CN108949660A - 烷醇酰胺及酰胺胺的微生物生产及其用途 - Google Patents

烷醇酰胺及酰胺胺的微生物生产及其用途 Download PDF

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Publication number
CN108949660A
CN108949660A CN201810830455.4A CN201810830455A CN108949660A CN 108949660 A CN108949660 A CN 108949660A CN 201810830455 A CN201810830455 A CN 201810830455A CN 108949660 A CN108949660 A CN 108949660A
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Prior art keywords
fatty acid
acid amide
polypeptide
recombinant microorganism
fatty
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CN201810830455.4A
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Chinese (zh)
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贾森·J·鲁特斯
斯蒂芬·德尔卡戴雷
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LS9 Inc
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LS9 Inc
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • C12P13/00Preparation of nitrogen-containing organic compounds
    • C12P13/02Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • CCHEMISTRY; METALLURGY
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10Transferases (2.)
    • C12N9/1025Acyltransferases (2.3)
    • C12N9/1029Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • CCHEMISTRY; METALLURGY
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    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/16Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18Carboxylic ester hydrolases (3.1.1)
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    • C12YENZYMES
    • C12Y203/00Acyltransferases (2.3)
    • C12Y203/01Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01086Fatty-acyl-CoA synthase (2.3.1.86)
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y301/00Hydrolases acting on ester bonds (3.1)
    • C12Y301/01Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01005Lysophospholipase (3.1.1.5)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y301/00Hydrolases acting on ester bonds (3.1)
    • C12Y301/02Thioester hydrolases (3.1.2)
    • C12Y301/02014Oleoyl-[acyl-carrier-protein] hydrolase (3.1.2.14), i.e. ACP-thioesterase
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/52Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
CN201810830455.4A 2012-04-13 2013-03-12 烷醇酰胺及酰胺胺的微生物生产及其用途 Pending CN108949660A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261623711P 2012-04-13 2012-04-13
US61/623,711 2012-04-13
CN201380026545.3A CN104379735A (zh) 2012-04-13 2013-03-12 烷醇酰胺及酰胺胺的微生物生产及其用途

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CN108949660A true CN108949660A (zh) 2018-12-07

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CN201810830455.4A Pending CN108949660A (zh) 2012-04-13 2013-03-12 烷醇酰胺及酰胺胺的微生物生产及其用途
CN201380026545.3A Pending CN104379735A (zh) 2012-04-13 2013-03-12 烷醇酰胺及酰胺胺的微生物生产及其用途
CN202011494386.8A Pending CN112522170A (zh) 2012-04-13 2013-03-12 烷醇酰胺及酰胺胺的微生物生产及其用途

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CN202011494386.8A Pending CN112522170A (zh) 2012-04-13 2013-03-12 烷醇酰胺及酰胺胺的微生物生产及其用途

Country Status (13)

Country Link
US (3) US9683247B2 (https=)
EP (2) EP4170026A1 (https=)
JP (1) JP6251241B2 (https=)
KR (3) KR102278343B1 (https=)
CN (3) CN108949660A (https=)
AU (1) AU2013246405B2 (https=)
BR (1) BR112014025519B1 (https=)
CA (2) CA3081178C (https=)
CO (1) CO7200250A2 (https=)
IN (1) IN2014DN09217A (https=)
MX (2) MX391947B (https=)
MY (1) MY167227A (https=)
WO (1) WO2013154721A1 (https=)

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MX391947B (es) 2012-04-13 2025-03-21 Genomatica Inc Produccion microbiana de alcanolamidas y amidoaminas y usos de las mismas.
WO2015085271A1 (en) * 2013-12-05 2015-06-11 REG Life Sciences, LLC Microbial production of fatty amines
CN105884643B (zh) * 2016-05-12 2018-03-27 浙江海正药业股份有限公司 一种不饱和脂肪酸酰胺类化合物及其制备方法和用途
CN107022513A (zh) * 2017-03-17 2017-08-08 河北美邦工程科技股份有限公司 一种重组大肠杆菌菌株生产长链二元酸的方法
CN109082387B (zh) * 2018-03-14 2022-03-18 重庆理工大学 一种可低温去除高氨氮的异养硝化-好氧反硝化复合菌剂及其应用
US12221644B2 (en) 2018-08-31 2025-02-11 Genomatica, Inc. Production of non-native monounsaturated fatty acids in bacteria
EP3931330A4 (en) 2019-02-25 2023-03-15 Ginkgo Bioworks, Inc. BIOSYNTHESIS OF CANNABINOIDS AND CANNABINOID PRECURSORS
US11441162B2 (en) * 2019-03-08 2022-09-13 Massachusetts Institute Of Technology Human gut microbiome-derived biosynthetic enzymes for production of fatty acid amides
GB202019175D0 (en) * 2020-12-04 2021-01-20 Univ Tartu Biosynthesis method
US11286467B1 (en) 2020-12-14 2022-03-29 United Arab Emirates University System and method for production of fatty acid ethanolamides
EP4493683A1 (en) 2022-03-16 2025-01-22 Genomatica, Inc. Acyl-acp thioesterase variants and uses thereof
US20250207159A1 (en) 2022-03-16 2025-06-26 Genomatica, Inc. Microorganisms And Methods For Production Of Fatty Acid Derivatives With Reduced Levels Of Byproducts

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Publication number Publication date
CN104379735A (zh) 2015-02-25
US10975402B2 (en) 2021-04-13
JP2015516808A (ja) 2015-06-18
CA2870257C (en) 2020-07-28
CO7200250A2 (es) 2015-02-27
AU2013246405B2 (en) 2018-08-02
BR112014025519A2 (https=) 2017-08-15
BR112014025519B1 (pt) 2022-01-11
MX391947B (es) 2025-03-21
US20150079643A1 (en) 2015-03-19
WO2013154721A1 (en) 2013-10-17
KR20210091353A (ko) 2021-07-21
JP6251241B2 (ja) 2017-12-20
CA3081178C (en) 2023-02-21
KR102278343B1 (ko) 2021-07-16
MX2014012350A (es) 2015-06-04
KR102190262B1 (ko) 2020-12-14
MX354883B (es) 2018-03-23
AU2013246405A1 (en) 2014-10-30
EP4170026A1 (en) 2023-04-26
EP2836593A1 (en) 2015-02-18
US20200232001A1 (en) 2020-07-23
MY167227A (en) 2018-08-14
US10392637B2 (en) 2019-08-27
KR20200105535A (ko) 2020-09-07
CA3081178A1 (en) 2013-10-17
KR20150031230A (ko) 2015-03-23
CA2870257A1 (en) 2013-10-17
US20170292120A1 (en) 2017-10-12
US9683247B2 (en) 2017-06-20
IN2014DN09217A (https=) 2015-07-10
CN112522170A (zh) 2021-03-19

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