CN108785415A - A kind of drug and preparation method thereof for treating sow mammitis - Google Patents
A kind of drug and preparation method thereof for treating sow mammitis Download PDFInfo
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/738—Rosa (rose)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
The invention belongs to technical field of traditional Chinese medicines, especially a kind of drug for treating sow mammitis and preparation method thereof uses Sculellaria barbata, the coptis, rose, Red Psychotria Leaf, frankincense, the seed of cowherb and madder are raw material, pass through rational proportion design, so that forming synergistic effect between drug, and then with promoting blood circulation and removing blood stasis, it is clearing heat and detoxicating, swelling and pain relieving, blood activating and promoting tissue regeneration, it sterilizes antipruritic, benefiting qi and nourishing blood, breast and other effects under promoting menstruation, swine udder can effectively be treated, cure rate reaches 75% or more, drug of the present invention is of low cost, securely and reliably, it is significant in efficacy, control difficulty in relapse after healing.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, especially a kind of drug and preparation method thereof for treating sow mammitis.
Background technology
Sow mammitis is a kind of sow disease relatively conventional in nursing period, and during morbidity, the mammary gland of sow can go out
Now apparent lesion, and show redness so that sow breast will appear heating paresthesia, while sow breast will appear significantly
Feeling of pain, galactosis can gradually decrease, and when serious, no appetite can be caused not eat, lassitude, and body temperature increases, Milking ability funeral
Lose etc.;For the disease time of the illness generally within 1~4 week postpartum, summer is season occurred frequently;At present both at home and abroad to sow mammitis
Treatment still based on antibiotic, but it is a large amount of use antibiotic to make drug residue severe overweight in pig body, directly influence
Human health;And in recent years, with Chinese herbal treatment sow mammitis, oneself highlights advantage, can effectively avoid medicament residue
Problem, but most of Chinese herbal medicine cure rate is undesirable, and the later stage easily recurs.
Invention content
In order to solve the above technical problems existing in the prior art, the present invention provides a kind of sow mammitises for the treatment of
Drug and preparation method thereof.
It is realized especially by following manner.
A kind of drug for treating sow mammitis, raw material are in parts by weight:100~200 parts of Sculellaria barbata, the coptis 100~
200 parts, 100~200 parts of rose, 50~100 parts of Red Psychotria Leaf, 50~100 parts of frankincense, 10~50 parts of the seed of cowherb, madder 10
~50 parts.
The raw material in parts by weight be 140~170 parts of Sculellaria barbata, 110~150 parts of the coptis, 130~160 parts of rose,
60~90 parts of Red Psychotria Leaf, 60~90 parts of frankincense, 100~3 parts of the seed of cowherb, 10~30 parts of madder.
The raw material is 160 parts of Sculellaria barbata, 140 parts of the coptis, 140 parts of rose, 70 parts of Red Psychotria Leaf, frankincense in parts by weight
70 parts, 20 parts of the seed of cowherb, 10 parts of madder.
The rose is that the fresh roseleaf of picking is put into 30~40 DEG C of water after 20~30min of immersion, is pulled out,
Dry 1~3min is put into microwave, and drying temperature is 70~90 DEG C, by the roseleaf after drying with vinegar according to 1:1 ratio
After mixing, it is put into 3~5d of immersion in 40~50 DEG C of conditions, is pulled out, it is dry to moisture≤10%, then it is ground into powder i.e.
It can.
The preparation method of the drug of above-mentioned treatment sow mammitis, includes the following steps:
(1) Sculellaria barbata, the coptis, Red Psychotria Leaf, frankincense are measured according to formula, after being mixed, added water to cook 2 times, added every time
Water is 6~8 times of waters of mixture, and first time decocting time is 2~3h, and second of decocting time is 1.5~2.5h steps, is closed
And decoction liquor twice, after filtering filtrate;
(2) rose, the seed of cowherb, madder are measured according to formula, crushed 60~80 mesh sieve respectively, stirred after mixing equal
It is even to obtain crushed material;
(3) filtrate and crushed material are mixed, is stirred evenly, obtained mixture is heated to 40~50 DEG C, and keeps temperature
1~2h is handled under permanence condition, after cooling, filtering.
The drug of the treatment sow mammitis is preparing the purposes in treating swine udder.
Additive capacity of the drug in pannage is 0.1~0.5%.
Advantageous effect
The present invention uses Sculellaria barbata, the coptis, rose, Red Psychotria Leaf, frankincense, the seed of cowherb and madder for raw material, passes through conjunction
The proportion design of reason so that synergistic effect is formed between drug, and then with promoting blood circulation and removing blood stasis, clearing heat and detoxicating, swelling and pain relieving, promoting blood circulation life
Breast and other effects under flesh, the antipruritic, benefiting qi and nourishing blood of sterilizing, promoting menstruation, can effectively treat swine udder, cure rate reach 75% with
On, drug of the present invention is of low cost, safe and reliable, significant in efficacy, controls difficulty in relapse after healing.
Specific implementation mode
Tuberculosis specific embodiment is limited technical scheme of the present invention is further below, but claimed
Range describes made by being not only limited to.
Embodiment 1
A kind of drug for treating sow mammitis, raw material are in parts by weight:Sculellaria barbata 100g, coptis 100g, rose
100g, Red Psychotria Leaf 50g, frankincense 50g, seed of cowherb 10g, madder 10g.
The rose is that the fresh roseleaf of picking is put into 30 DEG C of water after immersion 20min, pulls out, is put into microwave
Middle dry 1min, drying temperature are 70 DEG C, by the roseleaf after drying with vinegar according to 1:After the mixing of 1 ratio, it is put into 40 DEG C
3d is impregnated in condition, is pulled out, and drying to moisture is 1%, then is ground into powder.
The preparation method of the drug of above-mentioned treatment sow mammitis, includes the following steps:
(1) Sculellaria barbata, the coptis, Red Psychotria Leaf, frankincense are measured according to formula, after being mixed, added water to cook 2 times, added every time
Water is 6 times of waters of mixture, and first time decocting time is 2h, and second of decocting time is 1.5h steps, and merging decocts twice
Liquid obtains filtrate after filtering;
(2) rose, the seed of cowherb, madder are measured according to formula, crushed 60 mesh sieve respectively, is stirred evenly after mixing
To crushed material;
(3) filtrate and crushed material are mixed, is stirred evenly, obtained mixture is heated to 40 DEG C, and keeps temperature-resistant
Under the conditions of handle 1h, after cooling, filtering.
The drug of the treatment sow mammitis is preparing the purposes in treating swine udder.
Additive capacity of the drug in pannage is 0.1%.
Embodiment 2
A kind of drug for treating sow mammitis, raw material are in parts by weight:Sculellaria barbata 200g, coptis 200g, rose
200g, Red Psychotria Leaf 100g, frankincense 100g, seed of cowherb 50g, madder 50g.
The rose is that the fresh roseleaf of picking is put into 40 DEG C of water after immersion 30min, pulls out, is put into microwave
Middle dry 3min, drying temperature are 90 DEG C, by the roseleaf after drying with vinegar according to 1:After the mixing of 1 ratio, it is put into 50 DEG C
5d is impregnated in condition, is pulled out, and drying to moisture is 10%, then is ground into powder.
The preparation method of the drug of above-mentioned treatment sow mammitis, includes the following steps:
(1) Sculellaria barbata, the coptis, Red Psychotria Leaf, frankincense are measured according to formula, after being mixed, added water to cook 2 times, added every time
Water is 8 times of waters of mixture, and first time decocting time is 3h, and second of decocting time is 2.5h steps, and merging decocts twice
Liquid obtains filtrate after filtering;
(2) rose, the seed of cowherb, madder are measured according to formula, crushed 80 mesh sieve respectively, is stirred evenly after mixing
To crushed material;
(3) filtrate and crushed material are mixed, is stirred evenly, obtained mixture is heated to 50 DEG C, and keeps temperature-resistant
Under the conditions of handle 2h, after cooling, filtering.
The drug of the treatment sow mammitis is preparing the purposes in treating swine udder.
Additive capacity of the drug in pannage is 0.5%.
Embodiment 3
A kind of drug for treating sow mammitis, raw material are in parts by weight:Sculellaria barbata 140g, coptis 110g, rose
130g, Red Psychotria Leaf 60g, frankincense 60g, seed of cowherb 10g, madder 10g.
The rose is that the fresh roseleaf of picking is put into 32 DEG C of water after immersion 25min, pulls out, is put into microwave
Middle dry 1.5min, drying temperature are 75 DEG C, by the roseleaf after drying with vinegar according to 1:After the mixing of 1 ratio, it is put into 48
4d is impregnated in DEG C condition, is pulled out, dry to moisture is 6%, then is ground into powder.
The preparation method of the drug of above-mentioned treatment sow mammitis, includes the following steps:
(1) Sculellaria barbata, the coptis, Red Psychotria Leaf, frankincense are measured according to formula, after being mixed, added water to cook 2 times, added every time
Water is 6 times of waters of mixture, and first time decocting time is 3h, and second of decocting time is 2h steps, merges decoction liquor twice,
Filtrate is obtained after filtering;
(2) rose, the seed of cowherb, madder are measured according to formula, crushed 80 mesh sieve respectively, is stirred evenly after mixing
To crushed material;
(3) filtrate and crushed material are mixed, is stirred evenly, obtained mixture is heated to 45 DEG C, and keeps temperature-resistant
Under the conditions of handle 1.5h, after cooling, filtering.
The drug of the treatment sow mammitis is preparing the purposes in treating swine udder.
Additive capacity of the drug in pannage is 0.2%.
Embodiment 4
A kind of drug for treating sow mammitis, raw material are in parts by weight:Sculellaria barbata 170g, coptis 150g, rose
160g, Red Psychotria Leaf 90g, frankincense 90g, seed of cowherb 30g, madder 30g.
The rose is that the fresh roseleaf of picking is put into 32 DEG C of water after immersion 20min, pulls out, is put into microwave
Middle dry 1min, drying temperature are 85 DEG C, by the roseleaf after drying with vinegar according to 1:After the mixing of 1 ratio, it is put into 42 DEG C
3d is impregnated in condition, is pulled out, and drying to moisture is 8%, then is ground into powder.
The preparation method of the drug of above-mentioned treatment sow mammitis, includes the following steps:
(1) Sculellaria barbata, the coptis, Red Psychotria Leaf, frankincense are measured according to formula, after being mixed, added water to cook 2 times, added every time
Water is 7 times of waters of mixture, and first time decocting time is 2h, and second of decocting time is 1.5h steps, and merging decocts twice
Liquid obtains filtrate after filtering;
(2) rose, the seed of cowherb, madder are measured according to formula, crushed 70 mesh sieve respectively, is stirred evenly after mixing
To crushed material;
(3) filtrate and crushed material are mixed, is stirred evenly, obtained mixture is heated to 45 DEG C, and keeps temperature-resistant
Under the conditions of handle 1h, after cooling, filtering.
The drug of the treatment sow mammitis is preparing the purposes in treating swine udder.
Additive capacity of the drug in pannage is 0.4%.
Embodiment 5
A kind of drug for treating sow mammitis, raw material are in parts by weight:Sculellaria barbata 160g, coptis 140g, rose
140g, Red Psychotria Leaf 70g, frankincense 70g, seed of cowherb 20g, madder 10g.
The rose is that the fresh roseleaf of picking is put into 35 DEG C of water after immersion 25min, pulls out, is put into microwave
Middle dry 2.5min, drying temperature are 82 DEG C, by the roseleaf after drying with vinegar according to 1:After the mixing of 1 ratio, it is put into 44
5d is impregnated in DEG C condition, is pulled out, dry to moisture is 5%, then is ground into powder.
The preparation method of the drug of above-mentioned treatment sow mammitis, includes the following steps:
(1) Sculellaria barbata, the coptis, Red Psychotria Leaf, frankincense are measured according to formula, after being mixed, added water to cook 2 times, added every time
Water is 7 times of waters of mixture, and first time decocting time is 3h, and second of decocting time is 2h steps, merges decoction liquor twice,
Filtrate is obtained after filtering;
(2) rose, the seed of cowherb, madder are measured according to formula, crushed 60 mesh sieve respectively, is stirred evenly after mixing
To crushed material;
(3) filtrate and crushed material are mixed, is stirred evenly, obtained mixture is heated to 46 DEG C, and keeps temperature-resistant
Under the conditions of handle 1h, after cooling, filtering.
The drug of the treatment sow mammitis is preparing the purposes in treating swine udder.
Additive capacity of the drug in pannage is 0.3%.
Test example 1
Affected pig totally 72 is selected in experiment, shows as clinical type swine udder, and affected pig is randomly divided into 6 groups, test group totally 5
Group, test group affected pig add drug prepared by 1~embodiment of the embodiment of the present invention, 5 scheme in its feed respectively, and control group is suffered from
Pig injects Cefquinome sulfate 7mg according to every kg body weight, while muscle or intravenous injection increase and exempt from fast food needle, and the test period is
7d, test result such as the following table 1:
Efficacy determination:It cures, breast is red, swollen, hot, pain disappears, and milk switchs to normally;Effectively, breast is red, swollen, hot, pain is bright
Aobvious to mitigate, milk floccule disappears or substantially reduced substantially;In vain, for breast inflammation without improvement, milk is still rare and turns to be yellow, and has wadding
Shape object;
Table 1
Group | Infected cattle number | Cure number | Significant figure | Invalid number | Cure rate % |
Embodiment 1 | 10 | 8 | 2 | 0 | 80.0 |
Embodiment 2 | 13 | 10 | 2 | 1 | 76.9 |
Embodiment 3 | 11 | 9 | 2 | 0 | 81.8 |
Embodiment 4 | 13 | 11 | 1 | 1 | 84.6 |
Embodiment 5 | 12 | 11 | 1 | 0 | 91.7 |
Control group 1 | 13 | 9 | 2 | 2 | 69.2 |
By test data in table 1 it is found that can effectively treat sow mammitis using drug of the present invention, and above-mentioned control
More the sick pig after takes the sick pig of the drug of the present invention, does not recur by scheduling to last the observation period of half a year, and uses
In the sick pig of Cefquinome sulfate treatment, there is 1 to recur, therefore, had the characteristics that using drug of the present invention uneasy to recur.
It is important to point out that, above example and test example are only limitted to do further technical scheme of the present invention herein
Elaboration and understanding, should not be understood as it is further to technical scheme of the present invention limited, what those skilled in the art made
The innovation and creation of non-protruding essential characteristics and marked improvement still fall within the protection category of the present invention.
Claims (7)
1. a kind of drug for treating sow mammitis, which is characterized in that raw material is in parts by weight:100~200 parts of Sculellaria barbata,
100~200 parts of the coptis, 100~200 parts of rose, 50~100 parts of Red Psychotria Leaf, 50~100 parts of frankincense, the seed of cowherb 10~50
Part, 10~50 parts of madder.
2. the drug for the treatment of sow mammitis as described in claim 1, which is characterized in that the raw material is half in parts by weight
140~170 parts of lotus, 110~150 parts of the coptis, 130~160 parts of rose, 60~90 parts of Red Psychotria Leaf, 60~90 parts of frankincense, king are not
Stay 10~30 parts of row, 10~30 parts of madder.
3. the drug for the treatment of sow mammitis as claimed in claim 1 or 2, which is characterized in that the raw material is in parts by weight
160 parts of Sculellaria barbata, 140 parts of the coptis, 140 parts of rose, 70 parts of Red Psychotria Leaf, 70 parts of frankincense, 20 parts of the seed of cowherb, 10 parts of madder.
4. as claimed in claim 3 treatment sow mammitis drug, which is characterized in that the rose be will pick it is fresh
Roseleaf is put into 30~40 DEG C of water after 20~30min of immersion, is pulled out, and dry 1~3min is put into microwave, and drying temperature is
70~90 DEG C, by the roseleaf after drying with vinegar according to 1:1 ratio mixing after, be put into 40~50 DEG C of conditions impregnate 3~
5d is pulled out, dry to moisture≤10%, then is ground into powder.
5. the preparation method of the drug for the treatment of sow mammitis as claimed in claim 1 or 2, which is characterized in that including following step
Suddenly:
(1) Sculellaria barbata, the coptis, Red Psychotria Leaf, frankincense are measured according to formula, after being mixed, added water to cook 2 times, each amount of water
For 6~8 times of waters of mixture, first time decocting time is 2~3h, and second of decocting time is 1.5~2.5h steps, merges two
Secondary decoction liquor obtains filtrate after filtering;
(2) rose, the seed of cowherb, madder are measured according to formula, crushed 60~80 mesh sieve respectively, is stirred evenly after mixing
To crushed material;
(3) filtrate and crushed material are mixed, is stirred evenly, obtained mixture is heated to 40~50 DEG C, and keeps temperature-resistant
Under the conditions of handle 1~2h, after cooling, filtering.
6. the drug for the treatment of sow mammitis is preparing the purposes in treating swine udder as claimed in claim 1 or 2.
7. the drug for the treatment of sow mammitis as claimed in claim 1 or 2, which is characterized in that the drug adding in pannage
It is 0.1~0.5% to add dosage.
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Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1140596A (en) * | 1995-07-19 | 1997-01-22 | 任鹤鹏 | Ointment for treating burn and scald and promoting tissue regeneration |
CN105878439A (en) * | 2016-06-02 | 2016-08-24 | 隆昌锐智恒创生物科技有限公司 | Traditional Chinese medicine spray film agent for preventing and treating cow mastitis and preparation method thereof |
CN106173326A (en) * | 2016-07-18 | 2016-12-07 | 安徽奥力欣生物科技有限公司 | A kind of milch cow Chinese herbal medicine probiotic bacteria composite biological agent and preparation method thereof |
-
2018
- 2018-08-23 CN CN201810968128.5A patent/CN108785415A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1140596A (en) * | 1995-07-19 | 1997-01-22 | 任鹤鹏 | Ointment for treating burn and scald and promoting tissue regeneration |
CN105878439A (en) * | 2016-06-02 | 2016-08-24 | 隆昌锐智恒创生物科技有限公司 | Traditional Chinese medicine spray film agent for preventing and treating cow mastitis and preparation method thereof |
CN106173326A (en) * | 2016-07-18 | 2016-12-07 | 安徽奥力欣生物科技有限公司 | A kind of milch cow Chinese herbal medicine probiotic bacteria composite biological agent and preparation method thereof |
Non-Patent Citations (2)
Title |
---|
彭义梁: "中草药治疗猪乳房炎的观察 ", 《贵州畜牧兽医》 * |
鲜凌瑾等: "《养猪与猪病防治》", 31 August 2013, 西南交通大学出版社 * |
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Application publication date: 20181113 |