JPS5955820A - Plaster for adhesive salve preparation - Google Patents

Abstract

PURPOSE:To provide a plaster for adhesive salve preparation having improved long-term preservation stability of the drug in the plaster, by compounding sesamol to a plaster composed of a rubber-based adhesive substance. CONSTITUTION:A plaster for adhesive salve preparation composed of a rubber- based adhesive mixture such as natural rubber, a synthetic rubber or their mixture, etc. is compounded with about 0.002-5wt%, especially about 0.01-2wt%, based on the whole plaster, of sesamol. The additive is effective to prevent the lowering of the drug action in the plster, especially action of a compound containing phenolic OH, e.g. a salicyclic acid derivative and an amino compound such as diphenhydramine, etc. which exhibits remarkable decrease of the content in said plaster. Sesame oil containing about 0.1wt% of sesamol or sesamoline produces sesamoline by hydrolysis can be used in place of sesamol, and a third component such as tackifier, etc. can be compounded to the above plaster.

Description

[Detailed Description of the Invention] Kinei FJ'l relates to a form for adhesive patch preparations and an adhesive patch (-1 formulation) using the same. The present invention relates to an improvement in a patch made of a rubber-based adhesive substance which is considered to be suitable for use in adhesive patch preparations, and a viscous patch preparation comprising the improved bone paste and (5) a drug.

Conventionally, the drugs administered to the outer skin are bactericides and disinfectants.

The purpose was to have a topical effect on the outer skin and underlying tissue of skin irritants and the like. However, in recent years, attempts have been made to administer drugs that have systemic effects through the skin, and various drugs have been proposed or attempted to be administered through the skin.

Dermal administration of drugs is carried out, for example, in the form of an adhesive patch, in which the drug is mixed into a plaster made of an adhesive substance.
When a preparation using a plaster made of a rubber-based adhesive substance is stored for a long period of time, the therapeutic effect of the preparation tends to be significantly reduced due to decomposition and volatilization of the drug.

By the way, volatilization and photodecomposition of drugs can be prevented by sealing them with aluminum laminate packaging and shielding them from light. , amine compounds, etc., the decomposition of drugs continues to proceed even with aluminum laminated packaging, resulting in
There are many items that become unusable due to storage of 84f-. Therefore, there is a need for the development of a plaster or a rubber-thread plaster preparation made of a rubber-based adhesive material in which the decomposition of the drug does not proceed even when the drug is mixed therein.

Under these circumstances, the inventors of the present invention have repeatedly conducted research on the gods, and have found that 1 sezamol (s
It has been found that if esamol) is blended into the paste, the drug will not decompose and will exist stably even if the drug is blended into the paste.

It was completed based on the new findings from the tree development, and includes one adhesive patch preparation made of a paste made of a rubber-based adhesive substance and one part of sezamol, and a drug added to the present paper. This invention relates to an adhesive patch preparation.

Kihatsu [! Examples of the rubber adhesive substance used in 1 include synthetic rubber and mixtures thereof. Examples of the synthetic rubber include styrene-in-prene-styrene 10x copolymer rubber, styrene rubber, polyphthene rubber, polyin prene rubber, glutyl rubber, and silicone rubber. In the negative body consisting of rubber thread dead f1 member,
Furthermore, the third j component and [7, Derben-based resin 1] Adhesive agent such as oil-based resin, sulfur paraffin, animal and vegetable oil (for example, olive oil, soybean oil, beef tallow, tonne fat), poly 1
Adhesive car retention modifiers such as Deci, lower isoprene, socks, fillers such as titanium oxide, zinc oxide, meth, aluminum silicate, calcium sulfate, calcium phosphate, water and emulsifiers (e.g. sorbitan monooleate, lauryl sulfonic acid) (sodium), emulsifying aids (for example, magnesium stearate, aluminum stearate), etc.

Since sezamol used in the present invention is contained in sesame oil in an amount of about 0.1 weight j, it may be incorporated into the paste as sesame oil or sesame oil concentrate. Well, sezamol is obtained by hydrolysis of sesamolin (sesamo Iin), so even if it is mixed in the form of sezamolin at the time of making the plaster, it will not be hydrolyzed during the plaster manufacturing process. Becomes Cezamor.

Therefore, it also includes an embodiment in which sezamorin is blended in place of Kien + tih sezamol.

The amount of sezamol added is about 0.002 to 5% by weight, preferably 0.002 to 5% by weight, based on the paste made of a rubber-based adhesive substance. O
It is about 1 to 2% by weight, and when it is added in the form of sesame oil or sesame oil concentrate, it is sufficient to mix H(H) corresponding to the above blending ratio as sezamol.

The trunk of the tree can be formulated into an adhesive 1f1/patch+I preparation by adding a drug that can be applied to the outer skin. Face to face, according to the present invention! The 111 viscous patch A + Jf agent has the full effect of keeping the drug compounded there stable without being decomposed.

If the drug to be incorporated into the N-isomer of the present invention is a drug that is formulated and administered in a patch preparation, 4. ) limit r
For example, drugs that can be absorbed transdermally (however, they may be absorbed transdermally with the help of a transdermal absorption aid, and they may be topical drugs or all-one drug).
, drugs for treating skin diseases, drugs for skin irritation, drugs for treating indefinite complaints, etc. In particular, phenolic hydroxyl group-containing compounds and amine compounds have a significant reduction in kW in plasters made of conventional rubber-based adhesive substances, so
The t-form is particularly advantageous when formulating such products. Examples of compounds containing phenolic hydroxyl groups include salicylic acid derivatives (monoglycol salicylate, methyl salicylate, etc.), vitamin E and its derivatives, and kabsaicin, and examples of amine compounds include ethanolamine antihistamines such as diphenhydramine, and chloride. Examples include ethylenediamine antihistamine drugs such as feramine, and lidocaine. Other medicinal ingredients include, for example, t-menthol.

Rapid skin irritation drugs such as di-camphor, thymol, d-borneol, and indomethacin.

Nonsteroid itoconates such as cyclofenac sodium, fungicides such as acrinol, hot pepper extract, nonylic acid panillylamide, cabzaicin.

Warm-sensitive skin irritating drugs such as ginger extract, cangris tincture, and cancrisin, as well as ginger, ginger, and sun stains. You can also open herbal medicines such as licorice, ginger, and pansho.

It goes without saying that when preparing the adhesive patch preparation that causes spillage, it is possible to first add the drug to the rubber-based sticky substance and then add cezamol. , Kinei Mei's anti-inflammatory patch preparation is 7rlj? ? 1',
It is used by spreading it on a support such as cloth or plastic film.

Examples and experimental examples will be shown below to more specifically overcome the limitations of Kimi et al. However, the present invention is not limited to these examples.

In addition, in the following description, "part" means "jubibu".

Example 1 Styrene-golden-styrene rubber 43FIS and 25 natural rosins were mixed in a kneader kept at 150"C.
Knead for 0 minutes, add 3 parts of Sezamol and mix, 1
Knead for 0 minutes. Next, poly 1 desi 2 cities, Gomae 1
0 parts, 6 parts of titanium oxide powder, 5 parts of talc added, 10 parts
Knead for minutes to obtain a body for adhesive patch preparation.

Example 2 5 monoglycol salicylate, 0.02 part of nonylic acid vanillylamide and 0.8 part of diphenhydramine were further added and mixed to the backing material obtained in Example 1 at 90°C, and the mixture was coated on a woven fabric. to obtain an adhesive patch preparation.

Example 3 An adhesive patch preparation was obtained in the same manner as in Example 1 and Example 2, using bargain paraffin instead of sesame oil in Example 1.

Comparative Example 1 Excluding Sezamo from the formulation of Example 3, Example 1 and 2
An adhesive patch preparation is obtained in the same manner as above.

Example Decomposition rate (%) of the drug when the preparations obtained in Examples 2 and 3 and Comparative Example 1 were stored at 40°C for 3 months in a light-shielded and sealed package made of aluminum-polyethylene laminate. ) and the results are shown in Table 1.

(Margin below) Table 1 Drug degradation rate (section)

Claims (1)

[Claims] A body for an adhesive patch preparation comprising a stick body made of a rubber-based viscous material v1 and a whole compound of sezamol.