CN108926429A - 一种麻醉科药用海绵及制备方法 - Google Patents
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Abstract
本发明公开一种麻醉科药用海绵及制备方法，所述药用海绵分为三层，分别为：两个止血海绵层，所述止血海绵层设置于所述药用海绵的两侧，且所述止血海绵层由海绵状缓释材料制成，所述止血海绵层内含有止血药物；载药纤维层，所述载药纤维层设置于两个所述止血海绵层的中间，所述载药纤维层内含有消炎镇痛药剂。且，所述止血海绵层和所述载药纤维层之间连接紧密，没有空隙。通过上述药用海绵及制备方法解决了口服或者输液的方式对术后伤口进行止血消炎，药效不佳的技术问题，达到了在伤口处缓慢释放止血药和消炎镇痛药，药效好，费用少的技术效果。
Description
技术领域
本发明涉及医药卫生技术领域，特别涉及一种麻醉科药用海绵及制备方法。
背景技术
目前，手术是外科常用的手段，手术后外科医生一般用医用纱布对伤口进行包扎，通过口服消炎药或者输液的方式对伤口进行止血消炎。
但本申请发明人在实现本申请实施例中技术方案的过程中，发现上述现有技术至少存在如下技术问题：
口服消炎药或者输液的方式对伤口进行止血消炎，进过血液的稀释，到达伤口的止血消炎药的药物浓度有限，止血消炎效果大打折扣。
发明内容
本发明提供了一种麻醉科药用海绵及制备方法，解决了口服或者输液的方式对术后伤口进行止血消炎，药效不佳的技术问题，达到了在伤口处缓慢释放止血药和消炎镇痛药，药效好，费用少的技术效果。
一方面，本发明提供了一种麻醉科药用海绵，所述药用海绵分为三层，分别为：两个止血海绵层，所述止血海绵层设置于所述药用海绵的两侧，且所述止血海绵层由海绵状缓释材料制成，所述止血海绵层内含有止血药物；载药纤维层，所述载药纤维层设置于两个所述止血海绵层的中间，所述载药纤维层内含有消炎镇痛药剂；且，所述止血海绵层和所述载药纤维层之间连接紧密，没有空隙。
优选的，所述止血海绵层选用胶原蛋白。
优选的，所述消炎镇痛药剂为氟比洛芬酯。
另一方面，本发明提供了一种麻醉科药用海绵的制备方法，所述方法包括：制备水溶性聚合物和消炎镇痛药的混合溶液，将所述混合溶液通过静电纺丝制备得到载药纤维层；将止血海绵材料溶于溶剂中，再向溶剂中加入戊二醛，得到止血海绵溶液；将所述止血海绵溶液置于模具中，静置30分钟，将所述载药纤维层放置在止血海绵溶液上，再加入所述止血海绵溶液，静置12小时，对模具中的产物进行冷冻干燥，得到所述麻醉科用药用海绵。
优选的，所述水溶性聚合物为胶原蛋白。
本发明实施例中的上述一个或多个技术方案，至少具有如下一种或多种技术效果：
1、本发明实施例提供的一种麻醉科药用海绵，所述药用海绵分为三层，分别为：两个止血海绵层，所述止血海绵层设置于所述药用海绵的两侧，且所述止血海绵层由海绵状缓释材料制成，所述止血海绵层内含有止血药物；载药纤维层，所述载药纤维层设置于两个所述止血海绵层的中间，所述载药纤维层内含有消炎镇痛药剂；且，所述止血海绵层和所述载药纤维层之间连接紧密，没有空隙。通过上述药用海绵解决了口服或者输液的方式对术后伤口进行止血消炎，药效不佳的技术问题，达到了在伤口处缓慢释放止血药和消炎镇痛药，药效好，费用少的技术效果。
2、本发明实施例提供的一种麻醉科药用海绵的制备方法，所述方法包括：制备水溶性聚合物和消炎镇痛药的混合溶液，将所述混合溶液通过静电纺丝制备得到载药纤维层；将止血海绵材料溶于溶剂中，再向溶剂中加入戊二醛，得到止血海绵溶液；将所述止血海绵溶液置于模具中，静置30分钟，将所述载药纤维层放置在止血海绵溶液上，再加入所述止血海绵溶液，静置12小时，对模具中的产物进行冷冻干燥，得到所述麻醉科用药用海绵。通过上述制备方法解决了口服或者输液的方式对术后伤口进行止血消炎，药效不佳的技术问题，达到了在伤口处缓慢释放止血药和消炎镇痛药，药效好，费用少的技术效果。
3、本发明实施例通过所述止血海绵层选用胶原蛋白，达到减少伤口感染，加快伤口愈合的技术效果。
上述说明仅是本发明技术方案的概述，为了能够更清楚了解本发明的技术手段，而可依照说明书的内容予以实施，并且为了让本发明的上述和其它目的、特征和优点能够更明显易懂，以下特举本发明的具体实施方式。
附图说明
图1为本发明实施例中一种麻醉科药用海绵的结构示意图；
图2为图1所示一种麻醉科药用海绵的制备方法的流程图。
附图标记说明：止血海绵层1；载药纤维层2。
具体实施方式
本发明实施例提供了一种麻醉科药用海绵及制备方法，解决了口服或者输液的方式对术后伤口进行止血消炎，药效不佳的技术问题，达到了在伤口处缓慢释放止血药和消炎镇痛药，药效好，费用少的技术效果。
本发明实施例中的技术方案，总体结构如下：
本发明提供了一种麻醉科药用海绵，所述药用海绵分为三层，分别为：两个止血海绵层，所述止血海绵层设置于所述药用海绵的两侧，且所述止血海绵层由海绵状缓释材料制成，所述止血海绵层内含有止血药物；载药纤维层，所述载药纤维层设置于两个所述止血海绵层的中间，所述载药纤维层内含有消炎镇痛药剂；且，所述止血海绵层和所述载药纤维层之间连接紧密，没有空隙。通过上述药用海绵解决了口服或者输液的方式对术后伤口进行止血消炎，药效不佳的技术问题，达到了在伤口处缓慢释放止血药和消炎镇痛药，药效好，费用少的技术效果。
为使本发明实施例的目的、技术方案和优点更加清楚，下面将结合本发明实施例中的附图，对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
实施例一
本发明实施例提供了一种麻醉科药用海绵，请参考图1，所述药用海绵分为三层，分别为：
两个止血海绵层1，所述止血海绵层1设置于所述药用海绵的两侧，且所述止血海绵层1由海绵状缓释材料制成，所述止血海绵层1内含有止血药物。
具体而言，所述药用海绵为三层夹心结构，两个所述止血海绵层1设置在所述三层夹心结构的两侧。所述止血海绵层1由海绵状缓释材料制成，所述海绵缓释材料中含有止血药物，所述海绵状缓释材料可以缓慢释放所述止血药物，达到对伤口进行止血的技术效果。
载药纤维层2，所述载药纤维层2设置于两个所述止血海绵层1的中间，所述载药纤维层2内含有消炎镇痛药剂；
进一步的，所述消炎镇痛药剂为氟比洛芬酯。
具体而言，所述载药纤维层2设置在所述三层夹心结构的中间，所述载药纤维层2中含有消炎镇痛药剂，所述消炎镇痛药剂可通过所述止血海绵层1缓慢释放，为伤口进行持续消炎镇痛，减轻病人痛苦，所述消炎镇痛药选用氟比洛芬酯。
所述止血海绵层1和所述载药纤维层2之间连接紧密，没有空隙。
具体而言，所述止血海绵层1和所述载药纤维层2之间通过交联剂紧密连接在一起，使所述止血海绵1和所述载药纤维层2成为一体的三层夹心结构，兼具止血和消炎镇痛功能的同时，实现了药物的缓慢释放，本发明采用戊二醛为交联剂。
进一步的，所述止血海绵层1选用胶原蛋白。
具体而言，胶原蛋白是肌体自然蛋白，对皮肤表面的蛋白质分子具有较大的亲和力、较弱的抗原性、良好的生物相容性和生物降解安全性，可降解吸收，粘着力好。用胶原蛋白制作所述止血海绵层1,利于伤口止血、愈合。
在本实施例中，通过所述药用海绵解决了口服或者输液的方式对术后伤口进行止血消炎，药效不佳的技术问题，达到了在伤口处缓慢释放止血药和消炎镇痛药，药效好，费用少的技术效果。
实施例二
本发明还提供了一种麻醉科药用海绵的制备方法，请参考图2，所述方法包括：
步骤1：制备水溶性聚合物和消炎镇痛药的混合溶液，将所述混合溶液通过静电纺丝制备得到载药纤维层2。
进一步的，所述水溶性聚合物为胶原蛋白。
具体而言，所述的载药纤维层2的制备方法为：先配制水溶性聚合物和消炎镇痛药的混合溶液，将所述混合溶液通过静电纺丝制备得到所述载药纤维层2，所述水溶性聚合物为胶原蛋白。
步骤2：将止血海绵材料溶于溶剂中，再向溶剂中加入戊二醛，得到止血海绵溶液。
具体而言，将止血海绵材料溶于溶剂中，再向溶剂中加入戊二醛，得到止血海绵溶液，戊二醛作为交联剂交联所述载药纤维层2与所述止血海绵层1。
步骤3：将所述止血海绵溶液置于模具中，静置30分钟，将所述载药纤维层2放置在止血海绵溶液上，再加入所述止血海绵溶液，静置12小时，对模具中的产物进行冷冻干燥，得到所述麻醉科用药用海绵。
具体而言，将所述止血海绵溶液置于模具中，静置30分钟，让所述止血海绵溶液进行交联，防止放入所述载药纤维层2时，所述载药纤维层2下沉。再次加入所述止血海绵溶液后，静置交联12小时，且两次加入的所述止血海绵溶液体积相同，达到使两个所述止血海绵层1厚度相同的技术效果。
在本实施例中，通过所述方法解决了口服或者输液的方式对术后伤口进行止血消炎，药效不佳的技术问题，达到了在伤口处缓慢释放止血药和消炎镇痛药，药效好，费用少的技术效果。
本发明实施例中的上述一个或多个技术方案，至少具有如下一种或多种技术效果：
1、本发明实施例提供的一种麻醉科药用海绵，所述药用海绵分为三层，分别为：两个止血海绵层，所述止血海绵层设置于所述药用海绵的两侧，且所述止血海绵层由海绵状缓释材料制成，所述止血海绵层内含有止血药物；载药纤维层，所述载药纤维层设置于两个所述止血海绵层的中间，所述载药纤维层内含有消炎镇痛药剂；且，所述止血海绵层和所述载药纤维层之间连接紧密，没有空隙。通过上述药用海绵解决了口服或者输液的方式对术后伤口进行止血消炎，药效不佳的技术问题，达到了在伤口处缓慢释放止血药和消炎镇痛药，药效好，费用少的技术效果。
2、本发明实施例提供的一种麻醉科药用海绵的制备方法，所述方法包括：制备水溶性聚合物和消炎镇痛药的混合溶液，将所述混合溶液通过静电纺丝制备得到载药纤维层；将止血海绵材料溶于溶剂中，再向溶剂中加入戊二醛，得到止血海绵溶液；将所述止血海绵溶液置于模具中，静置30分钟，将所述载药纤维层放置在止血海绵溶液上，再加入所述止血海绵溶液，静置12小时，对模具中的产物进行冷冻干燥，得到所述麻醉科用药用海绵。通过上述制备方法解决了口服或者输液的方式对术后伤口进行止血消炎，药效不佳的技术问题，达到了在伤口处缓慢释放止血药和消炎镇痛药，药效好，费用少的技术效果。
3、本发明实施例通过所述止血海绵层选用胶原蛋白，达到减少伤口感染，加快伤口愈合的技术效果。
尽管已描述了本发明的优选实施例，但本领域内的技术人员一旦得知了基本创造性概念，则可对这些实施例做出另外的变更和修改。所以，所附权利要求意欲解释为包括优选实施例以及落入本发明范围的所有变更和修改。
显然，本领域的技术人员可以对本发明实施例进行各种改动和变型而不脱离本发明实施例的精神和范围。这样，倘若本发明实施例的这些修改和变型属于本发明权利要求及其等同技术的范围之内，则本发明也意图包含这些改动和变型在内。
Claims (5)
1.一种麻醉科药用海绵，其特征在于，所述药用海绵分为三层，分别为：
两个止血海绵层，所述止血海绵层设置于所述药用海绵的两侧，且所述止血海绵层由海绵状缓释材料制成，所述止血海绵层内含有止血药物；
载药纤维层，所述载药纤维层设置于两个所述止血海绵层的中间，所述载药纤维层内含有消炎镇痛药剂；
且，所述止血海绵层和所述载药纤维层之间连接紧密，没有空隙。
2.如权利要求1所述的一种麻醉科药用海绵的制备方法，其特征在于，所述方法包括：
制备水溶性聚合物和消炎镇痛药的混合溶液，将所述混合溶液通过静电纺丝制备得到载药纤维层；
将止血海绵材料溶于溶剂中，再向溶剂中加入戊二醛，得到止血海绵溶液；
将所述止血海绵溶液置于模具中，静置30分钟，将所述载药纤维层放置在止血海绵溶液上，再加入所述止血海绵溶液，静置12小时，对模具中的产物进行冷冻干燥，得到所述麻醉科用药用海绵。
3.如权利要求1所述的药用海绵，其特征在于，所述止血海绵层选用胶原蛋白。
4.如权利要求2所述的制备方法，其特征在于，所述水溶性聚合物为胶原蛋白。
5.如权利要求3所述的药用海绵，其特征在于，所述消炎镇痛药剂为氟比洛芬酯。
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