JPS59181213A - Rubber based adhesive plaster - Google Patents

Abstract

PURPOSE:A rubber based adhesive plaster, obtained by incorporating rosemary or/and sage with a plaster consisting of a rubber based adhesive material, and capable of improving the stability of a chemical to be incorporated with the above-mentioned plaster. CONSTITUTION:A rubber based adhesive plaster, obtained by incorporating preferably about 0.02-10wt%, based on the total weight thereof, dried powder of rosemary or/and sage, preferably about 0.01-5wt%, based on the total weight thereof, extract of the rosemary or/and sage with a polar solvent or preferably about 0.03-8wt%, based on the total weight thereof, extract of the rosemary or/ and sage with a nonpolar solvent with a plaster consisting of a rubber based adhesive material, e.g. natural rubber or/and synthetic rubber, and capable of suppressing the decomposition of a chemical to be incorporated with the above-mentioned plaster, e.g. a salicylic acid derivative such as monoglycol salicylate useful as an anti-inflammatory and analgesic agent or ethanolamine based antihistaminic agent such as ''Diphenhydramine'', having phenolic hydroxyl groups or/and amino groups reducing remarkably the content thereof particularly with time and keeping them stable for a long period.

Description

DETAILED DESCRIPTION OF THE INVENTION Zero-shot #iA relates to the improvement of a corpus luteum consisting of a rubber-based sticky substance.

Conventionally, drugs administered to the integument have been intended to locally act on the integument and its underlying tissues, such as lethal agents, disinfectants, and skin irritants. However, attempts have been made to administer drugs that have delayed systemic effects via the ectropion, and cutaneous administration of various drugs has been proposed or attempted.

Dermal administration of drugs is carried out in the form of an adhesive patch, in which the drug is mixed into a plaster made of a sticky substance; '
C#! If the drug is left in the drug for a long period of time, the therapeutic effect of the drug tends to decrease significantly due to decomposition and volatilization of the drug.

By the way, is it possible to prevent volatilization and photodecomposition of drugs by sealing them with aluminum laminate packaging and shielding them from light? , amine compounds, etc., the decomposition of drugs continues to proceed even with aluminum laminated packaging, resulting in
Many items become unusable after three years of storage. In particular, salicylic acid derivatives such as methyl salicylate and monoglycol salicylate as anti-inflammatory analgesics, skin irritants such as kabsaicin, nonyl panillyl amide, and pepper extract, and anti-inflammatory agents such as diphenhydran The content of vitamin E, such as raremin antihistamines and dt-α-toco7erol, decreases significantly over time.

Therefore, it is desired to develop a plaster or an adhesive patch made of a rubber-based adhesive material that does not allow the decomposition of the drug to progress even when the drug is mixed therein.

Under these circumstances, the present inventors have conducted various studies and have found that if rosemary and/or sage is mixed into a plaster made of a rubber-based adhesive substance, drugs can be added to the plaster. It was discovered that the drug exists stably without decomposition even when the drug is used.

Kihatsu 8A was completed based on this new knowledge, and includes a rubber thread adhesive plaster made of a rubber-based adhesive substance mixed with at least one selected from rosemary and sage. The present invention relates to a rubber thread adhesive paste, that is, an adhesive patch preparation, which is made by adding a drug to the paste.

Examples of rubber-based adhesive substances include diene-based polymer compounds conventionally used for rubber thread adhesive patch preparations, specifically natural rubber, synthetic rubber, and mixtures thereof. Synthetic rubbers include styrene-inbrene-styrene block copolymer rubber, styrene-butadiene rubber, polybutene rubber, polyisoprene rubber, butyl rubber.
Examples include resin rubber and silicone rubber.

The paste made of a rubber adhesive substance further contains as a third component a glaze layer imparting agent such as a polyurethane resin or a petroleum resin, liquid paraffin, or an animal or vegetable oil (for example, olive oil,
soybean oil, beef tallow, tonne fat), polybutene, low-grade imprene, adhesion/holding force regulator for socks, etc., titanium oxide,
Zinc oxide, Mekukui Gorge aluminum, calcium sulfate,
Phosphoric acid power: Contains fillers such as calcium, water, emulsifiers (e.g., Nrubikune monooleate, sodium lauri I resulfonate), emulsifiers (e.g., fC, magnesium stearate, aluminum stearate), etc. It's okay.

As for rosemary, ORosmar 1nus offici is used as a spice.
Dried powder of leaves such as Nalis L. is used. Mak
, rosemary may be used in the form of a solvent extracted extract. The solvent in this case is preferably water or a volatile and low toxicity organic solvent. Specific examples of solvents include lower atrecols (e.g., those having 1 to 3 carbon atoms, such as methanol, ethanol, n-propanol, and 1so-propanol), and lower ketones (e.g., carbon atoms such as acetone, methyl ethylecton, etc.). Numbers 1 to 4), ethyl acetate? Polar solvents such as xylem, benzene, ether? , acetonitrile, tetrahydrofuran, 1,4-dioxane,
Examples of suitable solvents include weakly polar solvents such as toluene, n-hexane, n-pentane, and cyclohexane, and mixed solvents of water and polar organic solvents such as those exemplified above. Among these, particularly preferred are methanol, FNO I, or a mixed solvent of acetone and water, and such a mixed solvent preferably has an organic solvent content of 40 to 90% (particularly 50 to 70%). It is also possible to use a rosemary extract that has its aroma components removed by exposing it to reduced pressure for a long time, steam distilling it, or the like. In this case, incense 9
8. It is possible to prevent preference due to ingredients.

As sage, sage that is usually used as a spice [5alvia triloba, 5alv
iaofficinalis L, , 5alvia
carnasa Daugl (all of the above are members of the family Syndae)
etc.] Dried leaf powder is used. Moreover, sage may be used in the form of a solvent extracted extract. As the solvent at this time, the same solvents as those exemplified above regarding rosemary are used.

The blending amount of rosemary is about 0.01 to 20% by weight in the case of dry powder, preferably about 0.02 to 10% by weight, based on the total amount of the paste made of the rubber thread viscous substance. In the case of solvent extracts, the amount is about 0.002 to 100 liters,
Preferably, the amount is about 0.01 to 5M, and in the case of non-polar solvent extracts, about 0.005 to 15% by weight, preferably about 0.
It is about 0.03 to 8 weight.

The amount of sage added is about the same as that of rosemary.

The plaster of the present invention can be formulated into an adhesive patch by incorporating a drug that can be applied to the outer skin. Therefore, the adhesive patch preparation using the plaster according to the present invention is as follows:
What is the effect of keeping the drug blended there stable without being decomposed?

There are no particular restrictions on the drug that can be incorporated into the paste of the present invention, as long as it can be administered in the form of an adhesive patch. Examples include drugs for treating skin diseases, drugs for skin irritation, and drugs for treating indefinite complaints. In particular, the content of phenolic hydroxyl group-containing compounds, amine thread compounds, etc., is significantly reduced in the conventional rubber thread sticky substance, so its significance is particularly significant when formulating such drugs. There is. Examples of compounds containing phenolic hydroxyl groups include salicylic acid derivatives (monoglycol salicylate, methyl salicylate, etc.), vitamin E and its derivatives, and kabsaicin, and examples of amine-based compounds include compounds such as diphenhydramine. Reamine-based antihistamine drugs, ethylenediamine-based antihistamine drugs such as chlorpheniramine, and lidocaine are available. Other medicinal ingredients include cold-sensitive skin irritating drugs such as t-menthol, dt-camphor, thymo I, and d-borneol, non-steroidal anti-inflammatory drugs such as indomethacin and cyclofenac sodium, and dexamethacin. , sulfuroid anti-inflammatory agents such as betamethadino, bactericidal agents such as talolhexidine diglyconate, acrinol,
Warm-sensitive skin irritation drugs such as pepper extract, nonylic acid vanillyl reamide, kabsaicin, ginger extract, canglis tincture, and cancrisin, as well as crude drugs such as chilium and chilium can be used.

It goes without saying that in step K of preparing the adhesive patch preparation of the present invention, a mass drug may be added to the rubber-based adhesive substance, and rosemary or sage may be added after step A.

Further, the adhesive patch preparation of the present invention is usually used by being spread on a support such as cloth or plastic film.

EXAMPLES The present invention will be explained in more detail below with reference to Examples and Experimental Examples, but the present invention is not limited thereto.

Example 1 Stycine-in-plain styrene rubber 401 natural rosin 10F aliphatic petroleum resin 85f bolybdenum
A rubber adhesive having the above formulation was prepared using a conventional method, and rosemary ethanol extract 22 and a drug having the following formulation were added thereto to obtain a drug-containing paste using a conventional method.

(Drug prescription) Salicylic acid monoglycol 51 t-menthol 52 dt-kaffir IgI intoxicant d-α-tocopherol 0.27 diphenylate salicylate/hydramine 0.21 nonylic acid panillylamide 0.02f Example 2 During the formulation of Example t, Rosemary ethanol extract 22
Teenage Rini Rosemary Eckno? A drug-containing bone extract was obtained in the same manner as in Example 1 using Extract 21, which had its aroma components removed by steam evaporation.

Example 8 A drug-containing paste was obtained in the same manner as in Example 1 except that rosemary toluene extract was used instead of rosemary ethanol extract in the formulation of Example 1.

Comparative Example 1 Example 117) Nine products were prepared by removing the stone-summary ethanol extract from the formulation. Te, 4
After surviving for 3 months at 0'''C, the amount of each drug was determined and the rate of decrease in content was determined, and the results are shown in Table 1.

Claims (3)

[Claims] (1) A rubber thread adhesive corpus luteum, characterized in that it is formed by blending at least one selected from rosemary and sage into a plaster consisting of a rubber-based adhesive substance. (2) A patented ice helmet made by adding a drug (
The rubber thread adhesive corpus luteum described in section 1). (3) Is the drug a phenolic hydroxyl group or/and an amino group?
T-Has I? 1iFiFV-Rubber-based depositable plaster according to claim ρ range (2) 0