CN108948004B - 作为fgfr4抑制剂的杂环化合物 - Google Patents
作为fgfr4抑制剂的杂环化合物 Download PDFInfo
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- CN108948004B CN108948004B CN201711229842.4A CN201711229842A CN108948004B CN 108948004 B CN108948004 B CN 108948004B CN 201711229842 A CN201711229842 A CN 201711229842A CN 108948004 B CN108948004 B CN 108948004B
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- fgfr4
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Abstract
Description
FGFR4 | |
化合物1 | <5 |
化合物13 | <5 |
化合物15 | <5 |
化合物16 | <5 |
化合物20 | <5 |
化合物21 | <5 |
Claims (14)
Applications Claiming Priority (3)
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CN201610364948 | 2016-05-27 | ||
PCT/CN2017/086445 WO2017202390A1 (zh) | 2016-05-27 | 2017-05-27 | 作为fgfr4抑制剂的杂环化合物 |
CNPCT/CN2017/086445 | 2017-05-27 |
Publications (2)
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CN108948004A CN108948004A (zh) | 2018-12-07 |
CN108948004B true CN108948004B (zh) | 2020-11-10 |
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CN201780031038.7A Active CN109153678B (zh) | 2016-05-27 | 2017-05-27 | 作为fgfr4抑制剂的杂环化合物 |
CN202010313695.4A Active CN111689959B (zh) | 2016-05-27 | 2017-05-27 | 作为fgfr4抑制剂的杂环化合物 |
CN201711229842.4A Active CN108948004B (zh) | 2016-05-27 | 2017-11-29 | 作为fgfr4抑制剂的杂环化合物 |
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CN201780031038.7A Active CN109153678B (zh) | 2016-05-27 | 2017-05-27 | 作为fgfr4抑制剂的杂环化合物 |
CN202010313695.4A Active CN111689959B (zh) | 2016-05-27 | 2017-05-27 | 作为fgfr4抑制剂的杂环化合物 |
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US (1) | US11352353B2 (zh) |
EP (1) | EP3483158B1 (zh) |
JP (1) | JP7008064B2 (zh) |
KR (2) | KR20190038485A (zh) |
CN (3) | CN109153678B (zh) |
WO (1) | WO2017202390A1 (zh) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
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EP3444250A4 (en) * | 2016-05-20 | 2019-09-25 | Jiangsu Hansoh Pharmaceutical Group Co., Ltd. | FGFR4 INHIBITOR, PROCESS FOR PREPARATION AND CORRESPONDING APPLICATIONS |
JP7088906B2 (ja) * | 2016-08-12 | 2022-06-21 | 江▲蘇▼豪森▲薬▼▲業▼集▲団▼有限公司 | Fgfr4阻害剤並びにその製造方法及び使用 |
CN112313207B (zh) * | 2018-06-22 | 2023-02-14 | 北京赛特明强医药科技有限公司 | 一种氰基取代吡啶及氰基取代嘧啶类化合物、制备方法及其应用 |
TWI723480B (zh) * | 2018-07-27 | 2021-04-01 | 大陸商北京加科思新藥研發有限公司 | 用作fgfr4抑制劑的稠環衍生物 |
CN114174303A (zh) | 2019-07-22 | 2022-03-11 | 印度鲁宾有限公司 | 作为sting激动剂的大环化合物及其方法和用途 |
CN116528866A (zh) * | 2020-11-02 | 2023-08-01 | 北京加科思新药研发有限公司 | Fgfr4抑制剂的盐的晶型 |
CN113527311B (zh) * | 2021-08-23 | 2022-05-06 | 中南大学湘雅医院 | Fgfr4抑制剂、组合物及其在药物制备中的用途 |
WO2023192502A1 (en) * | 2022-03-31 | 2023-10-05 | Acerand Therapeutics (Usa) Limited | Spirobicyclic compounds |
WO2023207944A1 (zh) * | 2022-04-26 | 2023-11-02 | 石药集团中奇制药技术(石家庄)有限公司 | Fgfr4抑制剂的晶型及应用 |
CN117479958A (zh) * | 2022-05-30 | 2024-01-30 | 石药集团中奇制药技术(石家庄)有限公司 | 用于治疗癌症的药物组合和药物组合物 |
CN116444485B (zh) * | 2023-03-30 | 2024-01-23 | 广西中医药大学 | 吡啶基取代不对称脲的非金属催化、免柱层析合成方法 |
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JP6152921B2 (ja) * | 2013-04-09 | 2017-06-28 | グアングジョウ フエイ ボー ルイ バイオロジカル ファーマシューティカル テクノロジー カンパニー,リミテッドGuangzhou Hui Bo Rui Biological Pharamaceutical Technology Co.,Ltd. | 抗血管新生化合物、中間体ならびにその使用 |
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WO2015095445A1 (en) * | 2013-12-20 | 2015-06-25 | Merck Sharp & Dohme Corp. | Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors |
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- 2017-05-27 CN CN201780031038.7A patent/CN109153678B/zh active Active
- 2017-05-27 WO PCT/CN2017/086445 patent/WO2017202390A1/zh unknown
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- 2017-05-27 CN CN202010313695.4A patent/CN111689959B/zh active Active
- 2017-05-27 KR KR1020217018993A patent/KR102499780B1/ko active IP Right Grant
- 2017-05-27 US US16/304,826 patent/US11352353B2/en active Active
- 2017-05-27 JP JP2019514174A patent/JP7008064B2/ja active Active
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Also Published As
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CN108948004A (zh) | 2018-12-07 |
EP3483158A4 (en) | 2020-07-29 |
CN111689959A (zh) | 2020-09-22 |
US20200199120A1 (en) | 2020-06-25 |
CN109153678A (zh) | 2019-01-04 |
US11352353B2 (en) | 2022-06-07 |
CN109153678B (zh) | 2020-04-14 |
KR20190038485A (ko) | 2019-04-08 |
KR20210092804A (ko) | 2021-07-26 |
KR102499780B1 (ko) | 2023-02-16 |
WO2017202390A1 (zh) | 2017-11-30 |
JP7008064B2 (ja) | 2022-01-25 |
EP3483158B1 (en) | 2022-08-10 |
EP3483158A1 (en) | 2019-05-15 |
JP2019518077A (ja) | 2019-06-27 |
CN111689959B (zh) | 2022-04-01 |
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