CN108676069A - 免疫原性wt-1肽及其使用方法 - Google Patents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001152—Transcription factors, e.g. SOX or c-MYC
- A61K39/001153—Wilms tumor 1 [WT1]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3520810A3 (en) | 2012-01-13 | 2019-11-06 | Memorial Sloan-Kettering Cancer Center | Immunogenic wt1 peptides and use thereof |
| BR112015013557B1 (pt) | 2012-12-11 | 2021-12-14 | Albert Einstein College Of Medicine | Sistema, método, método para determinar o efeito de um resíduo de aminoácido predeterminado de uma primeira proteína sobre a ligação da primeira proteína a uma segunda proteína e polipeptídeo pd-l1 mutante |
| WO2014093886A1 (en) * | 2012-12-13 | 2014-06-19 | The Trustees Of The University Of Pennsylvania | Wt1 vaccine |
| EP3134114A4 (en) * | 2014-04-24 | 2018-03-14 | Rhode Island Hospital | Aspartate-beta -hydroxylase induces epitope-specific t cell responses in tumors |
| CN108350411B (zh) * | 2015-06-25 | 2021-06-22 | 白川利朗 | 口服肿瘤疫苗 |
| WO2017044678A1 (en) * | 2015-09-10 | 2017-03-16 | Memorial Sloan Kettering Cancer Center | Methods of treating multiple myeloma and plasma cell leukemia by t cell therapy |
| EP3362929B1 (en) | 2015-10-12 | 2020-08-12 | Nantomics, LLC | Viral neoepitopes and uses thereof |
| RS63561B1 (sr) | 2015-11-20 | 2022-10-31 | Memorial Sloan Kettering Cancer Center | Kompozicija za lečenje raka |
| AU2017266905B2 (en) | 2016-05-18 | 2022-12-15 | Albert Einstein College Of Medicine, Inc. | Variant PD-L1 polypeptides, T-cell modulatory multimeric polypeptides, and methods of use thereof |
| CA3019005A1 (en) | 2016-05-18 | 2017-11-23 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| US11897927B2 (en) | 2016-11-30 | 2024-02-13 | Advaxis, Inc. | Immunogenic compositions targeting recurrent cancer mutations and methods of use thereof |
| JP7250677B2 (ja) | 2016-12-22 | 2023-04-03 | キュー バイオファーマ, インコーポレイテッド | T細胞調節多量体ポリペプチド及びその使用方法 |
| US10174122B2 (en) | 2017-01-06 | 2019-01-08 | Eutilex Co., Ltd. | Anti-human 4-1BB antibodies and uses thereof |
| US11851471B2 (en) | 2017-01-09 | 2023-12-26 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| KR102619015B1 (ko) | 2017-03-15 | 2023-12-28 | 큐 바이오파마, 인크. | 면역 반응을 조절하는 방법 |
| CA3074839A1 (en) | 2017-09-07 | 2019-03-14 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptide with conjugation sites and methods of use thereof |
| CA3081710A1 (en) * | 2017-11-08 | 2019-05-16 | Advaxis, Inc. | Immunogenic heteroclitic peptides from cancer-associated proteins and methods of use thereof |
| EP3737689A4 (en) | 2018-01-09 | 2021-12-01 | Cue Biopharma, Inc. | MULTIMER POLYPEPTIDES T-LYMPHOCYTE MODULATORS AND THEIR METHODS OF USE |
| JP2021525549A (ja) * | 2018-05-25 | 2021-09-27 | ザ ウィスター インスティテュート | 腫瘍特異的ネオ抗原およびその使用方法 |
| WO2020132366A2 (en) * | 2018-12-19 | 2020-06-25 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides with conjugation sites and methods of use thereof |
| CN110423723A (zh) * | 2019-07-18 | 2019-11-08 | 南方医科大学南方医院 | 一种外周血b细胞系的构建方法及其应用 |
| CA3162690A1 (en) | 2019-12-31 | 2021-07-08 | Minoru S. H. Ko | Temperature-based transient delivery of nucleic acids and proteins to cells and tissues |
| CA3169949A1 (en) | 2020-05-12 | 2021-11-18 | Cue Biopharma, Inc. | Multimeric t-cell modulatory polypeptides and methods of use thereof |
| JP2023541366A (ja) | 2020-09-09 | 2023-10-02 | キュー バイオファーマ, インコーポレイテッド | 1型真性糖尿病(t1d)を治療するためのmhcクラスii t細胞調節多量体ポリペプチド及びその使用方法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010037395A2 (en) * | 2008-10-01 | 2010-04-08 | Dako Denmark A/S | Mhc multimers in cancer vaccines and immune monitoring |
Family Cites Families (117)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA23766A (en) | 1886-04-06 | Albert M. Todd | Process of, and appartus for treating essential oils to obtain the concrete or crystalline part thereof separate and apart from the liquid portion | |
| CA8748A (en) | 1878-05-04 | George W. Ainsworth | Improvements on clothes dryers | |
| CA59350A (en) | 1898-02-26 | 1898-03-19 | Thomas Henry Simmonds | Brake for velocipede, tricycle, etc. |
| US4722848A (en) | 1982-12-08 | 1988-02-02 | Health Research, Incorporated | Method for immunizing animals with synthetically modified vaccinia virus |
| US5837249A (en) | 1985-04-19 | 1998-11-17 | The Wistar Institute | Method for generating an immunogenic T cell response protective against a virus |
| US5726288A (en) | 1989-11-13 | 1998-03-10 | Massachusetts Institute Of Technology | Localization and characterization of the Wilms' tumor gene |
| US5229115A (en) | 1990-07-26 | 1993-07-20 | Immunex Corporation | Adoptive immunotherapy with interleukin-7 |
| WO1992013878A2 (en) | 1991-02-07 | 1992-08-20 | Board Of Trustees Of The University Of Illinois | Conformationally restricted mimetics of beta turns and beta bulges and peptides containing the same |
| CA2158281A1 (en) | 1993-03-15 | 1994-09-29 | Jay A. Berzofsky | Peptide coated dendritic cells as immunogens |
| WO1995029240A1 (en) | 1994-04-22 | 1995-11-02 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Isolation and characterization of a novel primate t-cell lymphotropic virus and the use of this virus or components thereof in diagnostics assays and vaccines |
| US5622835A (en) | 1994-04-28 | 1997-04-22 | The Wistar Institute Of Anatomy & Biology | WT1 monoclonal antibodies |
| US5643786A (en) | 1995-01-27 | 1997-07-01 | The United States Of America As Represented By The Department Of Health And Human Services | Method for isolating dendritic cells |
| US6156316A (en) | 1995-05-08 | 2000-12-05 | Sloan-Kettering Institute For Cancer Research | Oncogene fusion protein peptide vaccines |
| JPH11171896A (ja) | 1995-09-19 | 1999-06-29 | Kirin Brewery Co Ltd | 新規ペプチド化合物およびその医薬組成物 |
| US5981217A (en) | 1995-12-11 | 1999-11-09 | Mayo Foundation For Medical Education And Research | DNA encoding TGF-β inducible early factor-1 (TIEF-1), a gene expressed by osteoblasts |
| ATE244300T1 (de) | 1996-01-17 | 2003-07-15 | Imp College Innovations Ltd | Immunotherapie mit verwendung von zytotoxischen t lymphozyten (ctl) |
| US5853719A (en) | 1996-04-30 | 1998-12-29 | Duke University | Methods for treating cancers and pathogen infections using antigen-presenting cells loaded with RNA |
| US6207375B1 (en) | 1996-12-11 | 2001-03-27 | Mayo Foundation For Medical Educational & Research | TGF-β inducible early factor-1 (TIEF-1) and a method to detect breast cancer |
| ID27813A (id) | 1998-01-28 | 2001-04-26 | Corixa Corp | Senyawa-senyawa untuk terapi dan diagnosa kanker paru-paru dan metoda untuk penggunaannya |
| CA2337743C (en) | 1998-07-31 | 2015-07-07 | Yoshihiro Oka | Tumor antigen based on products of the tumor suppressor gene wt1 |
| US20030072767A1 (en) | 1998-09-30 | 2003-04-17 | Alexander Gaiger | Compositions and methods for WT1 specific immunotherapy |
| US20030235557A1 (en) | 1998-09-30 | 2003-12-25 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| US7144581B2 (en) | 2000-10-09 | 2006-12-05 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| US7655249B2 (en) | 1998-09-30 | 2010-02-02 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| US7063854B1 (en) * | 1998-09-30 | 2006-06-20 | Corixa Corporation | Composition and methods for WTI specific immunotherapy |
| US7329410B1 (en) | 1998-09-30 | 2008-02-12 | Corixa Corporation | Compositions and method for WT1 specific immunotherapy |
| US7901693B2 (en) | 1998-09-30 | 2011-03-08 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| US20120301492A1 (en) | 1998-09-30 | 2012-11-29 | Corixa Corporation | Compositions and methods for wt1 specific immunotherapy |
| US7115272B1 (en) | 1998-09-30 | 2006-10-03 | Corixa Corporation | Compositions and methods for WT1 specific immunotherapy |
| GB9823897D0 (en) | 1998-11-02 | 1998-12-30 | Imp College Innovations Ltd | Immunotherapeutic methods and molecules |
| EP1144444A3 (en) | 1998-12-22 | 2002-01-02 | Genset | Dnas encoding proteins with signal sequences |
| AU3395900A (en) | 1999-03-12 | 2000-10-04 | Human Genome Sciences, Inc. | Human lung cancer associated gene sequences and polypeptides |
| EP1165144A2 (en) | 1999-03-15 | 2002-01-02 | Introgen Therapeutics, Inc. | Dendritic cells transduced with a wild-type self gene elicit potent antitumor immune responses |
| US6593299B1 (en) * | 1999-04-21 | 2003-07-15 | University Of Florida Research Foundation, Inc. | Compositions and methods for controlling pests |
| WO2001025273A2 (en) | 1999-10-04 | 2001-04-12 | Corixa Corporation | Compositions and methods for wt1 specific immunotherapy |
| AU2001247220A1 (en) * | 2000-02-22 | 2001-09-03 | Corixa Corporation | Compositions and methods for diagnosis and therapy of malignant mesothelioma |
| US20030082194A1 (en) | 2000-02-22 | 2003-05-01 | Alexander Gaiger | Compositions and methods for diagnosis and therapy of malignant mesothelioma |
| US20040002068A1 (en) | 2000-03-01 | 2004-01-01 | Corixa Corporation | Compositions and methods for the detection, diagnosis and therapy of hematological malignancies |
| US6861234B1 (en) | 2000-04-28 | 2005-03-01 | Mannkind Corporation | Method of epitope discovery |
| EP1209226A3 (en) | 2000-11-07 | 2002-06-05 | GSF-Forschungszentrum für Umwelt und Gesundheit GmbH | Maturation of dendritic cells by recombinant heat shock protein 70 (hsp70) |
| CN1281625C (zh) | 2001-03-22 | 2006-10-25 | 株式会社癌免疫研究所 | 经修饰的wt1肽 |
| US8771702B2 (en) | 2001-03-26 | 2014-07-08 | The Trustees Of The University Of Pennsylvania | Non-hemolytic LLO fusion proteins and methods of utilizing same |
| CN1320923C (zh) | 2001-06-29 | 2007-06-13 | 中外制药株式会社 | 含有基于癌抑制基因wt1的产物的癌抗原和阳离子脂质体的癌疫苗 |
| US7553494B2 (en) | 2001-08-24 | 2009-06-30 | Corixa Corporation | WT1 fusion proteins |
| US8735357B2 (en) | 2001-09-28 | 2014-05-27 | International Institute Of Cancer Immunology, Inc. | Method of inducing antigen-specific T cells |
| EP1447092A4 (en) | 2001-09-28 | 2007-07-11 | Haruo Sugiyama | METHODS OF INDUCING ANTIGEN-SPECIFIC T CELLS |
| US20030072761A1 (en) | 2001-10-16 | 2003-04-17 | Lebowitz Jonathan | Methods and compositions for targeting proteins across the blood brain barrier |
| US20030175272A1 (en) | 2002-03-07 | 2003-09-18 | Medcell Biologics, Inc. | Re-activated T-cells for adoptive immunotherapy |
| JP4365784B2 (ja) | 2002-06-12 | 2009-11-18 | 株式会社癌免疫研究所 | Hla−a24拘束性癌抗原ペプチド |
| JP4839209B2 (ja) | 2003-02-06 | 2011-12-21 | アンザ セラピューティクス,インコーポレイテッド | 改変された自由生活微生物、ワクチン組成物、およびそれらの使用方法 |
| US20050008618A1 (en) | 2003-02-27 | 2005-01-13 | Howard Kaufman | Composition for delivering an agent to a target cell and uses thereof |
| US7597894B2 (en) * | 2003-03-05 | 2009-10-06 | Dendreon Corporation | Compositions and methods employing alternative reading frame polypeptides for the treatment of cancer and infectious disease |
| EP2343083B1 (en) | 2003-06-27 | 2014-01-15 | International Institute of Cancer Immunology, Inc. | Method of diagnosing cancer comprising the measurement of WT1-specific CTL precursor cells |
| US20050147621A1 (en) | 2003-10-10 | 2005-07-07 | Higgins Darren E. | Use of bacterial 5' untranslated regions for nucleic acid expression |
| PL2071028T3 (pl) | 2003-11-05 | 2012-06-29 | Int Inst Cancer Immunology Inc | Pochodzący z WT1 peptyd antygenowy wiążący się z HLA-DR |
| EP2478913A1 (en) | 2003-12-01 | 2012-07-25 | Sloan-Kettering Institute For Cancer Research | Synthetic HLA binding peptide analogues and uses thereof |
| DE602004020266D1 (de) | 2003-12-05 | 2009-05-07 | Multimmune Gmbh | Therapeutische und diagnostische anti-hsp 70-antikörper |
| EP1550458A1 (en) | 2003-12-23 | 2005-07-06 | Vectron Therapeutics AG | Synergistic liposomal adjuvants |
| EP1720565A1 (en) | 2004-03-04 | 2006-11-15 | Corixa Corporation | Co-encapsulated wt1 polypeptide and immunostimulant microsphere formulations and methods thereof |
| US20050214268A1 (en) | 2004-03-25 | 2005-09-29 | Cavanagh William A Iii | Methods for treating tumors and cancerous tissues |
| US20050221481A1 (en) | 2004-03-30 | 2005-10-06 | Istituto Superiore Di Sanita' | Amplification of T cells from human cord blood in serum-deprived culture stimulated with stem cell factor, interleukin-7 and interleukin-2 |
| DK2186896T3 (en) | 2004-03-31 | 2015-12-21 | Int Inst Cancer Immunology Inc | Cancer antigen peptides derived from WT1 |
| US9629927B2 (en) | 2005-07-29 | 2017-04-25 | Sloan-Kettering Institute For Cancer Research | Single wall nanotube constructs and uses thereof |
| CA2626238C (en) | 2005-10-17 | 2015-10-06 | Sloan Kettering Institute For Cancer Research | Wt1 hla class ii-binding peptides and compositions and methods comprising same |
| WO2007063903A1 (ja) | 2005-11-30 | 2007-06-07 | International Institute Of Cancer Immunology, Inc. | 新規ペプチド化合物 |
| CN102250211A (zh) | 2006-02-22 | 2011-11-23 | 株式会社癌免疫研究所 | Hla-a*3303限制性wt1肽和包含此肽的药物组合物 |
| ES2387999T3 (es) | 2006-03-29 | 2012-10-05 | International Institute Of Cancer Immunology, Inc. | ARNsi específico de la isoforma WT1 17AA(-) y uso del mismo |
| EP2010209B1 (en) | 2006-04-10 | 2016-06-15 | Sloan Kettering Institute For Cancer Research | Immunogenic wt-1 peptides and methods of use thereof |
| WO2007120603A2 (en) | 2006-04-10 | 2007-10-25 | Sloan Kettering Institute For Cancer Research | Immunogenic bcr-abl peptides and methods of use thereof |
| CA2947292C (en) | 2006-12-27 | 2019-07-23 | Emory University | Compositions and methods for the treatment of infections and tumors |
| SI2341142T1 (sl) | 2006-12-28 | 2015-03-31 | International Institute Of Cancer Immunology, Inc. | HLA-A*1101-omejen WT1 peptid in farmacevtski sestavek, ki ga vsebuje |
| CN101646455A (zh) | 2007-02-07 | 2010-02-10 | 财团法人阪大微生物病研究会 | 用于癌症的治疗剂 |
| MY158219A (en) | 2007-02-27 | 2016-09-15 | Int Inst Cancer Immunology Inc | Method for activation of helper t cell and composition for use in the method |
| UY31101A1 (es) | 2007-05-24 | 2009-01-05 | Glaxosmithkline Biologicals Sa | Composición antigénica liofilizada |
| KR100995340B1 (ko) | 2007-11-19 | 2010-11-19 | 재단법인서울대학교산학협력재단 | 자연 살해 t 세포의 리간드와 항원을 적재한 단핵구 또는미분화 골수성 세포를 포함하는 백신 |
| TWI504407B (zh) | 2007-12-05 | 2015-10-21 | Int Inst Cancer Immunology Inc | 癌疫苗組合物 |
| KR100900837B1 (ko) | 2007-12-07 | 2009-06-04 | (주)두비엘 | 리포펩타이드와 폴리(i:c)를 아쥬반트로 포함하는 강력한백신 조성물 |
| US20110287055A1 (en) | 2008-05-19 | 2011-11-24 | Aduro Biotech | Compositions comprising prfa* mutant listeria and mehtods of use thereof |
| AR076349A1 (es) | 2009-04-23 | 2011-06-01 | Int Inst Cancer Immunology Inc | Peptido auxiliar del antigeno del cancer |
| US20130288236A1 (en) | 2009-11-11 | 2013-10-31 | Quest Diagnostics Investments Incorporated | Wt1 mutations for prognosis of myeloproliferative disorders |
| US20110136141A1 (en) | 2009-12-03 | 2011-06-09 | Abbott Laboratories | Peptide reagents and method for inhibiting autoantibody antigen binding |
| US20110223187A1 (en) | 2010-02-15 | 2011-09-15 | Vafa Shahabi | Live listeria-based vaccines for central nervous system therapy |
| AU2011293522B2 (en) | 2010-08-24 | 2015-03-19 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Interleukin-13 receptor alpha 2 peptide-based brain cancer vaccines |
| MX361299B (es) | 2010-10-05 | 2018-11-30 | Otsuka Pharmaceutical Co Ltd Star | Metodo para activar celulas auxiliares. |
| EP2683377A1 (en) | 2011-03-11 | 2014-01-15 | Gilead Calistoga LLC | Combination therapies for hematologic malignancies |
| CN107238706A (zh) | 2011-06-28 | 2017-10-10 | 株式会社癌免疫研究所 | 肽癌抗原‑特异性t细胞的受体基因 |
| WO2013018778A1 (ja) | 2011-07-29 | 2013-02-07 | 独立行政法人理化学研究所 | ウィルムス腫瘍遺伝子産物またはその断片をコードしている改変型核酸構築物を含んでいる免疫治療用細胞、当該細胞の製造方法、および当該核酸構築物 |
| US9539299B2 (en) | 2011-10-27 | 2017-01-10 | International Institute Of Cancer Immunology, Inc. | Combination therapy with WT1 peptide vaccine and temozolomide |
| JP6218175B2 (ja) | 2011-12-14 | 2017-10-25 | 国立大学法人高知大学 | ヘルパーt細胞誘導性ポリペプチドの改変 |
| EP3520810A3 (en) | 2012-01-13 | 2019-11-06 | Memorial Sloan-Kettering Cancer Center | Immunogenic wt1 peptides and use thereof |
| US10501512B2 (en) | 2012-04-02 | 2019-12-10 | Modernatx, Inc. | Modified polynucleotides |
| RU2018130123A (ru) | 2012-05-03 | 2018-11-07 | Фред Хатчинсон Кансэр Рисёч Сентер | Клетка, экспрессирующая t-клеточный рецептор (tcr), для применения в клеточной иммунотерапии |
| EP2868325B1 (en) | 2012-07-02 | 2017-11-01 | Sumitomo Dainippon Pharma Co., Ltd. | Transdermal cancer antigen peptide preparation |
| EP2911683B1 (en) | 2012-10-23 | 2019-09-25 | Ubivac, LLC | Allogeneic autophagosome-enriched composition for the treatment of disease |
| BR112015013697A2 (pt) | 2012-12-17 | 2017-11-14 | Univ Osaka | método para ativar célula t auxiliar |
| US9695444B2 (en) | 2012-12-26 | 2017-07-04 | BioComo Inc. | Vaccine prepared utilizing human parainfluenza virus type 2 vector |
| PL2945647T3 (pl) | 2013-01-15 | 2021-03-08 | Memorial Sloan Kettering Cancer Center | Immunogenne peptydy wt-1 i sposoby ich zastosowania |
| US10071051B2 (en) | 2013-02-05 | 2018-09-11 | Nitto Denko Corporation | WT1 peptide cancer vaccine composition for transdermal administration |
| RU2697443C2 (ru) | 2013-02-05 | 2019-08-14 | Нитто Денко Корпорейшн | Препарат противораковой вакцины, содержащий пептид wt1, в форме ленты трансдермального введения |
| CN103961307B (zh) | 2013-02-05 | 2019-11-29 | 日东电工株式会社 | 经皮给予用wt1肽癌症疫苗组合物 |
| RU2687026C2 (ru) | 2013-02-05 | 2019-05-06 | Нитто Денко Корпорейшн | Вакцинная композиция против злокачественной опухоли на основе пептида wt1 для мукозального введения |
| EP2956544B1 (en) | 2013-02-14 | 2017-11-01 | Immunocellular Therapeutics Ltd. | Cancer vaccines and vaccination methods |
| US9663563B2 (en) | 2013-03-12 | 2017-05-30 | Sumitomo Dainippon Pharma Co., Ltd. | Aqueous liquid composition |
| BR112015022367B1 (pt) | 2013-03-15 | 2021-06-22 | The Trustees Of The University Of Pennsylvania | Vacina, molécula de ácido nucleico, e, molécula de aminoácido |
| EP3461493A1 (en) | 2013-03-29 | 2019-04-03 | Sumitomo Dainippon Pharma Co., Ltd. | Wt1 antigen peptide conjugate vaccine |
| SG11201508521SA (en) | 2013-04-25 | 2015-11-27 | Vaximm Ag | Salmonella-based vectors for cancer immunotherapy targeting wilms' tumor gene wt1 |
| ES2954899T3 (es) | 2013-05-13 | 2023-11-27 | Int Inst Cancer Immunology Inc | Procedimiento para predecir el efecto clínico de una inmunoterapia |
| US10898555B2 (en) | 2013-07-02 | 2021-01-26 | Japanese Foundation For Cancer Research | Cellular immunity inducing vaccine |
| EP3071594A4 (en) | 2013-11-22 | 2017-05-03 | The Board of Trustees of the University of Illionis | Engineered high-affinity human t cell receptors |
| HUE045567T2 (hu) | 2013-12-18 | 2020-01-28 | Vaximm Gmbh | MSLN-t célzó DNS vakcina rák immunterápiához |
| CA2935375C (en) | 2014-01-06 | 2023-08-08 | The Trustees Of The University Of Pennsylvania | Pd1 and pdl1 antibodies and vaccine combinations and use of same for immunotherapy |
| MX375123B (es) | 2014-02-14 | 2025-03-06 | Immune Design Corp | Composición para usarse en mejorar la respuesta inmune contra el cáncer. |
| EP3112378B1 (en) | 2014-02-26 | 2020-06-24 | Tella, Inc. | Wt1 antigenic polypeptide, and anti-tumor agent containing said polypeptide |
| US10023841B2 (en) | 2014-05-23 | 2018-07-17 | Baylor Research Institute | Methods and compositions for treating breast cancer with dendritic cell vaccines |
| CN108064163B (zh) | 2014-12-11 | 2022-06-10 | 株式会社癌免疫研究所 | 血管生成性疾病的免疫疗法 |
| CN108350411B (zh) | 2015-06-25 | 2021-06-22 | 白川利朗 | 口服肿瘤疫苗 |
| US20190054112A1 (en) | 2015-09-18 | 2019-02-21 | Moderna Therapeutics, Inc. | Polynucleotide formulations for use in the treatment of renal diseases |
-
2013
- 2013-01-14 EP EP18215878.2A patent/EP3520810A3/en not_active Withdrawn
- 2013-01-14 CN CN201380014022.7A patent/CN104684577B/zh active Active
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-
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- 2017-05-30 US US15/608,964 patent/US10100087B2/en active Active
-
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- 2018-01-24 JP JP2018009786A patent/JP6995645B2/ja active Active
- 2018-02-20 AU AU2018201210A patent/AU2018201210B2/en active Active
- 2018-09-07 US US16/125,213 patent/US10815274B2/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010037395A2 (en) * | 2008-10-01 | 2010-04-08 | Dako Denmark A/S | Mhc multimers in cancer vaccines and immune monitoring |
Non-Patent Citations (3)
| Title |
|---|
| E. DOUBROVINA等: "Dose-Dependent and Epitope-Specific in Vivo Irradication of the Human Ovarian Carcinoma Cells Expressing the Willms Tumor Protein, WT1, in NOD/SCID Mice, by WT1 Specific T Cells Monitored by Bioluminescent Imaging", 《BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION》 * |
| GENBANK: "Human Wilms tumor WT1 mRNA for zinc finger protein,Krueppel-like", 《GENBANK: X51630.1》 * |
| M. GESSLER等: "The genomic organization and expression of the WT1 gene", 《GENOMICS》 * |
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| EP2802347B1 (en) | 2019-01-09 |
| EP3520810A2 (en) | 2019-08-07 |
| EP2802347A4 (en) | 2016-06-01 |
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