CN1088704C - 苯并噻吩的合成方法 - Google Patents

苯并噻吩的合成方法 Download PDF

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Publication number
CN1088704C
CN1088704C CN97198100A CN97198100A CN1088704C CN 1088704 C CN1088704 C CN 1088704C CN 97198100 A CN97198100 A CN 97198100A CN 97198100 A CN97198100 A CN 97198100A CN 1088704 C CN1088704 C CN 1088704C
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CN
China
Prior art keywords
reaction
compound
alkyl
acid
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN97198100A
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English (en)
Chinese (zh)
Other versions
CN1230957A (zh
Inventor
J·T·维琴兹
T·Y·张
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of CN1230957A publication Critical patent/CN1230957A/zh
Application granted granted Critical
Publication of CN1088704C publication Critical patent/CN1088704C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Catalysts (AREA)
CN97198100A 1996-09-25 1997-09-19 苯并噻吩的合成方法 Expired - Fee Related CN1088704C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2669596P 1996-09-25 1996-09-25
US60/026,695 1996-09-25

Publications (2)

Publication Number Publication Date
CN1230957A CN1230957A (zh) 1999-10-06
CN1088704C true CN1088704C (zh) 2002-08-07

Family

ID=21833302

Family Applications (1)

Application Number Title Priority Date Filing Date
CN97198100A Expired - Fee Related CN1088704C (zh) 1996-09-25 1997-09-19 苯并噻吩的合成方法

Country Status (31)

Country Link
US (1) US5977383A (enExample)
EP (1) EP0832889B1 (enExample)
JP (1) JP2001501208A (enExample)
KR (1) KR20000048539A (enExample)
CN (1) CN1088704C (enExample)
AR (1) AR013321A1 (enExample)
AT (1) ATE318805T1 (enExample)
AU (1) AU718919B2 (enExample)
BR (1) BR9712844A (enExample)
CA (1) CA2266617A1 (enExample)
CO (1) CO4900043A1 (enExample)
CZ (1) CZ92899A3 (enExample)
DE (1) DE69735339T2 (enExample)
EA (1) EA001914B1 (enExample)
EG (1) EG21037A (enExample)
ES (1) ES2257761T3 (enExample)
HU (1) HUP9904228A3 (enExample)
ID (1) ID21349A (enExample)
IL (1) IL129001A (enExample)
IN (1) IN183239B (enExample)
MY (1) MY118009A (enExample)
NO (1) NO991193L (enExample)
NZ (1) NZ334591A (enExample)
PE (1) PE2699A1 (enExample)
PL (1) PL332208A1 (enExample)
TR (1) TR199900672T2 (enExample)
TW (1) TW472053B (enExample)
UA (1) UA62938C2 (enExample)
WO (1) WO1998013363A1 (enExample)
YU (1) YU15399A (enExample)
ZA (1) ZA978372B (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002042289A2 (en) * 2000-11-27 2002-05-30 Eli Lilly And Company Process for preparing 3-aryl-benzo[b]thiophenes

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5523416A (en) * 1994-07-22 1996-06-04 Eli Lilly And Company Process for preparing 3-(4-aminoethoxy-benzoyl) benzo (B)-thiophenes

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1300575B (de) * 1965-05-21 1969-08-07 Bristol Myers Co Benzo[b]thiophene
US3394125A (en) * 1965-10-23 1968-07-23 Bristol Myers Co 2-phenyl-3-tertiary-aminoalkoxy phenyl-and corresponding tertiaryaminoalkyl thio benzfurans substituted in the benzo nucleus with an alkoxy or tertiaryamino alkoxy or alkylthio group
US4230862A (en) * 1975-10-28 1980-10-28 Eli Lilly And Company Antifertility compounds
US4133814A (en) * 1975-10-28 1979-01-09 Eli Lilly And Company 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents
AT364852B (de) * 1977-11-05 1981-11-25 Thomae Gmbh Dr K Verfahren zur herstellung von kondensierten isothiazol-3(2h)-on-1,1-dioxiden und von deren salzen
US4436748A (en) * 1980-10-20 1984-03-13 Hoechst-Roussel Pharmaceuticals Inc. Benzo[b]thiophenes
US4380635A (en) * 1981-04-03 1983-04-19 Eli Lilly And Company Synthesis of acylated benzothiophenes
IL65379A0 (en) * 1981-04-03 1982-05-31 Lilly Co Eli Process for preparing acylated benzothiophenes
US4418068A (en) * 1981-04-03 1983-11-29 Eli Lilly And Company Antiestrogenic and antiandrugenic benzothiophenes
IL65378A (en) * 1981-04-03 1986-02-28 Lilly Co Eli Process for preparing 3-(4-aminoethoxybenzoyl)benzo-(b)thiophenes
US4358593A (en) * 1981-04-03 1982-11-09 Eli Lilly And Company Process for preparing 3-(4-aminoethoxybenzoyl)benzo[b]thiophenes
NZ200204A (en) * 1981-04-03 1985-05-31 Lilly Co Eli Benzothiophene derivatives and process for preparation
US4544746A (en) * 1982-05-17 1985-10-01 Ciba-Geigy Corporation Process for preparing 2-anilinoacridone
US4916126A (en) * 1987-09-25 1990-04-10 Ciba-Geigy Corporation Diacyl derivatives of 4-(trialkylbenzyl)-piperazinyl compounds
US5395842A (en) * 1988-10-31 1995-03-07 Endorecherche Inc. Anti-estrogenic compounds and compositions
DE4117512A1 (de) * 1991-05-25 1992-11-26 Schering Ag 2-phenylbenzo(b)furane und -thiophene, verfahren zu deren herstellung und diese enthaltende pharmazeutische praeparate
JP3157882B2 (ja) * 1991-11-15 2001-04-16 帝国臓器製薬株式会社 新規なベンゾチオフエン誘導体
DE4204969A1 (de) * 1992-02-19 1993-08-26 Basf Ag Verfahren zur herstellung von benzo(b)thiophenen
US6756388B1 (en) * 1993-10-12 2004-06-29 Pfizer Inc. Benzothiophenes and related compounds as estrogen agonists
US5606075A (en) * 1995-06-07 1997-02-25 Eli Lilly And Company Process for the synthesis of benzo[b]thiophenes
US5606076A (en) * 1995-06-07 1997-02-25 Eli Lilly And Company Process for the synthesis of benzo[b]thiophenes

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5523416A (en) * 1994-07-22 1996-06-04 Eli Lilly And Company Process for preparing 3-(4-aminoethoxy-benzoyl) benzo (B)-thiophenes

Also Published As

Publication number Publication date
NO991193D0 (no) 1999-03-11
CO4900043A1 (es) 2000-03-27
UA62938C2 (en) 2004-01-15
IL129001A (en) 2003-06-24
TR199900672T2 (xx) 1999-06-21
US5977383A (en) 1999-11-02
KR20000048539A (ko) 2000-07-25
HUP9904228A2 (hu) 2001-05-28
MY118009A (en) 2004-08-30
CZ92899A3 (cs) 1999-09-15
EP0832889A1 (en) 1998-04-01
NZ334591A (en) 2000-07-28
EP0832889B1 (en) 2006-03-01
AU718919B2 (en) 2000-04-20
YU15399A (sh) 2001-07-10
BR9712844A (pt) 1999-11-16
CA2266617A1 (en) 1998-04-02
IN183239B (enExample) 1999-10-09
AR013321A1 (es) 2000-12-27
EA001914B1 (ru) 2001-10-22
AU4356197A (en) 1998-04-17
PL332208A1 (en) 1999-08-30
ES2257761T3 (es) 2006-08-01
ID21349A (id) 1999-05-27
PE2699A1 (es) 1999-02-04
DE69735339T2 (de) 2006-10-12
TW472053B (en) 2002-01-11
WO1998013363A1 (en) 1998-04-02
IL129001A0 (en) 2000-02-17
JP2001501208A (ja) 2001-01-30
EA199900330A1 (ru) 2000-06-26
DE69735339D1 (de) 2006-04-27
EG21037A (en) 2000-09-30
NO991193L (no) 1999-03-25
ATE318805T1 (de) 2006-03-15
CN1230957A (zh) 1999-10-06
ZA978372B (en) 1999-03-17
HUP9904228A3 (en) 2001-06-28

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Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
C19 Lapse of patent right due to non-payment of the annual fee
CF01 Termination of patent right due to non-payment of annual fee