JPS6053150A - Rubbery sticky bandage - Google Patents

Abstract

(57) [Summary] This bulletin contains application data before electronic filing, so abstract data is not recorded.

Description

DETAILED DESCRIPTION OF THE INVENTION (Technical Field) The present invention relates to improvements in plasters made of rubber-based adhesive substances.

(Prior Art) Conventionally, drugs administered to the integument, such as bactericides, disinfectants, and skin irritants, were intended to act locally on the integument and its underlying tissues. However, in recent years, attempts have been made to administer drugs with full-phase action through the epidermis, and various drugs have been proposed or attempted to be administered through the epidermis.

Dermal administration of drugs is carried out, for example, in the form of adhesive patch preparations in which the drug is mixed into a plaster made of an adhesive substance. When stored, the therapeutic effect of the preparation tends to decrease significantly due to decomposition, volatilization, etc. of the drug.

By the way, volatilization and photodecomposition of drugs can be prevented by sealing them with aluminum laminate packaging and shielding them from light. , amine compounds, etc., the decomposition of drugs continues to proceed even with aluminum laminated packaging, resulting in
Many products become unusable after being stored for up to three years. In particular, salicylic acid derivatives such as methyl salicylate and monoglycol salicylate as anti-inflammatory analgesics, skin irritants such as kabsaicin, nonylic acid vanillylamide, and hot pepper extract, ethanolamine antihistamines such as diphenhydramine, and vitamins such as dk-α-tocopherol. There is a significant decrease in the oral content of E and other drugs.

Therefore, it is desired to develop a plaster or an adhesive patch made of a rubber-based adhesive material that does not allow the decomposition of the drug to progress even when the drug is mixed therein.

Under these circumstances, the present inventors have conducted various studies and have found that if at least one selected from isocoumarin derivatives and coumarin derivatives of plants of the family Saxifrage family are blended into a plaster made of a rubber-based adhesive substance, It has been found that even when a drug is mixed into a plaster, the drug remains stable without being decomposed.

(Disclosure of the Invention) The present invention has been completed based on new findings, and includes at least one selected from isocoumarin derivatives and coumarin derivatives of the Saxifrage f1 plant in a plaster made of a rubber-based adhesive substance. The present invention relates to a rubber-based adhesive paste characterized by comprising: a rubber-based adhesive paste further containing a drug, that is, an adhesive patch preparation;

Examples of rubber-based adhesive substances include diene-based polymer compounds conventionally used for rubber-based adhesive patch preparations, specifically natural rubber, synthetic rubber, and mixtures thereof. As a synthetic rubber, styrene-isoprene-
Examples include styrene block copolymer rubber, styrene-butadiene rubber, polybutene rubber, butyl rubber, and silicone rubber.

The paste made of rubber-based sticky substances further contains terpene-based + Δ1 fats, petroleum-based cedar] fats, and other sticky agents (J''i agents, liquid paraffin, animal and vegetable oils (e.g., olive oil, soybean oil, etc.) as third components. , beef tallow, pork fat), polybutene, lower isoprene, wax and other adhesive/retention force regulators, titanium oxide, zinc oxide, aluminum metasilicate, calcium sulfate, calcium phosphate and other fillers, water and emulsifiers (e.g. sorbitan mono oleate, sodium lauryl sulfonate), emulsification aids (for example, magnesium stearate, aluminum stearate), etc. may be blended.

Examples of isocoumarin derivatives or coumarin derivatives of plants of the family Saxifrage used in the present invention include hydragel, hergenin, phyllodulcin, and the like. These may be synthetic or naturally derived.

Those of natural origin may be used as the Saxifrageae plant itself (usually its powder) or as an extract from the Saxifrageae plant. For example, phyllodulcin is widely distributed in the leaves of amacha, hydragenol in the flowers of hydrangea, and bergenin is widely distributed in the underground rhizomes of plants such as Saxifrage, Trifoliate, and Cornflower, so these dry powders,
Alternatively, it can be used as an extract extracted from these by means known per se.

Extraction solvents include water, alcohol (methanol,
(ethanol, etc.), acetone, etc.

The blending amount of the ink marine derivative and coumarin derivative is 0.005 to 10% by market weight based on the rubber adhesive substance.
The amount is preferably about 0.01 to 5% by weight, more preferably about 0.1 to 2% by weight, and when used as a dry powder or extract of plants, the total amount of isocoumarin derivatives and coumarin derivatives is less than the above amount. For example, as an extract, 0.01
~20% by weight, preferably about 0.02~10% by weight,
More preferably, the content is about 0.1 to 5% by weight, and the dry powder of the plant is about 0.01 to 30% by weight, preferably about 0.05 to 10% by weight, and more preferably 0.2 to 30% by weight. It is blended in an amount of about 5% by weight.

There are no particular restrictions on the drug that can be incorporated into the paste of the present invention as long as it can be administered in the form of an adhesive patch. Examples include drugs for treating skin diseases, drugs for skin irritation, and drugs for treating indefinite complaints.

In particular, the content of phenolic hydroxyl group-containing compounds, amine compounds, etc. is significantly reduced in plasters made of conventional rubber-based adhesive substances, so the paste of the present invention has particular significance when formulating such drugs. be. Examples of compounds containing phenolic hydroxyl groups include salicylic acid derivatives (monoglylic salicylate, methyl salicylate, etc.),
Vitamin E and its derivatives, cabsaicin, etc. are mentioned, and amine compounds include ethanolamine antihistamine drugs such as diphenhydramine, ethylenediamine antihistamine drugs such as chlorferamine,
Examples include lidocaine. Other medicinal ingredients include l-menthol, d7! - Cold-sensitive irritating drugs such as camphor, thymol, and d-borneol, non-steroidal anti-inflammatory drugs such as indomethacin and diclofenac sodium, steroidal anti-inflammatory drugs such as dexamethacin and hetamethacin, chlorhexidine diglycone-1, , fungicides such as acrinol, 1. Capsicum extract, nonylic acid vanillylamide, kabsaicin,
Examples include warm-sensitive skin irritating drugs such as ginger extract, cantharis tincture, and cantharidin, and herbal medicines such as shikon and l.

In addition, in preparing the adhesive patch of the present invention,
1. It goes without saying that the isocoumarin derivative or coumarin derivative of the Saxifraga fi plant may be added after first adding the drug to the rubber-based adhesive substance.

Further, the adhesive patch preparation of the present invention is usually used by being spread on a support such as cloth or plastic film.

The present invention will be explained in more detail with reference to Examples and Experimental Examples below, but the present invention is not limited thereto.

In the following description, "part-1" means "parts by weight."

Example 1 43 parts of styrene-butadiene-styrene rubber and 25 parts of natural rosin are kneaded for 20 minutes in a kneader maintained at 150 DEG C., 3 parts of sweet tea dry powder are added thereto, mixed, and kneaded for 70 minutes. Next, 5 parts of bolybdenum, 7 parts of liquid paraffin, 6 parts of titanium oxide powder, and 5 parts of talc were added, and after kneading for 10 minutes, the mixture was cooled to 90°C, and then 5 parts of monoglycol salicylate and 0.02 part of vanillyl nonylate acid were added. , add 0.8 parts of diphunhydramine, mix, and apply 0.2 parts on the woven fabric.
Apply to the same thickness to obtain a patch.

Example 2 A patch is obtained in the same manner as in Example 1 except that 3 parts of hydrangea ethanol extract is added instead of sweet tea.

Example 3 A patch was obtained in the same manner as in Example 1, except that 3 parts of dried root of Saxifrage was added instead of sweet tea.

Example 4 A patch was obtained in the same manner as in Example 1 except that 1 part of hydra gel was added instead of sweet tea.

Example 5 In Example 1, Hergenin 0.2 was used instead of old tea.
A patch was obtained in the same manner as in Example 1 except for the following.

Example 6 In Example 1, phylodulcin 0 was used instead of 1↑tea.
．． 5 parts, and 1 q of a patch was prepared in the same manner as in Example 1 except for the above.

Comparative Example 1 Same as Example 1 except that Kecha was not added.
A patch is obtained in the same manner.

Experimental Example 1 The samples obtained in Examples 1 to 6 and Comparative Example 1 were sealed in an aluminum polyethylene laminate film.
After storage at 0° C. for 3 months, each drug was tested to determine the rate of decrease in potency, and the results are shown in Table 1.

The decomposition rate in Table 1 is the theoretical value of 100% and O It is calculated as follows.

As is clear from the table below, the drug compounded in the paste of the present invention exists extremely stably.

Downwind margin

Claims (1)

[Scope of Claims] (11) Rubber-based adhesive characterized by blending at least one compound selected from isocoumarin derivatives and coumarin derivatives contained in plants of the Saxifrage family into a paste consisting of a rubber-based adhesive substance. Rubber-based adhesive paste according to Claim No. +11, wherein the compound is at least one selected from hydragel, bergenin, and phyllodulcin. (3) Claim No. 1 further comprising a drug. 1
The rubber adhesive paste described in item 1) or item (2). (4) The rubber adhesive paste according to claim (3), wherein the drug has a phenolic hydroxyl group and/or an amino group.