MX354883B - Produccion microbiana de alcanolamidas y amidoaminas y usos de las mismas. - Google Patents

Produccion microbiana de alcanolamidas y amidoaminas y usos de las mismas.

Info

Publication number
MX354883B
MX354883B MX2014012350A MX2014012350A MX354883B MX 354883 B MX354883 B MX 354883B MX 2014012350 A MX2014012350 A MX 2014012350A MX 2014012350 A MX2014012350 A MX 2014012350A MX 354883 B MX354883 B MX 354883B
Authority
MX
Mexico
Prior art keywords
amidoamines
alkanolamides
microbial production
recombinant microorganism
fatty amide
Prior art date
Application number
MX2014012350A
Other languages
English (en)
Other versions
MX2014012350A (es
Inventor
J Lutes Jason
Del Cardayre Stephen
Original Assignee
Reg Life Sciences Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reg Life Sciences Llc filed Critical Reg Life Sciences Llc
Publication of MX2014012350A publication Critical patent/MX2014012350A/es
Publication of MX354883B publication Critical patent/MX354883B/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y203/00—Acyltransferases (2.3)
    • C12Y203/01—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C12Y203/01086—Fatty-acyl-CoA synthase (2.3.1.86)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/01—Carboxylic ester hydrolases (3.1.1)
    • C12Y301/01005—Lysophospholipase (3.1.1.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)
    • C12Y301/02—Thioester hydrolases (3.1.2)
    • C12Y301/02014—Oleoyl-[acyl-carrier-protein] hydrolase (3.1.2.14), i.e. ACP-thioesterase
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

La presente invención se refiere a un microorganismo recombinante caracterizado porque comprende una secuencia de ácido nucleico exógena que codifica para una palmitoilputrescina sintasa (PPS) que tiene al menos 90% de identidad de secuencia con la secuencia de aminoácidos de la SEQ ID NO: 1, en donde la PPS cataliza la conversión de una amina primaria y un tioéster de acilo a una amida grasa en donde el microorganismo además expresa una tioesterasa exógena (EC3.12.14 o EC 3.1.1.5) y se cultiva en presencia de una fuente de carbono.
MX2014012350A 2012-04-13 2013-03-12 Produccion microbiana de alcanolamidas y amidoaminas y usos de las mismas. MX354883B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261623711P 2012-04-13 2012-04-13
PCT/US2013/030502 WO2013154721A1 (en) 2012-04-13 2013-03-12 Microbial production of alkanolamides and amidoamines and uses thereof

Publications (2)

Publication Number Publication Date
MX2014012350A MX2014012350A (es) 2015-06-04
MX354883B true MX354883B (es) 2018-03-23

Family

ID=47913634

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2014012350A MX354883B (es) 2012-04-13 2013-03-12 Produccion microbiana de alcanolamidas y amidoaminas y usos de las mismas.

Country Status (13)

Country Link
US (3) US9683247B2 (es)
EP (2) EP2836593A1 (es)
JP (1) JP6251241B2 (es)
KR (3) KR102190262B1 (es)
CN (3) CN108949660A (es)
AU (1) AU2013246405B2 (es)
BR (1) BR112014025519B1 (es)
CA (2) CA2870257C (es)
CO (1) CO7200250A2 (es)
IN (1) IN2014DN09217A (es)
MX (1) MX354883B (es)
MY (1) MY167227A (es)
WO (1) WO2013154721A1 (es)

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* Cited by examiner, † Cited by third party
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MY167227A (en) 2012-04-13 2018-08-14 Reg Life Sciences Llc Microbial production of alkanolamides and amidoamines and uses thereof
JP6553610B2 (ja) 2013-12-05 2019-07-31 アールイージー ライフ サイエンシズ リミテッド ライアビリティ カンパニー 脂肪アミンの微生物生産方法
CN105884643B (zh) * 2016-05-12 2018-03-27 浙江海正药业股份有限公司 一种不饱和脂肪酸酰胺类化合物及其制备方法和用途
CN107022513A (zh) * 2017-03-17 2017-08-08 河北美邦工程科技股份有限公司 一种重组大肠杆菌菌株生产长链二元酸的方法
CN109082387B (zh) * 2018-03-14 2022-03-18 重庆理工大学 一种可低温去除高氨氮的异养硝化-好氧反硝化复合菌剂及其应用
WO2020176547A1 (en) 2019-02-25 2020-09-03 Ginkgo Bioworks, Inc. Biosynthesis of cannabinoids and cannabinoid precursors
WO2020185627A1 (en) * 2019-03-08 2020-09-17 Massachusetts Institute Of Technology Human gut microbiome-derived biosynthetic enzymes for production of fatty acid amides
CN110272839B (zh) * 2019-05-08 2020-10-30 江南大学 一株不动杆菌及其在生产手性3-环己烯-1-甲酸中的应用
JP7380245B2 (ja) 2020-01-23 2023-11-15 富士電機株式会社 飲料供給装置
GB202019175D0 (en) * 2020-12-04 2021-01-20 Univ Tartu Biosynthesis method
US11286467B1 (en) 2020-12-14 2022-03-29 United Arab Emirates University System and method for production of fatty acid ethanolamides
WO2023178193A1 (en) 2022-03-16 2023-09-21 Genomatica, Inc. Acyl-acp thioesterase variants and uses thereof
WO2023178211A1 (en) 2022-03-16 2023-09-21 Genomatica, Inc. Microorganisms and methods for production of fatty acid derivatives with reduced levels of byproducts

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Also Published As

Publication number Publication date
KR20150031230A (ko) 2015-03-23
US10392637B2 (en) 2019-08-27
CN112522170A (zh) 2021-03-19
BR112014025519A2 (es) 2017-08-15
US10975402B2 (en) 2021-04-13
IN2014DN09217A (es) 2015-07-10
KR20210091353A (ko) 2021-07-21
US20200232001A1 (en) 2020-07-23
US9683247B2 (en) 2017-06-20
CA3081178C (en) 2023-02-21
AU2013246405A1 (en) 2014-10-30
CA3081178A1 (en) 2013-10-17
JP2015516808A (ja) 2015-06-18
MY167227A (en) 2018-08-14
CN108949660A (zh) 2018-12-07
AU2013246405B2 (en) 2018-08-02
CN104379735A (zh) 2015-02-25
US20150079643A1 (en) 2015-03-19
US20170292120A1 (en) 2017-10-12
CA2870257C (en) 2020-07-28
EP4170026A1 (en) 2023-04-26
CA2870257A1 (en) 2013-10-17
EP2836593A1 (en) 2015-02-18
JP6251241B2 (ja) 2017-12-20
KR102190262B1 (ko) 2020-12-14
KR102278343B1 (ko) 2021-07-16
WO2013154721A1 (en) 2013-10-17
BR112014025519B1 (pt) 2022-01-11
CO7200250A2 (es) 2015-02-27
MX2014012350A (es) 2015-06-04
KR20200105535A (ko) 2020-09-07

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