CN108635410A - A kind of traditional Chinese medicine injection that treating duck plague disease and its application - Google Patents

A kind of traditional Chinese medicine injection that treating duck plague disease and its application Download PDF

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CN108635410A
CN108635410A CN201810836911.6A CN201810836911A CN108635410A CN 108635410 A CN108635410 A CN 108635410A CN 201810836911 A CN201810836911 A CN 201810836911A CN 108635410 A CN108635410 A CN 108635410A
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chinese medicine
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medicine injection
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李俊
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Guizhou Wanli Rural Agricultural Development Co Ltd
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Guizhou Wanli Rural Agricultural Development Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56Materials from animals other than mammals
    • A61K35/63Arthropods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/254Acanthopanax or Eleutherococcus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/25Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258Panax (ginseng)
    • AHUMAN NECESSITIES
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/63Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P31/14Antivirals for RNA viruses
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Abstract

The present invention provides a kind of traditional Chinese medicine injection for treating duck plague disease and its applications, the traditional Chinese medicine injection, injection is made by Chinese blister beetle, ginseng, Radix Astragali, wilsonii, Radix Glycyrrhizae, winter jasmine extraction, the injection is for treating duck plague disease, effect highly significant, it overcomes and applies chemicals, more meet the production requirement of green ecological meat duck.

Description

A kind of traditional Chinese medicine injection that treating duck plague disease and its application
Technical field
The invention belongs to cultural technique fields, and in particular to a kind of traditional Chinese medicine injection that treating duck plague disease and its application.
Background technology
Duck, duck are the general designations of Anseriformes Anatidae duck subfamily aquatic bird, mainly with the toy (fish, shrimp, loach etc.) in water, Plant (water plant, barnyard grass, rice etc.) is food.It is divided into laying duck and duckling, duck's egg nutritive value is high, the aliphatic acid fusing point in duck It is low, it is easy to digest.Contained B family vitamin and vitamin E are more compared with other meats, are highly resistant to athlete's foot, neuritis and a variety of Inflammation, moreover it is possible to anti-aging.Containing the niacin compared with horn of plenty in duck, it be constitute two kinds of important coenzyme in human body at point it One, there is protective effect to heart disease patients such as myocardial infarctions.
Duck plague (Duck plape0) also known as duck viral enteritis (Duck virusenteritis, DVE), be duck, goose and A kind of acute, hot, Septic blood infectious disease of other Anseriformes birds.The disease is characterized in prevalence extensively, propagates rapid, morbidity Rate and the death rate are all high.This disease is found for the first time in Holland early in nineteen twenty-three BaudetShi, until BosShi in 1940 is put forward for the first time duck The title of pest, and confirm it is a kind of new virus disease different from checken pest.Currently, there is no specific drug, often aim at prevention, except carrying out Outside biological safety measure, the occurrence of this disease can effectively be prevented by carrying out immunity inoculation using duck plague attenuated live vaccines.Duck is mass-sended When sick, to healthy duck group or suspected infection duck, 3-4 times of amount of duck plague vaccine should be taken promptly to be inoculated with immediately;To sick duck, every The duck plague hyper-immune serum duck poison of the great high-tech of intramuscular injection state resists 0.5 milliliter or 0.5-1 milliliters of poly IC, injects 1 time within every 3 days, 2-3 is used in conjunction It is secondary, carry out early treatment.Also the mixed drink of water can be mixed with Moroxydine Hydrochloride soluble powder or Enrofloxacin soluble powder, it is l-2 times daily, It is used in conjunction 3-5 days, but is not applied to laying ducks, meat duck is pre-sales should to be discontinued 8 days.Sick duck slaughters without exception and buried processing.It is right simultaneously The all goods that sick duck may contact carry out thorough disinfection.But above-mentioned therapeutic effect is to be improved, and medicament residue is caused to pollute, It is unfavorable for the production of duck product.
Invention content
It is of the existing technology to overcome the problems, such as, the present invention provides a kind of traditional Chinese medicine injection for treating duck plague disease and its answer With injection is made by Chinese blister beetle, ginseng, Radix Astragali, wilsonii, Radix Glycyrrhizae, winter jasmine extraction in the traditional Chinese medicine injection, which uses In treatment duck plague disease, effect highly significant overcomes using chemicals, more meets the production requirement of green ecological meat duck.
Specifically, a kind of traditional Chinese medicine injection for treating duck plague disease, by weight, by 10-40 parts of Chinese blister beetle, ginseng 6-16 Part, 6-16 parts of Radix Astragali, 10-40 parts of wilsonii, 6-12 parts of Radix Glycyrrhizae, 6-12 parts of winter jasmine are made.
Preferably, the traditional Chinese medicine injection of the treatment duck plague disease, by weight, by 20-30 parts of Chinese blister beetle, ginseng 10- 12 parts, 10-12 parts of Radix Astragali, 20-30 parts of wilsonii, 8-10 parts of Radix Glycyrrhizae, 8-10 parts of winter jasmine be made.
It is highly preferred that the traditional Chinese medicine injection of the treatment duck plague disease, by weight, by 25 parts of Chinese blister beetle, 11 parts of ginseng, 11 parts of Radix Astragali, 25 parts of wilsonii, 9 parts of Radix Glycyrrhizae, 9 parts of winter jasmine are made.
The present invention also provides a kind of preparation methods for treating duck plague disease traditional Chinese medicine injection, include the following steps:
(1) Chinese blister beetle, ginseng, Radix Astragali, wilsonii, Radix Glycyrrhizae, winter jasmine are crushed, adds 6-10 times to measure water for injection, boiling carries 1-3h is taken, is filtered, filtrate is concentrated into medicinal extract, spare.
(2) take step (1) dregs of a decoction that 80% ethanol solution, refluxing extraction 40-60min, filtering, filtrate recycling second is added Alcohol is concentrated into medicinal extract;
(3) merge step (1) and step (2) medicinal extract, the water that 100-160 times of medicinal extract is measured is added, stirring and dissolving filters, and fills Dress, 110-120 DEG C of sterilizing, every bottle of 5ml.
Further, (1) crushes Chinese blister beetle, ginseng, Radix Astragali, wilsonii, Radix Glycyrrhizae, winter jasmine, adds 8 times of amount water, 2h is extracted in boiling, and filtering, filtrate is concentrated into medicinal extract, spare.
(2) take the ethanol solution of step (1) dregs of a decoction addition 80%, refluxing extraction 50min, filtering, filtrate recycling Ethyl alcohol is concentrated into medicinal extract;
Described (3) merging step (1) and step (2) medicinal extract, the waters for injection of addition 130 times of amounts of medicinal extract, stirring and dissolving, Filtering, filling, 115 DEG C of sterilizings, every bottle of 5ml.
Injection of the present invention is by every sick duck intramuscular injection 3-5ml in treatment use.
Beneficial effects of the present invention are:
The present invention is to meet the cultivation of green ecological duck, and administration of antibiotics and chemicals is overcome to pass through the pollution of duck Injection is made with Chinese blister beetle, ginseng, Radix Astragali, wilsonii, Radix Glycyrrhizae, winter jasmine extraction in a large amount of experimental study, final determine, the note It penetrates liquid and more meets the production requirement of green ecological meat duck for treating duck plague disease, effect highly significant.
Specific implementation mode
With reference to preferred embodiment, the present invention is further explained.It should be understood that these embodiments are merely to illustrate The present invention rather than limit the scope of the invention.In addition, it should also be understood that, after having read present disclosure, this field Technical staff can make various changes or modifications the present invention, and such equivalent forms equally fall within the application the appended claims Limited range.
Embodiment 1 treats the preparation of the traditional Chinese medicine injection of duck plague disease
Raw material:Chinese blister beetle 10g, ginseng 6g, Radix Astragali 6g, wilsonii 10g, Radix Glycyrrhizae 6g, winter jasmine 6g.
Preparation method:(1) Chinese blister beetle, ginseng, Radix Astragali, wilsonii, Radix Glycyrrhizae, winter jasmine are crushed, add 6 times of amount waters for injection, 1h is extracted in boiling, and filtering, filtrate is concentrated into medicinal extract, spare.
(2) take step (1) dregs of a decoction that 80% ethanol solution is added, refluxing extraction 40min is filtered, and filtrate recycling ethanol is dense It is reduced to medicinal extract;
(3) merging step (1) and step (2) medicinal extract, the water of 100 times of amounts of medicinal extract is added, stirring and dissolving, filtering is filling, 110 DEG C of sterilizings, every bottle of 5ml.
Embodiment 2 treats the preparation of the traditional Chinese medicine injection of duck plague disease
Raw material:Chinese blister beetle 20g, ginseng 10g, Radix Astragali 10g, wilsonii 20g, Radix Glycyrrhizae 8g, winter jasmine 8g
Preparation method:(1) Chinese blister beetle, ginseng, Radix Astragali, wilsonii, Radix Glycyrrhizae, winter jasmine are crushed, add 7 times of amount waters for injection, 2h is extracted in boiling, and filtering, filtrate is concentrated into medicinal extract, spare.
(2) take step (1) dregs of a decoction that 80% ethanol solution is added, refluxing extraction 40min is filtered, and filtrate recycling ethanol is dense It is reduced to medicinal extract;
(3) merging step (1) and step (2) medicinal extract, the water of 100 times of amounts of medicinal extract is added, stirring and dissolving, filtering is filling, 110 DEG C of sterilizings, every bottle of 5ml.
Embodiment 3 treats the preparation of the traditional Chinese medicine injection of duck plague disease
Raw material:Chinese blister beetle 25g, ginseng 11g, Radix Astragali 11g, wilsonii 25g, Radix Glycyrrhizae 9g, winter jasmine 9g;
Preparation method:(1) Chinese blister beetle, ginseng, Radix Astragali, wilsonii, Radix Glycyrrhizae, winter jasmine are crushed, add 8 times of amount waters for injection, 3h is extracted in boiling, and filtering, filtrate is concentrated into medicinal extract, spare.
(2) take step (1) dregs of a decoction that 80% ethanol solution is added, refluxing extraction 40min is filtered, and filtrate recycling ethanol is dense It is reduced to medicinal extract;
(3) merging step (1) and step (2) medicinal extract, the water of 130 times of amounts of medicinal extract is added, stirring and dissolving, filtering is filling, 115 DEG C of sterilizings, every bottle of 5ml.
Embodiment 4 treats the preparation of the traditional Chinese medicine injection of duck plague disease
Raw material:Chinese blister beetle 30g, ginseng 12g, Radix Astragali 12g, wilsonii 30g, Radix Glycyrrhizae 10g, winter jasmine 10g;
Preparation method:(1) Chinese blister beetle, ginseng, Radix Astragali, wilsonii, Radix Glycyrrhizae, winter jasmine are crushed, add 8 times of amount waters for injection, 3h is extracted in boiling, and filtering, filtrate is concentrated into medicinal extract, spare.
(2) take step (1) dregs of a decoction that 80% ethanol solution is added, refluxing extraction 60min is filtered, and filtrate recycling ethanol is dense It is reduced to medicinal extract;
(3) merging step (1) and step (2) medicinal extract, the water of 160 times of amounts of medicinal extract is added, stirring and dissolving, filtering is filling, 115 DEG C of sterilizings, every bottle of 5ml.
Embodiment 5 treats the preparation of the traditional Chinese medicine injection of duck plague disease
Raw material:Chinese blister beetle 40g, ginseng 16g, Radix Astragali 16g, wilsonii 40g, Radix Glycyrrhizae 12g, winter jasmine 12g;
Preparation method:(1) Chinese blister beetle, ginseng, Radix Astragali, wilsonii, Radix Glycyrrhizae, winter jasmine are crushed, add 8 times of amount waters for injection, 3h is extracted in boiling, and filtering, filtrate is concentrated into medicinal extract, spare.
(2) take step (1) dregs of a decoction that 80% ethanol solution is added, refluxing extraction 60min is filtered, and filtrate recycling ethanol is dense It is reduced to medicinal extract;
(3) merging step (1) and step (2) medicinal extract, the water of 160 times of amounts of medicinal extract is added, stirring and dissolving, filtering is filling, 120 DEG C of sterilizings, every bottle of 5ml.
Embodiment 6 treats the preparation of the traditional Chinese medicine injection of duck plague disease
Raw material:Chinese blister beetle 25g, Radix Astragali 11g, wilsonii 25g, Radix Glycyrrhizae 9g, winter jasmine 9g;
Preparation method:(1) Chinese blister beetle, Radix Astragali, wilsonii, Radix Glycyrrhizae, winter jasmine are crushed, 8 times of amount waters for injection, boiling is added to carry 3h is taken, is filtered, filtrate is concentrated into medicinal extract, spare.
(2) take step (1) dregs of a decoction that 80% ethanol solution is added, refluxing extraction 40min is filtered, and filtrate recycling ethanol is dense It is reduced to medicinal extract;
(3) merging step (1) and step (2) medicinal extract, the water of 130 times of amounts of medicinal extract is added, stirring and dissolving, filtering is filling, 115 DEG C of sterilizings, every bottle of 5ml.
Embodiment 7 treats the preparation of the traditional Chinese medicine injection of duck plague disease
Raw material:Chinese blister beetle 25g, ginseng 11g, Radix Astragali 11g, Radix Glycyrrhizae 9g, winter jasmine 9g;
Preparation method:(1) Chinese blister beetle, ginseng, Radix Astragali, Radix Glycyrrhizae, winter jasmine are crushed, adds 8 times of amount waters for injection, boiling extraction 3h, filtering, filtrate is concentrated into medicinal extract, spare.
(2) take step (1) dregs of a decoction that 80% ethanol solution is added, refluxing extraction 40min is filtered, and filtrate recycling ethanol is dense It is reduced to medicinal extract;
(3) merging step (1) and step (2) medicinal extract, the water of 130 times of amounts of medicinal extract is added, stirring and dissolving, filtering is filling, 115 DEG C of sterilizings, every bottle of 5ml.
1 duck plague injection control effect of the present invention of test example is investigated
800 duck plague sick ducks are randomly divided into 8 groups, test group 1-7 uses injection made from 1-7 of the embodiment of the present invention respectively It is treated, control group:0.5 milliliter for the treatment of is resisted using the duck plague hyper-immune serum duck poison of the great high-tech of intramuscular injection state;Investigate result Such as the following table 1:
1 duck plague injection control effect of the present invention of table is investigated
Test group Experiment quantity/only Cure rate %
Test group 1 100 82
Test group 2 100 83
Test group 3 100 85
Test group 4 100 84
Test group 5 100 85
Test group 6 100 46
Test group 7 100 54
Control group 100 63
It is above-mentioned experiments have shown that, for injection made of the present invention for preventing duck plague disease, effect is preferable, illustrate it is of the invention preferably Chinese blister beetle, ginseng, Radix Astragali, wilsonii, Radix Glycyrrhizae, traditional Chinese medicine injection made of winter jasmine, formula is reasonable, and cost is relatively low, very easily In operation.

Claims (7)

1. a kind of traditional Chinese medicine injection for treating duck plague disease, which is characterized in that by weight, by 10-40 parts of Chinese blister beetle, ginseng 6-16 Part, 6-16 parts of Radix Astragali, 10-40 parts of wilsonii, 6-12 parts of Radix Glycyrrhizae, 6-12 parts of winter jasmine are made.
2. the traditional Chinese medicine injection for the treatment of duck plague disease according to claim 1, it is characterised in that:By weight, by Chinese blister beetle 20-30 parts, 10-12 parts of ginseng, 10-12 parts of Radix Astragali, 20-30 parts of wilsonii, 8-10 parts of Radix Glycyrrhizae, 8-10 parts of winter jasmine be made.
3. the traditional Chinese medicine injection for the treatment of duck plague disease according to claim 1, it is characterised in that:By weight, by Chinese blister beetle 25 parts, 11 parts of ginseng, 11 parts of Radix Astragali, 25 parts of wilsonii, 9 parts of Radix Glycyrrhizae, 9 parts of winter jasmine be made.
4. a kind of preparation method for treating duck plague disease traditional Chinese medicine injection, which is characterized in that include the following steps:
(1) Chinese blister beetle, ginseng, Radix Astragali, wilsonii, Radix Glycyrrhizae, winter jasmine are crushed, adds 6-10 times to measure water for injection, 1- is extracted in boiling 3h, filtering, filtrate is concentrated into medicinal extract, spare;
(2) take step (1) dregs of a decoction that 80% ethanol solution is added, refluxing extraction 40-60min is filtered, and filtrate recycling ethanol is dense It is reduced to medicinal extract;
(3) merging step (1) and step (2) medicinal extract, the water that 100-160 times of medicinal extract is measured is added, stirring and dissolving, filtering is filling, 110-120 DEG C of sterilizing, every bottle of 5ml.
5. the preparation method for the treatment of duck plague disease traditional Chinese medicine injection according to claim 4, it is characterised in that:(1) Chinese blister beetle, ginseng, Radix Astragali, wilsonii, Radix Glycyrrhizae, winter jasmine are crushed, add 8 times of amount water, boiling to extract 2h, filtering, filtrate is concentrated into Medicinal extract, it is spare.
6. the preparation method for the treatment of duck plague disease traditional Chinese medicine injection according to claim 4, it is characterised in that:The step (2) take step (1) dregs of a decoction that 80% ethanol solution is added, refluxing extraction 50min is filtered, and filtrate recycling ethanol is concentrated into leaching Cream.
7. the preparation method for the treatment of duck plague disease traditional Chinese medicine injection according to claim 4, it is characterised in that:(3) Merge step (1) and step (2) medicinal extract, the water for injection of 130 times of amounts of medicinal extract is added, stirring and dissolving, filtering, filling, 115 DEG C go out Bacterium, every bottle of 5ml.
CN201810836911.6A 2018-07-26 2018-07-26 A kind of traditional Chinese medicine injection that treating duck plague disease and its application Pending CN108635410A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1823884A (en) * 2005-12-20 2006-08-30 北京天新园医药科技开发有限公司 Preparation method of aidi injection agent
CN104491505A (en) * 2014-12-02 2015-04-08 河南牧业经济学院 Compound fermented coptis chinensis paste and preparation method thereof
CN107308324A (en) * 2017-06-29 2017-11-03 贞丰县食源特种养殖有限公司 A kind of traditional Chinese medicine injection for treating duck plague disease and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1823884A (en) * 2005-12-20 2006-08-30 北京天新园医药科技开发有限公司 Preparation method of aidi injection agent
CN104491505A (en) * 2014-12-02 2015-04-08 河南牧业经济学院 Compound fermented coptis chinensis paste and preparation method thereof
CN107308324A (en) * 2017-06-29 2017-11-03 贞丰县食源特种养殖有限公司 A kind of traditional Chinese medicine injection for treating duck plague disease and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
周希平等: "中草药清瘟疏肝散治疗鸭瘟等疫病", 《江西畜牧兽医杂志》 *

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Application publication date: 20181012