CN108699052B - 驱虫缩酚酸肽化合物 - Google Patents

驱虫缩酚酸肽化合物 Download PDF

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Publication number
CN108699052B
CN108699052B CN201680082548.2A CN201680082548A CN108699052B CN 108699052 B CN108699052 B CN 108699052B CN 201680082548 A CN201680082548 A CN 201680082548A CN 108699052 B CN108699052 B CN 108699052B
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CN
China
Prior art keywords
independently
substituted
alkyl
haloalkyl
group
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CN201680082548.2A
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English (en)
Chinese (zh)
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CN108699052A (zh
Inventor
L·勒伊德法洛斯
G·帕考斯基
A·龙
C·孟
H·I·李
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Boehringer Ingelheim Animal Health USA Inc
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Merial Inc
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Expired - Fee Related legal-status Critical Current
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/15—Depsipeptides; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Agronomy & Crop Science (AREA)
  • Environmental Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN201680082548.2A 2015-12-28 2016-12-14 驱虫缩酚酸肽化合物 Expired - Fee Related CN108699052B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562272040P 2015-12-28 2015-12-28
US62/272,040 2015-12-28
PCT/US2016/066497 WO2017116702A1 (en) 2015-12-28 2016-12-14 Anthelmintic depsipeptide compounds

Publications (2)

Publication Number Publication Date
CN108699052A CN108699052A (zh) 2018-10-23
CN108699052B true CN108699052B (zh) 2022-04-29

Family

ID=57868331

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680082548.2A Expired - Fee Related CN108699052B (zh) 2015-12-28 2016-12-14 驱虫缩酚酸肽化合物

Country Status (23)

Country Link
US (3) US10344056B2 (https=)
EP (1) EP3397638B1 (https=)
JP (1) JP6943859B2 (https=)
KR (2) KR102427124B1 (https=)
CN (1) CN108699052B (https=)
AR (1) AR107249A1 (https=)
AU (2) AU2016380868B2 (https=)
BR (1) BR112018013369A2 (https=)
CA (1) CA3009867C (https=)
CL (1) CL2018001744A1 (https=)
CO (1) CO2018006527A2 (https=)
HK (1) HK1255391A1 (https=)
HU (1) HUE065907T2 (https=)
IL (1) IL260262B2 (https=)
MX (1) MX2018007948A (https=)
MY (1) MY194716A (https=)
NZ (1) NZ743913A (https=)
PH (1) PH12018501367B1 (https=)
RU (2) RU2715556C2 (https=)
SG (1) SG11201805368YA (https=)
TW (1) TWI787165B (https=)
UY (1) UY37050A (https=)
WO (1) WO2017116702A1 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107835818B (zh) * 2015-05-20 2022-04-29 勃林格殷格翰动物保健美国公司 驱虫缩酚酸肽化合物
BR112018013369A2 (pt) 2015-12-28 2019-02-19 Merial, Inc. compostos depsipeptídicos anti-helmínticos
WO2018039508A1 (en) 2016-08-25 2018-03-01 Merial, Inc. Method for reducing unwanted effects in parasiticidal treatments
EP3541789A1 (en) 2016-11-16 2019-09-25 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic depsipeptide compounds
PT3579696T (pt) 2017-02-08 2023-07-19 Boehringer Ingelheim Animal Health Usa Inc Modelo in vivo para infeção por vermes parasitários e métodos para avaliação de compostos antiparasíticos, que incluem compostos ativos contra a dirofilariose canina
EP3480195A1 (en) 2017-11-07 2019-05-08 Bayer Animal Health GmbH Method for the synthesis of cyclic depsipeptides
IL274283B2 (en) 2017-11-07 2025-03-01 Bayer Animal Health Gmbh Method for the synthesis of cyclic depsipeptides
MX2020005573A (es) * 2017-11-29 2020-09-10 Zoetis Services Llc Depsipeptidos endoparasitarios.
US11583545B2 (en) 2018-02-08 2023-02-21 Boehringer Ingelheim Animal Health USA Inc. Parasiticidal compositions comprising eprinomectin and praziquantel, methods and uses thereof
US20220071183A1 (en) 2019-01-10 2022-03-10 Zoetis Services Llc Anthelmintic laboratory animal model for heartworm
MX2021011302A (es) 2019-03-19 2022-01-19 Boehringer Ingelheim Animal Health Usa Inc Compuestos de aza-benzotiofeno y aza-benzofurano como antihelminticos.
JP2023516754A (ja) * 2020-03-06 2023-04-20 ライフマックス ラボラトリーズ インコーポレイテッド 環状デプシペプチドの局所医薬製剤
KR20230028268A (ko) 2020-05-29 2023-02-28 뵈링거 잉겔하임 애니멀 헬스 유에스에이 인코포레이티드 구충성 헤테로시클릭 화합물
CN116897044A (zh) 2020-12-21 2023-10-17 勃林格殷格翰动物保健有限公司 包含异噁唑啉化合物的杀寄生虫环
US12258193B2 (en) 2022-02-17 2025-03-25 Boehringer Ingelheim Vetmedica Gmbh Method and system for providing a fluid product mailer
AU2024339424A1 (en) * 2023-09-15 2026-03-26 Animol Discovery, Inc. Antiparasitic cyclic depsipeptides
WO2025202940A2 (en) * 2024-03-27 2025-10-02 Animol Discovery, Inc. Antiparasitic cyclic depsipeptides

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1121429A (zh) * 1994-01-11 1996-05-01 拜尔公司 杀体内寄生虫组合物
US6369028B1 (en) * 1993-05-26 2002-04-09 Bayer Aktiengesellschaft Octacyclodepsipeptides having an endoparasiticidal action
CN1352559A (zh) * 1999-05-12 2002-06-05 拜尔公司 杀内寄生虫组合物
WO2016187534A1 (en) * 2015-05-20 2016-11-24 Merial, Inc. Anthelmintic depsipeptide compounds

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO176766C (no) 1989-02-07 1995-05-24 Meiji Seika Kaisha Fremgangsmåte for fremstilling av en forbindelse med anthelmintaktivitet
NZ249588A (en) 1992-03-17 1996-08-27 Fujisawa Pharmaceutical Co Anthelmintic agent
US5747448A (en) 1993-02-19 1998-05-05 Meiji Seika Kaisha, Ltd. Derivatives of cyclodepsipeptide PF 1022
DE4317432A1 (de) 1993-05-26 1994-12-01 Bayer Ag Octacyclodepsipeptide mit endoparasitizider Wirkung
NZ271739A (en) 1993-09-06 1996-09-25 Fujisawa Pharmaceutical Co Cyclodepsipeptide compounds and pharmaceutical compositions thereof
SE9303657D0 (sv) 1993-11-05 1993-11-05 Astra Ab Short-acting dihydropyridines
DE4437198A1 (de) 1994-10-18 1996-04-25 Bayer Ag Verfahren zur Sulfonylierung, Sulfenylierung und Phosphorylierung von cyclischen Depsipeptiden
DE19520275A1 (de) 1995-06-02 1996-12-05 Bayer Ag Endoparasitizide Mittel
ATE299871T1 (de) 1995-09-22 2005-08-15 Meiji Seika Kaisha Neue zyklische depsipeptid pf1022 derivate
WO1998015523A1 (en) 1996-10-07 1998-04-16 Fujisawa Pharmaceutical Co., Ltd. Process for producing depsipeptide derivatives and novel intermediates therefor
DE19713626A1 (de) 1997-04-02 1998-10-08 Bayer Ag Neue Thiodepsipeptide zur Bekämpfung von Endoparasiten und ein einfaches Verfahren zu ihrer Herstellung
JP2002502398A (ja) 1997-06-04 2002-01-22 バイエル・アクチエンゲゼルシヤフト デソキシシクロデプシペプチド及び内部寄生性生物の防除のためのその使用
DE19811559A1 (de) 1998-03-17 1999-09-23 Bayer Ag Cyclooctadepsipeptide
DE19828043A1 (de) 1998-06-24 1999-12-30 Bayer Ag Ektoparasitizide Mittel
DE19962147A1 (de) 1999-12-22 2001-06-28 Bayer Ag Schädlingsbekämpfungsmittel / PF 1022-221
DE19962145A1 (de) 1999-12-22 2001-06-28 Bayer Ag Schädlingsbekämpfungsmittel/Depsipeptide
DE10008128A1 (de) 2000-02-22 2001-08-23 Bayer Ag Endoparasitizide Mittel
DE10031044A1 (de) 2000-06-26 2002-01-03 Bayer Ag Endoparasitizide Mittel zur freiwilligen oralen Aufnahme durch Tiere
DE10104362A1 (de) 2001-02-01 2002-08-08 Bayer Ag Kristallmodifikation eines cyclischen Depsipeptids mit besserer Wirksamkeit
UY26592A1 (es) 2001-02-20 2001-09-28 Bayer Ag Agentes endoparasiticidas
US6893652B2 (en) * 2001-08-27 2005-05-17 Wyeth Endoparasiticidal gel composition
US20040236191A1 (en) 2003-05-19 2004-11-25 Poliska Steven A. System and method for identifying and labeling livestock products, and managing data associated with those products
DE10358525A1 (de) 2003-12-13 2005-07-07 Bayer Healthcare Ag Endoparasitizide Mittel zur topischen Applikation
ES2351972T3 (es) 2004-02-27 2011-02-14 Ic Services Procedimiento y set para la identificación de animales.
DE102004055316A1 (de) 2004-11-16 2006-05-18 Bayer Healthcare Ag Verhinderung vertikaler Endoparasiten-Infektionen
US20060202835A1 (en) 2005-02-25 2006-09-14 Osborne Industries, Inc. Dual frequency identification device
DE102008022520A1 (de) 2008-05-07 2009-11-12 Bayer Animal Health Gmbh Feste Arzneimittelformulierung mit verzögerter Freisetzung
DE102008030764A1 (de) 2008-06-28 2009-12-31 Bayer Animal Health Gmbh Kombination von Amidin-Derivaten mit cyclischen Depsipeptiden
DE102008031283A1 (de) 2008-07-02 2010-01-07 Bayer Schering Pharma Aktiengesellschaft Neue Bekämpfungsmöglichkeit von durch Trichomonadida hervorgerufenen Krankheiten
DE102008031284A1 (de) 2008-07-02 2010-01-07 Bayer Schering Pharma Aktiengesellschaft Neue Bekämpfungsmöglichkeit der Giardiose
KR20110095350A (ko) 2008-12-16 2011-08-24 바이엘 애니멀 헬스 게엠베하 로셀리니아 유형 및 자일라리에이시의 다른 종의 진균 균주를 사용하는, 락트산 및 페닐락트산을 포함하며 24개의 고리 원자를 갖는, 광학 활성의 시클릭 뎁시펩티드의 제조 방법
KR101002530B1 (ko) 2009-02-18 2010-12-17 삼성에스디아이 주식회사 알에프아이디 통신 장치
EP2509967B1 (en) 2009-12-11 2016-02-17 Bayer Intellectual Property GmbH Novel 24-membered cyclooctadepsipeptides from fungal strains and their use as anthelmintics or endoparasiticides
WO2012028556A1 (en) 2010-08-31 2012-03-08 Bayer Animal Health Gmbh Macrocyclic lactones and their use and their combinations with other active substances
US20120124387A1 (en) 2010-11-11 2012-05-17 Skocic Ruth E Animal Data Management
US9848290B2 (en) 2011-03-10 2017-12-19 Aruba Networks, Inc. Location based computerized system and method thereof
CN104023710A (zh) 2011-12-21 2014-09-03 拜耳知识产权有限责任公司 包含无定形艾默德斯的制剂
KR20150037766A (ko) 2012-06-13 2015-04-08 메이지 세이카 파루마 가부시키가이샤 신규한 환상 뎁시펩티드 유도체 및 이를 포함하는 해충 방제제
US20140306005A1 (en) 2013-04-14 2014-10-16 Forever Yours, Inc. Method for Data Transport and Recovery of Dependent Creatures
BR112018013369A2 (pt) 2015-12-28 2019-02-19 Merial, Inc. compostos depsipeptídicos anti-helmínticos
EP3541789A1 (en) 2016-11-16 2019-09-25 Boehringer Ingelheim Animal Health USA Inc. Anthelmintic depsipeptide compounds

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6369028B1 (en) * 1993-05-26 2002-04-09 Bayer Aktiengesellschaft Octacyclodepsipeptides having an endoparasiticidal action
CN1121429A (zh) * 1994-01-11 1996-05-01 拜尔公司 杀体内寄生虫组合物
CN1352559A (zh) * 1999-05-12 2002-06-05 拜尔公司 杀内寄生虫组合物
WO2016187534A1 (en) * 2015-05-20 2016-11-24 Merial, Inc. Anthelmintic depsipeptide compounds
CN107835818A (zh) * 2015-05-20 2018-03-23 梅里亚股份有限公司 驱虫缩酚酸肽化合物

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Anthelmintic cyclooctadepsipeptides:complex in structure and mode of action;Jürgen Krücken，等;《Trends in Parasitology》;20120930;第28卷(第9期);第385-394页 *
Chimeric cyclodepsipeptides as mimetics for the anthelmintic PF1022A;Hubert Dyker，等;《Bioorganic & Medicinal Chemistry Letters》;20041018;第14卷(第24期);第6129–6132页 *
PF1022A - A NOVEL ANTHELMINTIC CYCLOOCTADEPSIPEPTIDE.MODIFICATION AND EXCHANGE OF THE N-METHYL LEUCINE RESIDUES;Jürgen Scherkenbeck，等;《Bioorganic & Medicinal Chemistry Letters》;19981231;第8卷;第1035-1040页 *

Also Published As

Publication number Publication date
TWI787165B (zh) 2022-12-21
RU2715556C2 (ru) 2020-03-02
CA3009867C (en) 2022-05-31
EP3397638B1 (en) 2023-08-23
RU2018127195A3 (https=) 2020-01-30
US20190248840A1 (en) 2019-08-15
RU2020107484A (ru) 2020-03-19
US12018048B2 (en) 2024-06-25
AU2020200854A1 (en) 2020-02-27
US11230571B2 (en) 2022-01-25
NZ743913A (en) 2019-04-26
KR102427124B1 (ko) 2022-07-28
JP6943859B2 (ja) 2021-10-06
HK1255391A1 (zh) 2019-08-16
HUE065907T2 (hu) 2024-06-28
MY194716A (en) 2022-12-15
WO2017116702A1 (en) 2017-07-06
KR20220003663A (ko) 2022-01-10
AU2016380868A1 (en) 2018-07-19
PH12018501367B1 (en) 2022-10-21
AR107249A1 (es) 2018-04-11
IL260262B2 (en) 2023-06-01
JP2019504050A (ja) 2019-02-14
CA3009867A1 (en) 2017-07-06
US20170233438A1 (en) 2017-08-17
BR112018013369A2 (pt) 2019-02-19
CO2018006527A2 (es) 2018-07-10
TW201726670A (zh) 2017-08-01
CL2018001744A1 (es) 2018-08-17
IL260262A (en) 2018-07-31
US20220098241A1 (en) 2022-03-31
AU2016380868B2 (en) 2019-11-28
PH12018501367A1 (en) 2019-02-27
UY37050A (es) 2017-07-31
KR20180100349A (ko) 2018-09-10
EP3397638A1 (en) 2018-11-07
SG11201805368YA (en) 2018-07-30
RU2018127195A (ru) 2020-01-30
AU2020200854B2 (en) 2021-08-05
CN108699052A (zh) 2018-10-23
US10344056B2 (en) 2019-07-09
MX2018007948A (es) 2018-08-01

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