JPS6051108A - Rubber pressure-sensitive adhesive plaster - Google Patents

Abstract

PURPOSE:Rubber pressure-sensitive adhesive plaster obtained by blending plaster consisting of rubber pressure-sensitive adhesive with a purified oil contained in a plant belonging to the genus Citrus, existing stably without causing decomposition of drug after long period preservation. CONSTITUTION:Rubber pressure-sensitive adhesive plaster obtained by blending plaster consisting of a rubber pressure-sensitive adhesive substance (e.g., natural rubber, styrene-butadiene rubber, or polybutene rubber) with a purified oil (e.g., lemon oil, orange oil, pummelo oil, lime oil) contained in a plant belonging to the genus Citrus. When a phenolic hydroxyl group-containing compound, an amine compound, etc. is used as a drug, it has tendency to lower remedying effect by decomposition or volatilization, etc., but the use of the plaster can keep the drug stably. The plaster may be further blended with a tackifier, an adjustor for bond strength and retention power, a filler, an emulsifying agent, etc.

Description

DETAILED DESCRIPTION OF THE INVENTION (Technical Field) The present invention relates to improvements in plasters made of rubber-based adhesive substances.

(Prior Art) Conventionally, drugs administered to the integument include bactericidal agents, disinfectants, dermal irritants, and the like, intended to locally act on the integument and its underlying tissues. However, in recent years, attempts have been made to administer drugs with systemic effects through the skin.
Transdermal administration of various drugs has been proposed or attempted.

Therapeutic administration of drugs is carried out, for example, in the form of adhesive patch preparations in which the drug is blended into a plaster made of an adhesive substance, but long-term administration of drugs in which the drug is blended into a paste made of a rubber-based adhesive substance is carried out over a long period of time. When stored, the therapeutic effect of the preparation tends to decrease significantly due to decomposition, volatilization, etc. of the drug. Among LJ phenolic hydroxyl group-containing compounds, amine compounds, etc., many become unusable after being stored for 2 to 3 years. In particular, salicylic acid derivatives such as methyl salicylate and monoglycol salicylate as anti-inflammatory analgesics, skin irritants such as kabsaicin, nonylic acid vanillylamide, and hot pepper extract, ethanolamine type antihistamines such as diphenhydramine, and d4-α-
The content of vitamin E such as tocopherol is significantly reduced by oral administration.

Therefore, it is desired to develop a plaster or an adhesive patch made of a rubber-based adhesive material that does not allow the decomposition of the drug to progress even when the drug is mixed therein.

(Disclosure of the Invention) Under these circumstances, the present inventors have conducted various studies and found that if the essential oil of a citrus plant is blended into a plaster made of a rubber-based adhesive substance, drugs can be added to the plaster. It was discovered that the drug existed stably without decomposition even when mixed with the drug.

The present invention has been completed based on this new knowledge, and includes a rubber-based adhesive paste comprising a rubber-based adhesive substance mixed with essential oil of a plant of the genus Citrus;
A rubber-based adhesive paste formed by further blending a drug into the paste,
That is, it relates to adhesive patch preparations.

According to the plaster of the present invention, not only the drug is stabilized, but also the odor characteristic of poultices, for example, is alleviated by the essential oil of the Citrus genus plant.

As a rubber-based adhesive substance, rubber-based adhesive paste τ1 is used.
Diene-based polymer compounds conventionally used for pharmaceutical preparations include natural rubber, synthetic rubber, and mixtures thereof. Examples of the synthetic rubber include styrene-isoprene-styrene block copolymer rubber, styrene-butadiene rubber, polybutene rubber, butyl rubber, and silicone rubber.

The paste made of rubber-based adhesive substances further contains tackifiers such as terpene-based resins and petroleum-based resins, liquid paraffin, animal and vegetable oils (for example, olive oil, soybean oil, beef tallow, etc.) as third components. Adhesion/retention force regulators such as tonne (tonne resin), polybutene, lower isoprene, wax, fillers such as titanium oxide, zinc oxide, aluminum metasilicate, calcium sulfate, calcium phosphate, water and emulsifiers (for example, sorbitan monooleate, (sodium lauryl sulfonate), emulsification aids (eg, magnesium stearate, aluminum stearate), etc. may also be blended.

Examples of plants of the genus Citrus used in the present invention include lemon, citron, lime, daidai, berkamosoto,
Grapefruit, zapon, orange, orchid mandarin orange, ponkan, kumquat, yuzu, kabosu, hatsusaku, navel orange, kokan, summer orange, etc. are listed.

Examples of essential oils of the citrus genus include lemon oil, orange oil, zapon oil, and lime oil.

These may be synthetic products or those derived from plants of the genus Citrus, but it is preferable to use multiple types of essential oils. Therefore, it is preferable to use naturally derived essential oils as they are without separating the specific essential oils, and it is preferable to use a mixture of two or more types of synthetic essential oils. Of course, it is not necessary to use all kinds of essential oils contained in a given Citrus genus plant, and any plural kinds of essential oils among them may be used.

As for those collected from natural Citrus genus plants, those obtained by steam distillation, those obtained by pressing point, those obtained by solvent extraction, etc. are preferably used.

The blending amount of the essential oil of the Citrus genus plant is about 0.01 to 5% by weight, preferably about 0.1 to 2% by weight, and more preferably about 0.2 to 1% by weight based on the rubber adhesive substance. be.

There are no particular restrictions on the drug that can be incorporated into the paste of the present invention, as long as it can be administered in the form of an adhesive patch. Examples include drugs for treating skin diseases, drugs for skin irritation, and drugs for treating indefinite complaints. In particular, the content of phenolic hydroxyl group-containing compounds, amine compounds, etc. in the c9 complex is significantly lower than that of conventional rubber-based adhesive substances, so the paste of the present invention has particular significance when formulating such drugs. There is. Examples of phenolic hydroxyl group-containing compounds include salicylic acid derivatives (monoglylic salicylate, methyl salicylate, etc.), vitamin E and its derivatives, kabsaicin, and amine compounds include ethanolamine antihistamines such as diphenhydramine; Examples include ethylenediamine antihistamine drugs such as chlorphalamine, and lidocaine. Other medicinal ingredients include β-menthol, d7! - Cold-sensitive irritants such as camphor, thymol, d-borneol, nonsteroidal anti-inflammatory drugs such as indomethacin, diclofenac sodium, steroidal anti-inflammatory drugs such as dexamethacin, betamethacin, chlorhexidine diglyconate, acrinol Fungicides such as chili pepper extract, nonylic acid vanillylamide, kabsaicin,
Examples include heat-sensitive skin irritating drugs such as ginger extract, cantharis tincture, and cantharidin, and crude drugs such as sycamore and turmeric.

It goes without saying that in preparing the adhesive patch preparation of the present invention, the drug may be added to the rubber-based adhesive substance first, and then the essential oil of the Citrus genus plant may be added.

Further, the adhesive patch preparation of the present invention is usually used by being spread on a support such as cloth or plastic film.

EXAMPLES The present invention will be described in more detail below with reference to Examples and Experimental Examples, but the present invention is not limited thereto.

In the following description, "parts" means "parts by weight."

Example 1 43 parts of styrene-butadiene-styrene rubber and 25 parts of natural rosin were kneaded for 20 minutes in a Niguu maintained at 15 liters, and 1 part of lemon hydraulically squeezed essential oil was added thereto and mixed.
Knead for a minute. Next, 5 parts of bolybdenum, 7 parts of liquid paraffin, 6 parts of titanium oxide powder, and 5 parts of talc were added, and after kneading for 1 part, the mixture was cooled to 90°C, and then 5 parts of monoglycol salicylate, vanillylamide nonylate, 0.02
fa and 0.8 parts of diphunhydramine are added and mixed, and the mixture is coated on a woven fabric to a thickness of 0.21 to obtain a patch.

Example 2 A patch is obtained in the same manner as in Example 1, except that 1 part of vermoso oil (steam distilled product) is blended in place of the lemon oil pressure-pressed essential oil.

Comparative Example 1 A patch is obtained in the same manner as in Example 1, except that the lemon oil pressure extraction essential oil is not added.

Experimental Example 1 The samples obtained in Examples 1 to 2 and Comparative Example 1 were sealed in an aluminum polyethylene laminate film, and
After storing at 0°C for 3 months, each drug was quantified.
The content reduction rate was determined and the results are shown in Table 1.

The decomposition rates in Table 1 are calculated based on the theoretical value of 100%.

As is clear from the table below, the drug compounded in the paste of the present invention exists extremely stably.

Table 1 Patent applicant: Nitto Electric Industry Co., Ltd. 0

Claims (4)

[Claims] (1) A rubber-based adhesive paste comprising a paste made of a rubber-based adhesive substance mixed with an essential oil contained in a plant of the genus Citrus. (2) A patent claim in which the Citrus genus plants are lemons, citrons, limes, daidai daisies, vermilots, grapefruits, zapons, oranges, mandarin oranges, ponkans, kumquats, yuzu, kabosu, honeysuckle, navel oranges, iyocans, and summer oranges. A rubber-based adhesive paste according to item (1). (3) Claim No.
The rubber adhesive paste described in item 1) or item (2). (4) The rubber adhesive paste according to claim (3), wherein the drug has a phenolic hydroxyl group and/or an amino group.