MX362495B - Un metodo para la seleccion de agentes que afectan los trastornos de motilidad intestinal y el dolor. - Google Patents

Un metodo para la seleccion de agentes que afectan los trastornos de motilidad intestinal y el dolor.

Info

Publication number
MX362495B
MX362495B MX2015002792A MX2015002792A MX362495B MX 362495 B MX362495 B MX 362495B MX 2015002792 A MX2015002792 A MX 2015002792A MX 2015002792 A MX2015002792 A MX 2015002792A MX 362495 B MX362495 B MX 362495B
Authority
MX
Mexico
Prior art keywords
intestinal motility
selection
motility disorders
treatment
agent
Prior art date
Application number
MX2015002792A
Other languages
English (en)
Other versions
MX2015002792A (es
Inventor
Connolly Eamonn
Kunze Wolfgang
Bienenstock John
Original Assignee
Biogaia Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49115523&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX362495(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Biogaia Ab filed Critical Biogaia Ab
Publication of MX2015002792A publication Critical patent/MX2015002792A/es
Publication of MX362495B publication Critical patent/MX362495B/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135Bacteria or derivatives thereof, e.g. probiotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66Microorganisms or materials therefrom
    • A61K35/74Bacteria
    • A61K35/741Probiotics
    • A61K35/744Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747Lactobacilli, e.g. L. acidophilus or L. brevis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/0004Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10Laxatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12Antidiarrhoeals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20Bacteria; Culture media therefor
    • C12N1/205Bacterial isolates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • G06T7/0002Inspection of images, e.g. flaw detection
    • G06T7/0012Biomedical image inspection
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00Image analysis
    • G06T7/10Segmentation; Edge detection
    • G06T7/13Edge detection
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K2035/11Medicinal preparations comprising living procariotic cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12RINDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00Microorganisms ; Processes using microorganisms
    • C12R2001/01Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/225Lactobacillus
    • GPHYSICS
    • G06COMPUTING; CALCULATING OR COUNTING
    • G06TIMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00Indexing scheme for image analysis or image enhancement
    • G06T2207/30Subject of image; Context of image processing
    • G06T2207/30004Biomedical image processing
    • G06T2207/30092Stomach; Gastric

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Theoretical Computer Science (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Rheumatology (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Urology & Nephrology (AREA)
  • Nutrition Science (AREA)
  • Toxicology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Quality & Reliability (AREA)

Abstract

Se proporciona un método para evaluar los agentes para el tratamiento de diferentes trastornos de motilidad intestinal, usando distintas partes metodológicas relacionadas con la musculatura y los nervios del tracto GI que se comunican con el cerebro. Particularmente, la presente invención proporciona un método para la selección de un agente efectivo para el tratamiento de un trastorno de motilidad intestinal, donde el método comprende: a) una etapa de mapeo espaciotemporal (ST, por sus siglas en inglés) realizado en un segmento gastrointestinal para analizar el efecto de dicho agente en la motilidad gastrointestinal; y b) una etapa de grabación del haz nervioso ex vivo realizada en un segmento gastrointestinal para analizar el efecto de dicho agente en la descarga del nervio aferente mesentérico. También se proporcionan las cepas bacterianas seleccionadas por los métodos de la invención y el uso de las cepas bacterianas en el tratamiento de los trastornos de motilidad intestinal motilidad.
MX2015002792A 2012-09-03 2013-09-03 Un metodo para la seleccion de agentes que afectan los trastornos de motilidad intestinal y el dolor. MX362495B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261696277P 2012-09-03 2012-09-03
PCT/EP2013/068202 WO2014033330A1 (en) 2012-09-03 2013-09-03 A method for selection of agents influencing intestinal motility disorders and pain

Publications (2)

Publication Number Publication Date
MX2015002792A MX2015002792A (es) 2015-05-07
MX362495B true MX362495B (es) 2019-01-21

Family

ID=49115523

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2015002792A MX362495B (es) 2012-09-03 2013-09-03 Un metodo para la seleccion de agentes que afectan los trastornos de motilidad intestinal y el dolor.
MX2018013097A MX2018013097A (es) 2012-09-03 2015-03-03 Un metodo para la seleccion de agentes que afectan los trastornos de motilidad intestinal y el dolor.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2018013097A MX2018013097A (es) 2012-09-03 2015-03-03 Un metodo para la seleccion de agentes que afectan los trastornos de motilidad intestinal y el dolor.

Country Status (27)

Country Link
US (5) US9555065B2 (es)
EP (2) EP2893045B1 (es)
JP (3) JP6259458B2 (es)
KR (1) KR102293438B1 (es)
CN (4) CN109966511A (es)
AU (1) AU2013308299B2 (es)
CA (1) CA2883440A1 (es)
CL (2) CL2015000490A1 (es)
CO (1) CO7350654A2 (es)
DK (1) DK2893045T3 (es)
ES (1) ES2681974T3 (es)
GE (1) GEP201706775B (es)
HK (3) HK1211848A1 (es)
HR (1) HRP20181033T1 (es)
IL (2) IL237397B (es)
IN (1) IN2015DN01572A (es)
LT (1) LT2893045T (es)
MX (2) MX362495B (es)
MY (2) MY182358A (es)
NZ (1) NZ705358A (es)
PH (1) PH12015500452A1 (es)
RU (1) RU2701348C2 (es)
SG (3) SG10201608055XA (es)
SI (1) SI2893045T1 (es)
UA (2) UA118339C2 (es)
WO (1) WO2014033330A1 (es)
ZA (1) ZA201501472B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ618935A (en) 2010-08-04 2014-03-28 Karma Medical Prod Co Ltd Compositions for fecal floral transplantation and methods for making and using them and devices for delivering them
CN108094541A (zh) * 2018-01-11 2018-06-01 黑龙江完达山林海液奶有限公司 一种具有保健益生功能的风味发酵乳及其制备方法
BR112020023868A2 (pt) 2018-07-24 2021-04-06 Biogaia Ab Cepa bacteriana de ácido láctico, métodos para a seleção de uma cepa bacteriana de ácido láctico e para produzir melatonina em um indivíduo, produto de combinação, e, uso de uma cepa bacteriana de ácido láctico.
CN113966284B (zh) * 2019-06-05 2024-09-10 Avl移动技术公司 车辆轴组件
CN110186922B (zh) * 2019-06-25 2021-07-23 西安交通大学医学院第一附属医院 一种监测结肠移行性复合运动的实验装置及方法
US11843097B2 (en) 2019-09-10 2023-12-12 Avl Powertrain Engineering, Inc. Power supply control systems and methods
CN112710823B (zh) * 2020-12-17 2024-03-29 中国科学院深圳先进技术研究院 一种肠移行性复合运动的离体检测系统及其应用
CN114342878B (zh) * 2022-01-10 2022-09-30 南京鼓楼医院 一种慢传输型便秘动物模型的建立方法
CN117384804A (zh) * 2023-12-12 2024-01-12 北京三元食品股份有限公司 格氏乳杆菌b1-26及其应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5438989A (en) * 1990-08-10 1995-08-08 Hochman; Darryl Solid tumor, cortical function, and nerve tissue imaging methods and device
ES2257869T3 (es) * 1998-08-21 2006-08-01 Novartis Ag Nueva formulacion oral para agonistas o antagonistas de 5-ht4.
IL147312A0 (en) * 1999-07-06 2002-08-14 Enpharma L P Methods for compositions for regulating gut motility and food intake
NZ537706A (en) * 2002-06-28 2008-03-28 Puleva Biotech Sa Probiotic microbial strains, comprising non-pathogenic strains which are capable of surviving in and being transferred to breast milk and/or amniotic fluid after oral intake in healthy individuals without colonizing other internal organs except mucousas
EP1384483A1 (en) * 2002-07-23 2004-01-28 Nestec S.A. Probiotics for treatment of irritable bowel disease (IBS) through improvement of gut neuromuscular function
TWI241912B (en) * 2002-10-30 2005-10-21 Food Industry Res & Dev Inst Novel Acid-and bile salt-resistant Lactobacillus isolates having the ability to lower and assimilate cholesterol
CN1663573B (zh) * 2004-03-04 2010-04-28 青岛东海药业有限公司 一种稳定安全的微生态制剂及其制备方法和用途
US20090233888A1 (en) * 2005-03-23 2009-09-17 Usc Stevens, University Of Southern California Treatment of disease conditions through modulation of hydrogen sulfide produced by small intestinal bacterial overgrowth
JP5036020B2 (ja) * 2005-11-30 2012-09-26 雪印メグミルク株式会社 腎周囲脂肪蓄積抑制剤
US7374924B2 (en) * 2006-06-05 2008-05-20 Biogaia Ab Use of selected lactic acid bacteria for reducing infantile colic
JP5019563B2 (ja) * 2006-06-16 2012-09-05 旭化成ケミカルズ株式会社 腸内細菌賦活剤
EP2200443B2 (en) * 2007-09-17 2021-06-30 Cornell University Branched chain fatty acids for prevention or treatment of gastrointestinal disorders
CN102481323A (zh) * 2009-07-31 2012-05-30 雀巢产品技术援助有限公司 含有益生菌和所选营养物的用于母乳喂养的婴幼儿或宠物的营养组合物
US20110110905A1 (en) * 2009-11-06 2011-05-12 Ritchie Jennifer A Infant Colic Supplement
WO2011148219A1 (en) * 2010-05-28 2011-12-01 Compagnie Gervais Danone Probiotic strains for use in improving the enteric nervous system
US20120034198A1 (en) * 2010-08-04 2012-02-09 Microbios, Inc. Carriers for storage and delivery of biologics
CN102304489B (zh) * 2011-09-23 2013-06-12 北京龙科方舟生物工程技术有限公司 一株罗伊氏乳杆菌及其应用

Also Published As

Publication number Publication date
UA118339C2 (uk) 2019-01-10
IL259652A (en) 2018-07-31
US20220306984A1 (en) 2022-09-29
US9816150B2 (en) 2017-11-14
DK2893045T3 (en) 2018-07-30
MY182358A (en) 2021-01-20
AU2013308299A1 (en) 2015-03-26
MX2018013097A (es) 2020-09-02
SI2893045T1 (en) 2018-08-31
MX2015002792A (es) 2015-05-07
IL237397A0 (en) 2015-04-30
CN108753645A (zh) 2018-11-06
WO2014033330A1 (en) 2014-03-06
EP3369808A1 (en) 2018-09-05
SG10202101556WA (en) 2021-03-30
US9555065B2 (en) 2017-01-31
ES2681974T3 (es) 2018-09-17
HRP20181033T1 (hr) 2018-08-24
US20190112676A1 (en) 2019-04-18
JP6259458B2 (ja) 2018-01-10
JP2015529329A (ja) 2015-10-05
IL259652B (en) 2020-03-31
KR102293438B1 (ko) 2021-08-25
CO7350654A2 (es) 2015-08-10
CN104918640A (zh) 2015-09-16
HK1211848A1 (en) 2016-06-03
CN104918640B (zh) 2019-03-19
SG11201501297TA (en) 2015-03-30
JP2018090616A (ja) 2018-06-14
KR20150048201A (ko) 2015-05-06
US20180023150A1 (en) 2018-01-25
RU2015112102A (ru) 2016-10-20
NZ705358A (en) 2018-09-28
PH12015500452A1 (en) 2015-04-20
JP2018029588A (ja) 2018-03-01
CA2883440A1 (en) 2014-03-06
GEP201706775B (en) 2017-11-27
EP2893045B1 (en) 2018-05-16
AU2013308299B2 (en) 2019-04-18
CL2017002826A1 (es) 2018-04-06
CL2015000490A1 (es) 2015-05-29
RU2701348C2 (ru) 2019-09-26
HK1258774A1 (zh) 2019-11-22
HK1258778A1 (zh) 2019-11-22
EP2893045A1 (en) 2015-07-15
JP6322326B2 (ja) 2018-05-09
CN109966511A (zh) 2019-07-05
US20170114422A1 (en) 2017-04-27
SG10201608055XA (en) 2016-11-29
ZA201501472B (en) 2016-06-29
IN2015DN01572A (es) 2015-07-03
LT2893045T (lt) 2018-07-25
IL237397B (en) 2018-10-31
US20150231186A1 (en) 2015-08-20
CN108753645B (zh) 2019-10-22
US10174388B2 (en) 2019-01-08
JP6476328B2 (ja) 2019-02-27
MY195532A (en) 2023-01-31
UA126374C2 (uk) 2022-09-28
CN108904545A (zh) 2018-11-30

Similar Documents

Publication Publication Date Title
MX2018013097A (es) Un metodo para la seleccion de agentes que afectan los trastornos de motilidad intestinal y el dolor.
EP3692909A4 (en) DIFFERENTIATION DEVICE, DEPRESSION SYMPTOMS DIFFERENTIATION PROCESS, DEPRESSION SYMPTOM LEVEL DETERMINATION METHOD, DEPRESSION PATIENT STRATIFICATION METHOD, DEPRESSION SYMPTOM TREATMENT EFFECTS DETERMINATION AND DEPRESSION SYMPTOMS TREATMENT PROCESS, DETERMINATION DEVICE '' BRAIN ACTIVITY
EP3041405A4 (en) Apparatus and methods for diagnosis and treatment of patterns of nervous system activity affecting disease
MX2022004300A (es) Composicion y metodo para el diagnostico y tratamiento de enfermedades asociadas con la degeneracion de neuritas.
WO2011112652A8 (en) Method and device for removing eeg artifacts
EP3876834A4 (en) SYSTEMS AND METHODS FOR COOPERATIVE INVASIVE AND NON-INVASIVE BRAIN STIMULATION
GB201016812D0 (en) Method and apparatus for treating respiratory diesease
EP2667237A4 (en) DEVICE AND METHOD FOR THE INVESTIGATION, DIAGNOSIS OR DIAGNOSTIC ASSISTANCE AND THERAPY OF FUNCTIONAL VISIBILITY PROBLEMS
PH12015500114A1 (en) HUMAN ANTIBODIES TO GFRa3 AND METHODS OF USE THEREOF
MX358991B (es) Uso de moleculas de enlace a la semaforina-4d para promover la neurogenesis despues de la apoplejia.
MX356933B (es) Composicion y metodo para el diagnostico y tratamiento de trastornos relacionados con hierro.
MX2018008882A (es) Composicion y metodo para el diagnostico y tratamiento de trastornos relacionados con hierro.
WO2018107853A3 (en) N-methyl-d-aspartate receptor allosteric modulators and methods for their use
EP3624685A4 (en) NEEDLE IMPEDANCE ELECTROMYOGRAPHY AND ELECTRIC IMPEDANCE IMAGING FOR IMPROVED MUSCLE DIAGNOSIS
WO2014145432A3 (en) Method for improving cognitive and motor abilities
EP3287987A4 (en) Three-dimensional reconstruction visual integration method for human body peripheral nerve internal tract type structure
ZA201803483B (en) Method of treating disease by auricular anesthesia of cranial nerves
WO2011106785A3 (en) Methods of identifying agents effective to treat cognitive decline and diseases associated therewith
EP3719754A4 (en) THREE-DIMENSIONAL VISUAL RECONSTRUCTION PROCESS FOR HUMAN PERIPHERAL NERVE TRACT STRUCTURE
EP3975970A4 (en) REAL-TIME PRECISION-GUIDED CPR METHOD TO IMPROVE NEUROLOGICAL OUTCOMES AND BRAIN DAMAGE PREDICTION
EP2326165A4 (en) ANIMAL MODEL FOR CENTRAL NEUROPATHIC PAIN AND METHOD FOR ITS MANUFACTURE AND USE
GB2505833A (en) Assessment method
EP3232902A4 (en) Method and apparatus for fixation, alignment, and/or saccadic measurements to identify and/or track brain function
EP3998355A4 (en) METHOD FOR DIAGNOSIS OF A BRAIN TUMOR USING BACTERIAL METAGENOMIC ANALYSIS
WO2016112382A3 (en) Intranasal administration of glutamate carboxypeptidase (gcp-ii) inhibitors

Legal Events

Date Code Title Description
FG Grant or registration