CN109045234B - Callicarpa nudiflora-containing Chinese herbal medicine feed additive for dairy cows as well as preparation method and application thereof - Google Patents
Callicarpa nudiflora-containing Chinese herbal medicine feed additive for dairy cows as well as preparation method and application thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/86—Violaceae (Violet family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9062—Alpinia, e.g. red ginger or galangal
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
Abstract
The invention provides a Chinese herbal medicine feed additive containing callicarpa nudiflora for dairy cows and application thereof, which can effectively prevent mastitis of the dairy cows, comprehensively improve the physique of the dairy cows, improve the immunity and disease resistance and effectively prevent and treat the mastitis. The Chinese herbal medicine is subjected to superfine grinding, so that the release of effective components is facilitated, the action time of the Chinese herbal medicine is shortened, the effect can be achieved with small amount, the utilization efficiency is improved, the milk yield of the dairy cow is improved, the content of somatic cells is reduced, the milk quality is improved, and the Chinese herbal medicine is suitable for popularization and application in dairy cow breeding in the lactation period.
Description
Technical Field
The invention belongs to the field of animal feed additives, and particularly relates to a milk cow Chinese herbal medicine feed additive containing callicarpa nudiflora and application thereof.
Background
Callicarpa nudiflora is a callicarpa plant of Verbenaceae, is mainly produced in China Hainan, Guangxi, Guangdong, Jiangxi and the like, is distributed in Vietnam, India, Malaya and the like, and has the effects of detoxifying, diminishing inflammation, removing blood stasis and relieving pain when used as part of roots and leaves of the medicine. The nudiflower amethyst tablet is widely applied to human medicine clinically and is mainly used for inflammation caused by bacterial infection, acute infectious hepatitis and respiratory tract and digestive tract bleeding.
At present, the residue of antibiotics in milk is the primary problem of the safety of milk food in China. The dairy cow breeding industry in China has unscientific feeding structure and breeding, so that the incidence rate of mastitis of dairy cows is generally higher than that of mastitis of dairy cows abroad, the economic serious loss of the dairy cow breeding industry is caused, and the antibiotic treatment is inevitable. Along with the long-term abusing of antibiotics, not only the generation of pathogenic bacteria drug resistance is caused, but also the antibiotics inevitably remain in the milk, and the residual content of the antibiotics is often high. In addition, many farms often add antibiotics to the feed to prevent disease in the cows, which directly results in the antibiotic remaining in the milk. Antibiotic residues not only reduce the quality of milk, but also bring serious potential safety hazards to people drinking milk, and possibly cause environmental pollution. Therefore, the search for a new safe and effective measure for preventing and treating mastitis in dairy cows is urgent.
Disclosure of Invention
The invention aims to provide a Chinese herbal medicine feed additive containing callicarpa nudiflora for dairy cows.
The invention also aims to provide a preparation method of the milk cow Chinese herbal medicine feed additive containing callicarpa nudiflora.
The invention also aims to provide the application of the Chinese herbal medicine feed additive containing callicarpa nudiflora for the dairy cattle.
The technical scheme adopted by the invention is as follows:
an animal Chinese herbal medicine feed additive comprises 10-20 parts of callicarpa nudiflora, 5-15 parts of Chinese violet, 1-10 parts of wild chrysanthemum, 10-20 parts of ficus pumila, 5-15 parts of schisandra chinensis, 5-15 parts of angelica sinensis, 5-15 parts of astragalus membranaceus, 1-10 parts of fructus alpiniae oxyphyllae and 5-15 parts of revolute grass; the parts are parts by mass.
Further, the Chinese herbal medicine feed additive comprises 20 parts of callicarpa nudiflora, 10 parts of philippine violet herb, 5 parts of wild chrysanthemum flower, 15 parts of ficus pumila, 10 parts of Chinese magnoliavine fruit, 10 parts of Chinese angelica, 10 parts of astragalus membranaceus, 5 parts of fructus alpiniae oxyphyllae and 10 parts of revolute grass.
Further, the specific extraction method of the Chinese herbal medicine feed additive comprises the following steps: weighing dry callicarpa nudiflora powder, dry Chinese violet powder, dry wild chrysanthemum flower powder, dry ficus pumila powder, dry schisandra chinensis powder, dry angelica sinensis powder, dry astragalus membranaceus powder, dry alpinia oxyphylla powder and dry revolute grass powder according to the formula, and uniformly mixing the dry powders to obtain the Chinese herbal medicine feed additive.
Further, the animal is a cow.
Application of Callicarpa nudiflora in preparing feed or feed additive for preventing and/or treating cow mastitis is provided.
Application of Callicarpa nudiflora in preparing feed or feed additive for increasing milk secretion of milk cow is provided.
Application of Callicarpa nudiflora in preparing feed or feed additive for improving milk quality of milk cow is provided.
The invention has the beneficial effects that:
the invention combines the Chinese veterinarian theory and the physiological characteristics of the dairy cow, elaborately selects materials and scientifically combines the prescription, fully exerts the function of comprehensively regulating the organism function of the dairy cow by the Chinese herbal medicines and keeps the dynamic balance of the environment in the organism of the dairy cow. Improves the physique of the dairy cow comprehensively, improves the immunity and disease resistance, and effectively prevents and treats the mastitis. The Chinese herbal medicine is subjected to superfine grinding, so that the release of effective components is facilitated, the action time of the Chinese herbal medicine is shortened, the effect can be achieved by using a small amount of the Chinese herbal medicine, and the utilization efficiency is improved.
Detailed Description
An animal Chinese herbal medicine feed additive comprises 10-20 parts of callicarpa nudiflora, 5-15 parts of Chinese violet, 1-10 parts of wild chrysanthemum, 10-20 parts of ficus pumila, 5-15 parts of schisandra chinensis, 5-15 parts of angelica sinensis, 5-15 parts of astragalus membranaceus, 1-10 parts of fructus alpiniae oxyphyllae and 5-15 parts of revolute grass; the parts are parts by mass.
Preferably, the Chinese herbal medicine feed additive comprises 20 parts of callicarpa nudiflora, 10 parts of philippine violet herb, 5 parts of wild chrysanthemum flower, 15 parts of ficus pumila, 10 parts of Chinese magnoliavine fruit, 10 parts of Chinese angelica, 10 parts of astragalus membranaceus, 5 parts of fructus alpiniae oxyphyllae and 10 parts of revolute grass.
Preferably, the specific extraction method of the Chinese herbal medicine feed additive comprises the following steps: weighing dry callicarpa nudiflora powder, dry Chinese violet powder, dry wild chrysanthemum flower powder, dry ficus pumila powder, dry schisandra chinensis powder, dry angelica sinensis powder, dry astragalus membranaceus powder, dry alpinia oxyphylla powder and dry revolute grass powder according to the formula, and uniformly mixing the dry powders to obtain the Chinese herbal medicine feed additive.
Preferably, the animal is a cow.
Application of Callicarpa nudiflora in preparing feed or feed additive for preventing and/or treating cow mastitis is provided.
Application of Callicarpa nudiflora in preparing feed or feed additive for increasing milk secretion of milk cow is provided.
Application of Callicarpa nudiflora in preparing feed or feed additive for improving milk quality of milk cow is provided.
The present invention will be further described with reference to the following examples.
Example 1 an animal feed additive and a method for preparing the same
(1) Weighing 15 parts of beautyberry dry powder, 5 parts of Chinese violet dry powder, 3 parts of wild chrysanthemum dry powder, 10 parts of climbing fig dry powder, 5 parts of Chinese magnoliavine fruit dry powder, 5 parts of Chinese angelica dry powder, 5 parts of astragalus dry powder, 3 parts of fructus alpiniae oxyphyllae dry powder and 5 parts of revolute grass dry powder;
(2) and (3) uniformly mixing the Chinese herbal medicine dry powder obtained in the step (a), thus obtaining the Chinese herbal medicine feed additive.
Example 2 an animal feed additive and a method for preparing the same
(1) Weighing 20 parts of beautyberry dry powder, 10 parts of Chinese violet dry powder, 5 parts of wild chrysanthemum dry powder, 15 parts of climbing fig dry powder, 10 parts of Chinese magnoliavine fruit dry powder, 10 parts of Chinese angelica dry powder, 10 parts of astragalus dry powder, 5 parts of fructus alpiniae oxyphyllae dry powder and 10 parts of revolute grass dry powder;
(2) and (3) uniformly mixing the Chinese herbal medicine dry powder obtained in the step (a), thus obtaining the Chinese herbal medicine feed additive.
Example 3 an animal feed additive and a method for preparing the same
(1) Weighing 25 parts of beautyberry dry powder, 15 parts of Chinese violet dry powder, 10 parts of wild chrysanthemum dry powder, 15 parts of climbing fig dry powder, 15 parts of schisandra dry powder, 15 parts of angelica dry powder, 15 parts of astragalus dry powder, 10 parts of fructus alpiniae oxyphyllae dry powder and 15 parts of revolute grass dry powder;
(2) and (3) uniformly mixing the Chinese herbal medicine dry powder obtained in the step (a), thus obtaining the Chinese herbal medicine feed additive.
Example 4 an animal feed additive and a method for preparing the same
(1) Weighing 15 parts of beautyberry dry powder, 9 parts of Chinese violet dry powder, 6 parts of wild chrysanthemum dry powder, 15 parts of climbing fig dry powder, 10 parts of schisandra dry powder, 10 parts of angelica dry powder, 10 parts of astragalus dry powder, 6 parts of fructus alpiniae oxyphyllae dry powder and 10 parts of revolute grass dry powder;
(2) and (3) uniformly mixing the Chinese herbal medicine dry powder obtained in the step (a), thus obtaining the Chinese herbal medicine feed additive.
Example 5 an animal feed additive and a method for preparing the same
(1) Weighing 12 parts of beautyberry dry powder, 7 parts of Chinese violet dry powder, 6 parts of wild chrysanthemum dry powder, 12 parts of climbing fig dry powder, 8 parts of Chinese magnoliavine fruit dry powder, 9 parts of Chinese angelica dry powder, 7 parts of astragalus dry powder, 5 parts of fructus alpiniae oxyphyllae dry powder and 8 parts of revolute grass dry powder;
(2) and (3) uniformly mixing the Chinese herbal medicine dry powder obtained in the step (a), thus obtaining the Chinese herbal medicine feed additive.
EXAMPLE 6 clinical application Effect of Chinese herbal medicine feed additive
The test selects 75 clinically healthy lactating cows (1-2 months after delivery) in a certain culture farm in Guangdong, the indexes such as age, fetal number, time after delivery, daily secretion and the like are basically consistent, and the initial weights of all groups have no obvious difference (P is less than 0.05). The groups were randomly divided into 5 groups, including the control group and the example 1, 2, 3, 4, 5 groups, each group was set to 15 replicates, each replicate 1. The whole test period is 70 days, the pre-test period is 10 days, and the formal test period is 60 days. During the test period, the control group is fed with basic ration, and the Chinese herbal medicine feed additives prepared in examples 1 to 4 are added into the basic ration in examples 1 to 4 respectively.
Indexes and methods to be measured during the test:
(1) the incidence of mastitis: during the test period, the number of mastitis occurring in the cows of each group was recorded in detail.
(2) Daily lactation determination: weighing the milk after milking twice in the morning and at night every day, recording data, and adding the data of the two times to obtain daily milk yield;
(3) and (3) measuring the components of the milk: the milk components including milk fat, milk protein, lactose, and somatic cell content were measured from 60-day samples of the milk.
TABLE 1 preventive effect of Chinese herbal medicine feed additive on mastitis
As can be seen from the results of table 1: the incidence of mastitis in the milk cows of the groups of examples 1-4 is significantly reduced, compared with the control group, by 26.7%, 13.3%, 26.7% and 20%, respectively. The feed additive has the functions of resisting bacteria and diminishing inflammation, clearing heat and removing toxicity, can comprehensively coordinate the physiological functions of the dairy cows, improve the physique of the dairy cows, improve the immunity of the dairy cows and effectively prevent the occurrence of mastitis.
TABLE 2 influence of Chinese herbal medicine feed additive on daily milk yield of cow in kg/head/day
From the results of table 2 it can be seen that: the average daily milk yield of the dairy cows of the embodiments 1 to 4 is 23.6kg, 22.9kg and 22.7kg respectively in the pretest period and is obviously improved in the 60 days of the formal period; compared with the control group, the daily milk yield is respectively increased by 1.8kg, 1.4kg and 1.1kg, and the daily increase percentage is respectively 7.35%, 4.49%, 6.53% and 5.71%. The feed additive can promote the lactation of the dairy cows, obviously improve the milk yield and is beneficial to improving the production performance of the dairy cows.
TABLE 3 influence of Chinese herbal medicine feed additive on milk quality
As can be seen from the results of table 3: compared with the control group, the contents of the milk fat, the milk protein and the lactose in the milk of the dairy cows of the embodiments 1 to 4 have no obvious difference; the content of somatic cells is obviously reduced compared with that of the control group. The feed additive has no obvious improvement effect on milk fat, milk protein and lactose, but can obviously reduce the content of somatic cells and effectively improve the milk quality.
In summary, the Chinese herbal medicine feed additive of the invention can effectively prevent the mastitis of the dairy cows, improve the milk yield of the dairy cows, and reduce the content of somatic cells so as to improve the milk quality.
The above description is a preferred embodiment of the present invention, but the present invention is not limited to the above embodiment, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and they are included in the scope of the present invention.
Claims (5)
1. An animal Chinese herbal medicine feed additive is characterized in that the Chinese herbal medicine feed additive is prepared from 20 parts of callicarpa nudiflora, 10 parts of philippine violet herb, 5 parts of wild chrysanthemum flower, 15 parts of ficus pumila, 10 parts of Chinese magnoliavine fruit, 10 parts of Chinese angelica, 10 parts of astragalus root, 5 parts of fructus alpiniae oxyphyllae and 10 parts of revolute grass; the parts are parts by mass.
2. The Chinese herbal medicine feed additive according to claim 1, wherein the specific extraction method of the Chinese herbal medicine feed additive comprises the following steps: weighing dry callicarpa nudiflora powder, dry Chinese violet powder, dry wild chrysanthemum flower powder, dry ficus pumila powder, dry schisandra chinensis powder, dry angelica sinensis powder, dry astragalus membranaceus powder, dry alpinia oxyphylla powder and dry revolute grass powder according to the formula, and uniformly mixing the dry powders to obtain the Chinese herbal medicine feed additive.
3. The Chinese herbal medicine feed additive of claim 1, wherein the animal is a cow.
4. Use of the Chinese herbal medicine feed additive of any one of claims 1 to 3 in the preparation of a feed or feed additive for increasing the lactation yield of dairy cows.
5. Use of the Chinese herbal medicine feed additive of any one of claims 1 to 3 in the preparation of a feed or feed additive for improving milk quality of dairy cows.
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