JPS59134715A - Tacky plaster base - Google Patents

Abstract

PURPOSE:The titled plaster base that is made by adding INYOKAKU or SAISHIN to a rubber tacky substance, thus keeping the active ingredients stable without its decomposition. CONSTITUTION:INYOKAKU (a kind of herb drug prepared from Epimedium grandiflorum MOREEN) or SAISHIN (Asarum sieboldi MIRUEL), which may be in the form of an extract, is added to a tacky rubber substance such as natural or synthetic rubber or their mixture to prepare the objective plaster base. The amount of the herbs is 0.03-2wt% in INYOKAKU, 0.01-2wt% in the form of an extract, or 0.05-2wt% in SAISHIN, 0.01-2wt% in the form of an extract. It is very useful, when the plaster contains, as active ingredients, compounds bearing phenolic hydroxyls such as salicylic acid derivatives and amines such as ethanolamine antihistamics, which are remarkably lowered in its content in the conventional rubber plaster base.

Description

DETAILED DESCRIPTION OF THE INVENTION [Non-exposure] relates to a plaster for adhesive patch preparations and a sticky patch preparation in which the plaster is used as a pet. Learn more about the length from this book.
No. J relates to an improvement of a regular body made of a rubber-based adhesive substance used for a viscous patch preparation, and an adhesive patch prepared by further blending a drug into the improved paste.

Conventionally, drugs administered to the integument have been intended to act locally on the integument and its underlying tissues, such as bactericidal agents, browning agents, and dandruff stimulants. However, in recent years, attempts have been made to administer drugs that have systemic effects through the dermis, and cutaneous administration of drugs that have systemic effects has been proposed or attempted.

The application of drugs to the skin is carried out, for example, in the form of a viscous patch, in which the entire drug is mixed into a paste made of an adhesive substance, but it is also possible to apply the drug to a paste made of a sticky substance (6). When a preparation is stored for a long period of time, the therapeutic effect of the preparation tends to be significantly reduced due to decomposition, volatilization, etc. of the drug.

By the way, volatilization and photodecomposition of drugs can be prevented by sealing and blocking light with aluminum laminate packaging, etc. However, drugs distributed in a plaster made of adhesive rubber thread, especially phenolic Hydroxyl group-containing compounds, amine thread compounds, etc., are difficult to decompose due to aluminum laminated packaging.
~3 Many Hayabusa items become unusable due to storage. In particular, salicylic acid derivatives such as methyl salicylate and monoglycol salicylate as anti-inflammatory analgesic toxins, skin irritants such as kabsaicin, nonyl vanillyl amide, and tucara extract, ethanolamine antihistamines such as diphenhydramine, and dt-α-tocopherols. The content of vitamin L etc. decreases significantly due to menstrual H.

Therefore, it is desired to develop a skeleton or an adhesive patch made of a rubber-based adhesive material in which the decomposition of the drug does not proceed even if the drug is mixed therein.

The inventors of the present invention have repeatedly experimented with various methods to solve the problem of power and energy, and have found that if at least one selected from Inyozaki and Hosara is blended into the bonkyu, which is made of a rubber-based sticky substance, It was discovered that even when a drug is added to the paste, the drug remains stable without decomposition.

The present invention has been completed based on this new knowledge, and is an adhesive patch preparation comprising a bone body made of a rubber-based adhesive substance and at least one type selected from the group consisting of ramzaru and chili as a stabilizer. The present invention relates to an adhesive patch preparation which is made by adding an ingredient to the paste.

Examples of rubber-based sticky substances include diene thread molecular compounds conventionally used as plasters for rubber thread adhesive patch preparations, specifically natural rubber, synthetic rubber, and mixtures thereof. The budding rubbers include styrene-inprene-styrene glock copolymer rubber, styrene rubber, polybutene rubber, polyinprene rubber,
Examples include methyl rubber and silicone rubber.

The electric body made of a rubber-based adhesive substance further contains a tackifier such as terpene thread resin, petroleum-based m fat, etc. as a third component.
Liquid paraffin, promotion J plant? 'Ill] (for example, olive oil, soybean oil, beef tallow, tonne fat), polybutene, lower imprene, adhesion/retention force regulators such as wax, titanium oxide, zinc oxide, aluminum metasilicate, sulfuric acid, calcium phosphate, etc. fillers, water, emulsifiers (for example, sorbitan monooleate, sodium lauryl sulfonate), emulsification aids (for example, magnesium stearate, aluminum stearate), etc. may be blended.

The innenso used in the present invention is Epimedium (
Epimedium grandif forum M
URREN (E, macranthum MORREN
et DECAISNEvar, violace
um FRANC mouth ET)), Hosaki squid link (E,
sagittatum BAKER), 'IO/< Naikarisou (E, macranthum MORR)
It is a whole plant (aerial stem) such as EN et DECAISNE).

The said Inyouto is also an extract (in particular, a dried extract) prepared by extraction with a relatively polar crystalline solvent such as water, alcohol (methanol, ethanol, furopanol, etc.), ketone (acetone, methyl ethyl, etc.). It may be used in this manner.

The fine leather is from Asubasaicin [: Asa
rum 5ieboldi MIRIJEL (Asia
sarumsiebldi MAEKAWA)] rhizomes and roots - C-, S.

The chili pepper may also be used in the form of an extract prepared by extraction with a relatively highly polar solvent such as water, alcohol, or ketone as described above.

Inyōso, Hosashi and their extracts are generally provided in the present invention as a powder of their dried products (in particular, a fine powder of 100 mesh or less), and the blending amount is determined to be within the range of the rubber-based sticky substance. A sheep bud Vi of 0.01 to 10 layers and 4jjm (preferably about 0.03 to 2 layers) is suitable; O1-5% by weight kneading degree (preferably 0.05-2
% by weight) is suitable.

In addition, in these extract forms, the suitable amount of Inyōso extract is about 0.001 to 15% by weight (preferably about 0.01 to 2% by weight) based on the comb-based sticky substance, and Spicy extract is 0.001-I Mfki
A suitable amount is approximately 1 to 2% by weight (preferably approximately 0.01 to 2% by weight).

The plaster of the present invention can be formulated into an adhesive patch preparation by incorporating a drug that can be applied to the outer skin.

Therefore, the adhesive patch preparation using the paste according to Misfire 1 has the effect that the material blended therein is kept stable without being decomposed.

There are no particular restrictions on the drug to be incorporated into the bone body of the present invention, as long as it can be administered in the form of an adhesive patch. The drug may be a topical drug or a systemic drug), a drug for dermatological treatment, a drug that stimulates skin dandruff, a drug for treating indefinite complaints, and the like. 4 yen, phenolic hydroxyl group-containing compounds, amine compounds, etc., and the resultant force 1 in the bone body made of viscous material mortar of Jumei is markedly reduced, so we prepared 1 product for the unexploded F'iJ plaster. This is particularly significant when the

Examples of compounds containing phenolic hydroxyl groups include salicylic acid inducers (monoglylol salicylate, methyl salicylate, etc.), hitamine E and its 6-G form, kabsaicin, and amine compounds such as diphenhydramine. Examples include ethylamine and hiscumin products, ethylenediamine antihistamine drugs such as chlorpheniramine, and lidocaine. Other mulberry components include, for example, L-menthol, dt-
camphor, thymol, d-borneol nat 1% cold skin irritation drugs, non-steroidal anti-inflammatory drugs such as indomethacin, cyclofenac sodium, steroidal anti-inflammatory drugs such as dequeuemethasone, becmethasone, Bactericidal agents such as chlorhexidine siglyconate and acrinol, warm-sensitive skin irritating drugs such as chilium extract, noni-tetrahydric acid panillylamide, kabsaicin, ginger extract, cantharis tincture, and cantharidin, raw chestnuts such as Chinese radish and chilium, etc. can be given.

In addition, when preparing the adhesive patch preparation of the present invention, what are the following? It goes without saying that the stabilizer Ff may be added to the rubber thread adhesive substance after the drug has been poured into it.

! ．． In addition, the adhesive adhesive patch of the present invention is usually used by being spread on a support such as cloth or plastic film.

EXAMPLES The present invention will be explained in more detail by showing Examples and Experimental Examples below, but the present invention is not limited thereto.

In addition, in the following description, "1 capital" refers to "A-II part"
means.

Example 1 Styrene rubber 43sS and natural rosin were mixed in a kneader maintained at 150°C for 20 minutes.
Knead for a minute, add 2 parts of Ingyo Shimoki and Perilla bud extract (70%
% ethanol) and knead for 10 minutes. Next, 5 parts of Volipden, 7 parts of liquid paraffin, 6 parts of titanium oxide powder, and 5 parts of talc are added, and mixed for 10 minutes to obtain a carrier for an adhesive patch preparation.

Example 2 5 parts of monoglycol salicylate, 0.02 parts of vanillyl amide nonylate, and 0.8 parts of diphenhydramine were further added to the bone body obtained in Example 1 and kneaded for 5 minutes. Spread to shoulder 4 thickness and apply adhesive N1! get the agent.

Example 3 An adhesive patch preparation was obtained by the same method as in Examples 1 and 2 using the same formulation as in Example 1 except for the ram extract.

Example 4 In the formulation of Example 1, Tsumugi Shinmi was used instead of Ingyobud end.
An adhesive patch preparation was obtained in the same manner as in Examples 1 and 2, using a chili extract (made of ethanol) instead of the sheep bud extract.

Example 5 An adhesive patch preparation was obtained using the same recipe as in Example 4 except for the chili extract.

An adhesive patch preparation was obtained using the same method as in Examples 1 and 2.

Examples When the preparations obtained in Examples 2 and 3 and Comparative Example 1 were sealed and packaged with light-permeable aluminum-polyester laminate alk material and stored at 40°C for 3 months, the drug decomposition rate <
%) and the results are shown in Table 1.

Nomata bottom extra white Table 1 Drug degradation rate (%)

Claims (1)

[Claims] 1. An 'iIt' body for a sticky patch preparation, which is formed by blending at least one persimmon selected from the group consisting of succulents and chili peppers into a paste made of a com-based adhesive substance.