CN103330810A - Emergency medicine for snake wounds - Google Patents
Emergency medicine for snake wounds Download PDFInfo
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- CN103330810A CN103330810A CN2013102287444A CN201310228744A CN103330810A CN 103330810 A CN103330810 A CN 103330810A CN 2013102287444 A CN2013102287444 A CN 2013102287444A CN 201310228744 A CN201310228744 A CN 201310228744A CN 103330810 A CN103330810 A CN 103330810A
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Abstract
The invention relates to an emergency medicine for snake wounds. The medicine comprises the following components in parts by weight: 5-12 parts of Jacaranda flower root, 5-12 parts of Ainsliaea fragrans, 3-5 parts of radix angelicae, 5-10 parts of common andrographis Herb, 1-4 parts of Paris polyphylla, 5-10 parts of Circium japonicum root, and 7-12 parts of Chinese lobelia. The preparation method comprises the following steps of: 1) crushing Jacaranda flower root, Paris polyphylla and radix angelica and uniformly mixing to obtain fine powder; 2) adding water to Circium japonicum root, Ainsliaea fragrans, common andrographis Herb and Chinese lobelia, and decocting concentrating the filtrate to obtain clear paste; 3) adding Jacaranda flower root, Paris polyphylla and radix angelica fine powder into the clear paste filtrate and uniformly mixing; and 4) drying, crushing to obtain fine power to obtain the medicine. Through clinical use for many years, the medicine provided by the invention is an emergency and treatment medicine for snake wounds which has remarkable curative effect and no adverse effect, is convenient to take and store and low in cost. The medicine is used for treating various venomous snake bites and has the functions of clearing away heat, detoxifying, stopping bleeding, removing swelling and relieving pain.
Description
Technical field
The present invention relates to the snakebite medicine, be specifically related to a kind of snakebite first aid medicine.
Background technology
China is located in the temperate zone, subtropical zone, especially southern climates gentleness, and the rainfall is plentiful, is fit to the growth and breeding of Serpentis class.China's Serpentis class has 158 kinds more than approximately, and poisonous snake has 47 kinds approximately, wherein can directly cause the people in desperately have ten approximately surplus kind.The secreted venom of poisonous snake mainly is divided into these three kinds of neural poison, blood poison, admixture poison, and snakebite is mainly involved systems such as people's breathing, blood, urinary system, nerve, as can not be in time and correctly treat, can cause deformity even death.
At present the main medicine for the treatment of venom poisoning first-aid is antivenin, and it can effectively neutralize and be free on part toxin in the blood.But the antivenin of the clinical use of China is unit price at present, a kind of antivenin can only be treated a kind of snakebite targetedly, and antivenin only limits to the use of first aid phase, and the production cycle is long, the technological process complexity, belong to the biological preparation category, be the intravenous injection injection, need low temperature fortune to hide, preserve, be not easy to carry and use, expensive, the effect phase short (mostly being 1 year).Simultaneously, may there be certain curative effect difference in the made antivenin of different regions Serpentis kind snake venom.Therefore, this medicine is popularized in an all-round way to use and is also had certain difficulty, be difficult to guarantee the remote countryside patient can both be in time, effective medication.There is part serum weak curative effect in clinical practice report antivenin curative effect instability according to a large amount of.Antivenin is as a kind of foreign preteins, and clinical anaphylaxis rate is higher.
Chinese patent 201010580769.7 discloses a kind of first aid medicine for the treatment of snakebite; described first aid medicine is Chinese medicine composition, and component is: Calculus Bovis, Cornu Caprae seu Ovis, Moschus (manually), Pulvis Cornus Bubali Concentratus, Scorpio, Scolopendra, Periostracum Cicadae, Pheretima, Bombyx Batryticatus, Os Draconis, Margarita, Realgar, Radix Curcumae, Cinnabaris, Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri, Fructus Gardeniae, Flos Lonicerae, Flos Chrysanthemi, the Radix Rehmanniae, the Radix Angelicae Dahuricae, Fructus Forsythiae, Borneolum Syntheticum, Rhizoma Paridis.But the required component of this snakebite first aid medicine is numerous and diverse.At such present situation, be badly in need of a kind of first aid and treatment medicine that simple, stable curative effect, preservation are treated venom easily that prepare.
Summary of the invention
The object of the present invention is to provide a kind for the treatment of venom oral drugs of stable curative effect.
The technical scheme that the present invention solves its technical problem is: adopt following method step to prepare snakebite first aid medicine: get 5～12 parts of Radix campsis flower roots; 5～12 parts of the fragrant Herba Ainsliaeae Glabrae of Fructus Pruni; 3～5 parts of the Radixs Angelicae Dahuricae; 5～10 parts of Herba Andrographis; 1～4 part of Rhizoma Paridis; 5～10 parts of cirsii japonici,radixs; 7～12 parts of Herba Lobeliae Chinensis;
1) get above-mentioned Radix campsis flower root, Rhizoma Paridis, Radix Angelicae Dahuricae pulverizing, mixing gets fine powder;
2) get the fragrant Herba Ainsliaeae Glabrae of above-mentioned cirsii japonici,radix, Fructus Pruni, Herba Andrographis, Herba Lobeliae Chinensis and decoct with water, filter medicinal residues and get filtrate, again filtrate is concentrated into the clear paste shape;
3) in clear paste shape filtrate, add the fine powder that step 1) makes, mixing;
4) crushed after being dried becomes fine powder.
For better performance drug effect, Radix campsis flower root, Rhizoma Paridis, Radix Angelicae Dahuricae fine powder are more evenly tiny, and Radix campsis flower root, Rhizoma Paridis, Radix Angelicae Dahuricae fine powder are crossed 80 mesh sieves in the described step 1).
In order better to extract the effective ingredient in the component, described step 2) in cirsii japonici,radix, the fragrant Herba Ainsliaeae Glabrae of Fructus Pruni, Herba Andrographis, Herba Lobeliae Chinensis to add mass ratio be that the decocting of 1:9～1:11 boils 2h, filter, get decocting liquid and medicinal residues; The water that with described medicinal residues with the mass ratio is 1:7～1:9 again continues to decoct 2h, filters, and gets secondary decocting liquid and medicinal residues; Merge decocting liquid and secondary decocting liquid and get filtrate.
For the effective ingredient of the medicine that do not damage, baking temperature is no more than 80 ℃ in the described step 4).
For making things convenient for drug use and preservation, fine powder incapsulates in the described step 4), and capsule is packed with bottle seal.
Using method of the present invention is each 1～1.5g, 2.5g first, or follow the doctor's advice.Each 4～6 of capsule (0.25g/ grain), four times on the one, first dose 10, or follow the doctor's advice.
The key property of medicine constituent of the present invention is as follows:
The fragrant Herba Ainsliaeae Glabrae of Fructus Pruni: bitter in the mouth, suffering, property is flat.Cure mainly: be used for upper respiratory tract infection, lung abscess, hemoptysis of pulmonary tuberculosis, jaundice, infantile malnutrition, dyspepsia, mastitis; Otitis media is controlled in external, venom.
The Radix Angelicae Dahuricae: acrid in the mouth; Warm in nature.Gui Jing: return lung meridian; Spleen channel; The stomach warp.Cure mainly: wind-damp dispelling, the evacuation of pus of invigorating blood circulation, granulation promoting pain relieving.Be used for headache, toothache, nasal sinusitis, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus.
Herba Andrographis: nature and flavor: bitter in the mouth, cold in nature.Gui Jing: GUIXIN warp, lung meridian, large intestine channel, urinary bladder channel.Cure mainly: cold, fever, laryngopharynx swelling and pain, aphtha of the mouth and tongue, pertussis chronic cough, dysentery, the puckery pain of pyretic stranguria, carbuncle skin infection, acute bacillary dysentery, gastroenteritis, flu, epidemic encephalitis, tracheitis, pneumonia, pertussis, pulmonary tuberculosis, lung abscess, cholecystitis, hypertension, epistaxis, burn due to hot liquid or fire, venom.
Rhizoma Paridis: cold nature, bitter in the mouth; Slightly poisonous.Gui Jing: return Liver Channel.Cure mainly: be used for the furuncle carbuncle, laryngopharynx swelling and pain, venom falls and pounces on the pain of injury, convulsion with spasms.
Cirsii japonici,radix: sweet in the mouth; Little hardship; Cool in nature.Gui Jing: GUIXIN warp; Liver Channel.Cure mainly: spit blood; Spitting of blood; Epistaxis; Have blood in stool; Hematuria; Woman uterine bleeding; Traumatic hemorrhage; Skin infection swells and ache; Scrofula; Eczema; Hepatitis; Nephritis.
Herba Lobeliae Chinensis: sweet in the mouth; Property is put down.Gui Jing: GUIXIN warp; Lung meridian; Small intestine meridian.Cure mainly: venom; The carbuncle furuncle; Tonsillitis; Warm rash; Tinea pedis; Traumatic injury; Jaundice due to damp-heat; Appendicitis; The intestinal inflammation; Nephritis; Cirrhotic ascites and multiple cancer.
Pharmacology analysis: through pharmacological testing, show that the present invention has slight excitation to nervus centralis, has weak inhibitory action to cardiac muscle, heavy dose has pressure reduction effect, weak peripheral vessel diastole effect and slight diuresis are arranged, simultaneously smooth muscle is had the atropine-like effect.After the Qimen antidote for snake bites is mixed one hour with snake venom, find the snake venom perform toxic attenuation.
Good effect of the present invention is, and is evident in efficacy through clinical use for many years, has no adverse reaction, conveniently take and store, and cheap snakebite first aid and medicine.Be used for the treatment of various venoms, can reach heat-clearing and toxic substances removing, hemostasis, detumescence, pain relieving.
The specific embodiment
The preparation of embodiment 1, a kind of snakebite first aid medicine
A kind of preparation of snakebite first aid medicine comprises following method step:
Get Radix campsis flower root 15g; The fragrant Herba Ainsliaeae Glabrae 15g of Fructus Pruni; Radix Angelicae Dahuricae 9g; Herba Andrographis 15g; Rhizoma Paridis 3g; Cirsii japonici,radix 15g; Herba Lobeliae Chinensis 21g part.
1) get above-mentioned Radix campsis flower root, Rhizoma Paridis, Radix Angelicae Dahuricae pulverizing, mixing gets fine powder, and fine powder is crossed 80 mesh sieves.
2) get the fragrant Herba Ainsliaeae Glabrae of above-mentioned cirsii japonici,radix, Fructus Pruni, Herba Andrographis, Herba Lobeliae Chinensis and add the 600g decocting and boil 2h, filter, get decocting liquid and medicinal residues; The water that with described medicinal residues with the mass ratio is 1:7 again continues to decoct 2h, filters, and gets secondary decocting liquid and medicinal residues; Merge decocting liquid and secondary decocting liquid and get filtrate, again filtrate is concentrated into the clear paste shape.
3) in clear paste shape filtrate, add the fine powder that step 1) makes, mixing;
4) crushed after being dried becomes fine powder, 80 ℃ of baking temperatures.
For making things convenient for drug use and preservation, fine powder incapsulates in the described step 4), and capsule is packed with bottle seal.
The preparation of embodiment 2, a kind of snakebite first aid medicine
A kind of preparation of snakebite first aid medicine comprises following method step:
Get Radix campsis flower root 36g; The fragrant Herba Ainsliaeae Glabrae 36g of Fructus Pruni; Radix Angelicae Dahuricae 15g; Herba Andrographis 30g; Rhizoma Paridis 12g; Cirsii japonici,radix 30g; Herba Lobeliae Chinensis 36g.
1) get above-mentioned Radix campsis flower root, Rhizoma Paridis, Radix Angelicae Dahuricae pulverizing, mixing gets fine powder; Fine powder is crossed 80 mesh sieves.
2) getting the fragrant Herba Ainsliaeae Glabrae of above-mentioned cirsii japonici,radix, Fructus Pruni, Herba Andrographis, Herba Lobeliae Chinensis, to add mass ratio be that the decocting of 1500g boils 2h, filters, and gets decocting liquid and medicinal residues; The water that with described medicinal residues with the mass ratio is 1:9 again continues to decoct 2h, filters, and gets secondary decocting liquid and medicinal residues; Merge decocting liquid and secondary decocting liquid and get filtrate; Again filtrate is concentrated into the clear paste shape.
3) in clear paste shape filtrate, add the fine powder that step 1) makes, mixing;
4) crushed after being dried becomes fine powder; 70 ℃ of baking temperatures.
For making things convenient for drug use and preservation, fine powder incapsulates in the described step 4), and capsule is packed with bottle seal.
The preparation of embodiment 3, a kind of snakebite first aid medicine
A kind of preparation of snakebite first aid medicine comprises following method step:
Get Radix campsis flower root 18g; The fragrant Herba Ainsliaeae Glabrae 15g of Fructus Pruni; Radix Angelicae Dahuricae 15g; Herba Andrographis 30g; Rhizoma Paridis 12g; Cirsii japonici,radix 30g; Herba Lobeliae Chinensis 21g.
1) get above-mentioned Radix campsis flower root, Rhizoma Paridis, Radix Angelicae Dahuricae pulverizing, mixing gets fine powder; Fine powder is crossed 80 mesh sieves.
2) getting the fragrant Herba Ainsliaeae Glabrae of above-mentioned cirsii japonici,radix, Fructus Pruni, Herba Andrographis, Herba Lobeliae Chinensis, to add mass ratio be that the decocting of 1000g boils 2h, filters, and gets decocting liquid and medicinal residues; The water that with described medicinal residues with the mass ratio is 1:8 again continues to decoct 2h, filters, and gets secondary decocting liquid and medicinal residues; Merge decocting liquid and secondary decocting liquid and get filtrate; Again filtrate is concentrated into the clear paste shape.
3) in clear paste shape filtrate, add the fine powder that step 1) makes, mixing;
4) crushed after being dried becomes fine powder; 65 ℃ of baking temperatures.
For making things convenient for drug use and preservation, fine powder incapsulates in the described step 4), and capsule is packed with bottle seal.
Clinical implementation example 1
The king * *, woman, 45 years old, the Shangrao City people of Jiangxi Province.The patient when on August 25th, 2005 open-air work accidentally by by the right foot of agkistrodon acutus bite 6 hours, companion's oral hemorrhage, wound oozing of blood.Shock was admitted to hospital in ten hours.When being admitted to hospital, the mind stupor, green around the gills, pulse touches unclear, extreme cold of the limbs, blood pressure does not detect, and whole skin has the lamellar petechia, and purpura is big as Semen Glycines, and is little of needle point, based on breast, abdomen, back, the nasal mucosa oozing of blood, the gingiva oozing of blood is more than.Right lower extremity is swelling to thigh, local pain is obvious.Chemical examination: hematochrome 10.5g, erythrocyte 4,900,000, leukocyte 14500, neutrality 86%, lymph 14%, urine examination albumen+, heart rate 120～130 times/minute.
After being admitted to hospital, namely use Qimen Serpentis pin 40ml, per six hours once, and 5% sodium bicarbonate 200ml, and vein injects.And grind outer smearing with the Qimen antivenom tablet.After waking up, use the snakebite first aid medicine of the embodiment of the invention 1 immediately, day clothes 4 times, each 6,10 first.Hinder limb after 12 days and swell and ache and obviously disappear, the recovery from illness in 18 days of being in hospital is left hospital.Clinical diagnosis: agkistrodon acutus bite poisoning (critical type).
Clinical implementation example 2
Open * *, the woman, 39 years old, the patient in JIUYUE in 2009 afternoon on the 17th because of the Trimeresurus stejnegeri left hand back of the body that bites, the severe pain distending pain was admitted to hospital in 26 hours.Check that there are two pieces of dental impressions in the left hand back of the body outside, height swelling, skin is the aubergine ecchymosis, inboard skin of soft tissue has a lamellar hemorrhage, left axillary gland enlargement, tenderness.Chemical examination: erythrocyte 6,270,000, leukocyte 21800, neutrality 92%, lymph 8%.After being admitted to hospital, inject Qimen antidote for snake bites pin 60ml and 5% sodium bicarbonate 200ml immediately, per six hours of intravenous drip once.Oral embodiments of the invention 2 snakebite first aid medicines, day clothes 4 times, each 5,10 first.The recovery from illness in 7 days of being in hospital is left hospital.Clinical diagnosis: Trimeresurus stejnegeri bite (critical type).
Claims (5)
1. snakebite first aid medicine is made by following method step:
Get 5～12 parts of Radix campsis flower roots; 5～12 parts of the fragrant Herba Ainsliaeae Glabrae of Fructus Pruni; 3～5 parts of the Radixs Angelicae Dahuricae; 5～10 parts of Herba Andrographis; 1～4 part of Rhizoma Paridis; 5～10 parts of cirsii japonici,radixs; 7～12 parts of Herba Lobeliae Chinensis;
1) get above-mentioned Radix campsis flower root, Rhizoma Paridis, Radix Angelicae Dahuricae pulverizing, mixing gets fine powder;
2) get the fragrant Herba Ainsliaeae Glabrae of above-mentioned cirsii japonici,radix, Fructus Pruni, Herba Andrographis, Herba Lobeliae Chinensis and decoct with water, filter medicinal residues and get filtrate, again filtrate is concentrated into the clear paste shape;
3) in clear paste shape filtrate, add the fine powder that step 1) makes, mixing;
4) crushed after being dried becomes fine powder.
2. snakebite first aid medicine as claimed in claim 1 is characterized in that: Radix campsis flower root, Rhizoma Paridis, Radix Angelicae Dahuricae fine powder are crossed 80 mesh sieves in the described step 1).
3. snakebite first aid medicine as claimed in claim 1 is characterized in that: described step 2) cirsii japonici,radix, the fragrant Herba Ainsliaeae Glabrae of Fructus Pruni, Herba Andrographis, Herba Lobeliae Chinensis to add mass ratio be that the decocting of 1:9～1:11 boils 2h, filter, get decocting liquid and medicinal residues; The water that with described medicinal residues with the mass ratio is 1:7～1:9 again continues to decoct 2h, filters, and gets secondary decocting liquid and medicinal residues; Merge decocting liquid and secondary decocting liquid and get filtrate.
4. snakebite first aid medicine as claimed in claim 1, it is characterized in that: baking temperature is no more than 80 ℃ in the described step 4).
5. snakebite first aid medicine as claimed in claim 1, it is characterized in that: fine powder incapsulates in the described step 4), and capsule is packed with bottle seal.
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| CN201310228744.4A CN103330810B (en) | 2013-06-08 | 2013-06-08 | Emergency medicine for snake wounds |
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| CN201310228744.4A CN103330810B (en) | 2013-06-08 | 2013-06-08 | Emergency medicine for snake wounds |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105535187A (en) * | 2015-12-25 | 2016-05-04 | 中山诺顿科研技术服务有限公司 | Snake wound medicine and preparation method thereof |
| CN106420856A (en) * | 2016-10-15 | 2017-02-22 | 黄田 | Traditional Chinese medicine for treating psoriasis, and extract thereof |
-
2013
- 2013-06-08 CN CN201310228744.4A patent/CN103330810B/en active Active
Non-Patent Citations (3)
| Title |
|---|
| 张金鼎: "《中医急症方剂手册》", 31 December 1999 * |
| 艾林川: "《毒蛇咬伤奶牛一例的诊治》", 《中国兽医科技》 * |
| 郑海峰: "《竹叶青蛇咬伤右耳廓1例救治体会》", 《蛇志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105535187A (en) * | 2015-12-25 | 2016-05-04 | 中山诺顿科研技术服务有限公司 | Snake wound medicine and preparation method thereof |
| CN106420856A (en) * | 2016-10-15 | 2017-02-22 | 黄田 | Traditional Chinese medicine for treating psoriasis, and extract thereof |
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| CN103330810B (en) | 2014-12-10 |
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