HK1258774A1 - 一種用於選擇影響腸道蠕動紊亂和疼痛的試劑的方法 - Google Patents

一種用於選擇影響腸道蠕動紊亂和疼痛的試劑的方法

Info

Publication number
HK1258774A1
HK1258774A1 HK19101134.4A HK19101134A HK1258774A1 HK 1258774 A1 HK1258774 A1 HK 1258774A1 HK 19101134 A HK19101134 A HK 19101134A HK 1258774 A1 HK1258774 A1 HK 1258774A1
Authority
HK
Hong Kong
Prior art keywords
pain
selection
intestinal motility
motility disorders
agents influencing
Prior art date
Application number
HK19101134.4A
Other languages
English (en)
Inventor
Eamonn Connolly
Kunze Wolfgang
Bienenstock John
Original Assignee
Biogaia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49115523&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1258774(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biogaia Ab filed Critical Biogaia Ab
Publication of HK1258774A1 publication Critical patent/HK1258774A1/zh

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • C12N1/205Bacterial isolates
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135Bacteria or derivatives thereof, e.g. probiotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • A61K35/741Probiotics
    • A61K35/744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747Lactobacilli, e.g. L. acidophilus or L. brevis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/0004Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10Laxatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12Antidiarrhoeals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • G06T7/0002Inspection of images, e.g. flaw detection
    • G06T7/0012Biomedical image inspection
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • G06T7/10Segmentation; Edge detection
    • G06T7/13Edge detection
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K2035/11Medicinal preparations comprising living procariotic cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/225Lactobacillus
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/30Subject of image; Context of image processing
    • G06T2207/30004Biomedical image processing
    • G06T2207/30092Stomach; Gastric

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Rheumatology (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Urology & Nephrology (AREA)
  • Nutrition Science (AREA)
  • Toxicology (AREA)
  • Quality & Reliability (AREA)
  • Radiology & Medical Imaging (AREA)
HK19101134.4A 2012-09-03 2019-01-23 一種用於選擇影響腸道蠕動紊亂和疼痛的試劑的方法 HK1258774A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261696277P 2012-09-03 2012-09-03

Publications (1)

Publication Number Publication Date
HK1258774A1 true HK1258774A1 (zh) 2019-11-22

Family

ID=49115523

Family Applications (3)

Application Number Title Priority Date Filing Date
HK15112741.0A HK1211848A1 (zh) 2012-09-03 2015-12-28 種用於選擇影響腸道蠕動紊亂和疼痛的試劑的方法
HK19101138.0A HK1258778A1 (zh) 2012-09-03 2019-01-23 一種用於選擇影響腸道蠕動紊亂和疼痛的試劑的方法
HK19101134.4A HK1258774A1 (zh) 2012-09-03 2019-01-23 一種用於選擇影響腸道蠕動紊亂和疼痛的試劑的方法

Family Applications Before (2)

Application Number Title Priority Date Filing Date
HK15112741.0A HK1211848A1 (zh) 2012-09-03 2015-12-28 種用於選擇影響腸道蠕動紊亂和疼痛的試劑的方法
HK19101138.0A HK1258778A1 (zh) 2012-09-03 2019-01-23 一種用於選擇影響腸道蠕動紊亂和疼痛的試劑的方法

Country Status (27)

Country Link
US (5) US9555065B2 (zh)
EP (2) EP3369808A1 (zh)
JP (3) JP6259458B2 (zh)
KR (1) KR102293438B1 (zh)
CN (4) CN104918640B (zh)
AU (1) AU2013308299B2 (zh)
CA (1) CA2883440A1 (zh)
CL (2) CL2015000490A1 (zh)
CO (1) CO7350654A2 (zh)
DK (1) DK2893045T3 (zh)
ES (1) ES2681974T3 (zh)
GE (1) GEP201706775B (zh)
HK (3) HK1211848A1 (zh)
HR (1) HRP20181033T1 (zh)
IL (2) IL237397B (zh)
IN (1) IN2015DN01572A (zh)
LT (1) LT2893045T (zh)
MX (2) MX362495B (zh)
MY (2) MY195532A (zh)
NZ (1) NZ705358A (zh)
PH (1) PH12015500452A1 (zh)
RU (1) RU2701348C2 (zh)
SG (3) SG10201608055XA (zh)
SI (1) SI2893045T1 (zh)
UA (2) UA118339C2 (zh)
WO (1) WO2014033330A1 (zh)
ZA (1) ZA201501472B (zh)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103124559B (zh) 2010-08-04 2017-03-29 托马斯·朱利叶斯·波洛迪 用于粪便菌群植入的组合物及其制备和使用方法以及递送该组合物的装置
CN108094541A (zh) * 2018-01-11 2018-06-01 黑龙江完达山林海液奶有限公司 一种具有保健益生功能的风味发酵乳及其制备方法
CN117487686A (zh) * 2018-07-24 2024-02-02 生命大地女神有限公司 选择和使用褪黑素支持细菌以减少婴儿绞痛
CN113966284A (zh) * 2019-06-05 2022-01-21 Avl动力工程公司 车辆轴组件
CN110186922B (zh) * 2019-06-25 2021-07-23 西安交通大学医学院第一附属医院 一种监测结肠移行性复合运动的实验装置及方法
US11843097B2 (en) 2019-09-10 2023-12-12 Avl Powertrain Engineering, Inc. Power supply control systems and methods
CN112710823B (zh) * 2020-12-17 2024-03-29 中国科学院深圳先进技术研究院 一种肠移行性复合运动的离体检测系统及其应用
CN114342878B (zh) * 2022-01-10 2022-09-30 南京鼓楼医院 一种慢传输型便秘动物模型的建立方法
CN117384804A (zh) * 2023-12-12 2024-01-12 北京三元食品股份有限公司 格氏乳杆菌b1-26及其应用

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5438989A (en) * 1990-08-10 1995-08-08 Hochman; Darryl Solid tumor, cortical function, and nerve tissue imaging methods and device
RS50104B (sr) * 1998-08-21 2009-01-22 Novartis Ag., Nova oralna formulacija za 5-th4 agoniste ili antagoniste
IL147312A0 (en) * 1999-07-06 2002-08-14 Enpharma L P Methods for compositions for regulating gut motility and food intake
EP1384483A1 (en) * 2002-07-23 2004-01-28 Nestec S.A. Probiotics for treatment of irritable bowel disease (IBS) through improvement of gut neuromuscular function
TWI241912B (en) * 2002-10-30 2005-10-21 Food Industry Res & Dev Inst Novel Acid-and bile salt-resistant Lactobacillus isolates having the ability to lower and assimilate cholesterol
CN1663573B (zh) * 2004-03-04 2010-04-28 青岛东海药业有限公司 一种稳定安全的微生态制剂及其制备方法和用途
US20090233888A1 (en) * 2005-03-23 2009-09-17 Usc Stevens, University Of Southern California Treatment of disease conditions through modulation of hydrogen sulfide produced by small intestinal bacterial overgrowth
JP5036020B2 (ja) * 2005-11-30 2012-09-26 雪印メグミルク株式会社 腎周囲脂肪蓄積抑制剤
US7374924B2 (en) * 2006-06-05 2008-05-20 Biogaia Ab Use of selected lactic acid bacteria for reducing infantile colic
JP5019563B2 (ja) * 2006-06-16 2012-09-05 旭化成ケミカルズ株式会社 腸内細菌賦活剤
EP2200443B2 (en) * 2007-09-17 2021-06-30 Cornell University Branched chain fatty acids for prevention or treatment of gastrointestinal disorders
RU2012107695A (ru) * 2009-07-31 2013-09-10 Нестек С.А. Питательная композиция для вскармливаемых грудью детей или домашних животных с пробиотиками и подобранными питательными веществами
US20110110905A1 (en) * 2009-11-06 2011-05-12 Ritchie Jennifer A Infant Colic Supplement
WO2011148219A1 (en) * 2010-05-28 2011-12-01 Compagnie Gervais Danone Probiotic strains for use in improving the enteric nervous system
US20120034198A1 (en) * 2010-08-04 2012-02-09 Microbios, Inc. Carriers for storage and delivery of biologics
CN102304489B (zh) * 2011-09-23 2013-06-12 北京龙科方舟生物工程技术有限公司 一株罗伊氏乳杆菌及其应用

Also Published As

Publication number Publication date
UA118339C2 (uk) 2019-01-10
CL2015000490A1 (es) 2015-05-29
JP2015529329A (ja) 2015-10-05
IL259652B (en) 2020-03-31
CN108753645A (zh) 2018-11-06
US20150231186A1 (en) 2015-08-20
JP6476328B2 (ja) 2019-02-27
IL237397A0 (en) 2015-04-30
US10174388B2 (en) 2019-01-08
JP6259458B2 (ja) 2018-01-10
HK1211848A1 (zh) 2016-06-03
CN104918640A (zh) 2015-09-16
ES2681974T3 (es) 2018-09-17
KR102293438B1 (ko) 2021-08-25
EP2893045B1 (en) 2018-05-16
US9555065B2 (en) 2017-01-31
SG11201501297TA (en) 2015-03-30
SI2893045T1 (en) 2018-08-31
HRP20181033T1 (hr) 2018-08-24
US20220306984A1 (en) 2022-09-29
WO2014033330A1 (en) 2014-03-06
NZ705358A (en) 2018-09-28
US20190112676A1 (en) 2019-04-18
MX2015002792A (es) 2015-05-07
MY195532A (en) 2023-01-31
PH12015500452A1 (en) 2015-04-20
EP2893045A1 (en) 2015-07-15
MX362495B (es) 2019-01-21
IL259652A (en) 2018-07-31
US20170114422A1 (en) 2017-04-27
DK2893045T3 (en) 2018-07-30
CN109966511A (zh) 2019-07-05
GEP201706775B (en) 2017-11-27
RU2015112102A (ru) 2016-10-20
US20180023150A1 (en) 2018-01-25
CO7350654A2 (es) 2015-08-10
AU2013308299A1 (en) 2015-03-26
CN108753645B (zh) 2019-10-22
KR20150048201A (ko) 2015-05-06
JP2018029588A (ja) 2018-03-01
AU2013308299B2 (en) 2019-04-18
CA2883440A1 (en) 2014-03-06
UA126374C2 (uk) 2022-09-28
CL2017002826A1 (es) 2018-04-06
MY182358A (en) 2021-01-20
SG10202101556WA (en) 2021-03-30
RU2701348C2 (ru) 2019-09-26
ZA201501472B (en) 2016-06-29
US9816150B2 (en) 2017-11-14
JP2018090616A (ja) 2018-06-14
LT2893045T (lt) 2018-07-25
SG10201608055XA (en) 2016-11-29
MX2018013097A (es) 2020-09-02
HK1258778A1 (zh) 2019-11-22
IN2015DN01572A (zh) 2015-07-03
CN104918640B (zh) 2019-03-19
EP3369808A1 (en) 2018-09-05
JP6322326B2 (ja) 2018-05-09
CN108904545A (zh) 2018-11-30
IL237397B (en) 2018-10-31

Similar Documents

Publication Publication Date Title
HK1258774A1 (zh) 一種用於選擇影響腸道蠕動紊亂和疼痛的試劑的方法
IL226401A0 (en) Methods for treating disorders related to @fgfBA
EP2675460A4 (en) TREATMENT OF FAT TISSUE UNDER CHIN
EP2874647A4 (en) METHOD FOR DIAGNOSIS AND TREATMENT
EP2844271A4 (en) PROCESSING METHOD AND AGENTS USEFUL THEREFOR
EP2691529A4 (en) METHOD AND COMPOSITIONS FOR TREATING BRAIN DISEASES
IL230433A0 (en) Pain management methods
GB201205448D0 (en) Apparatus for stimulating muscles of a subject and method of performing the same
IL234606A0 (en) Innovative methods and compounds for the treatment of diseases
HK1204573A1 (zh) 炎性皮膚病症的治療
EP2825173A4 (en) CALMODULIN INHIBITORS FOR THE TREATMENT OF RIBOSOMAL DISEASES AND RIBOSOMAPATHIES
HK1216504A1 (zh) 疾病的治療方法
EP2694168A4 (en) HEALTH CARE DEVICE AND METHOD FOR TREATMENT OF PAIN
HK1186986A1 (zh) 治療皮膚病的方法
HK1201741A1 (zh) 預防神經系統疾病的方法
PL2665602T3 (pl) Ultraelastyczny materiał i sposób jego wytwarzania
EP2825184A4 (en) COMPOSITIONS AND METHODS FOR THE TREATMENT OF PAIN
EP2911662A4 (en) METHOD OF TREATING A DISEASE
SG10201802808SA (en) Method of treating ocular disorders
GB201221032D0 (en) Method of treatment
GB201207894D0 (en) Method of treatment
GB201221118D0 (en) Methods of treatment
GB201216748D0 (en) Methods of treatment
GB201216740D0 (en) Methods of treatment
GB201206324D0 (en) Methods of treatment