CN108721595A - 一种内服外用相结合治疗痔疮的药物组合物及其制备方法 - Google Patents
一种内服外用相结合治疗痔疮的药物组合物及其制备方法 Download PDFInfo
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- CN108721595A CN108721595A CN201811073980.2A CN201811073980A CN108721595A CN 108721595 A CN108721595 A CN 108721595A CN 201811073980 A CN201811073980 A CN 201811073980A CN 108721595 A CN108721595 A CN 108721595A
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Abstract
本发明属于药物制剂技术领域,具体涉及一种内服外用相结合治疗痔疮的药物组合物及其制备方法与应用。本发明所述内服外用相结合治疗痔疮的药物制剂,通过内服制剂和外用制剂联合使用的方式,充分发挥各组分的药性,利用各成分药效君、臣、佐、使之间的有效配合,共奏其清瘀血、解热毒之功效,对痔疮具有较好的治疗作用。而本发明所述内服外用相结合治疗痔疮的药物制剂,通过内服制剂和外用制剂的共同作用下,对于各病程痔疮均有较好的治疗效果,且安全无任何毒副作用。
Description
技术领域
本发明属于药物制剂技术领域,具体涉及一种内服外用相结合治疗痔疮的药物组合物及其制备方法与应用。
背景技术
痔疮是指肛垫病理性肥大移位及肛周皮下血管丛血流淤滞形成的团块,是肛门直肠底部及肛门粘膜的静脉丛发生曲张而形成的一个或多个柔软的静脉团的一种慢性疾病,是最常见的肛肠科疾病,其发病率高达85%。俗话说“十人九痔,十人九不医”,即可见痔疮的发病率高及治疗不及时。
痔疮通常包括内痔、外痔、混合痔,最主要的症状为便血、疼痛、水肿、瘙痒、局部不适、分泌物增多和脱出等症状,且大便时反复多次的出血,会使体内丢失大量的铁,引起缺铁性贫血;而长期便血则可引起贫血,头晕,目眩,气喘,心悸,乏力等各种慢性消耗症状。而若有痔疮而不治疗,则很容易造成肛周脓肿或者肛瘘的情况,就更增加了治愈的难度。许多患者因痔疮而出现便血、脱出和疼痛等症状,已严重影响了生活和工作。
目前,治疗痔疮的方法主要有药物疗法、手术结扎和注射疗法。注射疗法主要是以注射消炎药为主;而手术疗法则存在不能治本及易复发的问题,而且大多数学者的意见是90%以上的痔疮患者可以非手术方法予以治疗,只有不到10%的痔疮患者需要外科治疗。由于药物疗法既能消肿止痛、缓解症状,又避免了手术的疼痛以及注射疗法的并发症,是大多数人所采用的治疗方法。因此,痔疮治疗药物的研发具有重要的价值。
发明内容
为此,本发明所要解决的技术问题在于提供一种内服外用相结合治疗痔疮的药物组合物,并进一步公开其制备方法。
为解决上述技术问题,本发明所述的一种内服外用相结合治疗痔疮的药物组合物,包括内服组合物及外用组合物:
所述内服组合物的原料药组成包括:防己25-35重量份、血竭4-8重量份、穿山龙15-25重量份、川乌10-15重量份、川牛膝10-15重量份、元胡15-25重量份、重楼25-35重量份、红花8-12重量份、透骨草8-12重量份、伸筋草15-25重量份、川椒8-12重量份、白花蛇草8-12重量份、独活15-25重量份、络石藤15-25重量份、海风藤15-25重量份、防风8-12重量份、丹参15-20重量份、苏木10-15重量份、蜈蚣10-15重量份、乳香1-3重量份、没药1-3重量份、全蝎10-15重量份;
所述外用组合物的原料药组成包括:大青叶15-25重量份、板蓝根10-15重量份、白芍25-35重量份、大蓟25-35重量份、白僵蚕10-15重量份、白芷25-35重量份、藁本10-15重量份、黄连10-15重量份、蛇床子25-35重量份、冰片15-25重量份、三七15-25重量份、艾叶15-25重量份、薄荷25-35重量份、金银花25-35重量份、当归8-12重量份、藿香15-25重量份、菊花8-12重量份、荷花10-15重量份、半枝莲15-25重量份、昆虫蛋白0.035-0.04重量份。
优选的,所述的内服外用相结合治疗痔疮的药物组合物中:
所述内服组合物的原料药组成包括:防己30重量份、血竭6重量份、穿山龙20重量份、川乌12重量份、川牛膝12重量份、元胡20重量份、重楼30重量份、红花10重量份、透骨草10重量份、伸筋草20重量份、川椒10重量份、白花蛇草10重量份、独活20重量份、络石藤20重量份、海风藤20重量份、防风10重量份、丹参18重量份、苏木12重量份、蜈蚣12重量份、乳香2重量份、没药2重量份、全蝎12重量份;
所述外用组合物的原料药组成包括:大青叶20重量份、板蓝根12重量份、白芍30重量份、大蓟30重量份、白僵蚕12重量份、白芷30重量份、藁本12重量份、黄连12重量份、蛇床子30重量份、冰片20重量份、三七20重量份、艾叶20重量份、薄荷30重量份、金银花30重量份、当归10重量份、藿香20重量份、菊花10重量份、荷花12重量份、半枝莲20重量份、昆虫蛋白0.038重量份。
进一步的,所述昆虫蛋白为以质量比为1:2:3的蟾酥、全蝎、壁虎为原料进行水提制得。
本发明还公开了所述的药物组合物用于制备治疗痔疮的内服外用相结合的药物制剂的用途。
本发明还公开了由所述的药物组合物,添加常规辅料,按照常规工艺制得的临床上可接受的内服外用相结合治疗痔疮的药物制剂。
进一步的,所述的药物制剂,包括内服制剂和外用制剂;
所述内服制剂包括片剂、胶囊剂、散剂、或合剂;
所述外用制剂包括喷剂、滴剂、擦剂、或涂剂。
本发明还公开了一种制备所述的内服外用相结合治疗痔疮的药物制剂的方法,包括制备所述内服制剂的步骤和制备所述外用制剂的步骤:
所述内服制剂的制备方法,包括如下步骤:
(1)取选定量的所述防己、血竭、穿山龙、川乌、川牛膝、元胡、重楼、红花、透骨草、伸筋草、川椒、白花蛇草、独活、络石藤、海风藤、防风、丹参、苏木、蜈蚣、乳香、没药、全蝎,并分别加水进行浸泡并熬制,收集滤液并浓缩后,加入白酒和山梨酸钾混匀,得到中药提取物,备用;
(2)将所得的中药提取物添加常规辅料,按照常规工艺制得临床上可接受的内服制剂;
所述外用制剂的制备方法,包括如下步骤:
(1’)取选定量的所述大青叶、板蓝根、白芍、大蓟、白僵蚕、白芷、藁本、黄连、蛇床子、冰片、三七、艾叶、薄荷、金银花、当归、藿香、菊花、荷花、半枝莲,并分别加水进行浸泡并熬制,收集滤液并浓缩后,得到中药提取物,备用;
(2’)按照1:2:3的质量比取蟾酥、全蝎、壁虎为原料,加水进行提取,收集滤液并冷冻干燥后,制得冻干粉,备用;
(3’)将所得中药提取物和选定量的所述冻干粉混匀,加入常规辅料,按照常规工艺制成临床上可接受的外用制剂。
所述步骤(1)中,所述血竭、川乌、川牛膝、川椒、独活、防风、丹参、乳香、没药的熬制时间为45min;所述防己、穿山龙、重楼、伸筋草、白花蛇草、海风藤、苏木、蜈蚣、全蝎、蜈蚣的熬制时间为40min;所述元胡、红花、透骨草、络石藤的熬制时间为20min;
所述步骤(1’)中,所述白芍、大蓟、藁本、蛇床子、冰片、当归的熬制时间为45min;所述大青叶、板蓝根、白僵蚕、黄连、三七、艾叶、薄荷的熬制时间为40min;所述白芷、金银花、藿香、菊花、荷花、半枝莲的熬制时间为20min。
所述步骤(1)中,所述白酒的加入量占各所述原料总量的5wt%;所述山梨酸钾的加入量占各所述原料总量的0.3wt%。
所述步骤(2)和所述步骤(2’)中,所述冷冻干燥步骤前还包括将所得滤液进行冷冻的步骤。
本发明所述内服外用相结合治疗痔疮的药物制剂,通过内服制剂和外用制剂联合使用的方式,所述内服制剂以防己、血竭、穿山龙、川乌、川牛膝、元胡、重楼、红花、透骨草、伸筋草、川椒、白花蛇草、独活、络石藤、海风藤、防风、丹参、苏木、蜈蚣、乳香、没药、全蝎为原料;所述外用制剂以大青叶、板蓝根、白芍、大蓟、白僵蚕、白芷、藁本、黄连、蛇床子、冰片、三七、艾叶、薄荷、金银花、当归、藿香、菊花、荷花、半枝莲为中药组分,并以蟾酥、全蝎、壁虎为原料提取昆虫蛋白;所述内服制剂和外用制剂分别充分发挥各组分的药性,利用各成分药效君、臣、佐、使之间的有效配合,共奏其清瘀血、解热毒之功效,对痔疮具有较好的治疗作用。而本发明所述内服外用相结合治疗痔疮的药物制剂,通过内服制剂和外用制剂的共同作用下,对于各病程痔疮均有较好的治疗效果,且安全无任何毒副作用。
具体实施方式
实施例1
本实施例所述内服外用相结合治疗痔疮的药物制剂,包括内服片剂及外用喷剂:
所述内服片剂的原料药组成包括:防己25kg、血竭8kg、穿山龙15kg、川乌15kg、川牛膝10kg、元胡25kg、重楼25kg、红花12kg、透骨草8kg、伸筋草25kg、川椒8kg、白花蛇草12kg、独活15kg、络石藤25kg、海风藤15kg、防风12kg、丹参15kg、苏木15kg、蜈蚣10kg、乳香3kg、没药1kg、全蝎15kg;
所述外用喷剂的原料药组成包括:大青叶15kg、板蓝根15kg、白芍25kg、大蓟35kg、白僵蚕10kg、白芷35kg、藁本10kg、黄连15kg、蛇床子25kg、冰片25kg、三七15kg、艾叶25kg、薄荷25kg、金银花35kg、当归8kg、藿香25kg、菊花8kg、荷花15kg、半枝莲15kg、昆虫蛋白0.04kg。
本实施例所述内服外用相结合治疗痔疮的药物制剂的制备方法,包括制备所述内服片剂的步骤和制备所述外用喷剂的步骤,其中,
所述内服片剂的制备方法,包括如下步骤:
(1)取选定量的所述防己、血竭、穿山龙、川乌、川牛膝、元胡、重楼、红花、透骨草、伸筋草、川椒、白花蛇草、独活、络石藤、海风藤、防风、丹参、苏木、蜈蚣、乳香、没药、全蝎,并分别加水进行浸泡30-60min;随后将浸泡后的所述血竭、川乌、川牛膝、川椒、独活、防风、丹参、乳香、没药进行熬制为45min;将浸泡后的所述防己、穿山龙、重楼、伸筋草、白花蛇草、海风藤、苏木、蜈蚣、全蝎、蜈蚣进行熬制40min;将浸泡后的所述元胡、红花、透骨草、络石藤进行熬制20min;收集上述熬制后的滤液混合并进行浓缩后,并加入白酒(占所有原料总量的5wt%)和山梨酸钾(占所有原料总量的0.3wt%)混匀,得到中药提取液,并进行稳定48h,备用;
(2)将上述所得的中药提取物添加常规辅料,按照常规工艺制得临床上可接受的内服片剂;
所述外用喷剂的制备方法,包括如下步骤:
(1’)取选定量的所述大青叶、板蓝根、白芍、大蓟、白僵蚕、白芷、藁本、黄连、蛇床子、冰片、三七、艾叶、薄荷、金银花、当归、藿香、菊花、荷花、半枝莲,并分别加水进行浸泡30-60min;随后将浸泡后的所述白芍、大蓟、藁本、蛇床子、冰片、当归进行熬制45min;将浸泡后的所述大青叶、板蓝根、白僵蚕、黄连、三七、艾叶、薄荷进行熬制40min;将浸泡后的所述白芷、金银花、藿香、菊花、荷花、半枝莲进行熬制20min;收集上述熬制后的滤液混合并进行浓缩后,得到适量中药提取液,并进行稳定48h,备用;
(2’)按照1:2:3的质量比取蟾酥、全蝎、壁虎为原料,经常规过筛及去尘土后,加水进行提取,离心10-30min后收集滤液,冷冻4h,随后进行冷冻干燥6h,制得冻干粉,于-30℃保存,备用;
(3’)将所得中药提取液按照每1000cc加入0.15g所述冻干粉的比例进行混匀,加入常规辅料,按照常规工艺制成临床上可接受的外用喷剂,进行灌装,常温下可保持一年,10℃避光可保存3年。
实施例2
本实施例所述内服外用相结合治疗痔疮的药物制剂,包括内服胶囊剂及外用喷剂:
所述内服胶囊剂的原料药组成包括:防己35kg、血竭4kg、穿山龙25kg、川乌10kg、川牛膝15kg、元胡15kg、重楼35kg、红花8kg、透骨草12kg、伸筋草15kg、川椒12kg、白花蛇草8kg、独活25kg、络石藤15kg、海风藤25kg、防风8kg、丹参20kg、苏木10kg、蜈蚣15kg、乳香1kg、没药3kg、全蝎10kg;
所述外用喷剂的原料药组成包括:大青叶25kg、板蓝根10kg、白芍35kg、大蓟25kg、白僵蚕15kg、白芷25kg、藁本15kg、黄连10kg、蛇床子35kg、冰片15kg、三七25kg、艾叶15kg、薄荷35kg、金银花25kg、当归12kg、藿香15kg、菊花12kg、荷花10kg、半枝莲25kg、昆虫蛋白0.035kg。
本实施例所述内服外用相结合治疗痔疮的药物制剂的制备方法同实施例1。
实施例3
本实施例所述内服外用相结合治疗痔疮的药物制剂,包括内服颗粒囊剂及外用喷剂:
所述内服颗粒剂的原料药组成包括:防己30kg、血竭6kg、穿山龙20kg、川乌12kg、川牛膝12kg、元胡20kg、重楼30kg、红花10kg、透骨草10kg、伸筋草20kg、川椒10kg、白花蛇草10kg、独活20kg、络石藤20kg、海风藤20kg、防风10kg、丹参18kg、苏木12kg、蜈蚣12kg、乳香2kg、没药2kg、全蝎12kg;
所述外用喷剂的原料药组成包括:大青叶20kg、板蓝根12kg、白芍30kg、大蓟30kg、白僵蚕12kg、白芷30kg、藁本12kg、黄连12kg、蛇床子30kg、冰片20kg、三七20kg、艾叶20kg、薄荷30kg、金银花30kg、当归10kg、藿香20kg、菊花10kg、荷花12kg、半枝莲20kg、昆虫蛋白0.038kg。
本实施例所述内服外用相结合治疗痔疮的药物制剂的制备方法同实施例1。
实施例4
本实施例所述内服外用相结合治疗痔疮的药物制剂,包括内服胶囊剂及外用喷剂:
所述内服胶囊剂的原料药组成包括:防己28kg、血竭7kg、穿山龙18kg、川乌13kg、川牛膝11kg、元胡22kg、重楼28kg、红花11kg、透骨草9kg、伸筋草22kg、川椒9kg、白花蛇草11kg、独活18kg、络石藤22kg、海风藤18kg、防风11kg、丹参16kg、苏木13kg、蜈蚣11kg、乳香2.5kg、没药1.5kg、全蝎14kg;
所述外用喷剂的原料药组成包括:大青叶18kg、板蓝根13kg、白芍28kg、大蓟32kg、白僵蚕11kg、白芷32kg、藁本11kg、黄连14kg、蛇床子28kg、冰片22kg、三七18kg、艾叶22kg、薄荷28kg、金银花32kg、当归9kg、藿香22kg、菊花9kg、荷花13kg、半枝莲18kg、昆虫蛋白0.039kg。
本实施例所述内服外用相结合治疗痔疮的药物制剂的制备方法同实施例1。
实施例5
本实施例所述内服外用相结合治疗痔疮的药物制剂,包括内服颗粒囊剂及外用喷剂:
所述内服颗粒剂的原料药组成包括:防己32kg、血竭5kg、穿山龙22kg、川乌11kg、川牛膝14kg、元胡18kg、重楼32kg、红花9kg、透骨草11kg、伸筋草18kg、川椒11kg、白花蛇草9kg、独活22kg、络石藤18kg、海风藤22kg、防风9kg、丹参19kg、苏木11kg、蜈蚣13kg、乳香1.5kg、没药2.5kg、全蝎11kg;
所述外用喷剂的原料药组成包括:大青叶22kg、板蓝根11kg、白芍32kg、大蓟28kg、白僵蚕14kg、白芷28kg、藁本13kg、黄连11kg、蛇床子32kg、冰片18kg、三七22kg、艾叶18kg、薄荷32kg、金银花28kg、当归11kg、藿香18kg、菊花11kg、荷花11kg、半枝莲22kg、昆虫蛋白0.036kg。
本实施例所述内服外用相结合治疗痔疮的药物制剂的制备方法同实施例1。
实验例
1、治疗例
临床收集诊断为痔疮的患者39例进行临床观察,其中,诊断为内痔患者11例,外痔患者16例,混合痔患者12例。
临床治疗效果的评价标准为:
(1)临床治愈:原有症状消失;
(2)有效:原有症状部分消失或有所减轻;
(3)无效:症状体征无变化。
给药方法:取实施例3制备的内服胶囊剂每次一粒,每日两次,取外用喷雾剂喷涂患处,每天3次,内外结合进行治疗,以7天为一疗程。
使用本发明实施例3制备的内服及外用直接联合治疗1个疗程后,观察39例患者的痔疮的治疗结果,记录于下表1。
表1临床治疗结果
毒副作用:在治疗结束后,复查血尿常规、大便、心、肝和肾功能未发现异常改变。3个月后对上述病例进行回访,无复发患者。
从上表数据可知,本发明所述内服外用相结合治疗痔疮的药物制剂对痔疮具有极好的治疗效果,且治疗周期较短,效果较好。
2、典型病例
1、林某,男,年龄50周岁,临床诊断为痔疮,病程半年左右,病情为痔疮发炎、疼痛,采用本发明实施例3中制剂进行治疗7天为一个疗程,病灶完全消失,病情治愈,6月后回访,无复发,且患处无不适症状。
2、齐某,男,年龄43周岁,临床诊断外痔严重,出现疼痛症状,严重影响日常生活,采用本发明实施例3中制剂进行治疗7天为一个疗程,完全治愈,3月后回访,无复发。
3、魏某,女,年龄35周岁,临床诊断痔疮发炎,疼痛强烈,并出现瘙痒,采用本发明实施例3中制剂进行治疗7天后,病情大为好转,继续使用一个疗程,病情痊愈。
4、吴某,男,年龄28周岁,临床症状表现为外痔发炎肿胀,患处疼痛,采用本发明实施例3中制剂进行治疗10天后,病情完全治愈,3月后回访,患处无复发。
5、李某,男,年龄58周岁,患病多年,多次治疗不能根治,病情反复发作,采用本发明实施例3中制剂进行治疗7天后,病情好转,继续治疗7天一个疗程后,病情已完全治愈,症状完全消失,6月后回访,病情无复发。
6、闫某,男,年龄51周岁,患病多年,病情出现痔疮发炎,痔核脱出,采用本发明实施例3中制剂进行治疗15天后,病情完全治愈,6个月后回访,病情无复发。
综上,本发明所述内服外用相结合治疗痔疮的药物制剂在治疗痔疮具有显著的治疗效果,且治疗周期较短,临床使用无任何副作用。
显然,上述实施例仅仅是为清楚地说明所作的举例,而并非对实施方式的限定。对于所属领域的普通技术人员来说,在上述说明的基础上还可以做出其它不同形式的变化或变动。这里无需也无法对所有的实施方式予以穷举。而由此所引伸出的显而易见的变化或变动仍处于本发明创造的保护范围之中。
Claims (10)
1.一种内服外用相结合治疗痔疮的药物组合物,包括内服组合物及外用组合物,其特征在于:
所述内服组合物的原料药组成包括:防己25-35重量份、血竭4-8重量份、穿山龙15-25重量份、川乌10-15重量份、川牛膝10-15重量份、元胡15-25重量份、重楼25-35重量份、红花8-12重量份、透骨草8-12重量份、伸筋草15-25重量份、川椒8-12重量份、白花蛇草8-12重量份、独活15-25重量份、络石藤15-25重量份、海风藤15-25重量份、防风8-12重量份、丹参15-20重量份、苏木10-15重量份、蜈蚣10-15重量份、乳香1-3重量份、没药1-3重量份、全蝎10-15重量份;
所述外用组合物的原料药组成包括:大青叶15-25重量份、板蓝根10-15重量份、白芍25-35重量份、大蓟25-35重量份、白僵蚕10-15重量份、白芷25-35重量份、藁本10-15重量份、黄连10-15重量份、蛇床子25-35重量份、冰片15-25重量份、三七15-25重量份、艾叶15-25重量份、薄荷25-35重量份、金银花25-35重量份、当归8-12重量份、藿香15-25重量份、菊花8-12重量份、荷花10-15重量份、半枝莲15-25重量份、昆虫蛋白0.035-0.04重量份。
2.根据权利要求1所述的内服外用相结合治疗痔疮的药物组合物,其特征在于:
所述内服组合物的原料药组成包括:防己30重量份、血竭6重量份、穿山龙20重量份、川乌12重量份、川牛膝12重量份、元胡20重量份、重楼30重量份、红花10重量份、透骨草10重量份、伸筋草20重量份、川椒10重量份、白花蛇草10重量份、独活20重量份、络石藤20重量份、海风藤20重量份、防风10重量份、丹参18重量份、苏木12重量份、蜈蚣12重量份、乳香2重量份、没药2重量份、全蝎12重量份;
所述外用组合物的原料药组成包括:大青叶20重量份、板蓝根12重量份、白芍30重量份、大蓟30重量份、白僵蚕12重量份、白芷30重量份、藁本12重量份、黄连12重量份、蛇床子30重量份、冰片20重量份、三七20重量份、艾叶20重量份、薄荷30重量份、金银花30重量份、当归10重量份、藿香20重量份、菊花10重量份、荷花12重量份、半枝莲20重量份、昆虫蛋白0.038重量份。
3.根据权利要求1或2所述的内服外用相结合治疗痔疮的药物组合物,其特征在于:所述昆虫蛋白为以质量比为1:2:3的蟾酥、全蝎、壁虎为原料进行水提制得。
4.权利要求1-3任一项所述的药物组合物用于制备治疗痔疮的内服外用相结合的药物制剂的用途。
5.由权利要求1-3任一项所述的药物组合物,添加常规辅料,按照常规工艺制得的临床上可接受的内服外用相结合治疗痔疮的药物制剂。
6.根据权利要求5所述的药物制剂,其特征在于,包括内服制剂和外用制剂;
所述内服制剂包括片剂、胶囊剂、散剂、或合剂;
所述外用制剂包括喷剂、滴剂、擦剂、或涂剂。
7.一种制备权利要求5或6所述的内服外用相结合治疗痔疮的药物制剂的方法,包括制备所述内服制剂的步骤和制备所述外用制剂的步骤,其特征在于:
所述内服制剂的制备方法,包括如下步骤:
(1)取选定量的所述防己、血竭、穿山龙、川乌、川牛膝、元胡、重楼、红花、透骨草、伸筋草、川椒、白花蛇草、独活、络石藤、海风藤、防风、丹参、苏木、蜈蚣、乳香、没药、全蝎,并分别加水进行浸泡并熬制,收集滤液并浓缩后,加入白酒和山梨酸钾混匀,得到中药提取物,备用;
(2)将所得的中药提取物添加常规辅料,按照常规工艺制得临床上可接受的内服制剂;
所述外用制剂的制备方法,包括如下步骤:
(1’)取选定量的所述大青叶、板蓝根、白芍、大蓟、白僵蚕、白芷、藁本、黄连、蛇床子、冰片、三七、艾叶、薄荷、金银花、当归、藿香、菊花、荷花、半枝莲,并分别加水进行浸泡并熬制,收集滤液并浓缩后,得到中药提取物,备用;
(2’)按照1:2:3的质量比取蟾酥、全蝎、壁虎为原料,加水进行提取,收集滤液并冷冻干燥后,制得冻干粉,备用;
(3’)将所得中药提取物和选定量的所述冻干粉混匀,加入常规辅料,按照常规工艺制成临床上可接受的外用制剂。
8.根据权利要求7所述的制备所述的内服外用相结合治疗痔疮的药物制剂的方法,其特征在于:
所述步骤(1)中,所述血竭、川乌、川牛膝、川椒、独活、防风、丹参、乳香、没药的熬制时间为45min;所述防己、穿山龙、重楼、伸筋草、白花蛇草、海风藤、苏木、蜈蚣、全蝎、蜈蚣的熬制时间为40min;所述元胡、红花、透骨草、络石藤的熬制时间为20min;
所述步骤(1’)中,所述白芍、大蓟、藁本、蛇床子、冰片、当归的熬制时间为45min;所述大青叶、板蓝根、白僵蚕、黄连、三七、艾叶、薄荷的熬制时间为40min;所述白芷、金银花、藿香、菊花、荷花、半枝莲的熬制时间为20min。
9.根据权利要求7或8所述的制备所述的内服外用相结合治疗痔疮的药物制剂的方法,其特征在于:所述步骤(1)中,所述白酒的加入量占各所述原料总量的5wt%;所述山梨酸钾的加入量占各所述原料总量的0.3wt%。
10.根据权利要求7-9任一项所述的制备所述的内服外用相结合治疗痔疮的药物制剂的方法,其特征在于:所述步骤(2)和所述步骤(2’)中,所述冷冻干燥步骤前还包括将所得滤液进行冷冻的步骤。
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