CN108671125A - A kind of Chinese medicine prescription for treating adenomyosis - Google Patents

A kind of Chinese medicine prescription for treating adenomyosis Download PDF

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CN108671125A
CN108671125A CN201810866779.3A CN201810866779A CN108671125A CN 108671125 A CN108671125 A CN 108671125A CN 201810866779 A CN201810866779 A CN 201810866779A CN 108671125 A CN108671125 A CN 108671125A
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chinese medicine
minutes
blood
radix
adenomyosis
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师伟
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/286—Carthamus (distaff thistle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • A61K36/296—Epimedium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/344—Codonopsis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/533—Leonurus (motherwort)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/67—Piperaceae (Pepper family), e.g. Jamaican pepper or kava
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps

Abstract

The invention discloses a kind of Chinese medicine prescriptions for treating adenomyosis, it is characterised in that：It takes the raw material of following weight proportions to be prepared, is parts by weight：Radix Astragali 5 13, cassia twig 6 33, safflower 28, Paris polyphylla 6 33, dragon's blood 10 20, the seed of cowherb 15 45, Radix Notoginseng 15 35, tonkin pepper herb 8 16, Radix Codonopsis 6 33, Semen Leonuri 10 20, HERBA EPIMEDII 6 33.Chinese medicine prescription of the present invention has good adenomyosis effect, can be used for treating adenomyosis, and menostaxis for alleviation, measures more, drop bleeding before and after menstruation, the symptoms such as dysmenorrhoea.

Description

A kind of Chinese medicine prescription for treating adenomyosis
Technical field
The invention discloses a kind of Chinese medicine prescriptions for treating adenomyosis, and uterine gland is treated more particularly, to a kind of The Chinese medicine prescription of myopathy, the invention belongs to traditional Chinese medicine fields.
Background technology
Adenomyosis is endometrial gland and interstitial intrusion mesometrium formation is diffused or the lesion of limitation, with son Endometriosis is the same, belongs to common gynecological disease and difficult disease.Adenomyosis mostly occur in 30~50 years old or so through production Woman, but also seen in the women that youth is not given birth to, this may perform the operation to increase with various uteroventral operations certain relationship.About 15% Patient merges endometriosis, and about 50% merges fibroid.
The cause of disease：Adenomyosis unknown etiology as yet.Current common recognition is because uterus lacks submucosa, therefore uterus The basal layer cell hyperplasia of inner membrance, invasion arrive mesometrium, and accompany by the muscle layer compensatory cellular hyperplasia of surrounding and formed Lesion.Chinese medicine thinks that this disease is burnt by the stagnation of the circulation of vital energy, cold solidifying, heat, the deficiency of vital energy, kidney deficiency cause stagnation of blood stasis punching to be appointed, uterus, and blockage of menstruation is then Dysmenorrhoea.Stagnation of blood stasis punching is appointed, uterus is main pathogenesis.Uterus adenomyosis clinical manifestation adenomyosis mostly occurs in 40 years old in the past Above multipara, but be in recent years gradual rejuvenation trend, this may increase with intrauterine surgicals such as Cesarean esction, induced abortion has It closes.
1. symptom：（1）Menstrual disorder（40%~50%）It is mainly shown as that menostaxis, hyper-menorrhea, some patientss are also It is likely to occur drop bleeding before and after menstruation, serious patient can lead to anaemia.（2）Dysmenorrhoea（25%）Feature is secondary progress Property aggravate dysmenorrhoea.Often start to occur in menstrual onset the last week, alleviate when menstrual period terminate dysmenorrhoea.Dysmenorrhoea initial stage takes analgesic Drug can be alleviated, but with disease progression, and dysmenorrhoea needs the analgesic drug product dosage taken to obviously increase, keeps patient resistance to By.（3）Other about 35% patient's non-evident symptons.2. sign：Gynecologial examination uterus often uniformly increases spherical in shape, uterus Adenomyoma can behave as the hard tubercle of matter.Uterus is usually no more than pregnant 12 weeks sizes.Menstrual period are closed on, uterus has tenderness to feel；Menstrual period, Uterus increases, and quality softens, and tenderness becomes apparent from than usual；After menstrual period, uterus reduces.Uterus is often especially subsequent straight with surrounding Intestinal adhesion and activity it is poor.15%~40% merges endometriosis, about half patient merges fibroid.
In the patent of existing treatment adenomyosis, 104997882 A of application publication number CN（Application number 201510512055.5）Chinese patent literature disclose it is a kind of for treating the Chinese medicine of adenomyosis, which is characterized in that it It is to be prepared by the raw medicinal material of following weight proportion：15 parts of hairy raspberry herb, 9 parts of Japanese anemone root, 9 parts of Jehol Ligusticum Rhizome, sieve of chopping off the tongues 9 parts, 10 parts of Aralia continentalis.Kitagawa, 15 parts of lopseed, 10 parts of the root of Chinese clematis, 10 parts of peach kernel.104857432 A of application publication number CN （Application number 201510245491.0）Chinese patent literature disclose a kind of Chinese medicine composition for treating adenomyosis, it is special Sign is, is made of the Chinese medicine material of following weight：5 ~ 15 parts of the tuber of pinellia, 5 ~ 15 parts of dried orange peel, Poria cocos 10 ~ 17 Part, 10 ~ 17 parts of rhizoma cyperi, 5 ~ 15 parts of Rhizoma Chuanxiong, 10 ~ 17 parts of curcuma zedoary, 10 ~ 17 parts of rhizoma atractylodis, 10 ~ 17 parts of root of Aucklandia lappa Decne, Radix Glycyrrhizae 5 ~ 15 parts, 20 ~ 28 parts of Radix Salviae Miltiorrhizae, 15 ~ 25 parts of Radix Angelicae Sinensis.
It can be seen that Chinese medicine plays a very important role in terms of adenomyosis, but do not have also in existing patent There is the Chinese medicine prescription dedicated for adenomyosis.
Invention content
The purpose of the present invention is overcoming the shortcomings of traditional treatment adenomyosis, provide it is a kind of to control based on blood, promoting blood circulation, only The medicament composing prescription of blood.
The above-mentioned purpose of the present invention is achieved through the following technical solutions：
A kind of Chinese medicine prescription for treating adenomyosis, takes the primary raw material of following weight proportions to be prepared, attaches most importance to Measure part：Radix Astragali 5-13, cassia twig 6-33, safflower 2-8, Paris polyphylla 6-33, dragon's blood 10-20, seed of cowherb 15-45, Radix Notoginseng 15-35, ten Eight disease 8-16, Radix Codonopsis 6-33, Semen Leonuri 10-20, HERBA EPIMEDII 6-33.
A kind of Chinese medicine prescription for treating adenomyosis, preferred scheme take the primary raw material of following weight proportions It is prepared, is parts by weight：Radix Astragali 8-10, cassia twig 10-25, safflower 3-7, Paris polyphylla 10-25, dragon's blood 13-18, the seed of cowherb 20-40, Radix Notoginseng 20-30, tonkin pepper herb 10-14, Radix Codonopsis 10-25, Semen Leonuri 13-18, HERBA EPIMEDII 10-25.
A kind of Chinese medicine prescription for treating adenomyosis, more preferably preferred scheme take the main of following weight proportions Raw material is prepared, and is parts by weight：Radix Astragali 9, cassia twig 20, safflower 5, Paris polyphylla 20, dragon's blood 15, the seed of cowherb 30, Radix Notoginseng 23, ten Eight diseases 12, Radix Codonopsis 20, Semen Leonuri 15, HERBA EPIMEDII 20.
Another object of the present invention is just to provide the preparation method of the Chinese medicine prescription of above-mentioned treatment adenomyosis.
A kind of preparation method of Chinese medicine prescription that treating adenomyosis, steps are as follows：
1）Cassia twig, Paris polyphylla, dragon's blood, Radix Notoginseng, Radix Codonopsis, HERBA EPIMEDII are impregnated 40-80 minutes with 30-40 DEG C of warm water, filtering is cut into Filament is placed on tinfoil, is baked 2-6 minutes, is dried in the air cool, is opened tinfoil, is mixed thoroughly with yellow rice wine, is baked 1-5 minutes again for use；
2）It takes dry pot to heat, is put into edible oil, when dry pot surrounding plays cigarette, be put into step 1 rapidly）Gained bulk pharmaceutical chemicals, frying are crisp It is crisp, it is ground into smalls, it is for use to cross 80-120 mesh sieve；
3）Radix Astragali, safflower, the seed of cowherb, tonkin pepper herb, Semen Leonuri are put into marmite, added water to cook twice, for the first time plus Radix Astragali, The clear water of safflower, the seed of cowherb, tonkin pepper herb, 3-5 times of Semen Leonuri weight decocts 40-60 minutes（It is preferred that 50 minutes）, filter, obtain Filtrate 1, filter residue add water, the dosage of water to be 2-4 times of filter residue dosage again, decoct 10-25 minutes, and filtering obtains filtrate 2, will filter Liquid 1 merges to obtain mixed liquor with filtrate 2, and mixed liquor is stood 10-14 hours, takes supernatant for use；
4）By step 2）Gained smalls is placed in step 3）In gained supernatant, bee is put into after 3-8 minutes are decocted while stirring Honey and dextrin, stir into thick liquid, dry, and bottle after cooling to obtain the final product.
The preparation method of the Chinese medicine prescription of above-mentioned treatment adenomyosis, step 1）By cassia twig, Paris polyphylla, dragon's blood, three Seven, Radix Codonopsis, HERBA EPIMEDII are impregnated 50-70 minutes with 33-38 DEG C of warm water（Preferably, by cassia twig, Paris polyphylla, dragon's blood, Radix Notoginseng, Radix Codonopsis, HERBA EPIMEDII is impregnated 60 minutes with 35 DEG C of warm water）.
The preparation method of the Chinese medicine prescription of above-mentioned treatment adenomyosis, step 1）The dosage of yellow rice wine is cassia twig, again Building, dragon's blood, Radix Notoginseng, 2-6 times of Radix Codonopsis, HERBA EPIMEDII weight（Preferably, the dosage of yellow rice wine is cassia twig, Paris polyphylla, dragon's blood, Radix Notoginseng, party 3-5 times of ginseng, HERBA EPIMEDII weight, more preferred, the dosage of yellow rice wine is cassia twig, Paris polyphylla, dragon's blood, Radix Notoginseng, Radix Codonopsis, HERBA EPIMEDII weight 4 times of amount）.
The preparation method of the Chinese medicine prescription of above-mentioned treatment adenomyosis, step 3）Add Radix Astragali, safflower, king for the first time The clear water of row, tonkin pepper herb, 3.5-4.5 times of Semen Leonuri weight is not stayed（Preferably, add Radix Astragali, safflower, the seed of cowherb, ten for the first time Eight diseases, 4 times of Semen Leonuri weight clear water）.
The preparation method of the Chinese medicine prescription of above-mentioned treatment adenomyosis, step 3）The dosage of water is filter residue dosage 2.5-3.5 again, decocting 15-20 minutes（Preferably, the dosage of water is 3 times of filter residue dosage, is decocted 18 minutes）.
The preparation method of the Chinese medicine prescription of above-mentioned treatment adenomyosis, step 3）Filtrate 1 is merged with filtrate 2 Mixed liquor is stood 11-13 hours by mixed liquor（Preferably, filtrate 1 is merged into obtain mixed liquor with filtrate 2, mixed liquor is stood 12 Hour）.
The pharmacological effect of each bulk pharmaceutical chemicals is respectively：
Cassia twig：Cold, fever with chilliness etc. can be treated.Acrid, sweet, warm enter lung, the heart, bladder warp.Cassia twig effect sweating expelling pathogenic factors from muscles and skin, Warming meridian, helps yang transforming qi.
Paris polyphylla：It is bitter in taste, it is slightly cold；It is slightly poisonous.Channel tropism return liver warp.Paris polyphylla effect is clearing heat and detoxicating, swelling and pain relieving, and cool liver is fixed It is frightened.Cure mainly furunculosis carbuncle swells, abscess of throat, snakebite and bugbite, the pain of injury caused by falling and tumbling, convulsion.
Dragon's blood：It is sweet, salty, it puts down.Channel tropism converge to heart and liver channels.Effect promoting blood circulation analgesic therapy, removing blood stasis and hemostasis, expelling pus and promoting granulation.It cures mainly for son Palace gland myopathy, trusted subordinate's stasis caused pain, traumatic hemorrhage, sore are not held back.
Radix Notoginseng：Sweet, slight bitter, temperature.Channel tropism Return liver, stomach.Effect dissipate stasis of blood hemostasis, detumescence ding-tong.It cures mainly for spitting blood, spits Blood, bleeding from five sense organs or subcutaneous tissue are had blood in stool, uterine bleeding, traumatic hemorrhage, chest and abdomen shouting pain, tumbling and swelling.
Radix Codonopsis：Sweet and neutral.Tonifying middle-Jiao and Qi, clearing heat and detoxicating, expelling phlegm and arresting coughing.For spleen eating less loose stool, weakness of limbs, palpitaition, Shortness of breath, dry, spontaneous perspiration, rectal prolapse, the prolapse of uterus.Root is used for weakness of the spleen and the stomach, qi-blood deficiency, and the tired inability of body, deficiency of food is thirsty, chronic diarrhea, takes off Anus.
HERBA EPIMEDII：HERBA EPIMEDII be called just before, Herba Epimedii, celestial spirit adjoin, Herba Epimedii, thousand liang of gold, dry chicken muscle, coptis ancestral, three Nine leaves etc., HERBA EPIMEDII have the effect of tonifying kidney and strengthening yang, dispelling wind and eliminating dampness, strengthening the muscles and bones, HERBA EPIMEDII to have treatment impotence and seminal emission, void cold not It educates, the effect that frequent micturition incontinence, dyspnea and cough due to deficiency of the kidney, soreness and weakness of waist and knees, arthralgia pain due to rheumatism, hemiplegia, four limbs are meciless.
Radix Astragali：It is warm-natured, it is sweet in flavor.It cures mainly：Invigorating qi for strengthening superficies, pus draining and toxin expelling, diuresis, myogenic.It is de- for treatment deficiency of vital energy weak, chronic diarrhea The long disunion of anus, spontaneous perspiration, oedema, sub-official prolapses, chronic rephrilis protinuria, diabetes, the open sore part.
Safflower：The ground such as main product Henan, Hunan, Sichuan, Xinjiang, Tibet.Invigorate blood circulation, removing blood stasis and analgesics, contribute to controlling through closing, Dysmenorrhoea, lochia, chest impediment and cardialgia, stasis of blood, chest side of body shouting pain, adenomyosis, sore swell and ache curative curative effect.Have it is promoting blood circulation and removing blood stasis, The effect of dissipate wet effect going to swell.
The seed of cowherb：The seed of cowherb, Chinese medicine name.For pinkwort cow-fat Vaccaria segetalis (Neck.) The dry mature seed of Garcke.Summer fruit taps plant when not yet cracking at heat, pericarp, dries, lays seed, removes impurity elimination Matter, then dry.In addition to south China, area in all parts of the country is all distributed.With invigorate blood circulation, lower breast detumescence, the effect of inducing diuresis for treating strangurtia.With In Amenorrhea, dysmenorrhoea, agalactia, acute mastitis swelling and pain, the puckery pain of stranguria.
Tonkin pepper herb：Chinese medicine name.This product is the complete stool of Piperaceae plant optical axis ramie.Whole year can adopt.Major function is：1. wide State army《Common Chinese herbal medicine handbook》：Expelling wind and clearing away cold disappears and examines analgesic.Control rheumatalgia, treating swelling and pain by traumatic injury, stomach cold pain；Poisonous snake, Centipde-bite.②《Yunnan Chinese herbal medicine choosing》：Control dysmenorrhoea, amenorrhoea, cold.
Semen Leonuri：For the dry mature fruit of labiate motherwort Leonurus japonicus Houtt..Autumn Aerial part is tapped when fruit maturation, is dried, fruit is laid, and removes impurity.It is distributed widely in all parts of the country.It is adjusted with promoting blood circulation Through the effect of clearing liver and improving vision.For irregular menstruation, closed dysmenorrhea, cataract, dizzy distending pain.
With prior art ratio, beneficial effects of the present invention are：
For the traditional Chinese medicine blood stasis basic pathogenesis of adenomyosis, this patent group emphasis considers it by blood stasis for because developing to hemostasis Attach most importance to and Jian Zhi Disorder lumps in the abdomen is this, is far apart the peculiar genius morbi of invasion and high relapse rate with malignant tumour, is hindered in conjunction with its passages through which vital energy circulates Every obstructed and notable dysmenorrhoea, new blood must not channel tropism and hyper-menorrhea pathogenic characteristic, propose that the big method for the treatment of of adenomyosis is " logical Mai Xiao Disorder, removing blood stasis and hemostasis method " has been founded using cassia twig, Paris polyphylla, dragon's blood, Radix Notoginseng, Radix Codonopsis, HERBA EPIMEDII as the Chinese prescription of core, has been matched Supplemented by Radix Astragali, safflower, the seed of cowherb, tonkin pepper herb, Semen Leonuri, form Wen Tong and removing summer-heat and use, promoting blood circulation with stop blooding it is mutually simultaneous Characteristic therapy on the basis of passing on adenomyosis syndrome of blood stasis basic pathogenesis there is malignant tumour to be far apart invasion and high relapse rate Genius morbi, breaks through " controlling based on blood " conventional thought under being instructed with blood stasis-hemostasis — Disorder lumps in the abdomen differentiation interpretation of the cause, onset and process of an illness, and proposition " promotes blood circulation and disappears Disorder " is the medicine of leading cassia twig, Paris polyphylla, dragon's blood to prescription, is founded in the AM of " Wen Tong and removing summer-heat and use, promoting blood circulation and hemostasis are mutually simultaneous " Medical treatment new theory.
Specific implementation mode
With reference to embodiment and the experimental example technical solution that the present invention will be described in detail, but protection domain is not limited by this.
A kind of Chinese medicine prescription that treating adenomyosis of embodiment 1, takes the primary raw material of following weight proportions to prepare It forms, is parts by weight：Radix Astragali 5, cassia twig 6, safflower 2, Paris polyphylla 6, dragon's blood 10, the seed of cowherb 15, Radix Notoginseng 15, tonkin pepper herb 8, Radix Codonopsis 6, Semen Leonuri 10, HERBA EPIMEDII 6.
The preparation method of the Chinese medicine prescription of above-mentioned treatment adenomyosis, steps are as follows：
1）Cassia twig, Paris polyphylla, dragon's blood, Radix Notoginseng, Radix Codonopsis, HERBA EPIMEDII to be impregnated 40 minutes with 30 DEG C of warm water, filament is cut into filtering, It is placed on tinfoil, bakes 2 minutes, dry in the air cool, open tinfoil, mixed thoroughly with yellow rice wine, the dosage of yellow rice wine is cassia twig, Paris polyphylla, dragon's blood, three Seven, Radix Codonopsis, 2 times of HERBA EPIMEDII weight, be baked again 1 minute it is for use；
2）It takes dry pot to heat, is put into edible oil, when dry pot surrounding plays cigarette, be put into step 1 rapidly）Gained bulk pharmaceutical chemicals, frying are crisp It is crisp, it is ground into smalls, it is for use to cross 80 mesh sieve；
3）Radix Astragali, safflower, the seed of cowherb, tonkin pepper herb, Semen Leonuri are put into marmite, added water to cook twice, for the first time plus Radix Astragali, The clear water of safflower, the seed of cowherb, tonkin pepper herb, 3 times of Semen Leonuri weight decocts 40 minutes, and filtering obtains filtrate 1, filter residue adds again Water, the dosage of water are 2 times of filter residue dosage, are decocted 10 minutes, and filtering obtains filtrate 2, and filtrate 1 is merged to obtain to mixing with filtrate 2 Mixed liquor is stood 10 hours, takes supernatant for use by liquid；
4）By step 2）Gained smalls is placed in step 3）In gained supernatant, honey is put into after 3 minutes are decocted while stirring And dextrin, it stirs into thick liquid, dries, bottle after cooling to obtain the final product.
Model case one：Ten thousand XX, female, 30 years old, Jinan City, Shandong Province personage produced a boy baby at 27 years old, is producing Complete later first time menstruation starts, and unbearably, menstrual flow is big for lower abdominal distention pain, also carries clot, the old man of family says, has given birth to child It is normal greatly through amount, continue for like this more than 2 years, when in the period, pain unbearably, goes to hospital to check and be diagnosed as son really Palace gland myopathy suggests treating using the Chinese medicine prescription in the embodiment of the present invention 1 through doctor.
Using 1 gained Chinese medicine prescription of embodiment, using Chinese medicine prescription of the present invention, every morning, noon, evening Half an hour after the meal, take 10g of the present invention, warm boiled water, using after two weeks, in the period, pain relief for the first time, and use one A month, pain disappeared.
Embodiment 2：A kind of Chinese medicine prescription for treating adenomyosis, takes the primary raw material of following weight proportions to prepare It forms, is parts by weight：Radix Astragali 8, cassia twig 10, safflower 3, Paris polyphylla 10, dragon's blood 13, the seed of cowherb 20, Radix Notoginseng 20, tonkin pepper herb 10, Radix Codonopsis 10, Semen Leonuri 13, HERBA EPIMEDII 10.
A kind of preparation method of Chinese medicine prescription that treating adenomyosis, steps are as follows：
1）Cassia twig, Paris polyphylla, dragon's blood, Radix Notoginseng, Radix Codonopsis, HERBA EPIMEDII to be impregnated 50 minutes with 33 DEG C of warm water, filament is cut into filtering, It is placed on tinfoil, bakes 3 minutes, dry in the air cool, open tinfoil, mixed thoroughly with yellow rice wine, the dosage of yellow rice wine is cassia twig, Paris polyphylla, dragon's blood, three Seven, Radix Codonopsis, 3 times of HERBA EPIMEDII weight, be baked again 2 minutes it is for use；
2）It takes dry pot to heat, is put into edible oil, when dry pot surrounding plays cigarette, be put into step 1 rapidly）Gained bulk pharmaceutical chemicals, frying are crisp It is crisp, it is ground into smalls, it is for use to cross 90 mesh sieve；
3）Radix Astragali, safflower, the seed of cowherb, tonkin pepper herb, Semen Leonuri are put into marmite, added water to cook twice, for the first time plus Radix Astragali, The clear water of safflower, the seed of cowherb, tonkin pepper herb, 3.5 times of Semen Leonuri weight decocts 45 minutes, and filtering obtains filtrate 1, filter residue adds again Water, the dosage of water are 2.5 times of filter residue dosage, are decocted 15 minutes, and filtering obtains filtrate 2, and filtrate 1 is merged to obtain to mixing with filtrate 2 Mixed liquor is stood 11 hours, takes supernatant for use by liquid；
4）By step 2）Gained smalls is placed in step 3）In gained supernatant, is decocted while stirring and be put into honey after five minutes And dextrin, it stirs into thick liquid, dries, bottle after cooling to obtain the final product.
Embodiment 3：A kind of Chinese medicine prescription for treating adenomyosis, it is characterised in that：Take following weight proportions Primary raw material is prepared, and is parts by weight：Radix Astragali 10, cassia twig 25, safflower 7, Paris polyphylla 25, dragon's blood 18, the seed of cowherb 40, Radix Notoginseng 30, tonkin pepper herb 14, Radix Codonopsis 25, Semen Leonuri 18, HERBA EPIMEDII 25.
A kind of preparation method of Chinese medicine prescription that treating adenomyosis, steps are as follows：
1）Cassia twig, Paris polyphylla, dragon's blood, Radix Notoginseng, Radix Codonopsis, HERBA EPIMEDII to be impregnated 70 minutes with 38 DEG C of warm water, filament is cut into filtering, It is placed on tinfoil, bakes 5 minutes, dry in the air cool, open tinfoil, mixed thoroughly with yellow rice wine, the dosage of yellow rice wine is cassia twig, Paris polyphylla, dragon's blood, three Seven, Radix Codonopsis, 4.5 times of HERBA EPIMEDII weight, be baked again 4 minutes it is for use；
2）It takes dry pot to heat, is put into edible oil, when dry pot surrounding plays cigarette, be put into step 1 rapidly）Gained bulk pharmaceutical chemicals, frying are crisp It is crisp, it is ground into smalls, it is for use to cross 110 mesh sieve；
3）Radix Astragali, safflower, the seed of cowherb, tonkin pepper herb, Semen Leonuri are put into marmite, added water to cook twice, for the first time plus Radix Astragali, The clear water of safflower, the seed of cowherb, tonkin pepper herb, 4.5 times of Semen Leonuri weight decocts 55 minutes, and filtering obtains filtrate 1, filter residue adds again Water, the dosage of water are 3.5 times of filter residue dosage, are decocted 20 minutes, and filtering obtains filtrate 2, and filtrate 1 is merged to obtain to mixing with filtrate 2 Mixed liquor is stood 13 hours, takes supernatant for use by liquid；
4）By step 2）Gained smalls is placed in step 3）In gained supernatant, honey is put into after 7 minutes are decocted while stirring And dextrin, it stirs into thick liquid, dries, bottle after cooling to obtain the final product.
Model case two：Lu XX, female, 48 years old, people from Shandong, master stated：In nearly year, menstruation is always irregular one Secondary half a year, just the time that is next primary and coming was also long, had the time of half a month, menstrual flow big fully, also with lower abdominal distention pain. It goes to hospital to check and is diagnosed as adenomyosis, suggest carrying out using the Chinese medicine prescription in the embodiment of the present invention 3 through doctor Treatment.
Using 3 gained Chinese medicine prescription of embodiment, using Chinese medicine prescription of the present invention, every morning, noon, evening Half an hour after the meal, take 10g of the present invention, warm boiled water, using after two weeks, in the period, pain relief for the first time, and use one A month, pain disappeared, menstruation rule.
Embodiment 4：A kind of Chinese medicine prescription for treating adenomyosis, it is characterised in that：Take following weight proportions Primary raw material is prepared, and is parts by weight：Radix Astragali 13, cassia twig 33, safflower 8, Paris polyphylla 33, dragon's blood 20, the seed of cowherb 45, Radix Notoginseng 35, tonkin pepper herb 16, Radix Codonopsis 33, Semen Leonuri 20, HERBA EPIMEDII 33.
A kind of preparation method of Chinese medicine prescription that treating adenomyosis, steps are as follows：
1）Cassia twig, Paris polyphylla, dragon's blood, Radix Notoginseng, Radix Codonopsis, HERBA EPIMEDII to be impregnated 80 minutes with 40 DEG C of warm water, filament is cut into filtering, It is placed on tinfoil, bakes 6 minutes, dry in the air cool, open tinfoil, mixed thoroughly with yellow rice wine, the dosage of yellow rice wine is cassia twig, Paris polyphylla, dragon's blood, three Seven, Radix Codonopsis, 5 times of HERBA EPIMEDII weight, be baked again 5 minutes it is for use；
2）It takes dry pot to heat, is put into edible oil, when dry pot surrounding plays cigarette, be put into step 1 rapidly）Gained bulk pharmaceutical chemicals, frying are crisp It is crisp, it is ground into smalls, it is for use to cross 120 mesh sieve；
3）Radix Astragali, safflower, the seed of cowherb, tonkin pepper herb, Semen Leonuri are put into marmite, added water to cook twice, for the first time plus Radix Astragali, The clear water of safflower, the seed of cowherb, tonkin pepper herb, 5 times of Semen Leonuri weight decocts 60 minutes, and filtering obtains filtrate 1, filter residue adds again Water, the dosage of water are 4 times of filter residue dosage, are decocted 25 minutes, and filtering obtains filtrate 2, and filtrate 1 is merged to obtain to mixing with filtrate 2 Mixed liquor is stood 14 hours, takes supernatant for use by liquid；
4）By step 2）Gained smalls is placed in step 3）In gained supernatant, honey is put into after 8 minutes are decocted while stirring And dextrin, it stirs into thick liquid, dries, bottle after cooling to obtain the final product.
Embodiment 5：A kind of Chinese medicine prescription for treating adenomyosis, it is characterised in that：Take following weight proportions Primary raw material is prepared, and is parts by weight：Radix Astragali 9, cassia twig 20, safflower 5, Paris polyphylla 20, dragon's blood 15, the seed of cowherb 30, Radix Notoginseng 23, tonkin pepper herb 12, Radix Codonopsis 20, Semen Leonuri 15, HERBA EPIMEDII 20.
A kind of preparation method of Chinese medicine prescription that treating adenomyosis, steps are as follows：
1）Cassia twig, Paris polyphylla, dragon's blood, Radix Notoginseng, Radix Codonopsis, HERBA EPIMEDII to be impregnated 60 minutes with 35 DEG C of warm water, filament is cut into filtering, It is placed on tinfoil, bakes 4 minutes, dry in the air cool, open tinfoil, mixed thoroughly with yellow rice wine, the dosage of yellow rice wine is cassia twig, Paris polyphylla, dragon's blood, three Seven, Radix Codonopsis, 4 times of HERBA EPIMEDII weight, be baked again 3 minutes it is for use；
2）It takes dry pot to heat, is put into edible oil, when dry pot surrounding plays cigarette, be put into step 1 rapidly）Gained bulk pharmaceutical chemicals, frying are crisp It is crisp, it is ground into smalls, is sieved with 100 mesh sieve for use；
3）Radix Astragali, safflower, the seed of cowherb, tonkin pepper herb, Semen Leonuri are put into marmite, added water to cook twice, for the first time plus Radix Astragali, The clear water of safflower, the seed of cowherb, tonkin pepper herb, 4 times of Semen Leonuri weight decocts 50 minutes, and filtering obtains filtrate 1, filter residue adds again Water, the dosage of water are 3 times of filter residue dosage, are decocted 18 minutes, and filtering obtains filtrate 2, and filtrate 1 is merged to obtain to mixing with filtrate 2 Mixed liquor is stood 12 hours, takes supernatant for use by liquid；
4）By step 2）Gained smalls is placed in step 3）In gained supernatant, honey is put into after 6 minutes are decocted while stirring And dextrin, it stirs into thick liquid, dries, bottle after cooling to obtain the final product.
Experimental example：1, selection of clinical：In order to verify the effect of Chinese medicine prescription of the present invention, we have extracted 400 trouble Person has carried out the experiment of drug, is equally divided into two groups, experimental group and control group.
2, inclusion criteria：Through make a definite diagnosis have menostaxis, measure more, drop bleeding before and after menstruation, the patient of the symptoms such as dysmenorrhoea, One month sick age to 3 years.
3, therapy：Using Chinese medicine prescription of the present invention, every morning, noon, at night half an hour after the meal, this is taken Invent 10g, warm boiled water, 10 days as a treatment course.
4, curative effect situation criterion：1, effectively：After Chinese medicine prescription, malaise symptoms mitigate or partial disappearance； 2, invalid：After Chinese medicine prescription, malaise symptoms are unchanged.We conducted the experiments of drug（Embodiment 5）, and it is accurate Statistics and mathematical analysis have been carried out to data.
Specific experiment result such as following table：
Table 1：
Table 2：
Group Therapy Case load Self status evaluation of patient
Control Group Traditional treatment uterus The drug of gland myopathy 200 people Body burden is big, costly, and treatment time is long, and therapeutic effect is not fine relatively, has 4 dizziness, drowsiness symptom occur in 200 patients, 50% People thinks to use traditional treatment adenomyosis, and need the partner treatment of doctor, body is big by burden, somewhat expensive, and spirit and human body is all very painful.
Experiment Group Chinese medicine medicine of the present invention Object prescription 200 people 95% people thinks to be treated with the present invention, can quickly and effectively mitigate every pain, the feeling of no discomfort, body is more healthy compared in the past, most important It is that can fundamentally improve body.
Clinical tests prove that using Chinese medicine prescription of the present invention and traditional treatment adenomyosis method the effect of phase Than, convenient to be applicable in, means of prevention is more fully thorough, without side-effects during use, clinical tests prove that, Chinese medicine medicine of the present invention The effective percentage of object prescription is 99%, has good adenomyosis effect, can be used for treating adenomyosis, and alleviation menstrual period prolong Long, more, the drop bleeding before and after menstruation of amount, the symptoms such as dysmenorrhoea.

Claims (9)

1. a kind of Chinese medicine prescription for treating adenomyosis, it is characterised in that：Take the primary raw material system of following weight proportions It is standby to form, it is parts by weight：Radix Astragali 5-13, cassia twig 6-33, safflower 2-8, Paris polyphylla 6-33, dragon's blood 10-20, seed of cowherb 15-45, Radix Notoginseng 15-35, tonkin pepper herb 8-16, Radix Codonopsis 6-33, Semen Leonuri 10-20, HERBA EPIMEDII 6-33.
2. a kind of Chinese medicine prescription for treating adenomyosis, it is characterised in that：Take the primary raw material system of following weight proportions It is standby to form, it is parts by weight：Radix Astragali 8-10, cassia twig 10-25, safflower 3-7, Paris polyphylla 10-25, dragon's blood 13-18, seed of cowherb 20- 40, Radix Notoginseng 20-30, tonkin pepper herb 10-14, Radix Codonopsis 10-25, Semen Leonuri 13-18, HERBA EPIMEDII 10-25.
3. a kind of Chinese medicine prescription for treating adenomyosis, it is characterised in that：Take the primary raw material system of following weight proportions It is standby to form, it is parts by weight：Radix Astragali 9, cassia twig 20, safflower 5, Paris polyphylla 20, dragon's blood 15, the seed of cowherb 30, Radix Notoginseng 23, tonkin pepper herb 12, Radix Codonopsis 20, Semen Leonuri 15, HERBA EPIMEDII 20.
4. the preparation method of the Chinese medicine prescription of the treatment adenomyosis according to claim 1-3, it is characterised in that： Steps are as follows：
1）Cassia twig, Paris polyphylla, dragon's blood, Radix Notoginseng, Radix Codonopsis, HERBA EPIMEDII are impregnated 40-80 minutes with 30-40 DEG C of warm water, filtering is cut into Filament is placed on tinfoil, is baked 2-6 minutes, is dried in the air cool, is opened tinfoil, is mixed thoroughly with yellow rice wine, is baked 1-5 minutes again for use；
2）It takes dry pot to heat, is put into edible oil, when dry pot surrounding plays cigarette, be put into step 1 rapidly）Gained bulk pharmaceutical chemicals, frying are crisp It is crisp, it is ground into smalls, it is for use to cross 80-120 mesh sieve；
3）Radix Astragali, safflower, the seed of cowherb, tonkin pepper herb, Semen Leonuri are put into marmite, added water to cook twice, for the first time plus Radix Astragali, The clear water of safflower, the seed of cowherb, tonkin pepper herb, 3-5 times of Semen Leonuri weight decocts 40-60 minutes（It is preferred that 50 minutes）, filter, obtain Filtrate 1, filter residue add water, the dosage of water to be 2-4 times of filter residue dosage again, decoct 10-25 minutes, and filtering obtains filtrate 2, will filter Liquid 1 merges to obtain mixed liquor with filtrate 2, and mixed liquor is stood 10-14 hours, takes supernatant for use；
4）By step 2）Gained smalls is placed in step 3）In gained supernatant, bee is put into after 3-8 minutes are decocted while stirring Honey and dextrin, stir into thick liquid, dry, and bottle after cooling to obtain the final product.
5. the preparation method of the Chinese medicine prescription of above-mentioned treatment adenomyosis, it is characterised in that：Step 1）By cassia twig, again Building, dragon's blood, Radix Notoginseng, Radix Codonopsis, HERBA EPIMEDII are impregnated 50-70 minutes with 33-38 DEG C of warm water（Preferably, by cassia twig, Paris polyphylla, dragon's blood, Radix Notoginseng, Radix Codonopsis, HERBA EPIMEDII are impregnated 60 minutes with 35 DEG C of warm water）.
6. the preparation method of the Chinese medicine prescription of above-mentioned treatment adenomyosis, it is characterised in that：Step 1）The dosage of yellow rice wine Be cassia twig, Paris polyphylla, dragon's blood, Radix Notoginseng, 2-6 times of Radix Codonopsis, HERBA EPIMEDII weight（Preferably, the dosage of yellow rice wine is cassia twig, Paris polyphylla, blood Exhaust, Radix Notoginseng, 3-5 times of Radix Codonopsis, HERBA EPIMEDII weight, more preferred, the dosage of yellow rice wine is cassia twig, Paris polyphylla, dragon's blood, Radix Notoginseng, party 4 times of ginseng, HERBA EPIMEDII weight）.
7. the preparation method of the Chinese medicine prescription of above-mentioned treatment adenomyosis, it is characterised in that：Step 3）It is for the first time plus yellow The clear water of stilbene, safflower, the seed of cowherb, tonkin pepper herb, 3.5-4.5 times of Semen Leonuri weight（Preferably, add Radix Astragali, safflower, king for the first time The clear water of row, tonkin pepper herb, 4 times of Semen Leonuri weight is not stayed）.
8. the preparation method of the Chinese medicine prescription of above-mentioned treatment adenomyosis, it is characterised in that：Step 3）The dosage of water is 2.5-3.5 times of filter residue dosage decocts 15-20 minutes（Preferably, the dosage of water is 3 times of filter residue dosage, is decocted 18 minutes）.
9. the preparation method of the Chinese medicine prescription of above-mentioned treatment adenomyosis, it is characterised in that：Step 3）By filtrate 1 and filter Liquid 2 merges to obtain mixed liquor, and mixed liquor is stood 11-13 hours（Preferably, filtrate 1 is merged into obtain mixed liquor with filtrate 2, will mixed It closes liquid and stands 12 hours）.
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CN111568989A (en) * 2020-07-09 2020-08-25 山东中医药大学附属医院 Application of cassia twig and rhizoma paridis dragon's blood extract in preparation of medicine for treating adenomyosis

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Publication number Priority date Publication date Assignee Title
CN111568989A (en) * 2020-07-09 2020-08-25 山东中医药大学附属医院 Application of cassia twig and rhizoma paridis dragon's blood extract in preparation of medicine for treating adenomyosis
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