CN108685985A - A kind of burns cream and preparation method thereof - Google Patents
A kind of burns cream and preparation method thereof Download PDFInfo
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- CN108685985A CN108685985A CN201810938213.7A CN201810938213A CN108685985A CN 108685985 A CN108685985 A CN 108685985A CN 201810938213 A CN201810938213 A CN 201810938213A CN 108685985 A CN108685985 A CN 108685985A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/41—Crassulaceae (Stonecrop family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
- A61K31/125—Camphor; Nuclear substituted derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/11—Pteridophyta or Filicophyta (ferns)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
Abstract
The present invention is a kind of ointment for treating burn, which is mainly prepared by rapeseed oil, sedum lineare, Selaginella tamariscina, vaseline, borneol, cooling ointment, Herba Menthae slice, Chinese gall, while providing the preparation method of the ointment.The improvement for also having passed through ointment preparation process simultaneously, makes ointment have better therapeutic effect, effective percentage to reach as high as 100%.
Description
Technical field
The invention belongs to external used medicine technical fields more particularly to a kind of burns cream and preparation method thereof.
Background technology
In Chinese Traditional Medicine external therapy, plaster, which is cured the disease, to be played an important role.In order to allow traditional medicine to go abroad, it
Not only need the major reform of dosage form and manufacture craft, but also require its curative effect faster, more it is clean it is more convenient can just have it is powerful
Vitality.
Clinical investigation various diseases patient, the people if any same 90% or more curative effect of curing the disease are ready to receive the outer method controlled
Treat disease.Because its administration route is directly to reach lesion from skin, blood circulation is participated in, it is often faster and straight than oral curative effect
It connects.It will be further appreciated that the illness less than medicine for oral administration, externally applied drug, which is used alone, very peculiar effect.Such as shoulder
Inflammation, synovitis neck Annulus Fibrosus of Lumbar Intervertebral Discs oedema, aseptic inflammation and ligament hyperplasia etc. belong to the illness of soft tissue injury, trident god
The severe pain disease of some unknown causes such as dysmenorrhoea, facial silt abnormal pigmentary deposit on the skin packing lump, dysmenorrhoea, nasopharyngitis can all have its special treatment
Effect.Its another advantage is not injure gastrointestinal tract and each organ of internal organ, does not influence oral medicine use, and the unlimited course for the treatment of can stop at any time
Medicine.
Furthermore skin can receive 1/3 blood circulation of human body, it has 20,000 square centimeter of surface area organs, has its huge
It is ready that the crowd for receiving external therapy is given full play to skin by medicine potential not yet.A kind of dose as percutaneous dosing of ointment
Type not only can reduce the variation of blood concentration peak valley, and have become and overcome drug pair to avoid the destruction of drug in the gastrointestinal tract
One of effective route of administration of effect, the extensive use in hospital dermatology department, surgery, and occupy one in the ordinary preparation of hospital
Fixed proportion." inner disease outer treat " is likely to become Chinese medicine ointment one of research and development direction from now on.But to the matrix of ointment, medicine
Object and matrix correlation, the research of several aspects such as cutaneous permeable agent and quality control also need further to inquire into and improve.
Burns cream is a kind of relatively common plaster, but the developer being frequently encountered by drug powder or
Grain is directly added in matrix, or will be added on the medium various improper situations of the higher matrix of temperature to hot unstable drug.Also deposit
The problems such as such as material combination is chaotic, this series of problems can all lead to the reduction of plaster curative effect.Though externally applied ointment prescription is certainly
By, but prescription is not freely the unordered accumulation for being drug, disorderly and unsystematic, a heap of a loose sand.Externally used paste mostly selects Chinese medicine, answers
This selects drug under the guidance of Basic Theories of Chinese Medicine.
Invention content
The present invention is disorderly with plaster preparation method for burn in the prior art, and raw material does not distinguish that good and the bad confusion used shows
Shape is selected suitable raw material to prepare a kind of ointment of burn meticulously and provides the ointment according to Basic Theories of Chinese Medicine
Preparation method.
The present invention can treat scald, knife wound, burn, have the works such as removing toxic substances, detumescence, analgesic, hemostasia and promoting granulation, anti-inflammation and sterilization
With.
Purpose of the present invention is to what is be achieved through the following technical solutions:
A kind of burns cream includes following raw material by weight:
20-40 parts of rapeseed oil, 5-15 parts of sedum lineare, 5-10 parts of Selaginella tamariscina, 10-40 parts of vaseline, 3-8 parts of borneol, cooling ointment
3-8 parts, 3-8 parts of Herba Menthae slice, 5-15 parts of Chinese gall.
Preferably, the borneol is L-Borneol.
Preferably, the Herba Menthae slice is dried peppermint leaf.
It is as follows to prepare above-mentioned burns herbal paste method:
(1) it after cleaning Selaginella tamariscina, Herba Menthae slice, Chinese gall, mashes, container is all added in all solids of gained and liquid
In A;
(2) it after cleaning sedum lineare, mashes, all solids of gained and liquid is all added in container B;
(3) solvent is added to container B, after stirring 30-60 minutes, filtrate is added in container A by filtering;
The weight of the solvent is the 50%-120% of vegetable seed weight of oil;
(4) rapeseed oil is added into container A, subsequent container A heats 20-30 minutes at 25-30 DEG C, then is warming up to 60-
80 DEG C are heated 2-3 hours, are down to room temperature naturally;
(5) medicine oil is filtered out with gauze, is put into container C;
(6) after sequentially adding cooling ointment and vaseline into container C, container C is warming up to 50-80 DEG C of 30-50 points of heating
Clock then stops heating, terminates heated liquid and pours into immediately in clean container D, when fluid temperature is not less than 50 DEG C, to
Borneol is added in container D, and is stirred 5-10 minutes at 50-80 DEG C in temperature control;
(7) container D is sealed, is taken out to get burns cream after 3-24 hours in the environment of being put into -10-0 DEG C.
Preferably, the solvent in above-mentioned preparation method described in step (3) is that any one in ether and water or both is mixed
Bonding solvent.
Preferably, it is (2-4) that the solvent in above-mentioned preparation method described in step (3), which is the weight ratio of ether and water,:1
Mixed solvent.
This burns cream is external application, daily to smear affected part 1-3 times.Avoid pungent food irritable food.Pregnant woman uses with caution.Forbid
It is for oral administration.It should be noted that systemic conditions when use, when if any symptoms such as fevers with aversion to cold, hospital admission should be removed.It is not suitable for severe, big face
Product scald.Centainly it is noted that the surface of a wound is clean, preferably with exposure method under cleaning ambient.Mild burn patient medication one
Symptom has purulence tongue that should remove hospital admission without improvement or part after to two days.Locally occurring the allergic manifestations such as fash person after medication should stop
With.To the raw material allergy sufferers disabling for including in this ointment, allergic constitution person uses with caution.This ointment character forbids making when changing
With.Children must use in the case where adult guards.This ointment is please placed on the place that children cannot contact.Using can not when this ointment
It is used simultaneously with other smearing drugs.
Specifically, rapeseed oil is the golden dragonfish board rapeseed oil that grain and oil (China) Co., Ltd produces in praising.
Sedum lineare, Selaginella tamariscina, Chinese gall, Herba Menthae slice are purchased to pacify in Baoding and win hall prepared slices of Chinese crude drugs sale Co., Ltd.
Vaseline is the medical ventolin of Guangzhou Duo De Chemical Co., Ltd.s production.
Borneol is in the present invention L-Borneol and dextrorotation without referring to synthetic borneol also known as borneolum syntheticum when illustrating
The mixture of borneol is purchased from the village An Huihua pharmaceutcal corporation, Ltd.
L-Borneol also known as L-Borneol are purchased from Hubei Dan Sheng Pharmaceutical Technology Co., Ltd.
Cooling ointment is the dragon and tiger board cooling ointment of Shanghai Zhonghua Pharmaceutical Co., Ltd's production.
Ether, CAS 60-29-7 are purchased from Sinopharm Chemical Reagent Co., Ltd..
The present invention remains the beneficiating ingredient in raw material to the full extent by the improvement of the selected and preparation method of raw material,
Better therapeutic effect is enabled the invention to.
Specific implementation mode
With reference to embodiment, the present invention is described in further detail, and following embodiment is merely illustrative this
Invention, is not intended to limit the present invention.
Embodiment 1
A kind of burns cream, including following raw material:
Rapeseed oil 20g, sedum lineare 10g, Selaginella tamariscina 8g, vaseline 20g, borneol 3g, cooling ointment 2g, dried peppermint leaf 3g, Chinese gall
10g。
It is as follows to prepare above-mentioned burns herbal paste method:
(1) it after cleaning Selaginella tamariscina, Herba Menthae slice, Chinese gall, is mashed with automatic grinding instrument, rotating speed is set as 150rpm, by institute
The all solids and liquid obtained are all added in container A;
(2) it after cleaning sedum lineare, is mashed with automatic grinding instrument, rotating speed is set as 150rpm, by all solids of gained
It is all added in container B with liquid;
(3) 16g water is added to container B, after forty minutes, filtrate is added in container A by filtering for stirring;
(4) rapeseed oil is added into container A, subsequent container A heats 30 minutes at 30 DEG C, then is warming up to 80 DEG C of heating 2
Hour, it is down to room temperature naturally;
(5) medicine oil is filtered out with 100 mesh gauzes, is put into container C;
(6) after sequentially adding cooling ointment and vaseline into container C, by container C be warming up to 80 DEG C heat 40 minutes, then
Stop heating, terminates heated liquid and pour into immediately in clean container D, ice is added into container D in 70 DEG C of fluid temperature
Piece, temperature control stir 10 minutes in 70 DEG C;
(7) container D is sealed, is taken out to get burns cream after 5 hours in the environment of being put into 0 DEG C.
The automatic grinding instrument is that the AM200 type mortar formulas of ant source scientific instrument (Beijing) Co., Ltd production are automatic
Beveller.
Embodiment 2
A kind of burns cream, including following raw material:
Rapeseed oil 20g, sedum lineare 10g, Selaginella tamariscina 8g, vaseline 20g, borneol 3g, cooling ointment 2g, dried peppermint leaf 3g, Chinese gall
10g。
It is as follows to prepare above-mentioned burns herbal paste method:
(1) it after cleaning Selaginella tamariscina, Herba Menthae slice, Chinese gall, is mashed with automatic grinding instrument, rotating speed is set as 150rpm, by institute
The all solids and liquid obtained are all added in container A;
(2) it after cleaning sedum lineare, is mashed with automatic grinding instrument, rotating speed is set as 150rpm, by all solids of gained
It is all added in container B with liquid;
(3) 16g water is added to container B, after forty minutes, filtrate is added in container A by filtering for stirring;
(4) rapeseed oil is added into container A, subsequent container A heats 30 minutes at 30 DEG C, then is warming up to 80 DEG C of heating 2
Hour, it is down to room temperature naturally;
(5) medicine oil is filtered out with 100 mesh gauzes, is put into container C;
(6) after sequentially adding cooling ointment and vaseline into container C, by container C be warming up to 80 DEG C heat 40 minutes, then
Stop heating, terminates heated liquid and pour into immediately in clean container D, ice is added into container D in 50 DEG C of fluid temperature
Piece, temperature control stir 10 minutes in 50 DEG C;
(7) container D is sealed, is taken out to get burns cream after 5 hours in the environment of being put into 0 DEG C.
The automatic grinding instrument is that the AM200 type mortar formulas of ant source scientific instrument (Beijing) Co., Ltd production are automatic
Beveller.
Embodiment 3
A kind of burns cream, including following raw material:
Rapeseed oil 20g, sedum lineare 10g, Selaginella tamariscina 8g, vaseline 20g, L-Borneol 3g, cooling ointment 2g, dried peppermint leaf 3g, five
Gall nut 10g.
It is as follows to prepare above-mentioned burns herbal paste method:
(1) it after cleaning Selaginella tamariscina, Herba Menthae slice, Chinese gall, is mashed with automatic grinding instrument, rotating speed is set as 150rpm, by institute
The all solids and liquid obtained are all added in container A;
(2) it after cleaning sedum lineare, is mashed with automatic grinding instrument, rotating speed is set as 150rpm, by all solids of gained
It is all added in container B with liquid;
(3) 16g water is added to container B, after forty minutes, filtrate is added in container A by filtering for stirring;
(4) rapeseed oil is added into container A, subsequent container A heats 30 minutes at 30 DEG C, then is warming up to 80 DEG C of heating 2
Hour, it is down to room temperature naturally;
(5) medicine oil is filtered out with 100 mesh gauzes, is put into container C;
(6) after sequentially adding cooling ointment and vaseline into container C, by container C be warming up to 80 DEG C heat 40 minutes, then
Stop heating, terminate heated liquid and pour into immediately in clean container D, is added into container D in 50 DEG C of fluid temperature left
Borneol is revolved, temperature control stirs 10 minutes in 50 DEG C;
(7) container D is sealed, is taken out to get burns cream after 5 hours in the environment of being put into 0 DEG C.
The automatic grinding instrument is that the AM200 type mortar formulas of ant source scientific instrument (Beijing) Co., Ltd production are automatic
Beveller.
Embodiment 4
A kind of burns cream, including following raw material:
Rapeseed oil 20g, sedum lineare 10g, Selaginella tamariscina 8g, vaseline 20g, L-Borneol 3g, cooling ointment 2g, dried peppermint leaf 3g, five
Gall nut 10g.
It is as follows to prepare above-mentioned burns herbal paste method:
(1) it after cleaning Selaginella tamariscina, Herba Menthae slice, Chinese gall, is mashed with automatic grinding instrument, rotating speed is set as 150rpm, by institute
The all solids and liquid obtained are all added in container A;
(2) it after cleaning sedum lineare, is mashed with automatic grinding instrument, rotating speed is set as 150rpm, by all solids of gained
It is all added in container B with liquid;
(3) 16g ether is added to container B, after forty minutes, filtrate is added in container A by filtering for stirring;
(4) rapeseed oil is added into container A, subsequent container A heats 30 minutes at 30 DEG C, then is warming up to 80 DEG C of heating 2
Hour, it is down to room temperature naturally;
(5) medicine oil is filtered out with 100 mesh gauzes, is put into container C;
(6) after sequentially adding cooling ointment and vaseline into container C, by container C be warming up to 80 DEG C heat 40 minutes, then
Stop heating, terminate heated liquid and pour into immediately in clean container D, is added into container D in 50 DEG C of fluid temperature left
Borneol is revolved, temperature control stirs 10 minutes in 50 DEG C;
(7) container D is sealed, is taken out to get burns cream after 5 hours in the environment of being put into 0 DEG C.
The automatic grinding instrument is that the AM200 type mortar formulas of ant source scientific instrument (Beijing) Co., Ltd production are automatic
Beveller.
Embodiment 5
A kind of burns cream, including following raw material:
Rapeseed oil 20g, sedum lineare 10g, Selaginella tamariscina 8g, vaseline 20g, L-Borneol 3g, cooling ointment 2g, dried peppermint leaf 3g, five
Gall nut 10g.
It is as follows to prepare above-mentioned burns herbal paste method:
(1) it after cleaning Selaginella tamariscina, Herba Menthae slice, Chinese gall, is mashed with automatic grinding instrument, rotating speed is set as 150rpm, by institute
The all solids and liquid obtained are all added in container A;
(2) it after cleaning sedum lineare, is mashed with automatic grinding instrument, rotating speed is set as 150rpm, by all solids of gained
It is all added in container B with liquid;
(3) 12g ether and 4g water is added to container B, after forty minutes, filtrate is added in container A by filtering for stirring;
(4) rapeseed oil is added into container A, subsequent container A heats 30 minutes at 30 DEG C, then is warming up to 80 DEG C of heating 2
Hour, it is down to room temperature naturally;
(5) medicine oil is filtered out with 100 mesh gauzes, is put into container C;
(6) after sequentially adding cooling ointment and vaseline into container C, by container C be warming up to 80 DEG C heat 40 minutes, then
Stop heating, terminate heated liquid and pour into immediately in clean container D, is added into container D in 50 DEG C of fluid temperature left
Borneol is revolved, temperature control stirs 10 minutes in 50 DEG C;
(7) container D is sealed, is taken out to get burns cream after 5 hours in the environment of being put into 0 DEG C.
The automatic grinding instrument is that the AM200 type mortar formulas of ant source scientific instrument (Beijing) Co., Ltd production are automatic
Beveller.
Test case 1
Beneficial effects of the present invention are illustrated with reference to clinical data.
1. clinical general information
All cases come from patient 2012-2017 totally 500 people, and the age is between 18-55 Sui.It is randomly divided into treatment group
1-5, there was no significant difference for the statistical procedures such as age, the course of disease, gender between five groups, is comparable.
2. therapy
Ointment made from 1-5 methods of the embodiment of the present invention is taken, it is daily to smear affected part 3 times.Avoid pungent food irritable food.
Symptom has no improvement in three days, is considered as and is not cured;Constitutional symptom disappears in ten days, and wound healing is considered as healing;Other situations are considered as
It improves.Wherein treatment group 1 is made using ointment made from embodiment 1, treatment group 2 using ointment, treatment group 3 made from embodiment 2
The ointment made from embodiment 3, treatment group 4 use medicine made from embodiment 5 using ointment made from embodiment 4, treatment group 5
Cream.Treatment group 6 uses ointment made from embodiment 6.
Therapeutic effect is as shown in the table:
1 therapeutic effect of table
| Case load | It cures | Cure rate | It improves | Total effective rate | |
| Treatment group 1 | 100 | 70 | 70% | 25 | 95% |
| Treatment group 2 | 100 | 77 | 77% | 20 | 97& |
| Treatment group 3 | 100 | 86 | 86% | 13 | 99% |
| Treatment group 4 | 100 | 88 | 88% | 12 | 100% |
| Treatment group 5 | 100 | 94 | 94% | 6 | 100% |
As seen from the above table, when the temperature that borneol is added is controlled 50 DEG C (treatment group 1) than controlling 70 DEG C (treatment groups 2)
There is better therapeutic effect, (treatment group 3) has better therapeutic effect than borneol (treatment group 2) when using L-Borneol, when
When the solvent used in preparation process (3) is the mixed solvent of ether and water (treatment group 5) than be used alone water (treatment group 3) or
Ether (treatment group 4) has better therapeutic effect.
Model case:
Just certain, male, careless when due to setting off firecrackers, and left-hand palm part scald after local clinic is slightly handled, starts to make
With the ointment prepared by embodiment 5, symptom is obviously improved two days later, and symptom disappears after five days, and the surface of a wound heals, do not leave completely
Scar.
Test case 2
Skin irritation is tested:
Test method:Healthy skin is selected, no tested crowd 30 of allergies, age 18-50 Sui, men and women is fifty-fifty.Room temperature
20℃±1℃;Humidity 50% ± 5%.Face is cleaned when experiment, and everyone face cleaning time is identical, and face is selected after skin dries
Cheek 5cm × 5cm skins are as test zone, and other side skin is as a contrast.Ointment 0.5g is taken to be coated directly on test by special messenger
On skin, two layers of gauze and the covering of one layer of glassine paper of 2.5cm × 2.5cm are then used, then with nonirritant adhesive plaster and bandage
It is fixed, using blocking test, the application time is 2 hours.After test residual ointment is removed with warm water.
Test ointment used is ointment prepared by embodiment 5.
All 30 subjects do not occur erythema or red and swollen phenomenon.It is safe and reliable to demonstrate this product.
In conclusion the present invention provides a kind of ointment that can treat burn, and controlled by process modification
The more preferably excellent ointment of therapeutic effect.
Claims (6)
1. a kind of burns cream includes following raw material by weight:
20-40 parts of rapeseed oil, 5-15 parts of sedum lineare, 5-10 parts of Selaginella tamariscina, 10-40 parts of vaseline, 3-8 parts of borneol, cooling ointment 3-8
Part, 3-8 parts of Herba Menthae slice, 5-15 parts of Chinese gall.
2. burns cream according to claim 1, which is characterized in that the borneol is L-Borneol.
3. burns cream according to claim 1, which is characterized in that the Herba Menthae slice is dried peppermint leaf.
4. it is as follows to prepare burns herbal paste method as described in claim 1:
(1) it after cleaning Selaginella tamariscina, Herba Menthae slice, Chinese gall, mashes, all solids of gained and liquid is all added in container A;
(2) it after cleaning sedum lineare, mashes, all solids of gained and liquid is all added in container B;
(3) solvent is added to container B, after stirring 30-60 minutes, filtrate is added in container A by filtering;
The weight of the solvent is the 50%-120% of vegetable seed weight of oil;
(4) rapeseed oil is added into container A, subsequent container A heats 20-30 minutes at 25-30 DEG C, then is warming up to 60-80 DEG C
Heating 2-3 hours, is down to room temperature naturally;
(5) medicine oil is filtered out with gauze, is put into container C;
(6) after sequentially adding cooling ointment and vaseline into container C, container C is warming up to 50-80 DEG C and is heated 30-50 minutes, with
Stop heating afterwards, terminate heated liquid and pour into immediately in clean container D, when fluid temperature is not less than 50 DEG C, to container D
Middle addition borneol, and stirred 5-10 minutes at 50-80 DEG C in temperature control;
(7) container D is sealed, is taken out to get burns cream after 3-24 hours in the environment of being put into -10-0 DEG C.
5. burns ointment preparation according to claim 4, which is characterized in that the solvent described in step (3) is
Any one in ether and water or both mixed solvent.
6. burns ointment preparation according to claim 5, which is characterized in that the solvent described in step (3) is
The weight ratio of ether and water is (2-4):1 mixed solvent.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810938213.7A CN108685985A (en) | 2018-08-17 | 2018-08-17 | A kind of burns cream and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810938213.7A CN108685985A (en) | 2018-08-17 | 2018-08-17 | A kind of burns cream and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108685985A true CN108685985A (en) | 2018-10-23 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110115734A (en) * | 2019-06-28 | 2019-08-13 | 李向阳 | A kind of traditional Chinese medicinal ointment and preparation method thereof for treating skin burn |
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| CN101837083A (en) * | 2010-05-07 | 2010-09-22 | 顾克斌 | Ointment for curing burns and scalds and preparation method thereof |
| CN105456326A (en) * | 2015-12-11 | 2016-04-06 | 覃兆龙 | Traditional Chinese medicine for treating scalds as well as preparation method and application of traditional Chinese medicine |
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|---|---|---|---|---|
| CN101837083A (en) * | 2010-05-07 | 2010-09-22 | 顾克斌 | Ointment for curing burns and scalds and preparation method thereof |
| CN105456326A (en) * | 2015-12-11 | 2016-04-06 | 覃兆龙 | Traditional Chinese medicine for treating scalds as well as preparation method and application of traditional Chinese medicine |
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| 陈文珍: "中药烧伤软膏的制备及应用", 《海峡药学》 * |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110115734A (en) * | 2019-06-28 | 2019-08-13 | 李向阳 | A kind of traditional Chinese medicinal ointment and preparation method thereof for treating skin burn |
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Application publication date: 20181023 |
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