CN108653498A - A kind of invigorating the spleen growth promotion medical composition and its use - Google Patents
A kind of invigorating the spleen growth promotion medical composition and its use Download PDFInfo
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- A—HUMAN NECESSITIES
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Abstract
The invention discloses a kind of preparation method and its usages of invigorating the spleen growth promotion pharmaceutical composition.The drug contains active constituent, and the active constituent is made of Cortex Eucommiae, Semen Cuscutae, rhizoma alismatis, citric acid, malic acid, vitamin C etc..Invigorating the spleen growth promotion pharmaceutical composition of the present invention has spleen benefiting and stimulating the appetite, improves a poor appetite, enhance body constitution, promote the effect of livestock and poultry fast-growth, can be effectively used for growth of animals or poultry slowly, the diseases such as have bad physiques and livestock and poultry recover after rehabilitation etc., pharmaceutical composition of the present invention has many advantages, such as raw material sources are extensive, safe and environment-friendly, preparation process is simple, production cost is low, dosage is few, can add for a long time.
Description
Technical field
The present invention relates to a kind of Preparation method and uses of invigorating the spleen growth promotion pharmaceutical composition, belong to field of veterinary.
Background technology
With the development of intensive culture industry, low dosage adds antibacterials in feed, can not only prevent disease, may be used also
To improve efficiency of feed utilization, promote growth of animal, to improve culture efficiency.But long-term low dose adds antivirus somatotropic agent
Pathogen can be induced to generate drug resistance, lead to animal derived food medicament residue, then cause food-safety problem and public defended
Raw problem, damages human health.In view of these problems, in recent years, European Union, the U.S. forbid using in food animal feed in succession
Antibacterials are as growth-promoting additive.The anti-cry of taboo in China is also growing to even greater heights, and the Ministry of Agriculture has issued will be in May, 2019
Forbid within 1st in food animal using 3 kinds of growth promotion veterinary drugs such as olaquindox, Arsanilic Acid, roxarsones.Therefore research and development are replaced
Anti-, safety, the growth promotion drug that can be added for a long time become herding intensive culture there is an urgent need to.
Diarrhea is an important factor for influencing growth of animals or poultry, can to reduce feed conversion rate, induces Other diseases, treatment is not in time
Or therapy is improper that dead or growth and development can be caused to be obstructed, and postpones marketing time, increases feeding cost.In recent years clinically
A large amount of and blindness uses all kinds of antibacterial drug therapy diarrhea, and the effect is unsatisfactory, so that bacterial drug resistance is increased instead, accelerates anti-
The enteron aisle diarrhea disease of the superseded speed of bacterium drug, livestock and poultry causes massive losses to aquaculture, and is sent out as animal husbandry is restricted
An important factor for exhibition.
According to Chinese veterinarian's basic theory, causing the cause of disease of early-weaned piglets diarrhea is caused since piglet is weakness of the spleen and the stomach
Indigestion is got ill from overeating caused by accumulated heat.Because damp evil invades, impairing the spleen and stomach, taste are by disease, then diet enters stomach, indigestion, it is precise and tiny not
Cloth, close it is dirty and under, cause into diarrhea.Therefore prevention diarrhea should be amusing with dampness elimination, based on invigorating the spleen qi-restoratives.Therefore, strengthening the spleen and replenishing qi is developed,
The Chinese herbal and crude drugs preparations of reinvigoration, can enhance piglet appetite, improve pigling immunity and to stress resistance, enhance piglet body
Matter reduces diarrhea harm, promotes growth.
CN200710017503.X discloses a kind of tonifying kidney and strengthening yang Chinese medicine preparation, which uses
22 taste Chinese medicines, wherein Semen Cuscutae, Cortex Eucommiae, rhizoma alismatis be mainly the effect of tonifying kidney and strengthening yang.CN201110023224.0 discloses one
Kind increases the Chinese herbal feed additive of fox nest litter size, which has used 18 taste Chinese medicines,
Middle Semen Cuscutae, Cortex Eucommiae, rhizoma alismatis are mainly the effect for filling up kidney essense, to improve body fertility.CN201410789490.8 sheets
Disclosure of the invention is a kind of to treat standby boar hyposexuality Chinese medicine, which has used 17 taste Chinese medicines, wherein Semen Cuscutae, Du
Secondary, rhizoma alismatis is mainly tonifying kidney and strengthening yang, to have the function that treat standby boar hyposexuality, improve sperm quantity.
The invention discloses a kind of boar food, the patent pannages, and 8 taste Chinese herbal medicines are added in pannage by CN201410789025.4,
Wherein Semen Cuscutae, Cortex Eucommiae, rhizoma alismatis are mainly tonifying kidney and benefiting sperm gas, to have the function that improve boar sperm quality.
CN201610917565.5 discloses a kind of Chinese herbal feed additive and preparation method thereof, which makes
With 23 taste Chinese medicines, wherein Semen Cuscutae, Cortex Eucommiae, rhizoma alismatis is mainly that kidney tonifying strengthens the bone, to have the function that disease-resistant raising survival rate.
CN201711020990.5 discloses a kind of Chinese herbal feed additive and preparation method thereof, which makes
With 14 taste Chinese medicines, wherein Semen Cuscutae, Cortex Eucommiae, rhizoma alismatis is mainly Kidney-invigorating and tendon-reinforcing, to have the function that disease-resistant raising survival rate.
In conclusion develop not only can with growth promotion but also can the drug of pre- anti-diarrhea will be the faced problem of livestock breeding industry
Solution, and urgent need.
Invention content
It is an object of the invention to overcome the deficiencies of the prior art and provide a kind of safe and environment-friendly and effective invigorating the spleen growth-promotings
Long pharmaceutical composition.
It is a further object of the present invention to provide the preparation methods of invigorating the spleen growth promotion pharmaceutical composition.
Invigorating the spleen growth promotion pharmaceutical composition provided by the invention, containing active constituent, the active constituent by Cortex Eucommiae, Tu
Son, rhizoma alismatis, citric acid, malic acid, vitamin C are made.
The active constituent is by 40-80 parts of Cortex Eucommiae, 30-60 parts of Semen Cuscutae, 10-30 parts of rhizoma alismatis, 1-10 parts of citric acid, apple
1-10 parts sour, 1-10 parts of vitamin C is made.
Further, the active constituent is by 50-60 parts of Cortex Eucommiae, 40-50 parts of Semen Cuscutae, 15-25 parts of rhizoma alismatis, citric acid 3-8
Part, 3-8 parts of malic acid, 3-8 parts of vitamin C are made.
Further, the active constituent is by 55 parts of Cortex Eucommiae, 45 parts of Semen Cuscutae, 20 parts of rhizoma alismatis, 5 parts of citric acid, malic acid 5
Part, 5 parts of vitamin C are made.
The present invention also provides the preparation methods of the invigorating the spleen growth promotion pharmaceutical composition, it includes the following steps：
(1) Cortex Eucommiae, Semen Cuscutae, rhizoma alismatis are weighed by weight ratio as drug component 1；
(2) citric acid, malic acid, vitamin C are weighed by weight ratio as drug component 2；
(3) drug component 1 claimed is crushed, after sieving, or by the drug component claimed once water or alcohol extracting, concentration
Afterwards, drug component 2 is added, mixing adds the available auxiliary material of pharmacy or complementary ingredient, is prepared.
Wherein, the dosage form of invigorating the spleen growth promotion pharmaceutical composition made from above-mentioned preparation method can be：Pre-mixing agent, pulvis,
Extract powder, powder, granule, oral solution.
The present invention also provides the invigorating the spleen growth promotion pharmaceutical compositions in terms of preparing livestock and poultry feed additive for promoting growth
Application.
The invigorating the spleen growth promotion pharmaceutical composition of the present invention is used separately as feed addictive, can also be with conventional other
Additive is applied in combination, and therefore, the present invention also provides the feed addictives containing the invigorating the spleen growth promotion pharmaceutical composition.
The present invention uses Cortex Eucommiae, Semen Cuscutae, rhizoma alismatis, it is intended to invigorating the spleen growth promotion, and three taste medicines and citric acid, malic acid, dimension
Raw element C is used in combination with synergistic effect, can reach notable growth promotion, prevention diarrhea effect.Cortex Eucommiae, Semen Cuscutae, rhizoma alismatis exist
CN200710017503.X、CN201110023224.0、CN201410789490.8、CN201410789025.4、
It is used simultaneously in the patents such as CN201610917565.5, CN201711020990.5, mainly plays its kidney tonifying and support kidney, benefiting male body essence and invigorating sex functions
The effect of.Chinese medicine Five elements theory points out that The liver and the kidney have a common source, and kidney is that water liver is wood, and kidney water can nourish edema with the liver involved, if but edema with the liver involved it is too strong just
Restraint can be made into local methods to spleen, taste are again in phase table, to influence digestion and absorption function.Therefore patent of the present invention and prior art phase
Than, its essence is different in terms of using this three tastes Chinese medicine, is only passed through numerous studies, just can properly be combined, to
Good growth-promoting effect is played, it otherwise can things turn out contrary to one's wishes.
Each drug component and its dosage in invigorating the spleen growth promotion pharmaceutical composition of the present invention are dialectical according to Chinese veterinarian's prescription
It is got by controlling and largely repeatedly practising.The main pain along spinal column of Cortex Eucommiae, bowl spares, strengthening the essence gas, hard muscles and bones, Qiang Zhi；Cortex Eucommiae has good
Growth promoting function.The continuous wound absolutely of Semen Cuscutae master, tonifying for the deficiency, benefiting energy, fertilizer are strong；Semen Cuscutae is sweet in flavor to help spleen, treat the card of spleen deficiency.Pool
Main wind-cold-dampness arthralgia is rushed down, disappear water, supports the five internal organs, benefiting energy, and fertilizer is good for；Rhizoma alismatis invigorating the spleen except damp evil, thus benefiting energy and fertilizer is strong.Medicine of the present invention
Object combines Cortex Eucommiae, Semen Cuscutae, rhizoma alismatis from the angle of invigorating the spleen, invigorating the spleen and growth promotion, effect are stronger, and can
With Long-term Feeding, without causing harmful effect to animal body.Citric acid, malic acid are organic acid, and Papillary has association
Same-action can significantly improve cultivated animals feed intake, improve food conversion ratio, and improve weightening, can also effectively kill cause of disease
Microorganism, pre- anti-diarrhea, to promote to grow.Vitamin C can improve immunity of organisms, improve cultivated animals disease resistance,
To make cultivated animals keep good health state.By Cortex Eucommiae, Semen Cuscutae, rhizoma alismatis and citric acid, malic acid, vitamin C into one
Step combination, shows more preferably growth-promoting effect, after being prepared into pharmaceutically common preparation, can effectively prevent weanling pig abdomen
It rushes down, enhances piglet appetite, improve the resistance of pigling immunity and piglet to weaning stress, enhance piglet constitution, reduce piglet
The harm of diarrhea promotes piglet growth.
Specific implementation mode
The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention..
1 medicine preparation of the present invention of embodiment and use
(1) raw material containing following weight is weighed：
80 parts of Cortex Eucommiae, 60 parts of Semen Cuscutae, 30 parts of rhizoma alismatis, 10 parts of citric acid, 10 parts of malic acid, 10 parts of vitamin C.
(2) after crushing Cortex Eucommiae, Semen Cuscutae, rhizoma alismatis, first plus water is by after medicinal material immersion 30min, decocts 3 times, 1.5 is small every time
When, merging filtrate is simultaneously condensed into paste, and citric acid, malic acid and vitamin C is added, is eventually adding appropriate amount of starch and dextrin
(or other auxiliary materials) is uniformly mixed, softwood is made, pelletize, drying, that is, is prepared into granule (being equivalent to crude drug in whole 1g per 1g).
(3) drug application method of the present invention：Invigorating the spleen, growth promotion, preventing post-weaning diarrhea；Mixed feeding：Pig, per 1kg feeds
Addition drug 0.5-2g of the present invention, is freely eaten；Mixed drink adds drug 0.25-1g of the present invention per 1L water, freely drinks.
2 medicine preparation of the present invention of embodiment and use
(1) raw material containing following weight is weighed：
40 parts of Cortex Eucommiae, 30 parts of Semen Cuscutae, 10 parts of rhizoma alismatis, 1 part of citric acid, 1 part of malic acid, 1 part of vitamin C.
(2) after crushing Cortex Eucommiae, Semen Cuscutae, rhizoma alismatis, first plus water is by after medicinal material immersion 30min, decocts 3 times, 1.5 is small every time
When, merging filtrate is simultaneously condensed into paste, and citric acid, malic acid and vitamin C is added, is eventually adding appropriate amount of starch and dextrin
(or other auxiliary materials) is uniformly mixed, softwood is made, pelletize, drying, that is, is prepared into granule (being equivalent to crude drug in whole 1g per 1g).
(3) drug application method of the present invention：Invigorating the spleen, growth promotion, preventing post-weaning diarrhea；Mixed feeding：Pig, per 1kg feeds
Addition drug 0.5-2g of the present invention, is freely eaten；Mixed drink adds drug 0.25-1g of the present invention per 1L water, freely drinks.
3 medicine preparation of the present invention of embodiment and use
(1) raw material containing following weight is weighed：
50 parts of Cortex Eucommiae, 40 parts of Semen Cuscutae, 15 parts of rhizoma alismatis, 3 parts of citric acid, 3 parts of malic acid, 3 parts of vitamin C.
(2) after crushing Cortex Eucommiae, Semen Cuscutae, rhizoma alismatis, first plus water is by after medicinal material immersion 30min, decocts 3 times, 1.5 is small every time
When, merging filtrate is simultaneously condensed into paste, and citric acid, malic acid and vitamin C is added, is eventually adding appropriate amount of starch and dextrin
(or other auxiliary materials) is uniformly mixed, softwood is made, pelletize, drying, that is, is prepared into granule (being equivalent to crude drug in whole 1g per 1g).
(3) drug application method of the present invention：Invigorating the spleen, growth promotion, preventing post-weaning diarrhea；Mixed feeding：Pig, per 1kg feeds
Addition drug 0.5-2g of the present invention, is freely eaten；Mixed drink adds drug 0.25-1g of the present invention per 1L water, freely drinks.
4 medicine preparation of the present invention of embodiment and use
(1) raw material containing following weight is weighed：
60 parts of Cortex Eucommiae, 50 parts of Semen Cuscutae, 25 parts of rhizoma alismatis, 8 parts of citric acid, 8 parts of malic acid, 8 parts of vitamin C.
(2) after crushing Cortex Eucommiae, Semen Cuscutae, rhizoma alismatis, first plus water is by after medicinal material immersion 30min, decocts 3 times, 1.5 is small every time
When, merging filtrate is simultaneously condensed into paste, and citric acid, malic acid and vitamin C is added, is eventually adding appropriate amount of starch and dextrin
(or other auxiliary materials) is uniformly mixed, softwood is made, pelletize, drying, that is, is prepared into granule (being equivalent to crude drug in whole 1g per 1g).
(3) drug application method of the present invention：Invigorating the spleen, growth promotion, preventing post-weaning diarrhea；Mixed feeding：Pig, per 1kg feeds
Addition drug 0.5-2g of the present invention, is freely eaten；Mixed drink adds drug 0.25-1g of the present invention per 1L water, freely drinks.
5 medicine preparation of the present invention of embodiment and use
(1) raw material containing following weight is weighed：
55 parts of Cortex Eucommiae, 45 parts of Semen Cuscutae, 20 parts of rhizoma alismatis, 5 parts of citric acid, 5 parts of malic acid, 5 parts of vitamin C.
(2) after crushing Cortex Eucommiae, Semen Cuscutae, rhizoma alismatis, first plus water is by after medicinal material immersion 30min, decocts 3 times, 1.5 is small every time
When, merging filtrate is simultaneously condensed into paste, and citric acid, malic acid and vitamin C is added, is eventually adding appropriate amount of starch and dextrin
(or other auxiliary materials) is uniformly mixed, softwood is made, pelletize, drying, that is, is prepared into granule (being equivalent to crude drug in whole 1g per 1g).
(3) drug application method of the present invention：Invigorating the spleen, growth promotion, preventing post-weaning diarrhea；Mixed feeding：Pig, per 1kg feeds
Addition drug 0.5-2g of the present invention, is freely eaten；Mixed drink adds drug 0.25-1g of the present invention per 1L water, freely drinks.
6 medicine preparation of the present invention of embodiment and use
(1) raw material containing following weight is weighed：
80 parts of Cortex Eucommiae, 30 parts of Semen Cuscutae, 25 parts of rhizoma alismatis, 10 parts of citric acid, 1 part of malic acid, 10 parts of vitamin C.
(2) after crushing Cortex Eucommiae, Semen Cuscutae, rhizoma alismatis, first plus water is by after medicinal material immersion 30min, decocts 3 times, 1.5 is small every time
When, merging filtrate is simultaneously condensed into certain volume (being equivalent to crude drug in whole 1g/ml), and ethanol content in ethyl alcohol to filtrate is added and is
70%, filtering, filtrate recycling ethanol is added citric acid, malic acid and vitamin C, mixing and adds appropriate amount of starch and dextrin
(or other auxiliary materials), mixes well, and is prepared into extract powder (being equivalent to crude drug in whole 1g per 1g)
(3) drug application method of the present invention：Invigorating the spleen, growth promotion, preventing post-weaning diarrhea；Mixed feeding：Pig, per 1kg feeds
Addition drug 0.5-2g of the present invention, is freely eaten；Mixed drink adds drug 0.25-1g of the present invention per 1L water, freely drinks.
7 medicine preparation of the present invention of embodiment and use
(1) raw material containing following weight is weighed：
60 parts of Cortex Eucommiae, 40 parts of Semen Cuscutae, 15 parts of rhizoma alismatis, 5 parts of citric acid, 2 parts of malic acid, 4 parts of vitamin C.
(2) each weight crude drug that will claim in step (1), mixing, ultramicro grinding are crossed 200 mesh, are prepared after mixing well
At powder.
(3) drug application method of the present invention：Invigorating the spleen, growth promotion, preventing post-weaning diarrhea；Mixed feeding：Pig, per 1kg feeds
Addition drug 0.5-2g of the present invention, is freely eaten.
8 medicine preparation of the present invention of embodiment and use
(1) raw material containing following weight is weighed：
60 parts of Cortex Eucommiae, 40 parts of Semen Cuscutae, 10 parts of rhizoma alismatis, 6 parts of citric acid, 2 parts of malic acid, 10 parts of vitamin C.
(2) after crushing Cortex Eucommiae, Semen Cuscutae, rhizoma alismatis, first plus water is by after medicinal material immersion 30min, decocts 3 times, 1.5 is small every time
When, merging filtrate is simultaneously condensed into certain volume (being equivalent to crude drug in whole 1g/ml), and ethanol content in ethyl alcohol to filtrate is added and is
70%, filtering, filtrate recycling ethanol is added citric acid, malic acid and vitamin C, mixing and adds appropriate amount of starch and dextrin
(or other auxiliary materials), mixes well, and is prepared into extract powder (being equivalent to crude drug in whole 1g per 1g)
(3) drug application method of the present invention：Invigorating the spleen, growth promotion, preventing post-weaning diarrhea；Mixed feeding：Pig, per 1kg feeds
Addition drug 0.5-2g of the present invention, is freely eaten.
9 medicine preparation of the present invention of embodiment and use
(1) raw material containing following weight is weighed：
80 parts of Cortex Eucommiae, 30 parts of Semen Cuscutae, 20 parts of rhizoma alismatis, 6 parts of citric acid, 2 parts of malic acid, 10 parts of vitamin C.
(2) after crushing Cortex Eucommiae, Semen Cuscutae, rhizoma alismatis, first plus water is by after medicinal material immersion 30min, decocts 3 times, 1.5 is small every time
When, merging filtrate is simultaneously condensed into certain volume (being equivalent to crude drug in whole 1g/ml), and ethanol content in ethyl alcohol to filtrate is added and is
70%, filtering is concentrated into every 1ml and is equivalent to crude drug in whole 0.5g, citric acid, malic acid and vitamin C is added, and finally filters, fills
Envelope, sterilizing, that is, be prepared into oral solution.(being equivalent to crude drug in whole 0.5g per 1ml)
(3) drug application method of the present invention：Invigorating the spleen, growth promotion, preventing post-weaning diarrhea；Mixed drink：Pig, per 1L water additions
Drug 0.5-2ml of the present invention, freely drinks.
To show effect of the drug of the present invention to invigorating the spleen growth promotion and pre- anti-diarrhea, clinical efficacy is carried out to drug of the present invention
Observation experiment, the advantageous effect of the present invention is further explained drug is carried out below by way of test example.
Test example 1
To verify curative effect of medication of the present invention, investigated in great Bei agricultures group animal health Technical Research Center experimental animal room
Influence of the drug of the present invention to folium sennae model mice screens treatment animal syndrome of spleen deficiency growth promotion with cassia angustifolia blade profile spleen deficiency molding method
Chinese medicine preparation, test result are as follows：
1 materials and methods
1.1 animal model replication
Take weight 24-26g mouse, folium sennae decocting liquid 0.3ml/20g gavages, continuous 8 days, during which fasting every other day, mouse
Occur the performances such as hair is withered, evacuation, loose stool, weight, muscle power and feed intake decline, chilly be modeling successfully.
Bi-syndrome with spleen deficiency standard：1. diarrhea severe patient even rectal prolapse；2. deficiency of food is indigestion and loss of appetite；3. it becomes thin, weight loss；4. essence
God is dispirited, 5. weakness of limbs rolls up poly- heap, the relatively low 6. fatiguability of body temperature.
It is prepared by 1.2 trial drugs
Cassia angustifolia leaf extract：Folium sennae is taken, after crushing, adds the decocting 3 times of 16 times of water, 1.5 hours every time, filters, filtrate is dense
It is reduced to 1g/ml, it is spare.
It is prepared by trial drug：Trial drug is prepared respectively by Medications Example 1-5 of the present invention.
Four gentleman dissipate, and self-control mainly becomes Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Radix Glycyrrhizae, Poria cocos.
1.3 experiment groupings and administration
Cleaning grade kunming mice 80 is taken only to be divided into 8 groups, every group 10.1 group is tested to prepare using Medications Example 1 of the present invention
Drug, drinking water administration adds drug 1g of the present invention per 1L water；Test 2 groups of medicines prepared using Medications Example 2 of the present invention
Object, drinking water administration add drug 1g of the present invention per 1L water；Test 3 groups of drugs prepared using Medications Example 3 of the present invention, drink
Water is administered, and drug 1g of the present invention is added per 1L water；4 groups of drugs prepared using Medications Example 4 of the present invention are tested, drinking-water is given
Medicine adds drug 1g of the present invention per 1L water；Test 5 groups using Medications Examples 5 of the present invention preparation drugs, drinking water administration, often
1L water adds drug 1g of the present invention；It tests 6 groups to dissipate using four gentleman, mixed feeding administration, per kilogram feed adds four gentleman and dissipates 2g；Examination
It is model group to test 7 groups；It is healthy control group to test 8 groups.In addition to healthy control group, remaining each administration group and model of spleen deficiency group are continuous
Gavage 8 days, during modeling, healthy control group drinks distilled water；After spleen deficiency symptom occurs in each group, administration group drinks experiment respectively
Liquid is used in conjunction 7, and healthy control group and spleen deficiency model of spleen deficiency group drink distilled water.It is consistent to test each group rearing conditions.
1.4 weight are investigated with feed intake
Per every group of experimental animal feed intake of day entry, before each test group modeling, after modeling and the off-test time-division is also known as heavy.
1.5 statistical method
Each group numerical value is with mean+SDIt indicates, comparison among groups use variance analysis, each group of data
Compare two-by-two, is that significant difference is statistically significant with P ＜ 0.05, total data uses PASW Statistics 18.0 editions
Analysis software carries out statistical disposition.
2 test results and analysis
Mouse occurs loose stool for second day in gavage folium sennae decocting liquid, and weight loss then just occurs rolling up chilly, erects
The State of Spleen Deficiency such as hair, body temperature are declined slightly, and activity is reduced.Above-mentioned condition has been after drug of the present invention and four gentleman dissipate treatment
Restore, close to normal group, and model group restores unobvious.Death condition and weight gain situation are shown in Table 1 during mouse test.
Test result of 1 drug of the present invention of table to mice with spleen deficiency increase heavy influence
Note：Gain weight, compared with healthy group, test group 1-5, four gentleman dissipate group and the p value of model group is respectively
0.000、0.003、0.000、0.002、0.229、0.000、0.000；Compared with model group, test group 1-5, four gentleman dissipate group
P value is respectively 0.000,0.000,0.000,0.000,0.000,0.038；Compared with four gentleman dissipate group, the p value of test group 1-5
It is 0.016,0.001,0.010,0.001,0.000.
Test result shows compared with model group, each test group of drug of the present invention can pole significantly improve the increasing of mouse
Weight (P<0.01), and significant effect of the drug of the present invention in terms of weightening dissipates (P better than four gentleman of control drug<0.05).Wherein
5 groups of drug test of the present invention is best to syndrome of spleen deficiency mouse gaining effect, is higher than other each drug test groups and four monarch of control drug
The scattered group of son.
Test example 2
To verify curative effect of medication of the present invention, great Bei agricultures group animal health Technical Research Center is in Hebei Yutian test pig
Field demonstrates drug of the present invention and tests weanling pig growth-promoting effect, and test result is as follows：
1 materials and methods
1.1 experimental animal
Du great Bai 28 days weanling pigs of three way cross.
1.2 feeds and drug
Feed：For the child care material of certain feed technology Co., Ltd production.
Trial drug：It is prepared by Medications Example 6 of the present invention.
Control drug 1：After 80 parts of Cortex Eucommiae, 30 parts of Semen Cuscutae, 25 parts of rhizoma alismatis are crushed, first plus medicinal material is impregnated 30min by water
Afterwards, it decocts 3 times, 1.5 hours every time, merging filtrate was simultaneously condensed into certain volume (being equivalent to crude drug in whole 1g/ml), and ethyl alcohol is added extremely
Ethanol content is 70% in filtrate, and filtering, filtrate recycling ethanol adds appropriate amount of starch and dextrin, mixes well, is prepared into and carries
Take composition powders (being equivalent to crude drug in whole 1g per 1g).
Control drug 2：10 parts of citric acid, 1 part of malic acid are taken, spare, drug 2 as a contrast are uniformly mixed.
Control drug 3：Vitamin C.
Control drug 4：By 1 part of 80 parts of prescription Cortex Eucommiae, 30 parts of Semen Cuscutae, 25 parts of rhizoma alismatis, 10 parts of citric acid, malic acid preparation
Control drug 4.After Cortex Eucommiae, Semen Cuscutae, rhizoma alismatis are crushed, first plus water is by after medicinal material immersion 30min, decocts 3 times, 1.5 is small every time
When, merging filtrate is simultaneously condensed into certain volume (being equivalent to crude drug in whole 1g/ml), and ethanol content in ethyl alcohol to filtrate is added and is
70%, citric acid, malic acid is added in filtering, filtrate recycling ethanol, and mixing adds appropriate amount of starch and dextrin, mixes well,
It is prepared into extract powder (being equivalent to crude drug in whole 1g per 1g).
Control drug 5：By 10 parts of 80 parts of prescription Cortex Eucommiae, 30 parts of Semen Cuscutae, 25 parts of rhizoma alismatis, vitamin C preparation control drugs
5.After Cortex Eucommiae, Semen Cuscutae, rhizoma alismatis are crushed, first plus water is by after medicinal material immersion 30min, decocts 3 times, 1.5 hours every time, merges filter
Liquid is simultaneously condensed into certain volume (being equivalent to crude drug in whole 1g/ml), and it is 70% that ethanol content in ethyl alcohol to filtrate, which is added, is filtered, filter
Liquid recycles ethyl alcohol, and vitamin C is added, and mixing adds appropriate amount of starch and dextrin, mixes well, and it is (every to be prepared into extract powder
1g is equivalent to crude drug in whole 1g).
Control drug 6：10 parts of citric acid, 1 part of malic acid, 10 parts of vitamin C are taken, is uniformly mixed, as a contrast drug 6.
Control drug 7：By 80 parts of prescription Cortex Eucommiae, 30 parts of Semen Cuscutae, 25 parts of rhizoma alismatis, 11 parts of fumaric acid, 10 parts of vitamin C
Prepare control drug 5.By Cortex Eucommiae, Semen Cuscutae, rhizoma alismatis crush after, first plus water will medicinal material impregnate 30min after, decoct 3 times, every time
1.5 hours, merging filtrate was simultaneously condensed into certain volume (being equivalent to crude drug in whole 1g/ml), and ethanol content in ethyl alcohol to filtrate is added
It is 70%, fumaric acid, vitamin C is added in filtering, filtrate recycling ethanol, and mixing adds appropriate amount of starch and dextrin, fully mixed
It is even, it is prepared into extract powder (being equivalent to crude drug in whole 1g per 1g).
1.3 experiment groupings
540 weanling pigs are randomly divided into 9 groups, 1 group of experiment is trial drug group, this hair is added by every 1 kg diet
Bright drug implements the drug 1g of 6 preparations, mixed feeding administration, successive administration 28 days；1 group of control drug is added by every 1 kg diet
The dosage of control drug 1 is 1g, mixed feeding administration, successive administration 28 days；2 groups of control drug adds comparison medicine by every 1 kg diet
The dosage of object 2 is 1g, mixed feeding administration, successive administration 28 days；3 groups of control drug adds control drug 3 by every 1 kg diet
Dosage is 1g, mixed feeding administration, successive administration 28 days；4 groups of control drug, the dosage that control drug 4 is added by every 1 kg diet are
1g, mixed feeding administration, successive administration 28 days；5 groups of control drug, the dosage that control drug 5 is added by every 1 kg diet are 1g, are mixed
Raise administration, successive administration 28 days；6 groups of control drug, the dosage that control drug 6 is added by every 1 kg diet is 1g, and mixed feeding is given
Medicine, successive administration 28 days；7 groups of control drug, the dosage that control drug 7 is added by every 1 kg diet are 1g, and mixed feeding administration connects
Continuous administration 28 days；Blank control group does not add any drug in feed.
1.4 inspection target
Each group is weighed at 28 ages in days, the 56 age in days morning 7 on an empty stomach respectively, and observes and record piglet feeding, body condition, hair
Situations such as color, behavior, defecation, diarrhea.
2 test results and analysis
Piglet Gain weight is shown in Table 2.
2 piglet weight increment test result of table
Test result shows that compared with blank control group, 1 to 7 pair of piglet of trial drug and control drug has well
Growth-promoting effect, wherein trial drug be by Medications Example 6 of the present invention preparation, growth-promoting effect is best.By the present invention
Drug prepared by Medications Example 6 is better than control drug 1 to the somatotrophic effect of piglet and (Cortex Eucommiae, Semen Cuscutae, rhizoma alismatis is used alone
Deng 3 taste Chinese medicine compositions) or control drug 2 (be used alone citric acid, apple acid composition) or control drug 3 (be used alone
Vitamin C), also it is better than control drug 4 (Cortex Eucommiae, Semen Cuscutae, rhizoma alismatis, citric acid, apple acid composition) or (Du of control drug 5
Secondary, Semen Cuscutae, rhizoma alismatis, vitamin C composition), also it is better than control drug 6 (citric acid, malic acid, vitamin C composition), table
Bright Cortex Eucommiae, Semen Cuscutae, rhizoma alismatis and citric acid, malic acid, vitamin C are used in combination, and have synergistic effect for growth promotion.By this
Drug prepared by invention Medications Example 6 is better than control drug 7 to the somatotrophic effect of piglet, shows the lemon that the present invention uses
Acid and malic acid are optimal selections, should not be substituted with other acidulants.
Test example 3
Further to verify drug of the present invention to weanling pig growth promoting function, the animal health technical research of great Bei agricultures group
Center has carried out contrast test on Hubei Huang Po experiments pig farm, and test result is as follows：
1 materials and methods
1.1 experimental animal
28 days weanling pigs of Ternary Pig three way cross.
1.2 feeds and drug
Feed：For the child care material of certain feed technology Co., Ltd production；
Trial drug：It is prepared by Medications Example 7 of the present invention.
Control drug：4% flavomycoin pre-mixing agent
1.3 experiment groupings
300 28 days weanling pigs are randomly divided into 3 groups, 1 group of experiment is trial drug group, is pressed by the addition of every 1 ton of feed
Drug 1k g prepared by Medications Example 7 of the present invention, mixed feeding administration, successive administration 28 days；It is control drug group to test 2 groups, is pressed
Every 1 ton of feed adds 4% flavomycoin pre-mixing agent 125g, mixed feeding administration, successive administration 28 days；It is blank control group to test 3 groups, is raised
Any drug is not added in material.
1.4 inspection target
Each group is weighed at 28 ages in days, the 56 age in days morning 7 on an empty stomach respectively, and observes and record piglet feeding, body condition, hair
Situations such as color, behavior, defecation, diarrhea.
2 test results and analysis
Piglet Gain weight is shown in Table 3.
3 piglet weight increment test result of table
Grice diarrhoea prophylactic tria the results are shown in Table 4.
4 grice diarrhoea prophylactic tria result of table
| Group | Death toll (head) | Diarrhea number (head) | Diarrhea rate (%) |
| Test 1 group | 0 | 0 | 0 |
| Test 2 groups | 1 | 2 | 2 |
| Test 3 groups | 3 | 15 | 15 |
Test result shows that compared with blank control group, trial drug and control drug have piglet good rush
The effect of growth result and prevention of diarrhea in piglets, the effect of the growth-promoting effect of drug of the present invention and pre- anti-diarrhea are substantially better than anti-
Bacterium growth promotion control drug flavomycoin.During experiment, pig is in good health, shows that drug of the present invention is safe, can add for a long time
Add.
Test example 4
Further to verify drug of the present invention to growing-finishing pig growth promoting function, great Bei agricultures group animal health technology is ground
Study carefully center and carried out contrast test on Zhucheng experiment pig farm, test result is as follows：
1 materials and methods
1.1 experimental animal
70 age in days growing-finishing pig of Ternary Pig three way cross.
1.2 feeds and drug
Feed：For the growing and fattening material of certain feed technology Co., Ltd production；
Trial drug：It is prepared by Medications Example 8 of the present invention.
1.3 experiment groupings
200 70 age in days growing-finishing pigs are randomly divided into 2 groups, 1 group of experiment is trial drug group, is added by every 1 ton of feed
Add the drug 0.5kg prepared by Medications Example 8 of the present invention, mixed feeding administration, successive administration 28 days；It is blank control to test 2 groups
Group does not add any drug in feed.
1.4 inspection target
Each group is weighed at 70 ages in days, the 98 age in days morning 7 on an empty stomach respectively, and observes and record pig feeding, body condition, hair
Situations such as color, behavior, defecation, diarrhea.
2 test results and analysis
Growing-finishing pig Gain weight is shown in Table 5.
5 growing-finishing pig growth promotion test result of table
Test result shows that compared with blank control group, trial drug has growing-finishing pig good growth promotion to make
With.During experiment, pig is in good health, shows that drug of the present invention is safe, can add for a long time.
Test example 5
To verify curative effect of medication of the present invention, great Bei agricultures group animal health Technical Research Center is in Tianjin Baodi test pig
Field demonstrates preventive effect of the drug of the present invention to diarrhea of weaned piglets, as a result as follows：
1 materials and methods
1.1 experimental animal
Piglet Du's miscellaneous 20 nest of piglet of great Bai ternarys, per nest 9~l2 heads, totally 209.Experiment piglet birth age in days difference does not surpass
2 days are spent, weight, parity are close, and sex ratio is consistent, and sow is without illness history.
1.2 feeds and drug
Feed：For the porket granule feedstuff of certain feed technology Co., Ltd production；
Trial drug：It is prepared by Medications Example 9 of the present invention.
1.3 experiment groupings
20 nest piglets are randomly divided into test group (10 103, nest) and control group (10 106, nest).Test group and control group
Wean in 28 age in days.Test group (49 say age) 3 weeks after 21 ages in days start to wean adds 1 in feed by feed per ton
Kilogram by Medications Example 9 of the present invention preparation drug, control group do not add any drug.
1.4 inspection target
Test group and control group claim at 21 ages in days, 28 ages in days, 35 ages in days, 42 ages in days, the 49 age in days morning 7 on an empty stomach respectively
Weight, and record from 21 say age daily each group feed injected volume and 28 ages in days, 35 ages in days, 42 ages in days, 49 say age feed surplus.
When daily 7 from 28 ages in days, 20 when respectively by head observe and record piglet discharge feces situation.
1.5 data statistics
Count before and after weaned piglet before feed intake, wean death head number after average weight, piglet weightening, feed-weight ratio, wean,
Diarrhea head number, diarrhea rate, diarrhea frequency.Total data carries out Statistics Division using 18.0 editions analysis softwares of PASW Statistics
Reason, and carry out significance analysis.
Diarrhea rate=diarrhea head number/total head number
Diarrhea frequency=diarrhea head/(testing number of days after every group of head number × wean)
2 test results
2.1 diarrhea preventive effects
From table 6：Dead 1 of test group, dead 5 of control group, two group differences significantly (P<0.05)；Test group abdomen
34 are rushed down, control group diarrhea 59, two groups are asked significant difference (P<0.05)；Test group diarrhea rate 33.0%, control group diarrhea rate
55.7%, two group differences significantly (P<0.05)；Test group diarrhea frequency 1.57, control group diarrhea frequency 2.65 are poor between two groups
Different significantly (P<0.05).
6 drug of the present invention of table is to diarrhea of weaned piglets preventive effect
| Group | Death toll (head) | Diarrhea number (head) | Diarrhea rate (%) | Diarrhea frequency (%) |
| Test group | 1 | 34 | 33.0 | 1.57 |
| Control group | 5 | 59 | 55.7 | 2.65 |
2.2 feed intake
From table 7：21-28 ages in days test group and control group feed intake difference is not notable；Test group is searched for food after 28 ages in days
Amount is apparently higher than control group feed intake, significant difference (P<0.05).
7 daily ingestion amount of table (kg)
| Group | 21-28 ages in days | 28-35 ages in days | 35-42 ages in days | 42-49 ages in days |
| Test group | 0.52 | 0.66 | 0.86 | 1.03 |
| Control group | 0.53 | 0.62 | 0.79 | 0.88 |
2.3 gaining effect
From table 8：Test group and control group average weight difference is not notable when 21-28 ages in days；Test group after 28 mesh ages
Piglet average weight compares significant difference raising with control group.
8 each age in days average weight (kg) of table
| Group | 21 ages in days | 28 ages in days | 35 ages in days | 42 ages in days | 49 ages in days |
| Test group | 5.35 | 7.67 | 10.91 | 13.79 | 18.31 |
| Control group | 5.33 | 7.42 | 10.58 | 12.65 | 15.53 |
2.4 feed conversion rate
From table 9：After wean test group feed-weight ratio be significantly lower than control group, illustrate test group feed conversion rate higher than pair
According to group.
9 each age in days feed-weight ratio of table
| Group | 21-28 ages in days | 28-35 ages in days | 35-42 ages in days | 42-49 ages in days |
| Test group | 1.77 | 1.61 | 1.99 | 1.58 |
| Control group | 1.65 | 1.77 | 2.73 | 1.83 |
3 discuss
Using indexs such as diarrhea head number, diarrhea rate, diarrhea frequencies, diarrhoea degree is investigated, test group and control group difference are bright
It is aobvious, it as a result can objectively reflect good result of the drug of the present invention to preventing post-weaning diarrhea.
After weaned piglet diarrhea is easy to happen since feeding environment and rearing conditions drastic change, piglet stress be larger simultaneously in 2 weeks
Other diseases are induced, therefore daily gain and feed conversion rate decline.This growth phase piglet is easy to happen disease, should reinforce raising
Management is supported, reducing to the greatest extent stress.
Wean starts to add drug of the present invention in pig starter feed for first 1 week, can improve piglet constitution, enhance to weaning stress
Resistance, reduce the harm of grice diarrhoea, promote piglet growth.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, without departing from the technical principles of the invention, several improvements and modifications can also be made, these improvements and modifications
Also it should be regarded as protection scope of the present invention.
Claims (8)
1. invigorating the spleen growth promotion pharmaceutical composition, containing active constituent, the active constituent is by Cortex Eucommiae, Semen Cuscutae, rhizoma alismatis, lemon
Acid, malic acid, vitamin C are made.
2. invigorating the spleen growth promotion pharmaceutical composition according to claim 1, which is characterized in that the active constituent is by Cortex Eucommiae
40-80 parts, 30-60 parts of Semen Cuscutae, 10-30 parts of rhizoma alismatis, 1-10 parts of citric acid, 1-10 parts of malic acid, 1-10 parts of vitamin C system
At.
3. invigorating the spleen growth promotion pharmaceutical composition according to claim 2, which is characterized in that the active constituent is by Cortex Eucommiae
50-60 parts, 40-50 parts of Semen Cuscutae, 15-25 parts of rhizoma alismatis, 3-8 parts of citric acid, 3-8 parts of malic acid, 3-8 parts of vitamin C be made.
4. invigorating the spleen growth promotion pharmaceutical composition according to claim 3, which is characterized in that the active constituent is by Cortex Eucommiae 55
Part, 45 parts of Semen Cuscutae, 20 parts of rhizoma alismatis, 5 parts of citric acid, 5 parts of malic acid, 5 parts of vitamin C are made.
5. a kind of preparation method of claim 1-4 any one of them invigorating the spleen growth promotion pharmaceutical composition, includes the following steps：
1) Cortex Eucommiae, Semen Cuscutae, rhizoma alismatis are weighed by weight ratio as drug component 1；
2) citric acid, malic acid, vitamin C are weighed by weight ratio as drug component 2；
3) drug component 1 claimed is crushed, after sieving, or the drug component 1 claimed is added after water or alcohol extracting, concentration
Enter drug component 2, mixing adds the available auxiliary material of pharmacy or complementary ingredient, is prepared.
6. the preparation method of invigorating the spleen growth promotion pharmaceutical composition according to claim 5, which is characterized in that dosage form obtained
It is：Pre-mixing agent, pulvis, extract powder, powder, granule or oral solution.
7. claim 1-4 any one of them invigorating the spleen growth promotion pharmaceutical composition is preparing livestock and poultry feed additive for promoting growth side
The application in face.
8. the feed addictive containing claim 1-4 any one of them invigorating the spleen growth promotion pharmaceutical compositions.
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2018
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| CN101785528A (en) * | 2010-02-01 | 2010-07-28 | 西安沃森生物科技有限公司 | Eucommia ulmoides feed additive and preparation method and application thereof |
| CN106615846A (en) * | 2017-01-10 | 2017-05-10 | 湘西芙蓉资源农业科技有限公司 | Traditional Chinese medicine health-care feed for middle and big pigs and preparation method of traditional Chinese medicine health-care feed |
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