CN108126145A - Goupi Gao - Google Patents

Goupi Gao Download PDF

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Publication number
CN108126145A
CN108126145A CN201810212063.1A CN201810212063A CN108126145A CN 108126145 A CN108126145 A CN 108126145A CN 201810212063 A CN201810212063 A CN 201810212063A CN 108126145 A CN108126145 A CN 108126145A
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China
Prior art keywords
parts
radix
goupi
root
pain
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CN201810212063.1A
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Inventor
王军
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Jiangxi Dikang Pharmaceutical Co Ltd
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Jiangxi Dikang Pharmaceutical Co Ltd
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Priority to CN201810212063.1A priority Critical patent/CN108126145A/en
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A61K36/714—Aconitum (monkshood)
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    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A61K31/125—Camphor; Nuclear substituted derivatives thereof
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Abstract

The present invention relates to technical field of traditional Chinese medicines, and in particular to a kind of expelling wind and clearing away cold, promoting blood circulation and stopping pain, the Goupi Gao significant in efficacy to acute soft tissue contusion.The Goupi Gao is prepared from the following materials：Radix Aconiti, Radix Aconiti Kusnezoffii, red halloysite, Radix Angelicae Pubescentis, caulis sinomenii, cortex periplocae, windproof, RADIX SMILACIS SIEBOLDI, rhizoma atractylodis, Radix Polygalae, frutus cnidii, moutan bark, galangal, fennel seeds, official osmanthus, Radix Angelicae Sinensis, the radix paeoniae rubrathe, fortune windmillpalm sheath-fibre, bush, rheum officinale, Pine Nodular Branch, teasel root, Rhizoma Chuanxiong, setose thistle, field thistle, the root of Dahurain angelica, frankincense, myrrh, borneol, camphor, cloves, Chinese cassia tree, cutaneous permeable agent；Preparation method prepares including mixed powder, fries material, lower red immersion, mixing beach.The Goupi Gao expelling wind and clearing away cold of the present invention, promoting blood circulation and stopping pain, Transdermal absorption are good, and to acute soft tissue bruise the effect of is notable.

Description

Goupi Gao
Technical field
The present invention relates to technical field of traditional Chinese medicines, and in particular to a kind of expelling wind and clearing away cold, promoting blood circulation and stopping pain, to acute soft tissue contusion Goupi Gao significant in efficacy.
Background technology
Acute soft tissue bruise refer to some or multiple positions of body caused by external force using damaging inflammation as Main local reaction and the general reaction based on the neuroendocrine system effect after wound.Show as local swelling, pain, skin Skin is crimson or livid purple, and functional activity is limited.
The method for the treatment of acute soft tissue bruise is more at present, such as embrocates ZHENGHONGHUA YOU, bonesetting liquid, mercurochrome, pastes rubber Glue plaster etc..Although these methods have the effect of certain, but often will appear work it is slow, inconvenient to use, influence it is beautiful, long-term The shortcomings of using easy skin allergy, lead to the poor compliance of user, therapeutic effect is less desirable.
The patent of publication No. CN104984209A discloses a kind of modified dog for treating acute jerk contused wound, rheumatism and pain Skin patch cream and preparation method thereof, including the medicine film layer on lining cloth and lining cloth, medicine film layer uses following bulk pharmaceutical chemicals：The dried venom of toads, life Monkshood, Radix Aconiti Kusnezoffii, Radix Angelicae Pubescentis, galangal, official osmanthus, Radix Angelicae Sinensis, tetrandra root, cassia twig, safflower, datura flower, greater celandine, Chinese prickly ash, Spiderflower Seed, Lopseed, myrrh, frankincense, menthol, borneol, camphor, gaultherolin, oil of badian, bagodryl hydrochloride, pressure sensitive adhesive, Azone.The effect of this hair is good with numbness relieving and pain relieving effect, not only inducing sweat and dispelling exogenous evils, but also warm passages through which vital energy circulates is to go cold-dampness, but inventor grinds Study carefully and find that the Goupi Gao needs to further improve to the effect of acute soft tissue bruise.
The present inventor is by being improved existing dogskin paste formulation and preparation process, it then follows traditional Chinese medicine monarch Principle, from expelling wind and clearing away cold, the function of promoting blood circulation and stopping pain, it is desirable to overcome that traditional Goupi Gao irritation is larger, transdermal absorption factor is low, The defects of poor to acute soft tissue bruise curative effect, obtain a kind of irritation is smaller, Transdermal absorption is good, to acute soft tissue The preferable Goupi Gao of bruise curative effect.
Invention content
In view of this, the present invention provides a kind of Goupi Gao, specifically provides recipe ingredient and its preparation of a kind of Goupi Gao Method, the Goupi Gao expelling wind and clearing away cold, promoting blood circulation and stopping pain, Transdermal absorption are good, and to acute soft tissue bruise the effect of is notable.
In order to achieve the above-mentioned object of the invention, the present invention provides following technical scheme：
One of the objects of the present invention is to provide a kind of Goupi Gaos, are prepared by the raw material of following parts by weight：Radix Aconiti 60-120 parts, 30-60 parts of Radix Aconiti Kusnezoffii, 30-60 parts of red halloysite, 10-35 parts of Radix Angelicae Pubescentis, 20-50 parts of caulis sinomenii, 15-50 parts of cortex periplocae, 20-50 parts windproof, 10-40 parts of RADIX SMILACIS SIEBOLDI, 15-50 parts of rhizoma atractylodis, 20-60 parts of Radix Polygalae, 10-45 parts of frutus cnidii, moutan bark 20- 50 parts, 6-20 parts of galangal, 10-30 parts of fennel seeds, 5-22 parts of official osmanthus, 12-35 parts of Radix Angelicae Sinensis, 20-50 parts of the radix paeoniae rubrathe, fortune windmillpalm sheath-fibre 10- 30 parts, 20-55 parts of bush, 20-60 parts of rheum officinale, 20-60 parts of Pine Nodular Branch, 30-74 parts of teasel root, 20-55 parts of Rhizoma Chuanxiong, setose thistle 5-20 Part, 5-20 parts of field thistle, 10-30 parts of the root of Dahurain angelica, 22-60 parts of frankincense, 20-56 parts of myrrh, 15-32 parts of borneol, 20-60 parts of camphor, fourth 12-35 parts fragrant, 6-20 parts of Chinese cassia tree, 3-8 parts of cutaneous permeable agent.
Preferably, the Goupi Gao is prepared by the raw material of following parts by weight：85 parts of Radix Aconiti, 40 parts of Radix Aconiti Kusnezoffii, It is 40 parts of red halloysite, 23 parts of Radix Angelicae Pubescentis, 40 parts of caulis sinomenii, 36 parts of cortex periplocae, 30 parts windproof, 32 parts of RADIX SMILACIS SIEBOLDI, 35 parts of rhizoma atractylodis, remote 40 parts of will, 30 parts of frutus cnidii, 40 parts of moutan bark, 11 parts of galangal, 20 parts of fennel seeds, 12 parts of official osmanthus, 20 parts of Radix Angelicae Sinensis, the radix paeoniae rubrathe 30 Part, 20 parts of fortune windmillpalm sheath-fibre, 43 parts of bush, 40 parts of rheum officinale, 40 parts of Pine Nodular Branch, 48 parts of teasel root, 30 parts of Rhizoma Chuanxiong, 13 parts of setose thistle, field thistle 12 Part, 25 parts of the root of Dahurain angelica, 35 parts of frankincense, 35 parts of myrrh, 20 parts of borneol, 36 parts of camphor, 18 parts of cloves, 12 parts of Chinese cassia tree, cutaneous permeable agent 4 Part.
Preferably, the cutaneous permeable agent by rose volatile oil and rhubarb total anthraquinone according to mass ratio 3-5:1 mixing is equal It is even to form.
Specifically, the meridian distribution of property and flavor of each Chinese medicine, effect are as follows in only angle cream of the invention：
Radix Aconiti, acrid flavour, hardship, property heat are included into the heart, spleen, liver and kidney channel.Dispelling wind and eliminating dampness, eliminating cold to stop pain, for wind-cold-dampness arthralgia, All cold pain, traumatic injury, narcotic analgesic, cold-dampness the moon subcutaneous ulcer.
Radix Aconiti Kusnezoffii, acrid flavour, hardship, property heat are included into the heart, spleen, liver and kidney channel.Dispelling wind and eliminating dampness, eliminating cold to stop pain, for wind-cold-dampness arthralgia, All cold pain, traumatic injury, narcotic analgesic, cold-dampness the moon subcutaneous ulcer.
Red halloysite, it is sweet in flavor, sour, puckery, it is warm-natured, return stomach, large intestine channel.Major function：Puckery intestines, hemostasis, myogenic sore.For long Rush down protracted dysentery, fecal blood, under uterine bleeding band；It controls sore outside not hold back, eczema pus contamination.
Radix Angelicae Pubescentis, acrid flavour, hardship are warm-natured, Return liver, kidney, bladder warp.Dispelling wind and eliminating dampness, numbness relieving and pain relieving, inducing diaphoresis.Cure mainly wind-cold-dampness arthralgia, Lumbocrural pain, few sun volt wind headache.Damp evil person and shaoyin headache etc. are had concurrently for arthralgia pain due to rheumatism, exterior syndrome due to wind-cold.
Caulis sinomenii, bitter are mild-natured.Wind-damp dispelling, diuresis.Control arthralgia pain due to rheumatism, the arthroncus of knee, oedema, tinea pedis.
Cortex periplocae, acrid flavour, hardship are warm-natured, Return liver, kidney, the heart channel of Hang-Shaoyin.Function is with curing mainly：Inducing diuresis for removing edema, wind-damp dispelling, strengthening the bones and muscles.With In oedema, difficult urination, arthralgia pain due to rheumatism, kidney deficiency and liver, muscles and bones impotence is powerless.
It is windproof, it is acrid flavour, sweet, it is warm-natured, return bladder, liver, the spleen channel.Function is with curing mainly：Inducing diaphoresis to dispel wind wins wet, relieving convulsion.For feeling Emit headache, arthralgia pain due to rheumatism, rubella itch, lockjaw.
RADIX SMILACIS SIEBOLDI, acrid flavour, slight bitter are mild-natured.Dispelling wind and eliminating dampness, relaxing tendons and activating collaterals, promoting blood circulation and stopping pain.For wind-cold-dampness arthralgia, close Pain is saved, all pains of waist foot, a lump in the abdomen causing distension and pain, heart diaphragm phlegm and retained fluid, the diseases such as fish-bone fishbone larynx.
Rhizoma atractylodis, bitter, pungent, warm-natured, returns spleen, stomach.It is drying damp and strengthening spleen, wind-dispelling, cold dispelling, improving eyesight.Abdominal fullness and distention is cured mainly, is let out It rushes down, oedema, tinea pedis is withered numbness, arthralgia pain due to rheumatism, anemofrigid cold, night blindness yctalopia.
Radix Polygalae, bitter, pungent, warm-natured, the thoughts of returning home, kidney, lung channel.Function is with curing mainly：Tranquilize the mind and promote the intelligence, eliminating the phlegm, detumescence.For heart kidney Caused insomnia and dreamful sleep is not handed over, and forgetful palpitation with fear is wandering, and expectoration is not well, sore swollen toxin, mastosis.
Frutus cnidii, acrid flavour, hardship are warm-natured, return kidney, the spleen channel.Function is with curing mainly：Warming kidney and enhancing body, (external application) removing dampness and destroying parasites.For Soreness and weakness of waist and knees, frequent micturition, fertility, leukorrhea pruritus vulvae, eczema of scrotum, sore tinea itch, impotence.
Moutan bark, bitter, pungent, cold nature, the thoughts of returning home, liver and kidney channel.Function is with curing mainly：Clearing heat and cooling blood, it is promoting blood circulation and removing blood stasis.For Febrile virulent maculae, hematemesis and epistaxis, night fever abating at dawn, lossless hectic fever due to yin, closed dysmenorrhea, carbuncle sore tumefacting virus, the pain of injury caused by falling and tumbling.
Galangal, acrid flavour, property heat, returns spleen, kidney channel.Function is with curing mainly：Heat dissipation analgesic, warming middle energizer to arrest vomiting.For coldness and pain in the epigastrium, Vomiting, turgor.
Fennel seeds, acrid flavour is warm-natured, Return liver, kidney, stomach.Function is with curing mainly：Cold-dispelling pain-relieving, regulating qi-flowing for harmonizing stomach.It is few for cold hernia Abdominal pain, testis swelling and hanging down of either of the testes pain, leukorrhea, epigastric pain is swollen bored, do not feel like eating, vomiting.
Official osmanthus, acrid flavour is warm-natured, returns spleen, kidney channel.Complement sun, warming spleen and stomach, removing internal cold, promoting blood circulation.The Yang-function insufficiency of kidneyzang is controlled, limb is cold Weak pulse, yang depletion collapse, abdominal pain diarrhea, cold hernia run quickly globefish, waist and knee crymodynia, Jing Bi Disorder lumps in the abdomen, cloudy subcutaneous ulcer, streamer and empty sun are floating more, under upper heat It is cold.
Radix Angelicae Sinensis, sweet in flavor, pungent, warm-natured, Return liver, the heart, the spleen channel.Function is with curing mainly：Replenishing and activating blood, menstruction regulating and pain relieving relax bowel. For blood deficiency chlorosis, dizziness palpitaition, irregular menstruation, closed dysmenorrhea, asthenia cold abdominalgia, dry constipation of intestines, arthralgia pain due to rheumatism, injury from falling down, Ulcer sores.Prepared RADIX ANGELICAE SINENSIS with yellow rice wine invigorate blood circulation.For closed dysmenorrhea, arthralgia pain due to rheumatism, injury from falling down.
The radix paeoniae rubrathe, bitter, cold nature, return liver warp.Function is with curing mainly：Clearing heat and cooling blood, removing blood stasis and analgesics.For febrile virulent maculae, spit Blood bleeding from five sense organs or subcutaneous tissue, red eye, swell pain, liver-depressed hypochondrium pain, closed dysmenorrhea, { note of the ancient Chinese } lump in the abdomen abdominal pain, injury from falling down, carbuncle swells sore.
Fortune windmillpalm sheath-fibre, bitter, puckery, mild-natured, Return liver, spleen, large intestine channel.Major function：Astringing to arrest bleeding.Main haematemesis, bleeding from five sense organs or subcutaneous tissue, just Blood, blood strangury, hematuria, metrorrhagia, traumatic hemorrhage.
Bush, sweet in flavor, salty, micro-pungent is mild-natured, the thoughts of returning home, liver, the spleen channel.Invigorate blood circulation, dispelling phlegm and alleviating pain.Closed dysmenorrhea is cured mainly, is produced Stasis blocking afterwards, chest and abdomen shouting pain, wound swelling and pain.
Rheum officinale, bitter is cold in nature, returns spleen, stomach, large intestine, liver, pericardium channel.Function is with curing mainly：Purge heat logical intestines, removing pattogenic heat from the blood and toxic material from the body, by Stasis of blood promoting menstruation.For real heat constipation, stagnate abdominal pain, and rush down dysentery is not well, jaundice with damp-heat pathogen, blood-head tells nosebleed, hot eyes, pharynx swelling, abdominalgia with intestinal abscess, carbuncle Swollen furunculosis, blood stasis closed, traumatic injury control scald outside；Upper gastrointestinal bleeding.
Pine Nodular Branch, it is bitter, pungent, it is warm-natured, return liver and kidney channel.Dispelling wind and eliminating dampness is removed obstruction in channels to relieve pain.
Teasel root, bitter, pungent, slightly warm in nature returns liver and kidney channel.Function is with curing mainly：Filling liver kidney, strengthening the bones and muscles continue injured, only uterine bleeding. For soreness and weakness of waist and knees, arthralgia pain due to rheumatism, uterine bleeding, threatened abortion, injury from falling down.Prepared RADIX DIPSACI with yellow rice wine is chiefly used in arthralgia pain due to rheumatism, injury from falling down.
Rhizoma Chuanxiong, acrid flavour is warm-natured, Return liver, courage, pericardium channel.Function is with curing mainly：Blood-activating and qi-promoting, wind-expelling pain-stopping.For menstruation not It adjusts, closed dysmenorrhea , Disorder lump in the abdomen is suffered from abdominal pain, chest side of body shouting pain, tumbling and swelling, headache, arthralgia pain due to rheumatism.
Setose thistle, sweet in flavor, bitter, cool in nature, converge to heart and liver channels.Function is with curing mainly：Cooling blood and hemostasis, eliminating stasis to resolve swelling.For bleeding from five sense organs or subcutaneous tissue, spit Blood, hematuria are had blood in stool, metrostaxis, traumatic hemorrhage, carbuncle sore tumefacting virus.
Field thistle, sweet in flavor, bitter, cool in nature, converge to heart and liver channels.Function is with curing mainly：Cooling blood and hemostasis, eliminating stasis to resolve swelling.For bleeding from five sense organs or subcutaneous tissue, spit Blood, hematuria are had blood in stool, metrostaxis, traumatic hemorrhage, carbuncle sore tumefacting virus.
The root of Dahurain angelica, acrid flavour is warm-natured, returns stomach, large intestine, lung channel.Function is with curing mainly：Relieve heat dehumidifies, sensible analgesic, detumescence and apocenosis. For cold headache, pain in the supra-orbital bone, nasal obstruction, nasosinusitis, toothache, leukorrhea, sore swell and ache curative.
Frankincense, acrid flavour, hardship are warm-natured, the thoughts of returning home, liver, the spleen channel.Function is with curing mainly：Promoting blood circulation and stopping pain, detumescence and promoting granulation.For bruise Damage, ulcer, pain in the chest and abdomen, contraction, sore diabrosis are not closed up long.
Myrrh, bitter is mild-natured, the thoughts of returning home, liver, the spleen channel.Dissipate blood and relieving pain, detumescence and promoting granulation.Cure mainly ulcer sore pain, trusted subordinate, muscles and bones All pains, traumatic blood stasis, external application can expelling pus and promoting granulations.
Borneol, acrid flavour, hardship, cold nature, the thoughts of returning home, spleen, lung channel.Function is with curing mainly：Inducing resuscitation of having one's ideas straightened out, clearing away heat to and alleviating pain.For heat Sick coma, convulsion are fainted, apoplexy coma due to blocking of the respiratory system, bstruction of the circulation of vital energy is fainted cruelly, middle evil is gone into a coma, hot eyes, aphtha, abscess of throat, and duct is suppurated.
Camphor, acrid flavour, property heat, the thoughts of returning home, the spleen channel.It takes orally to have one's ideas straightened out and wards off dirty, external application dehumidifying desinsection, warming and odynolysis.
Cloves, acrid flavour is warm-natured, returns spleen, stomach, kidney channel.Inverse, eliminating cold to stop pain, warming kidney and enhancing yang drop in middle benefit gas.For gastrofrigid vomiting, Hiccup, impotence due to deficiency of the kidney, Gong Leng.
Chinese cassia tree, acrid flavour, sweet, property heat, returns spleen, kidney, the heart, Liver Channel.Mends fire supporing yang, eliminating cold to stop pain, warming meridians and promoting circulation of qi.
Inventor surprisingly has found that the cutaneous permeable agent formed by rose volatile oil and rhubarb total anthraquinone compounding is to Goupi Gao In several kinds of Chinese medicinal materials be respectively provided with good transdermal facilitation, have certain value of exploiting and utilizing.
The present invention is made each herbal medicine generate good synergistic effect in curative effect, is dispelled by the reasonable compatibility of above all medicines Wind, dissipating cold, promoting blood circulation and stopping pain, warming and activating meridian, percutaneous absorbability is good, and the crux for the acute soft tissue bruise that can go directly is alleviated and controlled More related symptoms.
It is a further object of the present invention to provide the preparation methods of above-mentioned Goupi Gao, include the following steps：
1) prepared by mixed powder：It chooses qualified Radix Aconiti, Radix Aconiti Kusnezoffii, red halloysite, Radix Angelicae Pubescentis, caulis sinomenii, cortex periplocae, prevent Wind, RADIX SMILACIS SIEBOLDI, rhizoma atractylodis, Radix Polygalae, frutus cnidii, moutan bark, galangal, fennel seeds, official osmanthus, Radix Angelicae Sinensis, the radix paeoniae rubrathe, fortune windmillpalm sheath-fibre, Soviet Union Wood, rheum officinale, Pine Nodular Branch, teasel root, Rhizoma Chuanxiong, setose thistle, field thistle, the root of Dahurain angelica remove impurity respectively, cataclasm, and mixing is ground into fine powder, mistake Sieve, obtains mixed powder A；Qualified frankincense, myrrh, cloves, Chinese cassia tree, camphor, borneol are chosen, is ground into fine powder, is sieved, mixing Uniformly obtain mixed powder B；
2) material is fried：The vegetable oil of 3200-4000 parts by weight is added in pot, after pico- heating, be put into mixed powder A or It is soaked in vegetable oil 3-10 days, heats, frying surface dark brown, internal coke yellow is advisable, removes slag, and filters, then medicine oil is fried Dropping into a bead processed；
3) it is red under to impregnate：The red lead of 1000-1200 parts by weight is weighed, adds in medicine oil and stirs, receives blueness, plaster is soaked in cold In water；
4) beach is mixed：The medicinal slow boiling of take cream melts, treats temperature, adds in mixed powder B, cutaneous permeable agent, stirs evenly, beach It is applied on moderate animal skin or cloth.
Preferably, the step 1) is ground using vibration mill, rotating speed 600-800r/min, sieving makes With 200 mesh filter clothes.
Preferably, the step 2) is removed slag filtration using 200 mesh filter clothes.
It is stirred preferably, being added in medicine oil after the red lead slow boiling preheating of the step 3).
Melt preferably, the step 4) plaster is heated to 40-60 DEG C, treat temperature.
The preparation method of the Goupi Gao of the present invention is on the basis of the preparation of traditional paste, according to each taste Chinese medicine and raw material Physico-chemical property, be initially formed two kinds of mixed powders, then by fried material, it is lower it is red impregnate, mixing beach is prepared.Wherein, it shakes On the basis of the high speed grinding crushing of dynamic formula grinder enables to Chinese medicine and traditional artificial mortar grinder, grain size more refinement Small uniformly active ingredient release is more complete, can significantly more act on body surface, stimulate nerve endings, expand blood vessel, Promote local blood circulation, improve histotrophic nutrition supply, achieve the purpose that expelling wind and clearing away cold, promoting blood circulation and stopping pain.
The invention has the advantages that：Obtained by research for many years and clinical experience of the present invention as inventor, according to Chinese medicine The monarch principle of material, is improved traditional dogskin paste composition and preparation method, and preparation method is suitble to industrialized production, Expelling wind and clearing away cold, promoting blood circulation and stopping pain after medication can be used to treat numb limb, waist and leg ache, muscle arteries and veins contraction, traumatic injury, transdermal suction Receive good, to acute soft tissue bruise the effect of is notable.
Specific embodiment
The following examples will make the present invention more specifically to explain, but the present invention is not limited only to these implementations Example, these similary embodiments are not also limit the invention in any way.
Embodiment 1
A kind of Goupi Gao is prepared by the raw material of following parts by weight：85 parts of Radix Aconiti, 40 parts of Radix Aconiti Kusnezoffii, red halloysite 40 Part, 23 parts of Radix Angelicae Pubescentis, 40 parts of caulis sinomenii, 36 parts of cortex periplocae, 30 parts windproof, 32 parts of RADIX SMILACIS SIEBOLDI, 35 parts of rhizoma atractylodis, 40 parts of Radix Polygalae, 30 parts of frutus cnidii, 40 parts of moutan bark, 11 parts of galangal, 20 parts of fennel seeds, 12 parts of official osmanthus, 20 parts of Radix Angelicae Sinensis, 30 parts of the radix paeoniae rubrathe, fortune windmillpalm sheath-fibre 20 parts, 43 parts of bush, 40 parts of rheum officinale, 40 parts of Pine Nodular Branch, 48 parts of teasel root, 30 parts of Rhizoma Chuanxiong, 13 parts of setose thistle, 12 parts of field thistle, the root of Dahurain angelica 25 Part, 35 parts of frankincense, 35 parts of myrrh, 20 parts of borneol, 36 parts of camphor, 18 parts of cloves, 12 parts of Chinese cassia tree, 4 parts of cutaneous permeable agent.It is described Skin absorbent is by rose volatile oil and rhubarb total anthraquinone according to mass ratio 3-5:1 be uniformly mixed form.
The preparation method of above-mentioned Goupi Gao, includes the following steps：
1) prepared by mixed powder：It chooses qualified Radix Aconiti, Radix Aconiti Kusnezoffii, red halloysite, Radix Angelicae Pubescentis, caulis sinomenii, cortex periplocae, prevent Wind, RADIX SMILACIS SIEBOLDI, rhizoma atractylodis, Radix Polygalae, frutus cnidii, moutan bark, galangal, fennel seeds, official osmanthus, Radix Angelicae Sinensis, the radix paeoniae rubrathe, fortune windmillpalm sheath-fibre, Soviet Union Wood, rheum officinale, Pine Nodular Branch, teasel root, Rhizoma Chuanxiong, setose thistle, field thistle, the root of Dahurain angelica remove impurity respectively, cataclasm, and mixing is ground into fine powder, mistake Sieve, obtains mixed powder A；Qualified frankincense, myrrh, cloves, Chinese cassia tree, camphor, borneol are chosen, is ground into fine powder, is sieved, mixing Uniformly obtain mixed powder B；It grinds using vibration mill, rotating speed 600-800r/min, sieving is filtered using 200 mesh Cloth.
2) material is fried：The vegetable oil of 3200-4000 parts by weight is added in pot, after pico- heating, be put into mixed powder A or It being soaked in vegetable oil 3-10 days, heats, frying surface dark brown, internal coke yellow is advisable, and 200 mesh filter clothes remove slag, filtration, then By medicine oil frying dropping into a bead；
3) it is red under to impregnate：The red lead of 1000-1200 parts by weight is weighed, adds in medicine oil and stirs after slow boiling preheating, receives green, cream Medicine is soaked in cold water；
4) beach is mixed：The medicinal slow boiling of take cream is heated to 40-60 DEG C and melts, treats temperature, adds in mixed powder B, Transdermal absorption Agent stirs evenly, and beach is on moderate animal skin or cloth.
Embodiment 2
A kind of Goupi Gao is prepared by the raw material of following parts by weight：70 parts of Radix Aconiti, 52 parts of Radix Aconiti Kusnezoffii, red halloysite 50 Part, 16 parts of Radix Angelicae Pubescentis, 36 parts of caulis sinomenii, 23 parts of cortex periplocae, 42 parts windproof, 25 parts of RADIX SMILACIS SIEBOLDI, 40 parts of rhizoma atractylodis, 45 parts of Radix Polygalae, 20 parts of frutus cnidii, 30 parts of moutan bark, 14 parts of galangal, 15 parts of fennel seeds, 10 parts of official osmanthus, 20 parts of Radix Angelicae Sinensis, 30 parts of the radix paeoniae rubrathe, fortune windmillpalm sheath-fibre 20 parts, 43 parts of bush, 40 parts of rheum officinale, 40 parts of Pine Nodular Branch, 48 parts of teasel root, 30 parts of Rhizoma Chuanxiong, 13 parts of setose thistle, 12 parts of field thistle, the root of Dahurain angelica 25 Part, 35 parts of frankincense, 35 parts of myrrh, 20 parts of borneol, 36 parts of camphor, 18 parts of cloves, 12 parts of Chinese cassia tree, 4 parts of cutaneous permeable agent.It is described Skin absorbent is by rose volatile oil and rhubarb total anthraquinone according to mass ratio 3-5:1 be uniformly mixed form.
The preparation method is the same as that of Example 1 for the Goupi Gao of the present embodiment.
Embodiment 3
A kind of Goupi Gao is prepared by the raw material of following parts by weight：110 parts of Radix Aconiti, 36 parts of Radix Aconiti Kusnezoffii, red halloysite 40 Part, 32 parts of Radix Angelicae Pubescentis, 42 parts of caulis sinomenii, 40 parts of cortex periplocae, 38 parts windproof, 33 parts of RADIX SMILACIS SIEBOLDI, 30 parts of rhizoma atractylodis, 33 parts of Radix Polygalae, 40 parts of frutus cnidii, 40 parts of moutan bark, 16 parts of galangal, 20 parts of fennel seeds, 16 parts of official osmanthus, 30 parts of Radix Angelicae Sinensis, 40 parts of the radix paeoniae rubrathe, fortune windmillpalm sheath-fibre 25 parts, 48 parts of bush, 50 parts of rheum officinale, 30 parts of Pine Nodular Branch, 65 parts of teasel root, 45 parts of Rhizoma Chuanxiong, 16 parts of setose thistle, 15 parts of field thistle, the root of Dahurain angelica 15 Part, 50 parts of frankincense, 55 parts of myrrh, 30 parts of borneol, 50 parts of camphor, 30 parts of cloves, 18 parts of Chinese cassia tree, 6 parts of cutaneous permeable agent.It is described Skin absorbent is by rose volatile oil and rhubarb total anthraquinone according to mass ratio 3-5:1 be uniformly mixed form.
The preparation method is the same as that of Example 1 for the Goupi Gao of the present embodiment.
Comparative example 1
The Goupi Gao emplastrum that in the patent of reference publication No. CN104984209A prepared by embodiment 1.
Comparative example 2
It is identical with the preparation method of embodiment 1, lack the addition of moutan bark.
Comparative example 3
It is identical with the preparation method of embodiment 1, lack the addition of Rhizoma Chuanxiong.
Comparative example 4
It is identical with the preparation method of embodiment 1, lack the addition of setose thistle.
Comparative example 5
It is identical with the preparation method of embodiment 1, lack the addition of cutaneous permeable agent.
Above-described embodiment, comparative example Goupi Gao be external application, every net weight 12g cleans illing skin, cream using ginger After medicine heating softening, it is affixed on affected part or acupuncture point.Pregnant woman avoids patch waist and abdomen.
Clinical trial
It accepts for medical treatment and makes a definite diagnosis the patient 180 with arthralgia pain due to rheumatism, acute soft tissue bruise, age reckling 20 years old, age The maximum 76 years old, is randomly divided into 1 treatment group of embodiment and comparative example 1-5 treatment groups, every group 30.By Goupi Gao be affixed on affected part or At acupuncture point, 1 patch 5 days, 7 paste 1 course for the treatment of, minimum 1 course of outer patch, and most 10 courses for the treatment of observe and record clinical efficacy, concrete outcome It is shown in Table 1.
Curative effect determinate standard
It cures：Symptom all disappears, and functional activity restores normal.
It is effective：Symptomatology is eliminated or main symptom eliminates, function are restored substantially, can participate in normally working.
Effectively：Cardinal symptom substantially eliminates, and major joint function is restored substantially.
In vain：It is compared with before treatment, symptom is basically unchanged.
1. clinical trial results of table
As can be seen from Table 1, comparative example treatment group is substantially better than the effect of the treatment group of the embodiment of the present invention, to rheumatism numbness Bitterly, the cure rate of acute soft tissue bruise reaches 80%, and total effective rate reaches 93.33%.Comparative example 1 is existing dogskin Cream, comparative example 3 lack clearing heat and cooling blood, moutan bark promoting blood circulation and removing blood stasis, and comparative example 4 lacks the Rhizoma Chuanxiong of blood-activating and qi-promoting, wind-expelling pain-stopping, right Ratio 5 lack cooling blood and hemostasis, eliminating stasis to resolve swelling setose thistle, curative effect has certain decline.
Model case
1st, Mr. Wang, male's property, 45 years old, because double knee joint pain more than 2 months is medical, double Xiyan swelling, knee joint gentle activity by It limits, has tenderness at double Xiyans.Pale tongue is fat, white,slippery and moist fur, veins string are delayed.Tcm diagnosis：Arthralgia pain due to rheumatism.Through using outside Goupi Gao of the present invention Patch, double knee joint pain relief after the 3rd day, posterior joint swelling in the 10th day are ached apparent, and painful swelling of joints disappears within the 12nd day, joint It is movable normal.Symptom is fully recovered after 1 course for the treatment of.
2nd, river, women, 68 years old, because swelling, pain, moving obstacle are gone to a doctor for 2 days after right sprain of ankle, right ankle obvious tumefaction, Using external malleolus as very, local pain, tenderness, joint motion is limited.Right ankle photo has no fracture sign, is diagnosed as acute soft tissue torsion and frustrates Wound.By Goupi Gao outer patch of the present invention is used, 4 hours rear right ankle pain of medication starts to mitigate, and swelling in second day starts to mitigate.The Rear right ankle swelling and pain in 3 days disappear, and joint motion is normal.It is almost recovered after 2 courses for the treatment of.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications also should It is considered as protection scope of the present invention.

Claims (8)

1. a kind of Goupi Gao, which is characterized in that be prepared by the raw material of following parts by weight：60-120 parts of Radix Aconiti, Radix Aconiti Kusnezoffii 30-60 parts, 30-60 parts of red halloysite, 10-35 parts of Radix Angelicae Pubescentis, 20-50 parts of caulis sinomenii, 15-50 parts of cortex periplocae, 20-50 parts windproof, iron 10-40 parts of the root of Chinese clematis of silk, 15-50 parts of rhizoma atractylodis, 20-60 parts of Radix Polygalae, 10-45 parts of frutus cnidii, 20-50 parts of moutan bark, galangal 6- 20 parts, 10-30 parts of fennel seeds, 5-22 parts of official osmanthus, 12-35 parts of Radix Angelicae Sinensis, 20-50 parts of the radix paeoniae rubrathe, 10-30 parts of fortune windmillpalm sheath-fibre, bush 20-55 It is part, 20-60 parts of rheum officinale, 20-60 parts of Pine Nodular Branch, 30-74 parts of teasel root, 20-55 parts of Rhizoma Chuanxiong, 5-20 parts of setose thistle, 5-20 parts of field thistle, white 10-30 parts of the root of Dahurian angelica, 22-60 parts of frankincense, 20-56 parts of myrrh, 15-32 parts of borneol, 20-60 parts of camphor, 12-35 parts of cloves, Chinese cassia tree 6- 20 parts, 3-8 parts of cutaneous permeable agent.
2. Goupi Gao according to claim 1, which is characterized in that the Goupi Gao by following parts by weight raw material prepare and Into：85 parts of Radix Aconiti, 40 parts of Radix Aconiti Kusnezoffii, 40 parts of red halloysite, 23 parts of Radix Angelicae Pubescentis, 40 parts of caulis sinomenii, 36 parts of cortex periplocae, it is 30 parts windproof, 32 parts of RADIX SMILACIS SIEBOLDI, 35 parts of rhizoma atractylodis, 40 parts of Radix Polygalae, 30 parts of frutus cnidii, 40 parts of moutan bark, 11 parts of galangal, 20 parts of fennel seeds, 12 parts of official osmanthus, 20 parts of Radix Angelicae Sinensis, 30 parts of the radix paeoniae rubrathe, 20 parts of fortune windmillpalm sheath-fibre, 43 parts of bush, 40 parts of rheum officinale, 40 parts of Pine Nodular Branch, 48 parts of teasel root, 30 parts of Rhizoma Chuanxiong, 13 parts of setose thistle, 12 parts of field thistle, 25 parts of the root of Dahurain angelica, 35 parts of frankincense, 35 parts of myrrh, 20 parts of borneol, 36 parts of camphor, cloves 18 parts, 12 parts of Chinese cassia tree, 4 parts of cutaneous permeable agent.
3. Goupi Gao according to claim 1, which is characterized in that the cutaneous permeable agent is total by rose volatile oil and rheum officinale Anthraquinone is according to mass ratio 3-5:1 be uniformly mixed form.
4. according to the preparation method of claim 1-3 any one of them Goupi Gaos, which is characterized in that include the following steps：
1) prepared by mixed powder：Choose qualified Radix Aconiti, Radix Aconiti Kusnezoffii, red halloysite, Radix Angelicae Pubescentis, caulis sinomenii, cortex periplocae, windproof, iron It is the silk root of Chinese clematis, rhizoma atractylodis, Radix Polygalae, frutus cnidii, moutan bark, galangal, fennel seeds, official osmanthus, Radix Angelicae Sinensis, the radix paeoniae rubrathe, fortune windmillpalm sheath-fibre, bush, big Huang, Pine Nodular Branch, teasel root, Rhizoma Chuanxiong, setose thistle, field thistle, the root of Dahurain angelica remove impurity respectively, cataclasm, and mixing is ground into fine powder, is sieved, obtains To mixed powder A；Qualified frankincense, myrrh, cloves, Chinese cassia tree, camphor, borneol are chosen, is ground into fine powder, is sieved, is uniformly mixed Obtain mixed powder B；
2) material is fried：The vegetable oil of 3200-4000 parts by weight is added in pot, after pico- heating, mixed powder A is put into or impregnates 3-10 days in vegetable oil, heating, frying surface dark brown, internal coke yellow is advisable, removes slag, and filters, then medicine oil frying is dripped Water beading；
3) it is red under to impregnate：The red lead of 1000-1200 parts by weight is weighed, adds in medicine oil and stirs, receives blueness, plaster is soaked in cold water In；
4) beach is mixed：The medicinal slow boiling of take cream melts, treats temperature, adds in mixed powder B, cutaneous permeable agent, stirs evenly, beach in On moderate animal skin or cloth.
5. the preparation method of Goupi Gao according to claim 4, which is characterized in that the step 1) grinds use and shakes Dynamic formula grinder, rotating speed 600-800r/min, sieving use 200 mesh filter clothes.
6. the preparation method of Goupi Gao according to claim 4, which is characterized in that the step 2) uses 200 mesh filter clothes It removes slag filtration.
7. the preparation method of Goupi Gao according to claim 4, which is characterized in that the red lead slow boiling preheating of the step 3) After add in medicine oil and stir.
8. the preparation method of Goupi Gao according to claim 4, which is characterized in that the step 4) plaster is heated to 40- 60 DEG C melt, treat temperature.
CN201810212063.1A 2018-03-15 2018-03-15 Goupi Gao Pending CN108126145A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108653251A (en) * 2018-08-08 2018-10-16 丁武沛 A kind of plaster for treating ligament injury

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59181209A (en) * 1983-03-30 1984-10-15 Nitto Electric Ind Co Ltd Rubber based adhesive plaster
CN101020020A (en) * 2007-03-06 2007-08-22 林冶 Dogskin plaster and its prepn process
CN101020019A (en) * 2007-03-06 2007-08-22 林冶 Dogskin plaster and its prepn process
CN101336993A (en) * 2008-07-24 2009-01-07 广西源安堂药业有限公司 External tincture for treating wind-dampness arthralgia and urgent sprain and preparation method thereof
CN104906482A (en) * 2014-03-11 2015-09-16 姚金凤 Goupi plaster and preparation method thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59181209A (en) * 1983-03-30 1984-10-15 Nitto Electric Ind Co Ltd Rubber based adhesive plaster
CN101020020A (en) * 2007-03-06 2007-08-22 林冶 Dogskin plaster and its prepn process
CN101020019A (en) * 2007-03-06 2007-08-22 林冶 Dogskin plaster and its prepn process
CN101336993A (en) * 2008-07-24 2009-01-07 广西源安堂药业有限公司 External tincture for treating wind-dampness arthralgia and urgent sprain and preparation method thereof
CN104906482A (en) * 2014-03-11 2015-09-16 姚金凤 Goupi plaster and preparation method thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108653251A (en) * 2018-08-08 2018-10-16 丁武沛 A kind of plaster for treating ligament injury

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