JPS59181209A - Rubber based adhesive plaster - Google Patents

Abstract

PURPOSE:A rubber based adhesive plaster, obtained by incorporating an extract of a rosemary with an organic solvent with an extract of the rosemary with a hydrous organic solvent, and capable of keeping a chemical stable without decomposition thereof. CONSTITUTION:A rubber based adhesive plaster obtained by incorporating (A) 0.01-6wt% extract of a rosemary with an organic solvent with (B) 0.01-6wt% extract of the rosemary with a hydrous organic solvent at (1/10)-10 mixing ratio between the two components. A volatile polar solvent, e.g. a lower alcohol or lower ketone, compatible with water in any proportion or a weakly polar solvent, e.g. xylene, tetrahydrofuran (THF) or n-hexane, is cited as the solvent for the extract (A). Ethanol is preferred for the solvent for the extract (B). If the rubber based adhesive material is hydrophobic, the extract (A) is used in a larger amount. If the rubber based adhesive is hydrophilic, the amount of the extract (B) is preferably increased. In production of the plaster, these components are preferably added thereto in as early a period as possible.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention relates to improvements in plasters made of rubber-based adhesive substances.

Conventionally, drugs administered to the integument, such as bactericides, disinfectants, and skin irritants, have been used to locally act on the integument and its underlying tissues. However, in recent years, attempts have been made to administer drugs that have systemic effects via the whole envelope, and various methods of administering the drugs through the envelope have been proposed or attempted.

Dermal administration of drugs is carried out, for example, in the form of adhesive patch preparations in which the entire drug is mixed into a paste made of an adhesive substance. When stored for a long period of time, the therapeutic effect of the preparation tends to decrease significantly due to decomposition, volatilization, etc. of the drug.

By the way, volatilization and photodecomposition of drugs can be prevented by sealing them with aluminum laminate packaging and shielding them from light. , amine compounds, etc., the decomposition of drugs continues to proceed even with aluminum laminated packaging, resulting in
Many items become unusable after three years of storage. In particular, salicylic acid derivatives such as methyl salicylate and heptanoglycol salicylate as anti-inflammatory analgesics, skin irritants such as kabsaicin, nonylpanillylamide, and horsetail extract, ethanolamine antihistamines such as diphenhydramine, and dl! -The content of vitamin E such as α-tocopherol decreases significantly over time.

Therefore, there is interest in the development of adhesive patches (=J preparations), which are rubber thread adhesive substances that do not cause decomposition of the drug even if mulberry is added.

In view of this situation, the inventors of the present invention have conducted various studies and found that rosemary organic solvent extract and rosemary water-containing solvent extract have been added to the rubber-based adhesive paste.
If it is mixed, will the paste be a drug? It was found that the drug remains stable even when exposed to carbon without decomposition.

The present invention was completed based on the new knowledge of Katana Karu (C), and is made by blending rosemary organic solvent extract and rosemary hydrated organic director extract into a rubber-based adhesive material. Rubber adhesive η body.

Relevant ・1. The present invention relates to a rubber-based sticky substance, that is, a sticky knot preparation, which is made by roughly blending a drug into the F-form.

Rubber-based adhesive substances α have traditionally been used for rubber-based adhesive patch preparations (diene-based polymer compounds, specifically natural rubber, synthetic rubber, mixtures thereof, etc.). Single-component rubber includes styrene-isoprene-styrene block combination t = body-t, styrene-butadiene rubber, polybutene rubber, polyisogrene rubber,
Examples include butyl rubber and silicone rubber.

The four rubber-based sticky substances also include tackifiers such as terpene resins and petroleum resins, liquid paraffin, and animal and vegetable oils (for example, olive oil,
Adhesion/retention force regulators such as soybean oil, beef tallow, tonneau fat), polybutene, lower isoprene, wax, titanium oxide,
fillers such as zinc chloride, aluminum chloride, carunium sulfate, carunium phosphate, water and anti-fogging agents (
For example, sorbitano monooleate, lauryl sulfonic acid (IJ cum), emulsifying aids (eg, magnenium stearate, stearic aluminum), etc. may be blended.

Rosmarinus is usually used as a herb spice.
Dry powder of the leaves of P. cinalis is used. As the extraction solvent for the organic solvent extract of rosemary, a volatile solvent that is compatible with water in any proportion is used. Specifically, lower alcohols (e.g., methanol, ethanol, -Proper Tools, is.

polar solvents such as lower ketones (e.g., acetone, methyl ethyl lactone, etc.), xylene, benzene, acetonitrile, ffl Ethyl, tetrahydro7ran, 1,4-dioxene, toluene, n-hexane, n-
Examples include weakly polar solvents such as pentane and cyclohexane, with ethanol being particularly preferred.

As the solvent for the water-containing four-solvent extract of rosemary, in addition to the above-mentioned polar solvents, moderately polar solvents such as ethyl ether are used, and ethanol is particularly preferably used. What is the content of organic solvent divided into aqueous organic solvent?
Usually about 50-90%, good '2 L < il 60-7
The amount is about 0% (the rest is water).

When these rosemary extracts are blended into a rubber-based adhesive substance to produce the entire plaster of the present invention, it is preferable to add these ingredients as early as possible, and to impregnate them into the raw rubber. 〈It is effective. That is, it is preferable that the rosemary extract is dissolved in an oily component such as fully liquid paraffin or polygden, and then impregnated into the raw rubber in advance.

Rho 7: The blending amount of MaIJ-organic solvent extract and Hirosemary water-containing organic solvent extract is 0.002 to 10% by weight, respectively, based on the total amount of the rubber adhesive material V.
The amount is preferably about 0.01 to 6% by weight, and the blending ratio is about 1/2 to 20, preferably 1/2.
It is about 10-10. In addition, if the rubber adhesive substance is hydrophobic, it is desirable to increase the organic solvent extract acid, and if it is hydrophilic, it is desirable to use water-containing organic solvent extract Kaneko. It can be formulated into an adhesive patch by combining all the drugs to be applied. Therefore, the adhesive patch preparation using the plaster according to the present invention is as follows:
It has the effect of keeping the drug mixed therein stable without being decomposed.

There are no particular restrictions on the drug that can be incorporated into the paste of the present invention, as long as it can be administered in the form of an adhesive patch. Examples include drugs for the treatment of skin diseases, drugs for skin irritation, drugs for the treatment of anxiety complaints, etc. In particular, the content of compounds containing hydroxyl groups, amine compounds, etc., is significantly reduced in conventional adhesive pastes, so the present invention's pastes are also suitable for drug resistance. It is particularly meaningful in this case.

Examples of compounds containing phenolic hydroxyl groups include salicylic acid derivatives (monoglycol sulfate, methyl salicylate, etc.), vitamin E and its derivatives, cabsaicin, etc. Examples of the amine compounds include ethanolamine antihistamine drugs such as diphenhydramine, ethylenediamine antihistamine drugs such as chlorpheniramine, and lidocaine. Other medicinal ingredients include cold-sensitive antidermatological drugs such as l-menthol, dl-camphor, thymol, and d-borneolnat; non-steroidal anti-inflammatory drugs such as indomethacin and cyclofenac sodium;
Steroid anti-inflammatory agents such as dexamethacin and betamethacin, bactericidal agents such as chlorhexidine diglyconate and acrinol, E4-sensitive stimulants such as capsicum extract, nonylic acid vanillylamide, kabsaicin, shokiyoku extract, cantharis tincture, and cantharidin. Examples include crude drugs such as proboscis, shikon, and tokuki.

It goes without saying that when preparing the adhesive patch preparation of the present invention, the drug may be first added to the rubber-based adhesive substance, and then each extract of rosemary may be added. Adhesive patch preparations are usually used by being spread on a support such as cloth or plastic film.

The present invention will be explained in more detail below using practical examples and experimental examples, but the present invention is not limited thereto.

Example (10,000 spoonfuls of rubber adhesive) Natural rubber 30y Inbrene rubber 20y Natural rosin 30p Soybean oil 10y Liquid paraffin 5y Glycerin 52 0-Zumary ethanol extract 2y and Rosemary 7
0% ethanol (water: 30 V/V%) extract is dissolved in 22K soybean oil, impregnated into natural rubber and isoprene rubber, and then kneaded with other ingredients in the above rubber adhesive formulation in a conventional manner. In addition, the following drug formulation was added, and a drug-containing paste was obtained by a conventional method.

(Drug prescription) Monoglycol salicylate 5% (for plaster It (~
) Turnip, 0.015% () L-menthol 3% () Chloride maleate 0.2% () Phenylamino Example Rubber-based adhesive Made of gold, then the same two persimmon rosemary extracts as in Example 1. A drug-containing paste was obtained in the same manner as in Example 1, except that the same amount was added.

Comparative Example 1 Both rosemary extracts were removed from the formulation of Example 1 b7' (
I got something.

Comparative Example 2 Instead of both rosemary extracts in the formulation of Example 1, a rosemary ethanol extract containing 4% by weight based on the total ointment was obtained.

Comparative example 3 A product was obtained that contained 4% of the total amount of plaster.

Examples The samples obtained in Examples 1 to 3 and Comparative Examples 1 to 3 were sealed with an aluminum polyethylene laminate film and stored at 40°C for 3 months. The kick reduction rate was determined and the results are shown in Table 1.

Table 1 Drug degradation rate (H) Patent applicant: Nitto Electric Industry Co., Ltd.

Claims (2)

[Claims] (1) A rubber-based adhesive paste comprising a rubber-based adhesive material, Eri, mixed with an organic solvent extract of rosemary +7- and a water-containing organic solvent extract of rosemary. (2) A rubber-based adhesive paste according to claim (1), which further contains a drug.