CN108904545A - 一种用于选择影响肠道蠕动紊乱和疼痛的试剂的方法 - Google Patents

一种用于选择影响肠道蠕动紊乱和疼痛的试剂的方法 Download PDF

Info

Publication number
CN108904545A
CN108904545A CN201810593302.2A CN201810593302A CN108904545A CN 108904545 A CN108904545 A CN 108904545A CN 201810593302 A CN201810593302 A CN 201810593302A CN 108904545 A CN108904545 A CN 108904545A
Authority
CN
China
Prior art keywords
reagent
strain
mmc
gastrointestinal
lactobacillus reuteri
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201810593302.2A
Other languages
English (en)
Chinese (zh)
Inventor
埃蒙·康诺利
沃尔夫冈·孔泽
约翰·宾斯托克
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Goddess Of Life And Earth Ltd
Original Assignee
Goddess Of Life And Earth Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49115523&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN108904545(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Goddess Of Life And Earth Ltd filed Critical Goddess Of Life And Earth Ltd
Publication of CN108904545A publication Critical patent/CN108904545A/zh
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • C12N1/205Bacterial isolates
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135Bacteria or derivatives thereof, e.g. probiotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • A61K35/741Probiotics
    • A61K35/744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747Lactobacilli, e.g. L. acidophilus or L. brevis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/0004Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10Laxatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12Antidiarrhoeals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • G06T7/0002Inspection of images, e.g. flaw detection
    • G06T7/0012Biomedical image inspection
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • G06T7/10Segmentation; Edge detection
    • G06T7/13Edge detection
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K2035/11Medicinal preparations comprising living procariotic cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/225Lactobacillus
    • GPHYSICS
    • G06COMPUTING OR CALCULATING; COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/30Subject of image; Context of image processing
    • G06T2207/30004Biomedical image processing
    • G06T2207/30092Stomach; Gastric

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Rheumatology (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Nutrition Science (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Quality & Reliability (AREA)
CN201810593302.2A 2012-09-03 2013-09-03 一种用于选择影响肠道蠕动紊乱和疼痛的试剂的方法 Pending CN108904545A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261696277P 2012-09-03 2012-09-03
US61/696,277 2012-09-03
CN201380049249.5A CN104918640B (zh) 2012-09-03 2013-09-03 一种用于选择影响肠道蠕动紊乱和疼痛的试剂的方法

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201380049249.5A Division CN104918640B (zh) 2012-09-03 2013-09-03 一种用于选择影响肠道蠕动紊乱和疼痛的试剂的方法

Publications (1)

Publication Number Publication Date
CN108904545A true CN108904545A (zh) 2018-11-30

Family

ID=49115523

Family Applications (4)

Application Number Title Priority Date Filing Date
CN201810593302.2A Pending CN108904545A (zh) 2012-09-03 2013-09-03 一种用于选择影响肠道蠕动紊乱和疼痛的试剂的方法
CN201910121265.XA Pending CN109966511A (zh) 2012-09-03 2013-09-03 一种用于选择影响肠道蠕动紊乱和疼痛的试剂的方法
CN201810593303.7A Active CN108753645B (zh) 2012-09-03 2013-09-03 一种用于选择影响肠道蠕动紊乱和疼痛的试剂的方法
CN201380049249.5A Expired - Fee Related CN104918640B (zh) 2012-09-03 2013-09-03 一种用于选择影响肠道蠕动紊乱和疼痛的试剂的方法

Family Applications After (3)

Application Number Title Priority Date Filing Date
CN201910121265.XA Pending CN109966511A (zh) 2012-09-03 2013-09-03 一种用于选择影响肠道蠕动紊乱和疼痛的试剂的方法
CN201810593303.7A Active CN108753645B (zh) 2012-09-03 2013-09-03 一种用于选择影响肠道蠕动紊乱和疼痛的试剂的方法
CN201380049249.5A Expired - Fee Related CN104918640B (zh) 2012-09-03 2013-09-03 一种用于选择影响肠道蠕动紊乱和疼痛的试剂的方法

Country Status (27)

Country Link
US (5) US9555065B2 (enExample)
EP (2) EP3369808A1 (enExample)
JP (3) JP6259458B2 (enExample)
KR (1) KR102293438B1 (enExample)
CN (4) CN108904545A (enExample)
AU (1) AU2013308299B2 (enExample)
CA (2) CA3268968A1 (enExample)
CL (2) CL2015000490A1 (enExample)
CO (1) CO7350654A2 (enExample)
DK (1) DK2893045T3 (enExample)
ES (1) ES2681974T3 (enExample)
GE (1) GEP201706775B (enExample)
HK (1) HK1258778A1 (enExample)
HR (1) HRP20181033T1 (enExample)
IL (2) IL237397B (enExample)
IN (1) IN2015DN01572A (enExample)
LT (1) LT2893045T (enExample)
MX (2) MX362495B (enExample)
MY (2) MY195532A (enExample)
NZ (1) NZ705358A (enExample)
PH (1) PH12015500452B1 (enExample)
RU (1) RU2701348C2 (enExample)
SG (3) SG10201608055XA (enExample)
SI (1) SI2893045T1 (enExample)
UA (2) UA118339C2 (enExample)
WO (1) WO2014033330A1 (enExample)
ZA (1) ZA201501472B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112013002667B1 (pt) 2010-08-04 2020-02-04 Thomas Julius Borody composições para transplante da flora intestinal e métodos para fazê-las e usá-las e dispositivos para administrá-las
CN108094541A (zh) * 2018-01-11 2018-06-01 黑龙江完达山林海液奶有限公司 一种具有保健益生功能的风味发酵乳及其制备方法
CN117487686A (zh) * 2018-07-24 2024-02-02 生命大地女神有限公司 选择和使用褪黑素支持细菌以减少婴儿绞痛
WO2020247568A1 (en) * 2019-06-05 2020-12-10 Avl Powertrain Engineering, Inc. Vehicle axle assembly
EP3980285A1 (en) 2019-06-05 2022-04-13 AVL Powertrain Engineering, Inc. Vehicle frame assembly and power supply tray
US12263752B2 (en) 2019-06-05 2025-04-01 Avl Mobility Technologies, Inc. Vehicle frame and power supply assembly and related systems and methods
CN110186922B (zh) * 2019-06-25 2021-07-23 西安交通大学医学院第一附属医院 一种监测结肠移行性复合运动的实验装置及方法
US11843097B2 (en) 2019-09-10 2023-12-12 Avl Powertrain Engineering, Inc. Power supply control systems and methods
CN112710823B (zh) * 2020-12-17 2024-03-29 中国科学院深圳先进技术研究院 一种肠移行性复合运动的离体检测系统及其应用
CN114342878B (zh) * 2022-01-10 2022-09-30 南京鼓楼医院 一种慢传输型便秘动物模型的建立方法
CN117384804A (zh) * 2023-12-12 2024-01-12 北京三元食品股份有限公司 格氏乳杆菌b1-26及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101374533A (zh) * 2006-06-05 2009-02-25 生命大地女神有限公司 利用选择的乳酸杆菌减少婴儿腹痛

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5438989A (en) * 1990-08-10 1995-08-08 Hochman; Darryl Solid tumor, cortical function, and nerve tissue imaging methods and device
TR200100361T2 (tr) * 1998-08-21 2001-06-21 Novartis Ag Yeni oral formülasyon
CZ200213A3 (cs) * 1999-07-06 2002-08-14 Enpharma L. P. Prostředky k regulaci motility zaľívací soustavy a přijímání potravy
DK1565547T4 (da) * 2002-06-28 2013-01-14 Biosearch S A Probiotiske stammer, en fremgangsmåde til selektion deraf, præparater deraf samt anvendelse deraf
EP1384483A1 (en) * 2002-07-23 2004-01-28 Nestec S.A. Probiotics for treatment of irritable bowel disease (IBS) through improvement of gut neuromuscular function
TWI241912B (en) * 2002-10-30 2005-10-21 Food Industry Res & Dev Inst Novel Acid-and bile salt-resistant Lactobacillus isolates having the ability to lower and assimilate cholesterol
CN1663573B (zh) * 2004-03-04 2010-04-28 青岛东海药业有限公司 一种稳定安全的微生态制剂及其制备方法和用途
US20090233888A1 (en) * 2005-03-23 2009-09-17 Usc Stevens, University Of Southern California Treatment of disease conditions through modulation of hydrogen sulfide produced by small intestinal bacterial overgrowth
JP5036020B2 (ja) * 2005-11-30 2012-09-26 雪印メグミルク株式会社 腎周囲脂肪蓄積抑制剤
JP5019563B2 (ja) * 2006-06-16 2012-09-05 旭化成ケミカルズ株式会社 腸内細菌賦活剤
US9254275B2 (en) * 2007-09-17 2016-02-09 Cornell University Branched chain fatty acids for prevention or treatment of gastrointestinal disorders
SG177541A1 (en) * 2009-07-31 2012-02-28 Nestec Sa Nutritional composition for breast-fed infants or pets with probiotics and selected nutrients
US20110110905A1 (en) * 2009-11-06 2011-05-12 Ritchie Jennifer A Infant Colic Supplement
WO2011148219A1 (en) * 2010-05-28 2011-12-01 Compagnie Gervais Danone Probiotic strains for use in improving the enteric nervous system
US20120034198A1 (en) * 2010-08-04 2012-02-09 Microbios, Inc. Carriers for storage and delivery of biologics
CN102304489B (zh) * 2011-09-23 2013-06-12 北京龙科方舟生物工程技术有限公司 一株罗伊氏乳杆菌及其应用

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101374533A (zh) * 2006-06-05 2009-02-25 生命大地女神有限公司 利用选择的乳酸杆菌减少婴儿腹痛

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
FLAVIA INDRIO 等: "Lactobacillus reuteri accelerates gastric emptying and improves regurgitation in infants", 《EUR J CLIN INVEST》 *
FRANCESCO SAVINO 等: "Lactobacillus reuteri DSM 17938 in infantile colic: a randomized, double-blind, placebo-controlled trial", 《PEDIATRICS》 *
PAOLA COCCORULLO等: "Lactobacillus reuteri (DSM 17938) in Infants with Functional Chronic Constipation: A Double-Blind, Randomized, Placebo-Controlled Study", 《THE JOURNAL OF PEDIATRICS》 *

Also Published As

Publication number Publication date
AU2013308299A1 (en) 2015-03-26
EP3369808A1 (en) 2018-09-05
JP6259458B2 (ja) 2018-01-10
SG11201501297TA (en) 2015-03-30
PH12015500452A1 (en) 2015-04-20
SG10201608055XA (en) 2016-11-29
RU2015112102A (ru) 2016-10-20
MY195532A (en) 2023-01-31
US20170114422A1 (en) 2017-04-27
HK1258774A1 (zh) 2019-11-22
CN108753645A (zh) 2018-11-06
US20220306984A1 (en) 2022-09-29
MX362495B (es) 2019-01-21
AU2013308299B2 (en) 2019-04-18
IN2015DN01572A (enExample) 2015-07-03
CO7350654A2 (es) 2015-08-10
HK1211848A1 (en) 2016-06-03
GEP201706775B (en) 2017-11-27
RU2701348C2 (ru) 2019-09-26
JP2018090616A (ja) 2018-06-14
NZ705358A (en) 2018-09-28
JP2018029588A (ja) 2018-03-01
HRP20181033T1 (hr) 2018-08-24
US20190112676A1 (en) 2019-04-18
MY182358A (en) 2021-01-20
CA3268968A1 (en) 2025-11-29
PH12015500452B1 (en) 2023-01-20
KR20150048201A (ko) 2015-05-06
HK1258778A1 (zh) 2019-11-22
IL259652B (en) 2020-03-31
UA126374C2 (uk) 2022-09-28
CA2883440A1 (en) 2014-03-06
CN108753645B (zh) 2019-10-22
CN104918640A (zh) 2015-09-16
JP2015529329A (ja) 2015-10-05
ES2681974T3 (es) 2018-09-17
KR102293438B1 (ko) 2021-08-25
CL2015000490A1 (es) 2015-05-29
US9555065B2 (en) 2017-01-31
CN104918640B (zh) 2019-03-19
DK2893045T3 (en) 2018-07-30
LT2893045T (lt) 2018-07-25
ZA201501472B (en) 2016-06-29
US9816150B2 (en) 2017-11-14
IL259652A (en) 2018-07-31
SG10202101556WA (en) 2021-03-30
IL237397B (en) 2018-10-31
US20180023150A1 (en) 2018-01-25
MX2015002792A (es) 2015-05-07
JP6476328B2 (ja) 2019-02-27
US20150231186A1 (en) 2015-08-20
CL2017002826A1 (es) 2018-04-06
MX2018013097A (es) 2020-09-02
EP2893045B1 (en) 2018-05-16
UA118339C2 (uk) 2019-01-10
CN109966511A (zh) 2019-07-05
JP6322326B2 (ja) 2018-05-09
EP2893045A1 (en) 2015-07-15
US10174388B2 (en) 2019-01-08
IL237397A0 (en) 2015-04-30
SI2893045T1 (en) 2018-08-31
WO2014033330A1 (en) 2014-03-06

Similar Documents

Publication Publication Date Title
CN104918640B (zh) 一种用于选择影响肠道蠕动紊乱和疼痛的试剂的方法
US11371985B2 (en) Selection of agents modulating gastrointestinal pain
Cauble et al. 432 evidence that achalasia involves a systemic inflammatory response
HK1258774B (en) Method for selection of agents influencing intestinal motility disorders and pain
HK40004510A (en) A method for selection of agents influencing intestinal motility disorders and pain
HK1211848B (zh) 一种用於选择影响肠道蠕动紊乱和疼痛的试剂的方法
Lazebnik et al. 436 double-blind controlled randomized trial of probiotic efficiency for the correction of lactase deficiency in patients with postinfectious IBS
Kashyap et al. 435 Diet and Distal Gut Microbiota Interact to Alter Gastrointestinal Transit
Lang et al. 433 Characterization of and Neural Pathway for Pharyngeal Swallowing Activated by Esophageal Distension
Beck et al. Physiology: Colonic

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1258778

Country of ref document: HK

CB02 Change of applicant information
CB02 Change of applicant information

Country or region after: Sweden

Address after: S-103 64 Stockholm, Sweden

Applicant after: Baiogaya Co.,Ltd.

Address before: S-103 64 Stockholm, Sweden

Applicant before: BIOGAIA AB

Country or region before: Sweden