CN108888573A - Shu Min moisturizing frost and preparation method thereof - Google Patents
Shu Min moisturizing frost and preparation method thereof Download PDFInfo
- Publication number
- CN108888573A CN108888573A CN201810882143.8A CN201810882143A CN108888573A CN 108888573 A CN108888573 A CN 108888573A CN 201810882143 A CN201810882143 A CN 201810882143A CN 108888573 A CN108888573 A CN 108888573A
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Abstract
Shu Min moisturizing frost of the present invention, is prepared from the following raw materials in parts by weight：Two 1~1.5 part of asafoetide acyl methane of the double demethoxylations of 9~10 parts of pumpkin seed oil, 1~1.2 part of 3- amino propane sulfonic acid, 6~8 parts of Sodium Lauroamphoacetate, 3~4 parts of cyclohexasiloxane, 90~100 parts of pure water, 3~4 parts of maltodextrin, 0.5~0.8 part of water-soluble fullerene powder, tetrahydro, 3~3.5 parts of ascorbic acid glucoside, 4~5 parts of magnesium sulfate, 4.5~5 parts of tendril-leaved fritillary bulb extractive from fermentative, 4.5~5 parts of Pleurotus ferulae extract, 3.5~4 parts of Japanese apricot flower extract.Shu Min moisturizing of the present invention is white, and the synergistic effect between each component is prominent；Nourishing skin can not only be repaired, with excellent anti-oxidant and collaboration white-skinned face function；Especially also have the effect of releive antiallergic and moisturizing moisturizing outstanding.
Description
Technical field
The invention belongs to biology and cosmetic technical fields, and in particular to a kind of Shu Min moisturizing frost and its preparation side
Method.
Background technique
Anaphylactogen is the necessary condition that allergic reaction occurs, and has left anaphylactogen, so that it may avoid the generation of allergy, still
The original very big otherness of the human allergy of different constitutions, therefore there is be not to all allergy patients for the way far from anaphylactogen
It will effective defect；Use anti-histamine substance：Antihistamine refers to the biology using anti-histamine substance antagonizing histamine to human body
Effect.Anti-histamine substance can inhibit the allergins such as histamine release of mast cell, inhibit acidophic cell and mast cell
Splitting action alleviates inflammatory reaction, reaches therapeutic purposes to prevent this kind of cell in the aggregation of inflammation part.However anti-group
Amine substance is largely medicinal ingredient, be in cosmetics do not allow using；Remove free radical：It recent studies have shown that, allergy
The formation of constitution and the breaking-out of allergy are all excessively accumulated with the intracorporal free radical of machine related.And the environment being on the rise is dirty
Dye, the factors such as chemicals abuse and radiation can all directly contribute the accumulation of free radical in vivo.By removing free radical, machine is adjusted
Body is immune, can reach gradually improvement allergic constitution purpose, still, the time required to the symptom for improving skin allergy using the above method
Longer, short-term response is unobvious.The outermost layer of epidermis is cuticula, due to the water suction of cuticula itself, barrier function and angle
The effect of natural moisturizing factor, that is, amino acids, lactate and carbohydrate etc. contained in matter layer keeps cuticula centainly
Water content maintains the wet of skin.And the appearance of skin is related with the moisture content of cuticula, normal keratoderma is usual
Moisture containing 10%-30%, to maintain the softness and elasticity of skin.But with advancing age, keratoderma moisture content
It can gradually decrease, and when the moisture content of keratoderma is lower than 10%, skin just will appear dry, tight, coarse and furfur
Deng.
Summary of the invention
The object of the present invention is to provide a kind of with excellent anti-oxidant and collaboration white-skinned face function and it is outstanding releive it is anti-
Quick and moisturizing moisturizing effect Shu Min moisturizing frost.
Shu Min moisturizing frost of the present invention, is prepared from the following raw materials in parts by weight：9~10 parts of pumpkin seed oil, 3- amino
1~1.2 part of propane sulfonic acid, 6~8 parts of Sodium Lauroamphoacetate, 3~4 parts of cyclohexasiloxane, 90~100 parts of pure water, wheat
Two 1~1.5 part of asafoetide acyl methane of the double demethoxylations of 3~4 parts of bud dextrin, 0.5~0.8 part of water-soluble fullerene powder, tetrahydro resists
3~3.5 parts of bad hematic acid glucoside, 4~5 parts of magnesium sulfate, 4.5~5 parts of tendril-leaved fritillary bulb extractive from fermentative, Pleurotus ferulae extract 4.5~5
Part, 3.5~4 parts of Japanese apricot flower extract.
As optimization, which is prepared from the following raw materials in parts by weight：9.5 parts of pumpkin seed oil, 3- ammonia
1.1 parts of base propane sulfonic acid, 7 parts of Sodium Lauroamphoacetate, 3.5 parts of cyclohexasiloxane, 95 parts of pure water, maltodextrin 3.5
Part, double two 1.2 parts of the asafoetide acyl methane of demethoxylation of 0.6 part of water-soluble fullerene powder, tetrahydro, 3.2 parts of ascorbic acid glucoside,
4.5 parts of magnesium sulfate, 4.8 parts of tendril-leaved fritillary bulb extractive from fermentative, 4.6 parts of Pleurotus ferulae extract, 3.6 parts of Japanese apricot flower extract.
The method for preparing the Shu Min moisturizing frost, includes the following steps：
(1) by the pumpkin seed oil of the parts by weight, 3- amino propane sulfonic acid, Sodium Lauroamphoacetate, cyclohexasiloxane,
It is added in stirred tank, is heated to 75~80 DEG C, stirs evenly；
(2) it by the pure water of the parts by weight, maltodextrin, water-soluble fullerene powder, is added in stirred tank, is heated to 68
It~72 DEG C, stirs evenly；
(3) mixture in the mixture and step (1) in step (2) is mixed, is added in stirred tank, at 60~65 DEG C, stirs
It mixes uniformly；
(4) mixture in step (3) is cooled to 48~52 DEG C, be added the parts by weight the double demethoxylation of tetrahydro two Ah
Wei's acyl methane, ascorbic acid glucoside, magnesium sulfate, stir evenly；
(5) mixture in step (4) is cooled to 42~45 DEG C, be added the parts by weight tendril-leaved fritillary bulb extractive from fermentative, Ah
Wei mushroom extract, Japanese apricot flower extract, stir evenly；It discharges after cooling to obtain the final product.
In the present invention, cyclohexasiloxane is as smooth dose；Maltodextrin makees adsorbent and emulsion stabilizer.Lauroyl both sexes
Guanidine-acetic acid sodium, 3- amino propane sulfonic acid are mild surfactant.The double two asafoetide acyl methane of demethoxylation of tetrahydro are as anti-oxidant
Agent uses, Fullerene C20 can affine free radical, there is extremely strong oxidation resistance, play activating skin cells, prevent skin
The effect of decline.
Ascorbic acid glucoside, acyl sulfhydryl ethylamine sulfonic acid calcium can hinder the conversion of melanin as whitening composition；It is white
Plum blossom（Armeniaca mume）Extract, can effectively inhibit tyrosinase activity and melanin production；The above three components collaboration has uniform
The good effects of the colour of skin, whitening skin lightening.Tendril-leaved fritillary bulb Lactobacillus acidophilus' extract has and inhibits hyaluronidase, antiallergic of releiving
Prominent effect.Pleurotus ferulae extract has effects that moisturizing moisturizing outstanding.Pumpkin seed oil is rich in a large amount of VE, phytosterol, leaf
The nutrition such as green element, help skin cell metabolism, keep the collagen content of skin, maintain the elasticity of skin, reduce wrinkle
Line.Magnesium sulfate is used as filler and viscosity control.
Shu Min moisturizing of the present invention is white, and the synergistic effect between each component is prominent；Nourishing skin can not only be repaired,
With excellent anti-oxidant and collaboration white-skinned face function；Especially also have the effect of releive antiallergic and moisturizing moisturizing outstanding.
Detailed description of the invention
Fig. 1 various concentration hyaluronic acid enzyme inhibition rate result figure.
Fig. 2 difference group pastes class's experimental result picture.
Fig. 3 difference group processing moisture content of skin changes over time figure.
Specific embodiment
The embodiments given below are intended to further illustrate the invention, but is not to be construed as to the scope of the present invention
Limitation, content still falls within this to some nonessential modifications and adaptations of the invention to those skilled in the art according to the present invention
The protection scope of invention.
In the present invention, it is newly old to help Skin Cell rich in nutrition such as a large amount of VE, phytosterol, chlorophyll for pumpkin seed oil
Metabolism, keeps the collagen content of skin, maintains the elasticity of skin, reduces wrinkle.Magnesium sulfate is as filler and viscosity control
System uses.Cyclohexasiloxane can reduce surface tension as smooth dose, waterproofing agent, volatile silicone oils, apply product clearly well
It smears, does not stick greasy.Maltodextrin makees adsorbent in cosmetics and emulsion stabilizer uses.Sodium Lauroamphoacetate is mild
Surfactant has excellent decontamination, emulsification, dispersion, foam stabilizing, wetting, antistatic, foaming, penetrating power.3- aminopropane
Sulfonic acid is zwitterionic surfactant-sulfamic acid type；With excellent decontamination, it is antistatic, help water-soluble ability.Pantoyl sulfydryl
Aminoethanesulfonic acid calcium can hinder the conversion of melanin as whitening composition.The double two asafoetide acyl methane of demethoxylation of tetrahydro are as anti-
Oxidant uses.Ascorbic acid glucoside can inhibit tyrosinase as whitening composition, while have antioxidation, peace
Full property is very high.Water-soluble fullerene powder, Fullerene C20 can affine free radical, have extremely strong oxidation resistance, Neng Gouqi
To activating skin cells, the effect of delaying skin apoptosis.
Tendril-leaved fritillary bulb extractive from fermentative is tendril-leaved fritillary bulb Lactobacillus acidophilus extract, has and inhibits hyaluronidase, antiallergic of releiving
Prominent effect；It can be prepared by the following, tendril-leaved fritillary bulb is cleaned and is crushed to 50~60 mesh, 18~20 times of distillations are then added
Water, 115~121 DEG C of 15~30min of high pressure sterilization；The Lactobacillus acidophilus of activation are inoculated with, inoculum concentration is 2%~3%, and
It 28~32 DEG C, ferments 3~5 days；After homogenate of fermentation broth is crushed using high pressure homogenizer, 5000~6000r/min centrifugation 10~
12 minutes, supernatant, vacuum-concentrcted are taken, freeze-drying obtains.
Hyaluronic acid (HA) is distributed in extracellular matrix, is the main component for constituting extracellular matrix and cytoplasm,
After it is hydrolyzed by hyaluronidase HAase, iuntercellular then becomes non-sticky, and cell degranulation and the new medium of synthesis is caused to seep
Out, biological effect is played, the generation of type Ⅰ hypersensitivity reaction is often resulted in.Hyaluronidase Inhibition test：
It is measured using Elson-Morgan method, measures hyaluronic acid enzyme inhibition rate.Clean tube is taken, every test tube is added
0.5 mL hyaluronidase solution and 0.1mL0.25 mmol/L CaC12 solution, are placed in 37 DEG C of 20 min of incubator culture；
Certain density 0.5 mL of tendril-leaved fritillary bulb extractive from fermentative sample liquid is added, continues 37 DEG C of 20 min of heat insulating culture；Add O.5 mL
Sodium hyaluronate solution is placed in 37 DEG C of incubators and keeps the temperature 30 min, then takes out, 5 min of room temperature；It is added 0.1
ML0.4mol/LNaOH solution and 0.5 mL acetylacetone,2,4-pentanedione solution, are placed in boiling water bath after heating 15 min and are carried out immediately with ice water
Cooling 5 min；1.0 mL of Ehrlich's reagent is added and is diluted with 3.0 mL dehydrated alcohols, places 20 min colour developing, uses
Its absorbance value of spectrophotometric determination.Hyaluronic acid enzyme inhibition rate (%)：[(A-B) (C-D)]/(A-B) × 100%；In formula：
A is the OD value of contrast solution；B is the OD value for compareing blank solution；C is the OD value of testing sample solution；D is the OD of sample blank
Value, the result is shown in Figure 1.With the increase of tendril-leaved fritillary bulb extractive from fermentative concentration, when reaching lO g/L, hyaluronic acid enzyme inhibition rate is
92.78%.This shows that tendril-leaved fritillary bulb extractive from fermentative can reduce point of hyaluronic acid by the approach of inhibition hyaluronidase activity
Solution, and then the burst size of histamine and inflammatory factor is reduced, to play the role of certain antiallergic anti-irritant.
Pleurotus ferulae extract has effects that moisturizing moisturizing outstanding；It can be prepared by the following, Pleurotus ferulae is put into
50~60 DEG C of drying in oven, are crushed to 100~120 mesh；Aqueous solution, 3.5 W/ of microwave carrier fluid amount are made by material-water ratio 1: 20
ML, 8~10 min of action time；5000~6000 r/min are centrifuged 20~25 min, take supernatant, 3 times of volume ethanol precipitatings
Overnight, precipitating is filtered to take；50~60 DEG C drying to get.
Flos mume（Armeniaca mume）Extract, can effectively inhibit tyrosinase activity and melanin production, have even skin tone,
The good effects of bright color.Xi'an Ai Nuo medical sci-tech Co., Ltd 30 may be selected:1 Japanese apricot flower extract.
Embodiment 1：Shu Min moisturizing frost, is made up of following steps：
(1) by 9.5 parts of pumpkin seed oil, 1.1 parts of 3- amino propane sulfonic acid, 7 parts of Sodium Lauroamphoacetate, cyclohexasiloxane
It 3.5 parts, is added in stirred tank, is heated to 75~80 DEG C, stirs evenly；
(2) it by 95 parts of pure water, 3.5 parts of maltodextrin, 0.6 part of water-soluble fullerene powder, is added in stirred tank, is heated to 68
It~72 DEG C, stirs evenly；
(3) mixture in the mixture and step (1) in step (2) is mixed, is added in stirred tank, at 60~65 DEG C, stirs
It mixes uniformly；
(4) mixture in step (3) is cooled to 48~52 DEG C, be added two 1.2 parts of asafoetide acyl methane of the double demethoxylations of tetrahydro,
3.2 parts of ascorbic acid glucoside, 4.5 parts of magnesium sulfate, stir evenly；
(5) mixture in step (4) is cooled to 42~45 DEG C, 4.8 parts of tendril-leaved fritillary bulb extractive from fermentative, Pleurotus ferulae extract is added
4.6 parts, 3.6 parts of Japanese apricot flower extract, stir evenly；It discharges after cooling to obtain the final product.
Embodiment 2：Shu Min moisturizing frost, is made up of following steps：
(1) by 9 parts of pumpkin seed oil, 1 part of 3- amino propane sulfonic acid, 6 parts of Sodium Lauroamphoacetate, 3 parts of cyclohexasiloxane, add
Enter in stirred tank, is heated to 75~80 DEG C, stirs evenly；
(2) it by 90 parts of pure water, 3 parts of maltodextrin, 0.5 part of water-soluble fullerene powder, is added in stirred tank, it is heated to 68~
It 72 DEG C, stirs evenly；
(3) mixture in the mixture and step (1) in step (2) is mixed, is added in stirred tank, at 60~65 DEG C, stirs
It mixes uniformly；
(4) mixture in step (3) is cooled to 48~52 DEG C, two 1 part of asafoetide acyl methane of the double demethoxylations of tetrahydro is added, resists
3 parts of bad hematic acid glucoside, 4 parts of magnesium sulfate, stir evenly；
(5) mixture in step (4) is cooled to 42~45 DEG C, 4.5 parts of tendril-leaved fritillary bulb extractive from fermentative, Pleurotus ferulae extract is added
4.5 parts, 3.5 parts of Japanese apricot flower extract, stir evenly；It discharges after cooling to obtain the final product.
Embodiment 3：Shu Min moisturizing frost, is made up of following steps：
(1) by 10 parts of pumpkin seed oil, 1.2 parts of 3- amino propane sulfonic acid, 8 parts of Sodium Lauroamphoacetate, cyclohexasiloxane 4
Part, it is added in stirred tank, is heated to 75~80 DEG C, stirs evenly；
(2) it by 100 parts of pure water, 4 parts of maltodextrin, 0.8 part of water-soluble fullerene powder, is added in stirred tank, is heated to 68
It~72 DEG C, stirs evenly；
(3) mixture in the mixture and step (1) in step (2) is mixed, is added in stirred tank, at 60~65 DEG C, stirs
It mixes uniformly；
(4) mixture in step (3) is cooled to 48~52 DEG C, be added two 1.5 parts of asafoetide acyl methane of the double demethoxylations of tetrahydro,
3.5 parts of ascorbic acid glucoside, 5 parts of magnesium sulfate, stir evenly；
(5) mixture in step (4) is cooled to 42~45 DEG C, 5 parts of tendril-leaved fritillary bulb extractive from fermentative, Pleurotus ferulae extract 5 is added
Part, 4 parts of Japanese apricot flower extract, stir evenly；It discharges after cooling to obtain the final product.
Comparative example 1：Emollient cream is made up of following steps：
(1) by 9.5 parts of pumpkin seed oil, 1.1 parts of 3- amino propane sulfonic acid, 7 parts of Sodium Lauroamphoacetate, cyclohexasiloxane
It 3.5 parts, is added in stirred tank, is heated to 75~80 DEG C, stirs evenly；
(2) it by 95 parts of pure water, 3.5 parts of maltodextrin, 0.6 part of water-soluble fullerene powder, is added in stirred tank, is heated to 68
It~72 DEG C, stirs evenly；
(3) mixture in the mixture and step (1) in step (2) is mixed, is added in stirred tank, at 60~65 DEG C, stirs
It mixes uniformly；
(4) mixture in step (3) is cooled to 48~52 DEG C, be added two 1.2 parts of asafoetide acyl methane of the double demethoxylations of tetrahydro,
3.2 parts of ascorbic acid glucoside, 4.5 parts of magnesium sulfate, stir evenly；
(5) mixture in step (4) is cooled to 42~45 DEG C, 4.6 parts of Pleurotus ferulae extract, Japanese apricot flower extract is added
It 3.6 parts, stirs evenly；It discharges after cooling to obtain the final product.
Comparative example 2：Emollient cream is made up of following steps：
(1) by 9.5 parts of pumpkin seed oil, 1.1 parts of 3- amino propane sulfonic acid, 7 parts of Sodium Lauroamphoacetate, cyclohexasiloxane
It 3.5 parts, is added in stirred tank, is heated to 75~80 DEG C, stirs evenly；
(2) it by 95 parts of pure water, 3.5 parts of maltodextrin, 0.6 part of water-soluble fullerene powder, is added in stirred tank, is heated to 68
It~72 DEG C, stirs evenly；
(3) mixture in the mixture and step (1) in step (2) is mixed, is added in stirred tank, at 60~65 DEG C, stirs
It mixes uniformly；
(4) mixture in step (3) is cooled to 48~52 DEG C, be added two 1.2 parts of asafoetide acyl methane of the double demethoxylations of tetrahydro,
3.2 parts of ascorbic acid glucoside, 4.5 parts of magnesium sulfate, stir evenly；
(5) mixture in step (4) is cooled to 42~45 DEG C, 4.8 parts of tendril-leaved fritillary bulb extractive from fermentative, Japanese apricot flower extract is added
It 3.6 parts, stirs evenly；It discharges after cooling to obtain the final product.
Patch experiment：
38 people of volunteer is chosen, age composition and gender determine at random, meet 2007《Cosmetics health specification》It is included in, excludes mark
It is quasi-；Back spinal two sides skin is recipient site in selection, and skin is divided into three parts, is embodiment 1, comparative example 1, blank pair
According to the bottom-up patch jail of the spot tester adhesive tape that then will try object added with spot；The patch test time is 48h；After sticking 48h, removal
Spot tester observes and records test result after 30min and sees Fig. 2.Detailed operating procedures are referring to patch test diagnostic kit specification.
It is visible prominent using the other two groups of effects of the embodiment of the present invention comparison by Fig. 2, the tolerance of skin can be improved, and repair
It is damaged the effect of skin mitigates allergic symptom again.
Moisturizing test：
The design of test group：On a voluntary basis, health volunteer 40 are divided into embodiment 1, comparative example 2, glycerol, blank group
Four groups.Every group is selected subject 10 at random, marks good facial test point position.Measure sample use before, continuous use 1 d,
Change of moisture content after 7d, 14 d, 28 d.It allows after the daily morning and evening face cleaning of every subject, uniformly uses sample facial, no
It must not cross-reference with sample.Test condition：20 ~ 25 DEG C of temperature, the relative humidity % of 50 % ~ 60, subject need to be before testing
At least stablize 30 min under test condition.Moisture content of skin measurement：With SK-5D number skin tester (the municipal wound of Yueqing City willow
Measuring equipment Co., Ltd).It measures subject's inner forearm and facial markers point and uses the moisture content before and after sample, each survey
Pilot is measured in parallel 5 times, is averaged, is as a result indicated with percentage, as a result sees Fig. 3.It is visible using of the invention by Fig. 3
Embodiment 1, relative to other contrast groups, moistening effect is significant, and long-term continuous use can also play moisturizing moisturizing, maintenance skin
The effect of.
Claims (3)
1. a kind of Shu Min moisturizing frost, it is characterised in that be prepared from the following raw materials in parts by weight：9~10 parts of pumpkin seed oil,
1~1.2 part of 3- amino propane sulfonic acid, 6~8 parts of Sodium Lauroamphoacetate, 3~4 parts of cyclohexasiloxane, pure water 90~
100 parts, two asafoetide acyl methane 1 of the double demethoxylation of 3~4 parts of maltodextrin, 0.5~0.8 part of water-soluble fullerene powder, tetrahydro~
1.5 parts, 3~3.5 parts of ascorbic acid glucoside, 4~5 parts of magnesium sulfate, 4.5~5 parts of tendril-leaved fritillary bulb extractive from fermentative, Pleurotus ferulae extract
4.5~5 parts, 3.5~4 parts of Japanese apricot flower extract.
2. Shu Min moisturizing frost according to claim 1, it is characterised in that be prepared from the following raw materials in parts by weight：South
Melon seeds oil 9.5 parts, 1.1 parts of 3- amino propane sulfonic acid, 7 parts of Sodium Lauroamphoacetate, 3.5 parts of cyclohexasiloxane, pure water
95 parts, it is 3.5 parts of maltodextrin, 0.6 part of water-soluble fullerene powder, double two 1.2 parts of the asafoetide acyl methane of demethoxylation of tetrahydro, anti-bad
3.2 parts of hematic acid glucoside, 4.5 parts of magnesium sulfate, 4.8 parts of tendril-leaved fritillary bulb extractive from fermentative, 4.6 parts of Pleurotus ferulae extract, flos mume extract
3.6 parts of object.
3. a kind of method for preparing Shu Min moisturizing frost described in any of the above item claim, it is characterised in that including following step
Suddenly：
(1) by the pumpkin seed oil of the parts by weight, 3- amino propane sulfonic acid, Sodium Lauroamphoacetate, cyclohexasiloxane,
It is added in stirred tank, is heated to 75~80 DEG C, stirs evenly；
(2) it by the pure water of the parts by weight, maltodextrin, water-soluble fullerene powder, is added in stirred tank, is heated to 68
It~72 DEG C, stirs evenly；
(3) mixture in the mixture and step (1) in step (2) is mixed, is added in stirred tank, at 60~65 DEG C, stirs
It mixes uniformly；
(4) mixture in step (3) is cooled to 48~52 DEG C, be added the parts by weight the double demethoxylation of tetrahydro two Ah
Wei's acyl methane, ascorbic acid glucoside, magnesium sulfate, stir evenly；
(5) mixture in step (4) is cooled to 42~45 DEG C, be added the parts by weight tendril-leaved fritillary bulb extractive from fermentative, Ah
Wei mushroom extract, Japanese apricot flower extract, stir evenly；It discharges after cooling to obtain the final product.
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