CN108670934B - Medicinal toothpaste and preparation method thereof - Google Patents

Abstract

The invention discloses medicinal toothpaste, which consists of the following raw materials in parts by weight: 2-10 parts of traditional Chinese medicine extract, 10-18 parts of abrasive, 0.5-3 parts of surfactant, 4-7 parts of humectant, 2-6 parts of thickener, 0.5-3 parts of sweetener, 0.5-3 parts of aromatic, 0.5-2 parts of buffering agent, 0.3-0.9 part of foaming agent and 6-10 parts of distilled water; wherein the traditional Chinese medicine extract is a traditional Chinese medicine extract which is composed of at least one extract of lotus plumule, gardenia and lophatherum gracile and mixed extracts of four traditional Chinese medicines of coptis chinensis, bamboo leaves, trichosanthes root and scutellaria baicalensis according to any mass ratio.

Description

Medicinal toothpaste and preparation method thereof

Technical Field

The invention belongs to the technical field of daily chemicals, and particularly relates to medicinal toothpaste and a preparation method thereof.

Background

In daily life, people have various ways of treating mouth and tongue sores, gum swelling and pain, dental ulcer, halitosis, gingival bleeding, spermatorrhea caused by heart-kidney disharmony, vexation, thirst, jaundice due to damp-heat, conjunctival congestion, swelling and pain. The existing technical schemes of medicinal toothpaste and possible product formation on the market are compared and evaluated:

1. yunnan Baiyao toothpaste

4 kinds of Yunnan Baiyao toothpaste with spearmint flavor, mint refreshing flavor, fresh morning dew flavor, and ice lemon mint. It has the functions of bacteriostasis, moth prevention, gum repair and breath freshening. It does not have the functions of preventing and treating mouth and tongue sores, gum swelling and pain, dental ulcer, gum bleeding, cold kidney water, spermatorrhea, etc. The main medicine notoginseng is hepatotoxicity (national food and drug administration, comprehensive knowledge and skill in traditional Chinese medicine, seventh edition, Chinese medicine science and technology publishing agency, 2017, page 240), and the other medicine borneol has reproductive toxicity, so it should be used with caution in gestation (Jiangmen, Tianjin Chinese medicine institute, Tianjin Chinese medicine university, Tianjin Chinese medicine science and medicine university, research on influence of borneol on liver CYP450 and reproductive toxicity in 2005 "); the peppermint contains menthol and peppermint oil has strong paralysis effect on mammals, and the death caused by respiratory paralysis can be caused if the peppermint oil is taken excessively.

2. Yunnan pseudo-ginseng toothpaste

The effective medicine and components of the product are pseudo-ginseng extract, danpi acid, thromboxane and the like, the main effect is hemostasis, and the product is suitable for gingival bleeding, but has no effect on aphtha, oral ulcer, neurasthenia, insomnia, dreaminess, spermatorrhea and the like. The main drug, notoginseng, is hepatotoxic (national food and drug administration, integrated knowledge and skills in traditional Chinese medicine, seventh edition, published by Chinese medicine science and technology, 2017, page 240).

3. Lianmei lotus seed toothpaste

The main effective medicine of the product is radix zanthoxyli and the like 3, which is a traditional Chinese medicine, can prevent toothache related problems caused by excessive internal heat, bleeding, red swelling and the like, quickly relieve pain, and permanently relieve the toothache related problems of gingival bleeding, gingival red swelling, tooth sensitivity and the like, but has no effect on mouth and tongue sores, oral ulcer, neurasthenia, insomnia, dreaminess, spermatorrhea and the like. Shuangmianzhen (materia Medica) notes that the toxicity is small and the abdominal pain and diarrhea are usually caused after the poisoning.

4. Anti-inflammatory tooth-protecting halitosis-preventing toothpaste and preparation method thereof (CN201710591050.5)

The technical scheme meets the use requirements of modern aromatherapy and has certain refreshing effect. However, sub-analysis may find the following disadvantages:

1) the product has antiinflammatory and teeth protecting effects, and is different from the effects of the product in preventing and treating aphtha, gingival swelling and pain, stomatocace, gingival hemorrhage, heart and kidney communication, and nocturnal emission and spermatorrhea.

2) The effective components of the product are traditional Chinese medicines, but the action mechanism of the product is not clarified by the traditional Chinese medicine theory.

Lotus plumule is the young leaf and radicle of mature seed lotus seed of Nelumbo nucifera Gaertn, Nymphaeaceae, and was first loaded in Shennong Ben Cao Jing and in feeding Ben Cao. Lotus plumule has effects of clearing heart fire, calming liver fire, coordinating heart and kidney, and arresting seminal emission and stopping blood. Can be used for preventing and treating aphtha, gingival swelling and pain, oral ulcer, halitosis, spermatorrhea due to imbalance between heart-yang and kidney-yin, and gingival hemorrhage.

Fructus Gardeniae is dried mature fruit of Gardenia jasminoides Ellis of Rubiaceae. Has the effects of purging pathogenic fire, relieving restlessness, clearing away heat, promoting diuresis, cooling blood, and removing toxic substances; it can be used topically for relieving swelling and pain. Can be used for treating febrile vexation, damp-heat jaundice, stranguria with pain, hematemesis, epistaxis, conjunctival congestion, swelling and pain, and pyocutaneous disease due to fire toxin, and for treating sprain, contusion and pain.

The herba Lophatheri is dried stem and leaf of Lophatherum gracile Brongn of Gramineae. Has the functions of clearing away heat, purging fire, relieving restlessness, quenching thirst, inducing diuresis and treating stranguria. Can be used for treating fever, polydipsia, scanty and painful urine, and aphtha of the mouth and tongue.

The Coptidis rhizoma is dried rhizome of Coptidis rhizoma, Coptidis rhizoma or Coptis Teeta wall of Ranunculaceae. Has the functions of clearing away heat, eliminating dampness, purging fire and removing toxicity. Can be used for treating damp-heat distention and fullness, emesis, acid regurgitation, dysentery, jaundice, hyperpyrexia, excessive heart-fire, vexation, insomnia, palpitation, hematemesis, epistaxis, conjunctival congestion, toothache, diabetes, carbuncle, swelling, and furuncle; it is used externally to treat eczema, eczema and purulent ear canal.

The folium Bambusae is dried stem and leaf of herba Lophatheri of Gramineae. Has the functions of clearing away heat, relieving restlessness, promoting the production of body fluid and promoting urination. Can be used for treating aphtha, tongue sore, oliguria and red urine caused by excessive heart fire.

Trichosanthis radix is dry root of Trichosanthes kirilowii Maxim or Trichosanthes rosthornii Maxim of Cucurbitaceae. Has the functions of clearing away heat, purging fire, promoting the production of body fluid, quenching thirst, relieving swelling and expelling pus. Can be used for treating fever polydipsia, lung heat dry cough, internal heat diabetes, pyocutaneous disease and pyogenic infections.

Scutellariae radix is dried root of Scutellaria baicalensis Georgi of Labiatae. Has the functions of clearing heat, drying dampness, purging fire, removing toxin, stopping bleeding and preventing miscarriage. Can be used for treating damp-warm syndrome, summer-heat dampness, chest distress, emesis, dampness, dysentery, jaundice, cough due to lung heat, hyperpyrexia, polydipsia, hematemesis, carbuncle, swelling, sore, and threatened abortion.

Aphtha is aphtha of the mouth and tongue, the tongue tip is inflamed, oral ulcer (a shallow, small, round or oval ulcer appearing on the lip, tongue and oral mucosa) is swollen and painful, and is caused by flaming of heart fire, and the tongue is the heart seedling in traditional Chinese medicine. The tongue and the heart are both exterior and interior, and most pathological changes on the tongue are related to excessive heart fire, and are one of the common oral diseases; the gum swelling and pain and gum bleeding are caused by periodontal disease, gingivitis and the like in western medicine, all of which can cause inflammation and halitosis, and the traditional Chinese medicine considers fire toxin and needs to clear heat, purge fire and remove toxicity.

The traditional Chinese medicine considers that heart pertains to fire and kidney pertains to water and pertains to yin, under normal conditions, the heart fire must descend to the kidney to warm kidney water and make kidney water cold, and kidney water must ascend to the heart to help heart yin to make heart yang not excessive. The ancient people called the relationship "water-fire is good at" and "the heart and kidney intersect". If the heart and kidney are not crossed, the heart-fire will be flaming up, the kidney will be cold, seminal emission will be slippery.

In view of the fact that patients with various oral diseases, spermatorrhea caused by disharmony between heart and kidney, gingival bleeding, vexation, thirst, jaundice due to damp-heat and red eyes with swelling and pain have inconvenience in taking medicines or forget to take medicines easily, the habit of gargling every day is combined with the prevention and treatment of oral diseases, spermatorrhea caused by disharmony between heart and kidney, gingival bleeding, vexation, thirst, jaundice due to damp-heat and red eyes with swelling and pain into a whole, a novel traditional Chinese medicine toothpaste is developed, the product has a wide market prospect, and the formula is the direction of efforts of medical researchers.

Disclosure of Invention

The invention aims to overcome the defects of the prior art and provides medicinal toothpaste and a preparation method thereof.

In order to achieve the purpose, the technical scheme provided by the invention is as follows:

the medicinal toothpaste is prepared from the following raw materials in parts by weight: 2-10 parts of traditional Chinese medicine extract, 10-18 parts of friction agent, 0.5-3 parts of surfactant, 4-7 parts of humectant, 2-6 parts of thickening agent, 0.5-3 parts of sweetening agent, 0.5-3 parts of aromatic, 0.5-2 parts of buffering agent, 0.3-0.9 part of foaming agent and 6-10 parts of distilled water; wherein the traditional Chinese medicine extract is a traditional Chinese medicine extract which is composed of at least one extract of lotus plumule, gardenia and lophatherum gracile and a mixed extract of four traditional Chinese medicines of coptis chinensis, bamboo leaves, trichosanthes root and scutellaria baicalensis according to any mass ratio.

Preferably, the abrasive is calcium carbonate, aluminum hydroxide or calcium phosphate, etc.; the humectant is glycerol or propylene glycol and the like; the thickening agent is carboxymethyl cellulose CMC and the like; the sweetener is saccharin sodium, aspartame, xylitol, stevia rebaudiana or neotame; the aromatic is natural spice and synthetic essence such as oleum Menthae Dementholatum, spearmint oil, fruit sesame oil, wintergreen oil, oleum Foeniculi or Borneolum Syntheticum oil; the buffer is calcium hydrophosphate and the like; the foaming agent is sodium lauryl sulfate and the like.

The preparation method of the medicinal toothpaste comprises the following steps:

(1) weighing at least one of plumula Nelumbinis, fructus Gardeniae, and folium Bambusae;

(2) adding 75% ethanol by volume percent for extraction twice: the volume of the ethanol added for the first time is 6-8 times, preferably 7 times, of the volume of the multifunctional traditional Chinese medicine, the extraction is carried out for 1.5-2.5 h, preferably 2h, and then solid-liquid separation is carried out to obtain an extracting solution A and residues; adding ethanol into the residue for second extraction, wherein the volume of the added ethanol is 4-6 times, preferably 5 times, of the volume of the residue, extracting for 0.5-1.5 h, preferably 1h, and performing solid-liquid separation to obtain an extract B; mixing the extractive solution A and B, and concentrating under reduced pressure to recover ethanol to obtain Chinese medicinal extract A; mixing Coptidis rhizoma, folium Bambusae, Trichosanthis radix and Scutellariae radix, and extracting with water twice: adding water 6-8 times, preferably 7 times of the volume of the Chinese medicinal materials, extracting for 1.5-2.5 hr, preferably 2 hr, and separating to obtain extractive solution C and residue; adding water into the residue for second extraction, wherein the volume of the added water is 4-6 times, preferably 5 times, of the volume of the residue, extracting for 0.5-1.5 h, preferably 1h to obtain an extract D, combining the extract C and the extract D, and concentrating to obtain a traditional Chinese medicine extract B; the traditional Chinese medicine extract A and the traditional Chinese medicine extract B are combined into a traditional Chinese medicine extract according to any mass ratio;

(3) adding the Chinese medicinal extract, surfactant, humectant and distilled water into a high-speed stirrer, stirring at 60 deg.C at a stirring speed of 200-300 r/min for 8-12 min, preferably 10min, adding friction agent, thickener, sweetener, buffer and foaming agent, and stirring at 60 deg.C for 10-20 min to obtain semi-finished product;

(4) placing the semi-finished product in a sealed container, adding aromatic, stirring, vacuumizing until the vacuum degree reaches-0.096 Mpa for 45-55 min, and bottling and packaging to obtain the final product.

The invention is further illustrated below:

the medicinal toothpaste of the invention comprises the following main components:

1) lotus plumule: has the effects of clearing away heart-fire, tranquilizing mind, suppressing liver fire, restoring normal coordination between heart and kidney, and arresting seminal emission and hemostasis. Preventing and treating aphtha, gingival swelling and pain, oral ulcer, gingival hemorrhage, neurasthenia, insomnia, dreaminess, imbalance between heart-kidney, spermatorrhea, and spermatorrhea.

2) Fructus Gardeniae has effects in purging pathogenic fire, relieving restlessness, clearing away heat, promoting diuresis, cooling blood, and removing toxic substances; it can be used topically for relieving swelling and pain. Can be used for treating febrile vexation, damp-heat jaundice, stranguria with pain, hematemesis, epistaxis, conjunctival congestion, swelling and pain, and pyocutaneous disease due to fire toxin, and for treating sprain, contusion and pain.

3) Lophatherum gracile has the effects of clearing heat and purging fire, relieving restlessness and quenching thirst, and inducing diuresis for treating stranguria. Can be used for treating fever, polydipsia, scanty and painful urine, and aphtha of the mouth and tongue.

4) Coptis root has the effects of clearing heat, drying dampness, purging fire and removing toxicity. Can be used for treating damp-heat distention and fullness, emesis, acid regurgitation, dysentery, jaundice, hyperpyrexia, excessive heart-fire, vexation, insomnia, palpitation, hematemesis, epistaxis, conjunctival congestion, toothache, diabetes, carbuncle, swelling, and furuncle; it is used externally to treat eczema, eczema and purulent ear canal.

5) The bamboo leaves have the functions of clearing heat, relieving restlessness, promoting the production of body fluid and promoting urination. Can be used for treating aphtha, tongue sore, oliguria and red urine caused by excessive heart fire.

6) Trichosanthis radix has effects of clearing heat-fire, promoting fluid production to quench thirst, detumescence and expelling pus. Can be used for treating fever polydipsia, lung heat dry cough, internal heat diabetes, pyocutaneous disease and pyogenic infections.

7) Baikal skullcap root has the functions of clearing heat and drying dampness, purging fire and removing toxicity, stopping bleeding and preventing miscarriage. Can be used for treating damp-warm syndrome, summer-heat dampness, chest distress, emesis, dampness and heat distention, dysentery, jaundice, cough due to lung heat, hyperpyrexia, polydipsia, hematemesis, carbuncle, swelling, sore, and threatened abortion.

8) A friction agent: has friction effect, and is convenient for removing stains.

9) Surfactant (b): has the function of decontamination.

10) Humectant: preventing the water from evaporating and drying.

11) Thickening agent: increasing the viscosity.

12) A sweetening agent: improve the flavor.

13) Aromatic agent: improve the smell.

14) Buffering agent: the pH is adjusted.

15) Foaming agent: has foaming effect.

16) Distilled water: the hardness is adjusted to be moderate.

In the formula of the technical scheme, the traditional Chinese medicine extract is preferably proportioned, so that the traditional Chinese medicine extract is not too little, or is ineffective or too much, or the taste is not good; the friction agent is moderate, too little and not enough in sliding friction; too little surfactant has poor detergency; too little moisture in the moisturizer evaporates and dries; the sweetener and the aromatic improve the flavor; thickening agent, distilled water, buffering agent and foaming agent are used for regulating hardness and hardness, so that the finished product is stable. The optimal formula and the optimal proportion ensure that the product has quick response, lasting effect, beautiful appearance, stable product, excellent flavor and comfortable mouthfeel.

In a word, the invention adopts modern extraction separation technology to extract the effective components in the traditional Chinese medicine, and the toothpaste which is necessary for each person every day is prepared, and when gargling, the effective components of the medicine are absorbed through oral mucosa and sublingual vein blood vessels, thereby playing the better role of preventing and treating mouth and tongue sores, gum swelling and pain, dental ulcer and gum bleeding, coordinating heart and kidney, and arresting seminal emission. Has wide application range, can treat common oral cavity local diseases, can be absorbed through mucous membrane and sublingual vein plexus, and has remarkable local and systemic treatment effects. The invention mainly comprises lotus plumule, gardenia, lophatherum gracile, coptis, bamboo leaves, trichosanthes root and scutellaria, which are dual-purpose products of medicine and food. The lotus seeds are classified as dual-purpose products of medicine and food by the national health counseling, and can be used for food and health food, and the traditional herbal writings have no record of any toxic and side effect on human bodies and no study report of the toxic and side effect at present.

Detailed Description

Example 1

The formula is as follows: 4 parts of traditional Chinese medicine extract, 12 parts of abrasive, 1 part of surfactant, 5 parts of humectant, 3 parts of thickener, 0.5 part of sweetener, 0.5 part of aromatic, 0.5 part of buffering agent, 0.4 part of foaming agent and 6 parts of distilled water.

The preparation method comprises the following steps:

1) weighing at least one of plumula Nelumbinis, fructus Gardeniae and folium Bambusae as raw materials; preferably lotus plumule;

2) extracting the raw materials with 75% ethanol twice, wherein 7 times of ethanol is added for the first time, extracting for 2 hr, and separating solid and liquid; adding 5 times of ethanol into the residue after the first ethanol extraction for second ethanol extraction, extracting for 1 hr, and performing solid-liquid separation; mixing the secondary ethanol extractive solutions, and concentrating under reduced pressure to recover ethanol. Obtaining a traditional Chinese medicine extract A; mixing Coptidis rhizoma, folium Bambusae, Trichosanthis radix and Scutellariae radix, adding water, extracting twice, wherein the amount of drinking water added for the first time is 7 times that of the first time, extracting for 2 hr, and separating solid and liquid; adding 5 times of drinking water into the residue after the first extraction for second extraction for 1 hour, and performing solid-liquid separation; mixing the two extractive solutions, and concentrating to obtain Chinese medicinal extract B; the traditional Chinese medicine extract A and the traditional Chinese medicine extract B are combined into a traditional Chinese medicine extract according to any mass ratio;

3) adding the traditional Chinese medicine extract prepared in the step two, a surfactant, a humectant and distilled water into a high-speed stirrer according to a ratio, stirring at the stirring speed of 200-300 r/min and the temperature of 60 ℃ for 10min, adding an abrasive, a thickening agent, a sweetening agent, a buffering agent and a foaming agent, and stirring at the temperature of 60 ℃ for 10-20 min to obtain a semi-finished product;

4) placing the semi-finished product in a sealed container (vacuum paste maker), adding aromatic, stirring, vacuumizing until the vacuum degree reaches-0.096 Mpa for about 50min, bottling, and packaging to obtain the final product.

Example 2

The formula is as follows: 6 parts of traditional Chinese medicine extract, 14 parts of abrasive, 2 parts of surfactant, 6 parts of humectant, 4 parts of thickener, 1 part of sweetener, 1 part of aromatic, 1 part of buffering agent, 0.6 part of foaming agent and 8 parts of distilled water.

The preparation and use methods are the same as example 1.

Example 3

The formula is as follows: 8 parts of traditional Chinese medicine extract, 16 parts of abrasive, 3 parts of surfactant, 7 parts of humectant, 5 parts of thickener, 2 parts of sweetener, 2 parts of aromatic, 1.5 parts of buffering agent, 0.8 part of foaming agent and 10 parts of distilled water.

The preparation and use methods are the same as example 1.

Example 4 orthogonal design method preferred proportion of Chinese medicinal component and correctant

The traditional Chinese medicine toothpaste mainly comprises lotus plumule, gardenia and lophatherum gracile; the sweetener is aspartame, so that the taste is improved; the vanillyl butyl ether is used as essence, so that the fragrance of the product is adjusted, the acceptance and comfort of people are improved, and the 3 components are selected as investigation factors. The optimal formula is preferably selected, the onset time, the refreshing duration, the comfort level and the like are used as evaluation indexes, and the formula for waking up is preferably selected by an orthogonal design method. The factor levels are shown in Table 1.

TABLE 1 factor level table

Weighing traditional Chinese medicine extract, sweetener and aromatic according to the combination of the factor levels in the table 1 and the factor levels in the table 2, weighing the rest components according to the intermediate dose, and preparing by the method to obtain 9 samples.

And carrying out crowd trial experiments on the 9 experimental samples obtained by the orthogonal experiment. Each group observed 30 people, young 10, middle 10, old 10, male and female. Each group was brushed with 9 samples of orthogonal test in the morning and evening for 3-5 min each time, and observed for 60min after brushing.

The scoring method comprises the following steps: a is the mark of the onset of the pain of the aphtha and the tongue within 30sec of onset time, 1 point is reduced from 10sec of each delay, and the maximum is 10 points; b is the scoring method of the analgesic effect time of the oral ulcer and is the same as A; c, after the mouth wash and the tooth brushing with comfort levels such as smell and the like, the comfortable level is 10 minutes, the relatively comfortable level is 8 minutes, the comfortable level is 6 minutes, and the uncomfortable level is 4 minutes; the total is the sum of ABC. The calculation formula is as follows:

total score of A + B + C

TABLE 2L 9(34) orthographic table

The data of Table 2 were analyzed for variance, and the results are shown in Table 3.

TABLE 3 ANOVA TABLE

Note: f0.05(2,2) ═ 19.0F0.01(2,2) ═ 99.0

Through experimental optimization, the optimal combination A2B2C3 is obtained through visual analysis. Namely experiment No. 5 in the orthogonal table, the mixture ratio of the three components is 6: 1: 2, the total score is the highest and is 30 points, and other combinations are all worse than the combination.

Analysis of variance shows that the addition amount of the A factor traditional Chinese medicine extract has significant difference, and other factors have no significant difference.

Example 5 Lotus seed nut toothpaste safety test for clearing Heart fire and preventing aphtha

Adverse reactions were observed while trying to rinse and brush teeth for all groups in the orthogonal trial, and the results are shown in table 4.

TABLE 4 observation of adverse reactions

Experiments show that the product has no obvious toxic or side effect and adverse reaction and is safe to apply.

The invention solves the problems of mouth rinsing, tooth cleaning and oral disease prevention and treatment at the same time: lotus plumule has effects of clearing heart fire and calming liver fire. Cape jasmine has the functions of clearing away heat, promoting diuresis, cooling blood and detoxicating; it can be used topically for relieving swelling and pain. It can be used for treating pyocutaneous disease due to fire toxin. Lophatherum gracile has the effects of clearing heat and purging fire. Can be used for treating aphtha of the mouth and tongue. When the traditional Chinese medicine is used for gargling, the effective components in the extract are dissolved and diffused out, and the traditional Chinese medicine is directly contacted with oral mucosa to play a role in preventing and treating mouth and tongue sores, gum swelling and pain, oral ulcer and halitosis. Solves the problems of gargling and cleaning teeth and treating systemic diseases: lotus plumule has the effects of restoring normal coordination between heart and kidney, arresting seminal emission and stopping bleeding; gardenia and Lophatherum gracile have the effects of relieving restlessness, quenching thirst, clearing heat and purging fire. Can enter blood through oral mucosa and sublingual blood vessel absorption, has effects of stopping nocturnal emission, stopping bleeding, clearing heart fire, relieving restlessness, promoting diuresis, and eliminating jaundice, and can be used for treating nocturnal emission due to imbalance between heart and kidney, gingival hemorrhage, vexation, thirst, jaundice due to damp-heat, conjunctival congestion, swelling and pain, etc. The lotus nut toothpaste which is safe and has no toxic or side effect and combines the functions of gargling and disease prevention and treatment is prepared by the invention, not only has the function of cleaning teeth by gargling, but also has the function of disease prevention and treatment by medicaments, and the product has no irritation, no toxic or side effect, elegant and fresh fragrance and is convenient to carry and use.

Claims (3)

1. The medicinal toothpaste is characterized by comprising the following raw materials in parts by weight: 2-10 parts of traditional Chinese medicine extract, 10-18 parts of abrasive, 0.5-3 parts of surfactant, 4-7 parts of humectant, 2-6 parts of thickener, 0.5-3 parts of sweetener, 0.5-3 parts of aromatic, 0.5-2 parts of buffering agent, 0.3-0.9 part of foaming agent and 6-10 parts of distilled water; wherein the traditional Chinese medicine extract is a traditional Chinese medicine extract which is composed of at least one extract of lotus plumule, gardenia and lophatherum gracile and mixed extracts of four traditional Chinese medicines of coptis chinensis, bamboo leaves, trichosanthes root and scutellaria baicalensis according to any mass ratio;

the medicated toothpaste is used for preventing and treating aphtha, gingival swelling and pain, oral ulcer, and gingival hemorrhage;

the preparation method of the traditional Chinese medicine extract comprises the following steps:

A. weighing at least one of plumula Nelumbinis, fructus Gardeniae, and folium Bambusae;

B. adding 75% ethanol by volume percent for extraction twice: the volume of the ethanol added for the first time is 6-8 times of the volume of the traditional Chinese medicine, and after 1.5-2.5 h of extraction, solid-liquid separation is carried out to obtain an extracting solution A and residues; adding ethanol into the residue for secondary extraction, wherein the volume of the added ethanol is 4-6 times of that of the residue, extracting for 0.5-1.5 h, and carrying out solid-liquid separation to obtain an extracting solution B; mixing the extractive solution A and B, and concentrating under reduced pressure to recover ethanol to obtain Chinese medicinal extract A; mixing Coptidis rhizoma, folium Bambusae, Trichosanthis radix and Scutellariae radix, and extracting with water twice: adding water 6-8 times the volume of the Chinese medicinal materials for the first time, extracting for 1.5-2.5 hr, and separating to obtain extractive solution C and residue; adding water into the residue for secondary extraction, wherein the volume of the added water is 4-6 times of the volume of the residue, extracting for 0.5-1.5 h to obtain an extracting solution D, combining the extracting solution C and the extracting solution D, and concentrating to obtain a traditional Chinese medicine extract B; and (3) combining the traditional Chinese medicine extract A and the traditional Chinese medicine extract B according to any mass ratio to form the traditional Chinese medicine extract.

2. The pharmaceutical toothpaste according to claim 1, wherein said abrasive agent is calcium carbonate, aluminum hydroxide or calcium phosphate; the humectant is glycerol or propylene glycol; the thickening agent is carboxymethyl cellulose CMC; the sweetener is saccharin sodium, aspartame, xylitol, stevia rebaudiana or neotame; the aromatic is oleum Menthae Dementholatum, spearmint oil, fruit sesame oil, wintergreen oil, oleum Foeniculi or Borneolum Syntheticum oil; the buffer is calcium hydrophosphate; the foaming agent is sodium lauryl sulfate.

3. A process for preparing a pharmaceutical toothpaste according to claim 1 or 2, wherein said process comprises the steps of:

(1) weighing at least one of plumula Nelumbinis, fructus Gardeniae, and folium Bambusae;

(2) adding 75% ethanol by volume percent for extraction twice: the volume of the ethanol added for the first time is 6-8 times of the volume of the traditional Chinese medicine, and after 1.5-2.5 h of extraction, solid-liquid separation is carried out to obtain an extracting solution A and residues; adding ethanol into the residue for secondary extraction, wherein the volume of the added ethanol is 4-6 times of that of the residue, extracting for 0.5-1.5 h, and carrying out solid-liquid separation to obtain an extracting solution B; mixing the extractive solution A and B, and concentrating under reduced pressure to recover ethanol to obtain Chinese medicinal extract A; mixing Coptidis rhizoma, folium Bambusae, Trichosanthis radix and Scutellariae radix, and extracting with water twice: adding water 6-8 times the volume of the Chinese medicinal materials for the first time, extracting for 1.5-2.5 hr, and separating to obtain extractive solution C and residue; adding water to the residue for a second extraction, the volume of water added being the residue

Extracting for 0.5-1.5 h by 4-6 times of the volume of the extract to obtain an extracting solution D, combining the extracting solution C and the extracting solution D, and concentrating to obtain a traditional Chinese medicine extract B; the traditional Chinese medicine extract A and the traditional Chinese medicine extract B are combined into a traditional Chinese medicine extract according to any mass ratio;

(3) adding the Chinese medicinal extract, surfactant, humectant and distilled water into a high-speed stirrer, stirring at 60 deg.C for 8-12 min at a stirring speed of 200-300 r/min, adding friction agent, thickener, sweetener, buffer and foaming agent, and stirring at 60 deg.C for 10-20 min to obtain semi-finished product;

(4) placing the semi-finished product in a sealed container, adding aromatic, stirring, vacuumizing until the vacuum degree reaches-0.096 Mpa for 45-55 min, and bottling and packaging to obtain the final product.