CN109071392A - 苯环衍生物及其制备方法和在医药上的应用 - Google Patents
苯环衍生物及其制备方法和在医药上的应用 Download PDFInfo
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- CN109071392A CN109071392A CN201780020343.6A CN201780020343A CN109071392A CN 109071392 A CN109071392 A CN 109071392A CN 201780020343 A CN201780020343 A CN 201780020343A CN 109071392 A CN109071392 A CN 109071392A
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- alkyl
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- heterocyclic ring
- alkoxy
- yuan
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- 239000000651 prodrug Substances 0.000 claims abstract description 24
- 229940002612 prodrug Drugs 0.000 claims abstract description 24
- 150000003839 salts Chemical class 0.000 claims abstract description 23
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- 125000001424 substituent group Chemical group 0.000 claims abstract description 19
- 239000012453 solvate Substances 0.000 claims abstract description 18
- 239000002207 metabolite Substances 0.000 claims abstract description 17
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 9
- 125000000623 heterocyclic group Chemical group 0.000 claims description 101
- 229910052731 fluorine Inorganic materials 0.000 claims description 60
- 229910052801 chlorine Inorganic materials 0.000 claims description 51
- 229910052794 bromium Inorganic materials 0.000 claims description 49
- 229910052739 hydrogen Inorganic materials 0.000 claims description 47
- -1 normal-butyl Chemical group 0.000 claims description 47
- 229910052740 iodine Inorganic materials 0.000 claims description 44
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 41
- 229910052760 oxygen Inorganic materials 0.000 claims description 40
- 229910052717 sulfur Inorganic materials 0.000 claims description 37
- 125000003545 alkoxy group Chemical group 0.000 claims description 36
- 125000005842 heteroatom Chemical group 0.000 claims description 30
- 125000000217 alkyl group Chemical group 0.000 claims description 28
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- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 20
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 20
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- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 9
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- PZUGGGMHTYKRTR-SNVBAGLBSA-N N-[3-[(1R)-1-cyclopropylethyl]-4-hydroxy-5-propan-2-ylphenyl]acetamide Chemical compound C1(CC1)[C@@H](C)C=1C=C(C=C(C=1O)C(C)C)NC(C)=O PZUGGGMHTYKRTR-SNVBAGLBSA-N 0.000 description 8
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Abstract
涉及一种苯环衍生物及其制备方法和在医药上的应用,具体而言涉及如通式(A)所示的苯环衍生物,或者其立体异构体、溶剂化物、代谢产物、前药、药学上可接受的盐或者共晶,其制备方法、包含其的药物组合物以及化合物或者组合物在中枢神经领域的用途,其中,通式(A)中各取代基的定义与说明书的定义相同。
Description
PCT国内申请,说明书已公开。
Claims (8)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610409973X | 2016-06-08 | ||
CN201610409973 | 2016-06-08 | ||
PCT/CN2017/087484 WO2017211307A1 (zh) | 2016-06-08 | 2017-06-07 | 苯环衍生物及其制备方法和在医药上的应用 |
Publications (2)
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CN109071392A true CN109071392A (zh) | 2018-12-21 |
CN109071392B CN109071392B (zh) | 2020-10-02 |
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CN201780020343.6A Expired - Fee Related CN109071392B (zh) | 2016-06-08 | 2017-06-07 | 苯环衍生物及其制备方法和在医药上的应用 |
Country Status (2)
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CN (1) | CN109071392B (zh) |
WO (1) | WO2017211307A1 (zh) |
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WO2020205867A1 (en) | 2019-04-02 | 2020-10-08 | Aligos Therapeutics, Inc. | Compounds targeting prmt5 |
WO2021122645A1 (en) | 2019-12-20 | 2021-06-24 | Syngenta Crop Protection Ag | Pesticidally active azole-amide compounds |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014180305A1 (zh) * | 2013-05-09 | 2014-11-13 | 四川海思科制药有限公司 | 苯酚衍生物及其制备方法和在医药上的应用 |
WO2016034079A1 (zh) * | 2014-09-04 | 2016-03-10 | 四川海思科制药有限公司 | 一种gabaa受体增强剂用于制备镇静麻醉的药物中的用途 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1206934A1 (en) * | 2000-11-15 | 2002-05-22 | B. Braun Melsungen Ag | Blockade of sodium channels by phenol derivatives |
IL150302A (en) * | 2002-01-31 | 2008-07-08 | Naim Menashe | Bicyclic cb2 cannabinoid receptor ligands |
BRPI0609589A2 (pt) * | 2005-03-31 | 2010-04-20 | Sankyo Agro Co Ltd | processo de produção de derivados de ciclopropilfenol |
WO2009140275A1 (en) * | 2008-05-12 | 2009-11-19 | Pharmacofore, Inc. | Analogs of propofol, preparation thereof and use as anesthetics |
CN103896743B (zh) * | 2012-12-28 | 2017-04-05 | 四川海思科制药有限公司 | 一种2,6‑二异丙基‑4‑氟苯酚的制备方法 |
-
2017
- 2017-06-07 WO PCT/CN2017/087484 patent/WO2017211307A1/zh active Application Filing
- 2017-06-07 CN CN201780020343.6A patent/CN109071392B/zh not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014180305A1 (zh) * | 2013-05-09 | 2014-11-13 | 四川海思科制药有限公司 | 苯酚衍生物及其制备方法和在医药上的应用 |
WO2016034079A1 (zh) * | 2014-09-04 | 2016-03-10 | 四川海思科制药有限公司 | 一种gabaa受体增强剂用于制备镇静麻醉的药物中的用途 |
Non-Patent Citations (2)
Title |
---|
PHILIP WAI HONG CHAN等: "Silver Triflate Catalyzed Cyclopropyl Carbinol Rearrangement for Benzo[b]oxepine and 2H-Chromene Synthesis", 《EUROPEAN JOURNAL OF ORGANIC CHEMISTRY》 * |
REGISTRY: "ACS ON STN", 《STN》 * |
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Publication number | Publication date |
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WO2017211307A1 (zh) | 2017-12-14 |
CN109071392B (zh) | 2020-10-02 |
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