JPS59134718A - Tacky plaster base - Google Patents

Abstract

PURPOSE:The titled plaster base that is made by adding YOBAIHI and RYUJO to a rubber tacky substance, thus keeping the active ingredients stable without their decomposition. CONSTITUTION:RYUJO [a kind of herb drug: made from seeds of Salix babylonica, containing salicin (a saligenin glucoside) and populin (benzylsalicin)] and YOBAIHI (bark of Myrica rubra SIEBOLD et ZUCCARINI) are added to a rubber tacky substance such as natural rubber, synthetic rubber or their mixture. The amount of RYUJO is 0.1-4wt% and YOBAIHI, 0.1-5wt% based on the tacky base. When they are used in the form of extracts, the amounts are 0.01- 2wt%, respectively. The resultant base is very useful, when the plaster contains compounds bearing phenolic hydroxyls such as salicylic acid derivatives and amines such as ethylenediamine antihistamics as active ingredients, which are remarkably lowered in their contents in the conventional rubber base.

Description

DETAILED DESCRIPTION OF THE INVENTION The present invention is for use in mucilaginous adhesive preparations! 14. Concerning the body and a viscous patch preparation using the bone body. More specifically, the present invention relates to an improvement in bone healing made of an adhesive substance used for a viscous adhesive patch preparation, and the invention relates to an adhesive patch made of an adhesive substance used for a viscous patch preparation, and an adhesive patch prepared by adding a drug to the body. Regarding.

Conventionally, drugs administered to the integument have been intended to locally act on the integument and its lower structure, such as bactericidal agents, disinfectants, and skin irritants. However, in recent years, attempts have been made to administer drugs with systemic effects through the dermis, and cutaneous administration of divine drugs has been proposed or attempted.

For example, cutaneous administration of drugs is carried out in the form of a sticky patch, in which the drug is blended into a bone structure made of a sticky substance, but in some cases, the drug is blended into a bone structure made of a rubber-based adhesive substance. When a preparation is kept for a long period of time, the therapeutic effect of the preparation tends to decrease significantly due to decomposition and volatilization of the drug.

By the way, is it possible to prevent the volatilization and photodecomposition of drugs by closely covering them with aluminum laminate packaging and shielding them from light? Even with aluminum laminated packaging, the decomposition of drugs such as amine compounds continues to progress, resulting in
Many items become unusable after three years of storage. In particular, anti-inflammatory agents such as salicyl late methyl and salicyl monoglycol, skin irritants such as kabsaicin, nonylvanillylamide, and pepper extract, ethanolamine antihistamines such as diphenhydramine, and dt. -The content of vitamin E, such as α-tocopherol, decreases over time.

Therefore, it is desired to develop a plaster or an adhesive patch made of an adhesive substance in which the decomposition of the drug does not proceed even if the drug is mixed therein.

Under these circumstances, the inventors of the present invention have conducted extensive research and have found that if a paste made of a rubber-based adhesive substance is mixed with Yanagiji and @Umetan, then the drug will not be added to the body. It was discovered that the drug remains stable without decomposition even when the drug is used.

The present invention has been completed based on such new knowledge, and includes a adhesive patch preparation for the body, which is made of a paste made of a rubber-based adhesive substance and a paste containing willow ziyang plum peel, and a drug for the body. This invention relates to an adhesive patch preparation containing the following.

Examples of rubber-based adhesive substances include diene-based polymer compounds that have been conventionally used as adhesives for rubber-based adhesive patch preparations, specifically natural rubber, synthetic rubber, and mixtures thereof. Examples of synthetic rubber include styrene-isoprene-styrene block copolymer rubber, styrene-butadiene rubber, polybutene rubber, polyisoprene rubber, butyl rubber, and silicone rubber.

The paste made of rubber-based sticky substance further contains tackifiers such as terpene-based resins and petroleum-based resins as third components.
Liquid paraffin, animal products (t2, toeha, olive oil, soybean oil, beef tallow, ton JJf7), polybutene, lower isoprene, wax and other adhesion/retention force regulators, titanium oxide, oxidation! 11! lead, aluminum metasilicate,
Fillers such as calcium sulfate and calcium phosphate, water and emulsifiers (e.g. sorbitan monooleate, sodium lauryl sulfone), emulsifiers (e.g. magnesium stearate, aluminum stearate)
etc. may also be blended.

The willow purple used in the present invention is a seed of a species belonging to the Salicaceae family,
It refers to those containing salicin (saligenin glucoside) and boblin (pendylus salicin), such as weeping willow (5alix babylo-nica).
), cottonwood (Poplus 5ieboldi M
IQ-) yuzu is exemplified as a suitable one.

The willow purple is an extract extracted with water, alcohol (methanol, ethanol, n-propanol), a highly extensible melt such as ketone (acetone), or a mixed solvent thereof (mixed solvent such as water-alcohol). In particular, it may be used in the form of a dry extract.

The wk skin is from Myrica rub, a member of the Proteaceae family.
It is the bark of raSIEBOLDet ZUOCARINI).

The Yang Mei Peel may also be used in the form of an extract extracted and split with the same solvent as above, particularly in the form of a dried extract.

Willow purple, Yang plum peel and their extracts are usually provided in the present invention as a powder of their dried products, especially as a fine powder of 100 mesh or less. The compounding amount of Yanagi Purple is about 0.01-10% (preferably 0.01% by weight) based on the rubber adhesive substance.
．． 1 to 4M amount%) is preferable, and @ plum peel is 0.0
It is preferably about 1 to 10% by weight (preferably 0.1 to 5% by weight).

In addition, the blending amounts in these extract forms are as follows:
A preferable value is 0.001 to 20 mW% f'l iX (preferably 0.01 to 2 mW% pL), respectively.

The paste of the present invention is made of a sticky adhesive by incorporating a drug that can be applied to the outer skin.*1. It can be formulated into 1. Thus, the adhesive patch preparation using Sl/body according to the present invention has the effect that the drug compounded therein is kept stable without being decomposed.

There are no particular restrictions on the drug that can be incorporated into the medicine of the present invention as long as it can be administered in the form of an adhesive patch. It may be something that can be absorbed, and it may be either a topical or whole-body product), a medicine for treating peridermal diseases, an intradermal stinging drug, a drug for treating unrequited love complaints. etc. can be mentioned.

In particular, the content of phenolic hydroxyl group-containing compounds, amine thread compounds, etc. in the back body made of conventional rubber-based adhesive substances is significantly reduced, so the present invention is particularly useful when formulating such drugs. It's a sacrifice. Examples of compounds containing phenolic intoxicants include salicylic acid derivatives (
salicyl late monoglycol, methyl salicylate, etc.),
Examples of the amine compounds include ethanolamine antihistamines such as diphenhydramine, ethylenediamine antihistamines such as chlorpheniramine, and lidocaine. Other active ingredients include e-menthol, dt-camphor,
Thymol, d-borneol 4 (1 ton of bitter skin)
i++ aN drugs, non-steroidal anti-inflammatory drugs such as indomethacin and cyclofenac sodium, steroidal anti-inflammatory NH agents such as dexamethacin and betamethacin, chlorhexidine diglyconate, acrinol-specific anti-inflammatory agent, pepper extract, nonyl Vanillylamide, turnip saicin, ginger extract, cantharis tincture, cantharidin, and other hot herbs (herbal medicines such as chestnuts, Chinese radish, and Chinese angelica).

In preparing the adhesive patch preparation of the present invention, the commercial substance is first added to the stone-causing substance, and then a reconnaissance or
It goes without saying that persimmon peel may be added.

Further, the adhesive patch preparation of the present invention can be used by being spread on a support such as a plate, a stick, or a plastic film.

EXAMPLES The present invention will be explained in more detail by showing Examples and Experimental Examples below, but the present invention is not limited thereto.

In addition, in the following description, "part" means "stopping part".

Example 1 43 parts of styrene-butadiene-styrene rubber and 25 parts of natural rosin were mixed in a kneader kept at 150°C for 20 minutes, and 2 parts of scout powder (less than 100 mesh) and 1 part of scout ethanol extract were added. Add and mix and sip for 10 minutes. Next, 5 parts of bolybdenum, 7 parts of fluid rough-in, 6 parts of titanium oxide powder, and 5 parts of talc were added, and 1
Mix for 0 minutes to obtain a paste for adhesive patch preparation.

Example 2 5 parts of salicyl saturated monoglycol, 0.02 parts of nonylvanillylamide, and 0.8 parts of diphenhydramine were added to the bone extract obtained in Example 1, and the mixture was soaked for 5 minutes. The mixture is spread to a thickness of 0.2 mm to obtain a stone preparation.

Example 3 Fruit/? Using the reconnaissance extract from the formulation in Example 1 and 1, prepare an adhesive preparation using the method described in Examples 1 and 2.

Example 4 In the formulation of Example 1, instead of scout powder, 19Ji
Use iJ skin powder instead of scout ethanol extract.
Adhesive adhesive tape [Oki] was obtained by the same method as in Examples 1 and 2 using the acetone extract of balm skin.

Example 5 Using the formulation of Actual hIu Example 4 except for the acetone extract, a viscous 1.
The sex paste field is broken.

Comparative Example 1 An atrophic patch wound was obtained by the same method as in Examples 1 and 2 except that the willow purple powder and the citrus ethanol extract were removed from the formulation of Example 1.

Example The decomposition rate of Mulberry Iso when the preparations obtained in Examples 2 and 3 and Comparative Example 1 were packaged in aluminum-polyester laminate packaging with light shielding and hermetically sealed at 40°C for 3 months. %) and the results are shown in Table 1.

Table 1: Decomposition rate of industrial products (excluded)

Claims (1)

[Claims] 1. A material for an adhesive patch preparation, which is formed by blending at least one substance selected from 4I, llI and Yangmeipi into a comb-thickening substance.