CN108452251A

CN108452251A - A kind of plaster and the preparation method and application thereof for treating pain rheumatism

Info

Publication number: CN108452251A
Application number: CN201810332862.2A
Authority: CN
Inventors: 张国聪
Original assignee: Individual
Current assignee: Individual
Priority date: 2018-04-13
Filing date: 2018-04-13
Publication date: 2018-08-28

Abstract

The invention discloses a kind of plaster for treating pain rheumatism, including lopseed, vomiting nut, Centipeda minima, arisacma consanguineum schott, dried pinellia, Radix Aconiti, Radix Aconiti Kusnezoffii, Paris polyphylla, the rhizome of davallia, tongmai grass, iron sparrow, Fruticose Breyniae Leaf and Twig, iron general, toddalia, Entada phaseoloides, dipsacus root, angelica tail, curcuma zedoary, trigone, phnom penh eupolyphaga, Herba Lycopi, rheum officinale, Chinese hydrangeavine root-bark, Kadsura Root-bark, the root of Chinese clematis, flos caryophylli, native copper, calamitas urinae hominis, Cortex Periplocae, Rhizoma Chuanxiong, asarum, Asian puccoon, cassia twig, radix paeoniae rubra, radix scutellariae, Fructus Forsythiae, Cortex Phellodendri, stiff silkworm, worm moves back, the root of Dahurain angelica, Radix Glycyrrhizae, more than blood, honeysuckle flower, centipede, full worm, house lizard, Rhizoma Et Radix Notopterygii, rhizoma atractylodis, pericarpium zanthoxyli, bark of ash, the tuber of multiflower knotweed, hop, chaulmoogra, it is windproof, schizonepeta, Chinese ephedra, paniculate swallowwort, lycopodium calvatum, frankincense, myrrh, safflower, dragon's blood, gamboge, semen momordicae, castor bean, Borneolum, camphor, Moschus.Have the advantages that significant in efficacy, healing time is short, safe and have no toxic side effect.

Description

A kind of plaster and the preparation method and application thereof for treating pain rheumatism

Technical field

The present invention relates to technical field of traditional Chinese medicines, and in particular to a kind of plaster for treating pain rheumatism and preparation method thereof with answer With.

Background technology

The resistance of numbness, i.e. numbness is obstructed.Rheumatism refers to that human body machine table, channels and collaterals are closed caused by experiencing wind, cold, wet, heat etc. with limbs Section and DOMS numbness, weigh, joint stuffiness, even the scorching hot a kind of disease waited as primary symptom of arthrocele.Clinically have gradually The characteristics of into property or repeated relapsing.Main pathogenesis is that the resistance of qi and blood numbness is obstructed, and tendon and vessel joint is lost caused by supporting.Patient Chang Youguan Save a variety of symptoms such as pain, swelling, numbness, deformation, spur hyperplasia.

There are many current this kind of disease treatment method, but because etiology and pathogenesis is more complex, therapeutic effect is ideal not to the utmost, there is treatment It is not thorough, treatment cycle is long, the defect that western medicine has drug dependence, side effect larger and palliative, serious shadow People’s lives quality is rung.

Traditional Chinese medicine can be from disease entirety, and dialectical treatmert, cure rate is higher, and without side-effects.Plaster is outside Chinese medicine One kind, ancient name is thin paste are boiled into colloid substance with vegetable oil or animal oil dosing, are coated in the one side of cloth, paper or skin, can be compared with It is attached to affected part for a long time, is mainly used to treat boil, detumescence pain etc..

Plaster is widely used in long-term development since its is at low cost, easy to use, but due to using former Expect the difference of medicine, therapeutic effect is different, while when patient skin reaction is more sensitive or there are when slight skin lesion, Gao Minzhe is basic Plaster dare not be used, keeps patient compliance poor.

Invention content

Of the existing technology in order to solve the problems, such as, the purpose of the present invention is to provide a kind of plaster for treating pain rheumatism And preparation method thereof, plaster provided by the invention have it is significant in efficacy, healing time is short, patient compliance is good, it is safe and The advantages of having no toxic side effect.

To achieve the above object, the first aspect of the present invention provides a kind of plaster for treating pain rheumatism, by weight Number meter, the plaster includes following raw material：

Group one：40~60 parts of lopseed, 40~60 parts of vomiting nut, 40~60 parts of Centipeda minima, 13~18 parts of arisacma consanguineum schott, life 13~18 parts of the tuber of pinellia, 15~20 parts of Radix Aconiti, 15~20 parts of Radix Aconiti Kusnezoffii, 20~30 parts of Paris polyphylla, 20~30 parts of the rhizome of davallia, tongmai grass 15~25 parts, 22~30 parts of iron sparrow, 20~30 parts of Fruticose Breyniae Leaf and Twig, 20~30 parts of iron general, 26~35 parts of toddalia, Entada phaseoloides 25~33 parts, 20~30 parts of dipsacus root, 15~20 parts of angelica tail, 22~28 parts of curcuma zedoary, 15~20 parts of trigone, phnom penh eupolyphaga 22~28 Part, 20~30 parts of Herba Lycopi, 26~35 parts of rheum officinale, 28~33 parts of Chinese hydrangeavine root-bark, 25~34 parts of Kadsura Root-bark, 26~35 parts of the root of Chinese clematis, public affairs 20~28 parts of cloves, 15~20 parts of native copper, 14~18 parts of calamitas urinae hominis, 20~30 parts of Cortex Periplocae, 14~20 parts of Rhizoma Chuanxiong, asarum 25 ~32 parts, 13~19 parts of Asian puccoon, 21~28 parts of cassia twig, 14~20 parts of radix paeoniae rubra, 12~17 parts of radix scutellariae, 15~20 parts of Fructus Forsythiae, Cortex Phellodendri 14~20 parts, 12~20 parts of stiff silkworm, worm move back 14~20 parts, 15~22 parts of the root of Dahurain angelica, 13~20 parts of Radix Glycyrrhizae, blood more than 14~21 parts, silver Spend 12~20 parts, 15~20 parts of centipede, 14~22 parts of full worm, 15~25 parts of house lizard, 14~20 parts of Rhizoma Et Radix Notopterygii, 12~19 parts of rhizoma atractylodis, 10~18 parts of pericarpium zanthoxyli, 13~21 parts of bark of ash, 14~18 parts of the tuber of multiflower knotweed, 13~20 parts of hop, 14~21 parts of chaulmoogra, it is windproof 10~ 15 parts, 9~15 parts of schizonepeta, 10~15 parts of Chinese ephedra, 10~15 parts of paniculate swallowwort, 22~28 parts of lycopodium calvatum；

Group two：25~35 parts of frankincense, 25~35 parts of myrrh, 12~18 parts of safflower, 40~45 parts of dragon's blood, gamboge 33~40 Part, 23~30 parts of semen momordicae, 15~24 parts of castor bean, 18~25 parts of Borneolum, 7~13 parts of camphor, 6~12 parts of Moschus.

Further, it counts in parts by weight, the plaster includes following raw material：

Group one：50 parts of lopseed, 50 parts of vomiting nut, 50 parts of Centipeda minima, 16.5 parts of arisacma consanguineum schott, 16.5 parts of dried pinellia, life 17 parts of monkshood, 17 parts of Radix Aconiti Kusnezoffii, 25 parts of Paris polyphylla, 25 parts of the rhizome of davallia, 19 parts of tongmai grass, 26 parts of iron sparrow, 25 parts of Fruticose Breyniae Leaf and Twig, iron are incited somebody to action 25 parts of army, 31 parts of toddalia, 31 parts of Entada phaseoloides, 25 parts of dipsacus root, 17 parts of angelica tail, 25 parts of curcuma zedoary, 17 parts of trigone, phnom penh eupolyphaga 26 Part, 25 parts of Herba Lycopi, 31 parts of rheum officinale, 31 parts of Chinese hydrangeavine root-bark, 31 parts of Kadsura Root-bark, 31 parts of the root of Chinese clematis, 25 parts of flos caryophylli, 17 parts of native copper, 17 parts of calamitas urinae hominis, 25 parts of Cortex Periplocae, 17 parts of Rhizoma Chuanxiong, 28 parts of asarum, 17 parts of Asian puccoon, 25 parts of cassia twig, 17 parts of radix paeoniae rubra, 17 parts of radix scutellariae, 17 parts of Fructus Forsythiae, 17 parts of Cortex Phellodendri, 17 parts of stiff silkworm, worm move back 17 parts, 17 parts of the root of Dahurain angelica, 16.5 parts of Radix Glycyrrhizae, blood more than 16.5 parts, 17 parts of honeysuckle flower, 18 parts of centipede, 22 parts of full worm, 20 parts of house lizard, 17 parts of Rhizoma Et Radix Notopterygii, 17 parts of rhizoma atractylodis, 17 parts of pericarpium zanthoxyli, 17 parts of bark of ash, 17 parts of the tuber of multiflower knotweed, golden hop 17 parts of son, 16.5 parts of chaulmoogra, 13 parts windproof, 13 parts of schizonepeta, 13 parts of Chinese ephedra, 13 parts of paniculate swallowwort, 25 parts of lycopodium calvatum；

Group two：30 parts of frankincense, 30 parts of myrrh, 16 parts of safflower, 43.5 parts of dragon's blood, 36 parts of gamboge, 28 parts of semen momordicae, castor bean 19.5 parts, 22 parts of Borneolum, 11 parts of camphor, 10 parts of Moschus.

The second aspect of the present invention provides a kind of preparation method of the plaster of above-mentioned treatment pain rheumatism, the method Include the following steps：

Feedstock processing：The raw material meal for organizing one is broken, and the raw material for organizing two is ground into fine powder, spare；

Endure withered remove slag：Sesame oil is taken to set in pot, the raw material of input group one after low-grade fever is heated to 210~230 DEG C, and constantly stir It mixes, until raw material is fried to surface dark brown, it is internal sallow, remove the dregs of a decoction to get medicine oil；

Oil refining：Medicine oil is heated to 310~330 DEG C, until medicine oil dropping into a bead, oil refining is completed；

Pilling and pasting：The medicine oil refined is slightly cold from fire, when oil temperature is down to 280~300 DEG C, medicine is added portionwise in yellow lead It in oil, while being continuously agitated along a direction, until medicine oil is at sticky lotion；

It releases fire-toxin：The lotion that will have been refined, is put into cold water and impregnates, and changes water daily 1 time, impregnates 5~7 days；

Spread out plaster：The lotion to have released fire-toxin is heated to fusing at a temperature of 50~80 DEG C, the raw material for the group two got ready is added, It stirs evenly, is then evenly coated on stype, it is cooling.

Further, organize two raw material be ground into fine powder after, cross 100~120 mesh sieve.

Further, it counts in parts by weight, sesame oil is 1000~1200 parts.

Further, it counts in parts by weight, yellow lead is 500~600 parts.

The third aspect of the present invention provides a kind of application of above-mentioned plaster in the drug for preparing treatment pain rheumatism.

Further, the rheumatism includes but not limited to：Brothers' pain in back and loin, rheumatic arthritis, osteoproliferation, shoulder Inflammation, dodges pain caused by ecchymoma and all nameless sores or boils pain after contusion injury at myalgia.

The pharmacological property and effect of each raw material of the present invention are as follows：

Lopseed：Sweet in flavor, pungent, property enters lung, liver two passes through；Effect：Dispelling wind and eliminating dampness, relaxing tendons and activating collaterals, promoting blood circulation and stopping pain, solution poison Rash.Vomiting nut：It is bitter in taste, temperature, very toxic, Return liver, the spleen channel；Effect：It removes obstruction in channels to relieve pain, mass dissipating and swelling eliminating.Centipeda minima：Acrid flavour；Property Temperature, return lung, Liver Channel；Effect：Wind-dispelling is logical to steal, removing toxicity for detumescence.Arisacma consanguineum schott：It is bitterly, it is warm-natured, it is toxic, enter lung channel, Liver Channel, the spleen channel； Effect：It is eliminating dampness and eliminating phlegm, expelling wind and relieving convulsion, mass dissipating and swelling eliminating.Dried pinellia：Acrid flavour, warm-natured, returns spleen, stomach, lung channel；Effect：It is eliminating dampness and eliminating phlegm, Stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass；Externally used detumescence relieves pain.Radix Aconiti：Acrid flavour, hardship, property heat, enter the heart, spleen, liver and kidney channel；Effect：Wind-dispelling Dehumidifying, antalgic.Radix Aconiti Kusnezoffii：Acrid flavour, hardship, property heat, the thoughts of returning home, liver,kidney,spleen warp；Effect：Dispelling wind and eliminating dampness, antalgic.Weight Building：Bitter, cold nature, return liver warp；Effect：It is clearing heat and detoxicating, swelling and pain relieving, cool liver arresting convulsion.Frankincense：Acrid flavour, hardship, it is warm-natured, enter the heart, Liver, the spleen channel；Effect：Promoting blood circulation and stopping pain.Myrrh：Acrid flavour, hardship, mild-natured, the thoughts of returning home, liver, the spleen channel；Effect：Scattered stasis pain, detumescence and promoting granulation. The rhizome of davallia：Bitter, it is warm-natured, enter liver and kidney channel；Effect：The strong bone of kidney tonifying, continues and hinders pain relieving.Tongmai grass (Tylophora mollissima)：Acrid flavour, hardship, property It is cool, enter lung channel；Effect：Clearing lung-heat heat, cough-relieving asthma.Iron sparrow also known as thousand solution grass, blood and relieving pain, dispelling wind and eliminating dampness, reinforcing spleen to promote digestion.Black flour God：Slight bitter, cool, returns spleen, stomach；Effect：Clearing heat and expelling damp, promoting blood circulation and detoxication.Iron general：Also known as " horizontal through seat ", mildly bitter flavor is mild-natured； Wind-damp dispelling strengthens the bone, promoting blood circulation and stopping pain.Toddalia：Acrid flavour, slight bitter, warm-natured, return liver warp；Effect：Wind-expelling pain-stopping, dissipate stasis of blood hemostasis, Removing toxicity for detumescence.Entada phaseoloides：Acrid flavour, it is warm-natured, it is bitter, return bladder warp；Effect：Wind prevailing over dampness, relaxing tendons and activating collaterals are dredged, diuresis dissipates the stasis of blood.Dipsacus root： Bitterly, slightly warm in nature enters liver and kidney channel；Effect：Filling liver kidney, continuous muscles and bones adjust blood vessels.Safflower：Acrid flavour, warm-natured, thoughts of returning home warp；Effect： Invigorate blood circulation, removing blood stasis and analgesics.Dragon's blood：It is sweet, salty, it puts down, converge to heart and liver channels；Removing blood stasis and relieving pain, hemostasia and promoting granulation.Gamboge：It is sour, puckery, property It is cool；Detumescence, attacks poison, rotten sore of dispelling, hemostasis, desinsection.Curcuma zedoary：Acrid flavour, hardship, temperature, Return liver, the spleen channel；Promoting the circulation of qi blood-breaking, Xiao Ji Zhi Tong. Trigone：Nature and flavor are pungent, bitter, put down, Return liver, the spleen channel；Blood-breaking, Xiao Ji Zhi Tong.Phnom penh eupolyphaga：For the drying worm of insect phnom penh eupolyphaga Body, dissipating blood stasis with potent drugs, reunion of fractured tendons and bones.Herba Lycopi：It is bitter, pungent, tepor, Return liver, the spleen channel；Promoting blood circulation for regulating menstruation, dissolving stasis disappear carbuncle, inducing diuresis for removing edema.Greatly It is yellow：Bitter, cold in nature, returns spleen, stomach, large intestine, liver, pericardium channel；Purge heat logical intestines, removing pattogenic heat from the blood and toxic material from the body, dispelling stasis of blood and stimulating the menstrual flow.Chinese hydrangeavine root-bark：It is lightly seasoned, property It is cool, converge to the spleen channel；Relaxing tendons and activating collaterals, expelling wind and activating blood flow.Kadsura Root-bark：It is bitter in taste, it puts down, enters liver, spleen two passes through；Invigorate blood circulation, swelling and pain relieving, solution Poison.The root of Chinese clematis：Nature and flavor are pungent, salty, and temperature returns bladder warp；Dispelling wind and eliminating dampness is removed obstruction in channels to relieve pain.Flos caryophylli：It is acrid in flavour and warm in nature, returns spleen, stomach, lung, kidney Through；Inverse, eliminating cold to stop pain, warming kidney and enhancing yang drop in middle benefit gas.Native copper：Nature and flavor are pungent, put down.Return liver warp.Major function dissipates the stasis of blood, synthetism, analgesic. For tumbling and swelling, injured bone.Calamitas urinae hominis：Taste is salty, cool in nature, return lung, the heart, bladder warp；Effect：Heat-clearing and fire-reducing, hemostasia and dissipation blood stasis. Cortex Periplocae：Also known as periplocae,cortex, warm-natured, acrid flavour, hardship are toxic.Wind-damp dispelling strengthens the bone, strong waist and knee.Rhizoma Chuanxiong：It is acrid in flavour and warm in nature, enter liver, courage Through；Promote breath and open depression, method wind-dryness is wet, promoting blood circulation and stopping pain.Asarum：It is acrid in flavour and warm in nature, the thoughts of returning home, lung, kidney channel；Relieving exterior syndrome and dispelling cold, wind-expelling pain-stopping is sensible, Warming lung and resolving fluid.Asian puccoon：It is sweet in flavor, salty, cold in nature, converge to heart and liver channels；Cool blood, promoting blood circulation, promoting eruption of detoxifying.Cassia twig：Nature and flavor acrid, sweet, warm, return The heart, lung, bladder warp；Sweating expelling pathogenic factors from muscles and skin, warming meridian, helps yang transforming qi, flat gas that spins.Radix paeoniae rubra：Bitter, cold nature, return liver warp；Heat-clearing Cool blood, removing blood stasis and analgesics.Radix scutellariae：Bitter, cold in nature, return lung, courage, spleen, large intestine, small intestinl channel；Heat-clearing and damp-drying drug, purging intense heat and detonicating are stopped blooding, peace Tire.Fructus Forsythiae：Hardship is slightly cold, return lung, the heart, small intestinl channel；It is clearing heat and detoxicating, dispersing swelling and dissipating binds.Cortex Phellodendri：Bitter, cold in nature, kidney, bladder warp；Clearly Hot eliminating dampness, purging intense heat, except steaming, detoxification sore treatment.Stiff silkworm：Taste is salty, pungent, mild-natured, Return liver, lung, stomach；Inflammation Zhijing, wind-expelling pain-stopping are changed Phlegm dissipating bind.Worm moves back：Also known as cicada slough, it is sweet, it trembles with fear, return lung, Liver Channel；Dispelling wind and heat from the body, relieving sore-throat open sound, promoting eruption, removing nebula, and ceases wind is stopped Convulsion.The root of Dahurain angelica：Acrid flavour, warm-natured, return lung, spleen, stomach；Relieving exterior syndrome and dispelling cold, wind-expelling pain-stopping, clearing the nasal passage, eliminating dampness stops band, detumescence and apocenosis are dispelled Wind is antipruritic.Radix Glycyrrhizae：Sweet and neutral, the thoughts of returning home, lung, spleen, stomach；It invigorates the spleen and benefits qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain reconciles all Medicine.More than blood：Bitter, puckery, mild-natured, Return liver, stomach, kidney channel；Hemostasis, stagnation resolvation diuresis myogenic.Honeysuckle flower：It is sweet in flavor, cold in nature, return lung, the heart, stomach Through；It is clearing heat and detoxicating, fry charcoal cooling blood and hemostasis.Centipede：Taste is salty, pungent, warm-natured, Return liver, spleen, lung channel；Internal heat anticance, is moved back at relieving spasm by calming endogenous wind Inflammation controls sore.Full worm：Acrid flavour, mild-natured, return liver warp；Ceases wind antispastic, dispersing pathogen accumulation are removed obstruction in channels to relieve pain.House lizard：Also known as gecko, taste is salty, property It is cold；Wind-dispelling, active, dissipating bind.Rhizoma Et Radix Notopterygii：Acrid flavour, hardship, it is warm-natured, return bladder, kidney channel；Cold dispelling, wind-dispelling dehumidify, analgesic.Rhizoma atractylodis：Taste It is pungent, bitter, warm-natured, returns spleen, stomach, Liver Channel；It is drying damp and strengthening spleen, expelling wind and clearing away cold, improving eyesight.Pericarpium zanthoxyli：It is pungent, numb, temperature, returns spleen, stomach, kidney channel；Temperature Middle analgesic, desinsection are antipruritic.Bark of ash：It is pungent, bitter, it puts down, returns stomach, liver, gallbladder channel；Wind-damp dispelling, clearing away damp-heat, stopping numbness pain.The tuber of multiflower knotweed：Bitter, it is sweet, Puckery, slightly warm in nature returns liver and kidney channel；Nourishing the blood and yin, relax bowel, preventing malaria, wind-dispelling, removing toxic substances.Hop：Acrid flavour, hardship, it is warm-natured, return kidney Through；For impotence, Gong Leng, morbid leucorrhoea duye.Semen momordicae：Bitter, micro-sweet, cool in nature, Return liver, spleen, stomach；Mass dissipating and swelling eliminating attacks malicious treatment Sore.Chaulmoogra：Acrid flavour, property heat；Wind-dispelling, work(poison, desinsection.It is windproof：Acrid flavour, sweet, slightly warm in nature；It expels pathogenic wind from the body surface, expel endogenous wind to relieve convulsion, only Convulsion.Schizonepeta：Acrid flavour, slightly warm in nature, return lung, Liver Channel；Inducing diaphoresis relieve heat, promoting eruption.Chinese ephedra：Acrid flavour, slight bitter, warm-natured, return lung, bladder warp； Sweating cold dispelling, freeings lung and relieving asthma, inducing diuresis for removing edema.Paniculate swallowwort：Acrid flavour, warm-natured, Return liver, stomach；Wind-dispelling dampness elimination, antalgesic-antipruritic.Castor-oil plant Son：It is sweet in flavor, pungent, it is mild-natured, return large intestine, lung channel；Poison is dialled in detumescence, is rushed down lower logical stagnant.Borneolum：Acrid flavour, hardship, cold nature, thoughts of returning home warp, spleen Through, lung channel；Inducing resuscitation of having one's ideas straightened out, heat dissipation analgesic, shade removing.Camphor：It is acrid in flavour and warm in nature；It is sensible to ward off dirty, warm in pain, dampness removing desinsection.Musk deer It is fragrant：Acrid flavour, warm-natured, the thoughts of returning home, the spleen channel；Inducing resuscitation of having one's ideas straightened out, invigorate blood circulation, swelling and pain relieving.Lycopodium calvatum：Bitter, micro-pungent, it is warm-natured.Return liver, Spleen, kidney channel；Dispelling wind and eliminating dampness, relaxing tendons and activating collaterals.

The invention has the advantages that：

Recipe of plaster the effect of following differentiation of tcm, bulk pharmaceutical chemicals of the present invention, cures mainly principle with channel tropism, fully adjusts Dynamic drug coordinate mutually for efficiency, all medicines share plays promoting blood circulation and removing obstruction in channels, stasis-dispelling and pain-killing, the effect of detoxification is subsided a swelling, for controlling altogether It treats brothers' pain in back and loin, rheumatic arthritis, osteoproliferation, scapulohumeral periarthritis, myalgia, dodge pain caused by ecchymoma and one after contusion injury Cutting nameless sores or boils pain has that significant in efficacy, healing time is short, patient compliance is good, the safe and spy that has no toxic side effect Point.Since plaster is directly applied to body surface, by infiltrating through skin, interior transmission from one channel to another network, internal organs play regulating the qi flowing in the channels blood, degrading the channel, cold dispelling The effects that wet, detumescence pain, to reach therapeutic purposes, have the characteristics that it is simple, just, it is honest and clean.

Specific implementation mode

The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention..

Embodiment 1

A kind of plaster for treating pain rheumatism, is counted in parts by weight, including following raw material：

Group one：40 parts of lopseed, 45 parts of vomiting nut, 50 parts of Centipeda minima, 13 parts of arisacma consanguineum schott, 13 parts of dried pinellia, Radix Aconiti 18 parts, 15 parts of Radix Aconiti Kusnezoffii, 30 parts of Paris polyphylla, 27 parts of the rhizome of davallia, 15 parts of tongmai grass, 22 parts of iron sparrow, 20 parts of Fruticose Breyniae Leaf and Twig, iron general 30 Part, 30 parts of toddalia, 25 parts of Entada phaseoloides, 20 parts of dipsacus root, 18 parts of angelica tail, 26 parts of curcuma zedoary, 15 parts of trigone, 22 parts of phnom penh eupolyphaga, In 30 parts of Herba Lycopi, 28 parts of rheum officinale, 28 parts of Chinese hydrangeavine root-bark, 34 parts of Kadsura Root-bark, 26 parts of the root of Chinese clematis, 20 parts of flos caryophylli, 16 parts of native copper, people White 18 parts, 22 parts of Cortex Periplocae, 14 parts of Rhizoma Chuanxiong, 32 parts of asarum, 13 parts of Asian puccoon, 22 parts of cassia twig, 20 parts of radix paeoniae rubra, 15 parts of radix scutellariae, Fructus Forsythiae 20 parts, 14 parts of Cortex Phellodendri, 12 parts of stiff silkworm, worm move back 14 parts, 20 parts of the root of Dahurain angelica, 15 parts of Radix Glycyrrhizae, blood more than 18 parts, 12 parts of honeysuckle flower, 20 parts of centipede, It is complete 14 parts of worm, 15 parts of house lizard, 15 parts of Rhizoma Et Radix Notopterygii, 19 parts of rhizoma atractylodis, 12 parts of pericarpium zanthoxyli, 13 parts of bark of ash, 14 parts of the tuber of multiflower knotweed, 15 parts of hop, big 21 parts of wind, 14 parts windproof, 15 parts of schizonepeta, 10 parts of Chinese ephedra, 10 parts of paniculate swallowwort, 26 parts of lycopodium calvatum；

Group two：32 parts of frankincense, 28 parts of myrrh, 12 parts of safflower, 40 parts of dragon's blood, 40 parts of gamboge, 23 parts of semen momordicae, castor bean 15 Part, 20 parts of Borneolum, 8 parts of camphor, 12 parts of Moschus.

The preparation method of the plaster of the present embodiment, includes the following steps：

Feedstock processing：The raw material meal for organizing one is broken, and the raw material for organizing two is ground into the sieve of 100~120 mesh excessively after fine powder, standby With；

Endure withered remove slag：It takes 1000~1200 parts of sesame oil to set in pot, the raw material for organizing one is put into after low-grade fever, is heated to 210 ~230 DEG C, and be stirred continuously, until raw material is fried to surface dark brown, and it is internal sallow, remove the dregs of a decoction to get medicine oil；

Pilling and pasting：The medicine oil refined is slightly cold from fire, when oil temperature is down to 280~300 DEG C, by 500~600 parts of Huang Pellet is added portionwise in oil, while being continuously agitated along a direction, until medicine oil is at sticky lotion；

Embodiment 2

Group one：60 parts of lopseed, 40 parts of vomiting nut, 40 parts of Centipeda minima, 17 parts of arisacma consanguineum schott, 18 parts of dried pinellia, Radix Aconiti 15 parts, 16 parts of Radix Aconiti Kusnezoffii, 28 parts of Paris polyphylla, 20 parts of the rhizome of davallia, 25 parts of tongmai grass, 30 parts of iron sparrow, 28 parts of Fruticose Breyniae Leaf and Twig, iron general 20 Part, 26 parts of toddalia, 32 parts of Entada phaseoloides, 22 parts of dipsacus root, 15 parts of angelica tail, 28 parts of curcuma zedoary, 16 parts of trigone, 24 parts of phnom penh eupolyphaga, In 20 parts of Herba Lycopi, 26 parts of rheum officinale, 33 parts of Chinese hydrangeavine root-bark, 28 parts of Kadsura Root-bark, 32 parts of the root of Chinese clematis, 28 parts of flos caryophylli, 15 parts of native copper, people White 14 parts, 30 parts of Cortex Periplocae, 16 parts of Rhizoma Chuanxiong, 26 parts of asarum, 19 parts of Asian puccoon, 21 parts of cassia twig, 14 parts of radix paeoniae rubra, 17 parts of radix scutellariae, Fructus Forsythiae 15 parts, 15 parts of Cortex Phellodendri, 20 parts of stiff silkworm, worm move back 20 parts, 20 parts of the root of Dahurain angelica, 13 parts of Radix Glycyrrhizae, blood more than 14 parts, 20 parts of honeysuckle flower, 20 parts of centipede, It is complete 16 parts of worm, 22 parts of house lizard, 14 parts of Rhizoma Et Radix Notopterygii, 12 parts of rhizoma atractylodis, 18 parts of pericarpium zanthoxyli, 15 parts of bark of ash, 18 parts of the tuber of multiflower knotweed, 20 parts of hop, big 14 parts of wind, 10 parts windproof, 10 parts of schizonepeta, 12 parts of Chinese ephedra, 15 parts of paniculate swallowwort, 22 parts of lycopodium calvatum；

Group two：25 parts of frankincense, 25 parts of myrrh, 18 parts of safflower, 42 parts of dragon's blood, 38 parts of gamboge, 25 parts of semen momordicae, castor bean 16 Part, 25 parts of Borneolum, 7 parts of camphor, 6 parts of Moschus.

The preparation method is the same as that of Example 1 for the present embodiment.

Embodiment 3

Embodiment 4

Group one：55 parts of lopseed, 60 parts of vomiting nut, 60 parts of Centipeda minima, 18 parts of arisacma consanguineum schott, 14 parts of dried pinellia, Radix Aconiti 20 parts, 20 parts of Radix Aconiti Kusnezoffii, 20 parts of Paris polyphylla, 30 parts of the rhizome of davallia, 20 parts of tongmai grass, 24 parts of iron sparrow, 30 parts of Fruticose Breyniae Leaf and Twig, iron general 22 Part, 35 parts of toddalia, 33 parts of Entada phaseoloides, 30 parts of dipsacus root, 20 parts of angelica tail, 22 parts of curcuma zedoary, 20 parts of trigone, 28 parts of phnom penh eupolyphaga, In 28 parts of Herba Lycopi, 35 parts of rheum officinale, 31 parts of Chinese hydrangeavine root-bark, 25 parts of Kadsura Root-bark, 35 parts of the root of Chinese clematis, 28 parts of flos caryophylli, 20 parts of native copper, people White 15 parts, 20 parts of Cortex Periplocae, 20 parts of Rhizoma Chuanxiong, 25 parts of asarum, 15 parts of Asian puccoon, 28 parts of cassia twig, 18 parts of radix paeoniae rubra, 12 parts of radix scutellariae, Fructus Forsythiae 15 parts, 20 parts of Cortex Phellodendri, 20 parts of stiff silkworm, worm move back 15 parts, 15 parts of the root of Dahurain angelica, 20 parts of Radix Glycyrrhizae, blood more than 21 parts, 15 parts of honeysuckle flower, 18 parts of centipede, It is complete 15 parts of worm, 25 parts of house lizard, 20 parts of Rhizoma Et Radix Notopterygii, 15 parts of rhizoma atractylodis, 10 parts of pericarpium zanthoxyli, 21 parts of bark of ash, 15 parts of the tuber of multiflower knotweed, 13 parts of hop, big 20 parts of wind, 15 parts windproof, 9 parts of schizonepeta, 15 parts of Chinese ephedra, 11 parts of paniculate swallowwort, 28 parts of lycopodium calvatum；

Group two：35 parts of frankincense, 35 parts of myrrh, 17 parts of safflower, 45 parts of dragon's blood, 33 parts of gamboge, 30 parts of semen momordicae, castor bean 24 Part, 18 parts of Borneolum, 13 parts of camphor, 8 parts of Moschus.

Test example 1

Safety in order to illustrate plaster of the invention to skin, the present invention have carried out following skin irritation test.

1, general information

Chinese Rabbit 20 (1~1.2Kg of weight) is taken, 24 hours back backbone both sides to every rabbit before plaster are applied Carry out depilation processing, the left and right each 6cm × 8cm of unhairing range.Mode, every rabbit upper left spinal area are compareed using skin auto As intact skin irritant test area, upper right spinal area is as intact skin blank district；Lower-left spinal area is as damaged skin Skin irritant test area, bottom right spinal area is as damaged skin blank district.

2, test method

20 rabbit are equally divided into 2 groups, and each group uses plaster made from embodiment 1 and embodiment 2 respectively.

Intact skin acute irritation is tested：

The plaster of the rabbit backbone upper left side trial zone skin plaster present invention, backbone upper right side trial zone are applied without drug Patch is as a contrast.

Damaged skin acute irritation is tested：

It is in before application at rabbit back lower-left spinal area and bottom right spinal area recipient site skin, with the large size needle sterilized Head makees " # " printed words cut respectively, with the clearly visible cuticula of scratching of naked eyes and has slight oozing of blood for degree, trace is spaced about 0.5cm.The plaster of the backbone lower left side trial zone skin plaster present invention, backbone lower right side trial zone patch of the application without drug are made For control.

3, observation index

The patch of plaster and the no drug of the present invention is continuously applied on rabbit intact skin and damaged skin 7 days, daily 1 It is secondary, it is carried out at the same time observation；7th day administration after, after removing drug 1h, for 24 hours, 48h, 72h observe application site whether there is or not red Situations such as spot and oedema and its recovery.

4, result

After acute irritation experiment removes drug lh, in intact skin experiment and damaged skin experiment, test group occurs gently Micro- erythema situation, but occur without oedema；All application sites of control group are without erythema, without oedema situation.After for 24 hours, test group institute The slight erythema of appearance subsides.It is divided according to skin wound repair series and Skin Irritation Test evaluation table is it is found that belong to stingless Swash property.It the results are shown in Table 1.

Table 1

Note：" 0 " indicates no erythema, without oedema.

Test example 2

In order to illustrate ointment of the invention to the therapeutic effect of rheumatism, the present invention has carried out following clinical trial.

1, general information

In May, 2012 is chosen to the 316 rheumatism patients received during in May, 2016, is randomly divided into treatment group and right According to group, each 158.Male 82 in observation group, women 76, average age be (48 ± 3.5) year, average course of disease be (3.1 ± 0.4) year, brothers' pain in back and loin 20, rheumatic arthritis 42, osteoproliferation 24, scapulohumeral periarthritis 36, myalgia 15 Example dodges pain caused by ecchymoma 21 after contusion injury；Male 88 in control group, women 70, average age be (47 ± 8.6) year, Average course of disease is (2.8 ± 1.3) year, brothers' pain in back and loin 26, rheumatic arthritis 37, osteoproliferation 33, scapulohumeral periarthritis 35, myalgia 15, dodge contusion injury after pain caused by ecchymoma 12.Inclusion criteria：《Chinese medical disease Standardization of diagnosis and curative effect》In To the diagnostic criteria of rheumatism, and the serious diseases patient such as exclude liver, kidney, cardiovascular and cerebrovascular.The general information of two groups of patients is comparing Difference in terms of middle no statistics, P ＞ 0.05 are comparable.

2, criterion of therapeutical effect

It cures：The clinical symptoms such as affected part pain, numbness, swelling completely disappear alternatively, the mobility of limbs joint is extensive It is multiple normal；

Effectively：The clinical symptoms such as patient pain, numbness and swelling are mitigated；

In vain：Patient is not up to the above standard after treatment.

3, therapy

Treatment group：Medicinal liquor or ginger erasing are first massaged into affected part when use, after the fever of affected part, by plaster made from embodiment 3 Affected part is applied after warming, 3~4 days/patch, avoided pungent food marinated cold and cool food when pasting medicine.

Control group：What application pharmacy sold smears shangshi zhitong plaster, shangshi zhitong gao (Chinese medicines quasi-word Z20023035), 2 days/patch, avoids when pasting medicine Eat pungent marinated cold and cool food.

4, result

Two groups of clinical therapeutic efficacy comparison：Treatment group cures 106, and effective 41, invalid 11, total effective rate is 93.04%；Control group healing 47, effective 68, invalid 43, total effective rate 72.78%.The clinical treatment for the treatment of group is total Effective percentage is apparently higher than control group, P<0.05, concrete outcome is shown in Table 2.

Table 2

Group	It cures	Effectively	In vain	Total effective rate (%)
					Treatment group	106	41	11	93.04
Control group	47	68	43	72.78

Two groups of clinical symptoms comparison：The rheumatism symptom extinction time for the treatment of group and clinical total treatment time are respectively (13.2 ± 2.6) day, (23.6 ± 1.3) day；The rheumatism symptom extinction time of control group and clinical total treatment time are respectively (25.8 ± 2.3) day, (34.5 ± 1.7) day.Contrast difference has statistical significance, P between group<0.05, concrete outcome is shown in Table 3.

Table 3

Group	The thorough extinction time of rheumatism (day)	Treat total time (day)
			Treatment group	13.2±2.6	23.6±1.3
Control group	25.8±2.3	34.5±1.7

Model case：

1, Liu, female, 52 years old, in more than 10 years of private prosecution extremities joint pain, on rainy chill, then pain endlessly, was diagnosed as wind Wet arthritis is treated using antirheumatic analgesic type drug, and symptom is slightly alleviated, but withdrawal symptom is as before.The application present invention is real Plaster made from example 1 is applied, after two weeks, cold overcast and rainy pain symptom is clearly better to the wind, is after treatment, continues application 1 month, Symptom disappears, 1 year no relapse of rear follow-up.

2, flood certain, man 36 years old, has uncomfortable feeling because drenching heavy rain sick flu after flu is good in wind to body, The especially joint parts such as leg and heel are ached.Plaster made from the embodiment of the present invention 2 is applied, after three days, mitigation of aching, Continue application 5 days, all restore normal.

3, Ma, man, 58 years old, backache after nearest right shoulder, shoulder, hand cannot all lift, and all pains are turned in sleep, and diagnosis is shoulder Zhou Yan, massage have carried out 1 week, can relieve pain symptom at that time, and after physiotherapy stops, pain symptom is as before.The application present invention is real Plaster made from example 4 is applied, second day, pain relief, after a week, arm can lift activity, and after two weeks, symptom disappears It loses, 1 year no relapse of rear follow-up.

Although above having used general explanation and specific embodiment, the present invention is described in detail, at this On the basis of invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Therefore, These modifications or improvements without departing from theon the basis of the spirit of the present invention belong to the scope of protection of present invention.

Claims

1. a kind of plaster for treating pain rheumatism, which is characterized in that count in parts by weight, the plaster includes following raw material：

Group one：40~60 parts of lopseed, 40~60 parts of vomiting nut, 40~60 parts of Centipeda minima, 13~18 parts of arisacma consanguineum schott, dried pinellia 13~18 parts, 15~20 parts of Radix Aconiti, 15~20 parts of Radix Aconiti Kusnezoffii, 20~30 parts of Paris polyphylla, 20~30 parts of the rhizome of davallia, tongmai grass 15~ 25 parts, 22~30 parts of iron sparrow, 20~30 parts of Fruticose Breyniae Leaf and Twig, 20~30 parts of iron general, 26~35 parts of toddalia, Entada phaseoloides 25~ 33 parts, 20~30 parts of dipsacus root, 15~20 parts of angelica tail, 22~28 parts of curcuma zedoary, 15~20 parts of trigone, 22~28 parts of phnom penh eupolyphaga, pool 20~30 parts blue, 26~35 parts of rheum officinale, 28~33 parts of Chinese hydrangeavine root-bark, 25~34 parts of Kadsura Root-bark, 26~35 parts of the root of Chinese clematis, flos caryophylli 20 ~28 parts, 15~20 parts of native copper, 14~18 parts of calamitas urinae hominis, 20~30 parts of Cortex Periplocae, 14~20 parts of Rhizoma Chuanxiong, asarum 25~32 Part, 13~19 parts of Asian puccoon, 21~28 parts of cassia twig, 14~20 parts of radix paeoniae rubra, 12~17 parts of radix scutellariae, 15~20 parts of Fructus Forsythiae, Cortex Phellodendri 14~ 20 parts, 12~20 parts of stiff silkworm, worm move back 14~20 parts, 15~22 parts of the root of Dahurain angelica, 13~20 parts of Radix Glycyrrhizae, blood more than 14~21 parts, honeysuckle flower 12 ~20 parts, 15~20 parts of centipede, 14~22 parts of full worm, 15~25 parts of house lizard, 14~20 parts of Rhizoma Et Radix Notopterygii, 12~19 parts of rhizoma atractylodis, pericarpium zanthoxyli 10~18 parts, 13~21 parts of bark of ash, 14~18 parts of the tuber of multiflower knotweed, 13~20 parts of hop, 14~21 parts of chaulmoogra, windproof 10~15 Part, 9~15 parts of schizonepeta, 10~15 parts of Chinese ephedra, 10~15 parts of paniculate swallowwort, 22~28 parts of lycopodium calvatum；

Group two：25~35 parts of frankincense, 25~35 parts of myrrh, 12~18 parts of safflower, 40~45 parts of dragon's blood, 33~40 parts of gamboge, wood 23~30 parts of soft-shelled turtle, 15~24 parts of castor bean, 18~25 parts of Borneolum, 7~13 parts of camphor, 6~12 parts of Moschus.

2. the plaster for the treatment of pain rheumatism according to claim 1, which is characterized in that count in parts by weight, the plaster Including following raw material：

Group one：50 parts of lopseed, 50 parts of vomiting nut, 50 parts of Centipeda minima, 16.5 parts of arisacma consanguineum schott, 16.5 parts of dried pinellia, Radix Aconiti 17 parts, 17 parts of Radix Aconiti Kusnezoffii, 25 parts of Paris polyphylla, 25 parts of the rhizome of davallia, 19 parts of tongmai grass, 26 parts of iron sparrow, 25 parts of Fruticose Breyniae Leaf and Twig, iron general 25 Part, 31 parts of toddalia, 31 parts of Entada phaseoloides, 25 parts of dipsacus root, 17 parts of angelica tail, 25 parts of curcuma zedoary, 17 parts of trigone, 26 parts of phnom penh eupolyphaga, In 25 parts of Herba Lycopi, 31 parts of rheum officinale, 31 parts of Chinese hydrangeavine root-bark, 31 parts of Kadsura Root-bark, 31 parts of the root of Chinese clematis, 25 parts of flos caryophylli, 17 parts of native copper, people White 17 parts, 25 parts of Cortex Periplocae, 17 parts of Rhizoma Chuanxiong, 28 parts of asarum, 17 parts of Asian puccoon, 25 parts of cassia twig, 17 parts of radix paeoniae rubra, 17 parts of radix scutellariae, Fructus Forsythiae 17 parts, 17 parts of Cortex Phellodendri, 17 parts of stiff silkworm, worm move back 17 parts, 17 parts of the root of Dahurain angelica, 16.5 parts of Radix Glycyrrhizae, blood more than 16.5 parts, 17 parts of honeysuckle flower, centipede 18 parts, 22 parts of full worm, 20 parts of house lizard, 17 parts of Rhizoma Et Radix Notopterygii, 17 parts of rhizoma atractylodis, 17 parts of pericarpium zanthoxyli, 17 parts of bark of ash, 17 parts of the tuber of multiflower knotweed, hop 17 Part, 16.5 parts of chaulmoogra, 13 parts windproof, 13 parts of schizonepeta, 13 parts of Chinese ephedra, 13 parts of paniculate swallowwort, 25 parts of lycopodium calvatum；

Group two：30 parts of frankincense, 30 parts of myrrh, 16 parts of safflower, 43.5 parts of dragon's blood, 36 parts of gamboge, 28 parts of semen momordicae, castor bean 19.5 Part, 22 parts of Borneolum, 11 parts of camphor, 10 parts of Moschus.

3. a kind of preparation method of the plaster for the treatment of pain rheumatism as claimed in claim 1 or 2, which is characterized in that the method Include the following steps：

Endure withered remove slag：Sesame oil is taken to set in pot, the raw material of input group one after low-grade fever is heated to 210~230 DEG C, and be stirred continuously, directly It is fried to raw material to surface dark brown, it is internal sallow, remove the dregs of a decoction to get medicine oil；

Pilling and pasting：The medicine oil refined is slightly cold from fire, when oil temperature is down to 280~300 DEG C, medicine oil is added portionwise in yellow lead In, while being continuously agitated along a direction, until medicine oil is at sticky lotion；

Spread out plaster：The lotion to have released fire-toxin is heated to fusing at a temperature of 50~80 DEG C, the raw material for the group two got ready is added, stirs It is even, then it is evenly coated on stype, it is cooling.

4. the preparation method of the plaster for the treatment of pain rheumatism according to claim 3, which is characterized in that organize two raw material and grind Fine powder is worn into, 100~120 mesh sieve is crossed.

5. the preparation method of the plaster for the treatment of pain rheumatism according to claim 3, which is characterized in that in parts by weight Meter, sesame oil are 1000~1200 parts.

6. the preparation method of the plaster for the treatment of pain rheumatism according to claim 3, which is characterized in that in parts by weight Meter, yellow lead are 500~600 parts.

7. application of the plaster described in claim 1 in the drug for preparing treatment pain rheumatism.

8. application of the plaster according to claim 7 in the drug for preparing treatment pain rheumatism, which is characterized in that described Rheumatism includes but not limited to：Brothers' pain in back and loin, rheumatic arthritis, osteoproliferation, scapulohumeral periarthritis, myalgia, sudden strain of a muscle hurt Pain caused by ecchymoma after wound.