=)

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KR20180108822A (ko) 2018-10-04
JP2019504854A (ja) 2019-02-21
MA44008A (fr) 2018-12-19
WO2017139428A1 (en) 2017-08-17
EP3414233A1 (en) 2018-12-19
CN109071488B (zh) 2021-08-13
US10071988B2 (en) 2018-09-11
SG11201806750WA (en) 2018-09-27
US10233173B2 (en) 2019-03-19
IL261046A (en) 2019-02-28
JP6923543B2 (ja) 2021-08-18
BR112018016329A2 (pt) 2018-12-18
AU2017217542A1 (en) 2018-08-23
IL261046B (en) 2021-09-30
US20170226089A1 (en) 2017-08-10
US20190135791A1 (en) 2019-05-09
US10766880B2 (en) 2020-09-08
MX2018009752A (es) 2019-02-07
US20180334451A1 (en) 2018-11-22
CA3014314A1 (en) 2017-08-17
EA201891799A1 (ru) 2019-02-28
CN109071488A (zh) 2018-12-21

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