CN108619089A - 脱氧胆酸和其盐的制剂 - Google Patents
脱氧胆酸和其盐的制剂 Download PDFInfo
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- CN108619089A CN108619089A CN201810400642.9A CN201810400642A CN108619089A CN 108619089 A CN108619089 A CN 108619089A CN 201810400642 A CN201810400642 A CN 201810400642A CN 108619089 A CN108619089 A CN 108619089A
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- dexycholate
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- 239000002609 medium Substances 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000003158 myorelaxant agent Substances 0.000 description 1
- 238000006772 olefination reaction Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000003961 penetration enhancing agent Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 238000005498 polishing Methods 0.000 description 1
- LPNYRYFBWFDTMA-UHFFFAOYSA-N potassium tert-butoxide Chemical compound [K+].CC(C)(C)[O-] LPNYRYFBWFDTMA-UHFFFAOYSA-N 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- 235000011008 sodium phosphates Nutrition 0.000 description 1
- JAJWGJBVLPIOOH-IZYKLYLVSA-M sodium taurocholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(=O)NCCS([O-])(=O)=O)C)[C@@]2(C)[C@@H](O)C1 JAJWGJBVLPIOOH-IZYKLYLVSA-M 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 239000003204 tranquilizing agent Substances 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229940070710 valerate Drugs 0.000 description 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
- 239000005526 vasoconstrictor agent Substances 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Child & Adolescent Psychology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810400642.9A CN108619089A (zh) | 2011-08-23 | 2011-08-23 | 脱氧胆酸和其盐的制剂 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2011/048806 WO2013028177A1 (en) | 2011-08-23 | 2011-08-23 | Formulations of deoxycholic acid and salts thereof |
| CN201810400642.9A CN108619089A (zh) | 2011-08-23 | 2011-08-23 | 脱氧胆酸和其盐的制剂 |
| CN201180072842.2A CN103826608A (zh) | 2011-08-23 | 2011-08-23 | 脱氧胆酸和其盐的制剂 |
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| CN201180072842.2A Division CN103826608A (zh) | 2011-08-23 | 2011-08-23 | 脱氧胆酸和其盐的制剂 |
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| CN108619089A true CN108619089A (zh) | 2018-10-09 |
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| CN201180072842.2A Pending CN103826608A (zh) | 2011-08-23 | 2011-08-23 | 脱氧胆酸和其盐的制剂 |
| CN201810403291.7A Pending CN108743522A (zh) | 2011-08-23 | 2011-08-23 | 脱氧胆酸和其盐的制剂 |
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| CN201180072842.2A Pending CN103826608A (zh) | 2011-08-23 | 2011-08-23 | 脱氧胆酸和其盐的制剂 |
| CN201810403291.7A Pending CN108743522A (zh) | 2011-08-23 | 2011-08-23 | 脱氧胆酸和其盐的制剂 |
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| JP (1) | JP5919597B2 (ja) |
| KR (5) | KR101919269B1 (ja) |
| CN (3) | CN108619089A (ja) |
| AU (3) | AU2011375432B2 (ja) |
| BR (1) | BR112014000547B1 (ja) |
| CA (1) | CA2842177C (ja) |
| CR (1) | CR20140053A (ja) |
| EA (1) | EA029305B1 (ja) |
| IL (1) | IL230547A (ja) |
| IN (1) | IN2014CN02188A (ja) |
| MX (1) | MX350390B (ja) |
| MY (1) | MY184277A (ja) |
| NZ (1) | NZ620040A (ja) |
| PH (1) | PH12016501175A1 (ja) |
| SG (1) | SG2014013205A (ja) |
| UA (1) | UA113522C2 (ja) |
| WO (1) | WO2013028177A1 (ja) |
| ZA (1) | ZA201401027B (ja) |
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| US8101593B2 (en) | 2009-03-03 | 2012-01-24 | Kythera Biopharmaceuticals, Inc. | Formulations of deoxycholic acid and salts thereof |
| JP2018532806A (ja) * | 2015-11-04 | 2018-11-08 | キセラ バイオファーマシューティカルズ インコーポレイテッド | デオキシコール酸およびその塩による蓄積脂肪の処置方法 |
| KR101841193B1 (ko) * | 2016-09-22 | 2018-03-22 | 이경락 | 저장성 지방 분해 조성물 및 그의 제조 방법 |
| US20180078621A1 (en) * | 2016-09-22 | 2018-03-22 | Kyoung Lack Lee | Composition for hypotonic lipolysis and manufacturing method thereof |
| WO2019203511A1 (ko) * | 2018-04-16 | 2019-10-24 | 주식회사 펜믹스 | 데옥시콜릭산을 포함하는 약학 조성물 |
| KR102172439B1 (ko) * | 2018-12-05 | 2020-10-30 | 송미희 | 지방 분해용 조성물 및 이를 포함하는 주사제 조성물 |
| KR102064864B1 (ko) | 2019-02-08 | 2020-01-10 | (주)제테마 | 국소 주사용 조성물 |
| KR102111346B1 (ko) * | 2019-08-20 | 2020-05-22 | 아영창 | 침전으로부터 안정한 소듐디옥시콜레이트를 포함하는 수용액상 조성물 |
| KR20220026068A (ko) | 2020-08-25 | 2022-03-04 | 강명범 | 지방 분해용 주사제 조성물 |
| CN116617160A (zh) * | 2023-07-25 | 2023-08-22 | 山东则正医药技术有限公司 | 水性混悬液及制备方法、冻干粉及应用、脂肪消减注射剂 |
Citations (1)
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|---|---|---|---|---|
| CN1348360A (zh) * | 1998-07-24 | 2002-05-08 | 柳署弘 | 制备含有胆汁酸的澄清水溶液剂型 |
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| FR2754709B1 (fr) | 1996-10-23 | 1999-03-05 | Sanofi Sa | Composition cosmetique contenant un antagoniste des recepteurs du neuropeptide gamma et alpha 2 antagonistes susceptibles d'etre incorpores dans une telle composition |
| US6417179B1 (en) * | 1998-10-13 | 2002-07-09 | Craig G. Burkhart | Ear wax solution |
| US20050048126A1 (en) * | 2000-12-22 | 2005-03-03 | Barrett Rabinow | Formulation to render an antimicrobial drug potent against organisms normally considered to be resistant to the drug |
| DE10361067A1 (de) * | 2003-12-22 | 2005-07-14 | Aventis Pharma Deutschland Gmbh | Medikamentöse Lipolyse von Fettansammlungen |
| MXPA06013437A (es) | 2004-05-19 | 2007-03-23 | Los Angeles Biomed Res Inst | Uso de un detergente para la eliminacion no quirurgica de grasa. |
| US7754230B2 (en) | 2004-05-19 | 2010-07-13 | The Regents Of The University Of California | Methods and related compositions for reduction of fat |
| US20060127468A1 (en) | 2004-05-19 | 2006-06-15 | Kolodney Michael S | Methods and related compositions for reduction of fat and skin tightening |
| AU2006255097B2 (en) | 2005-06-06 | 2012-02-09 | Georgetown University | Compositions and methods for lipo modeling |
| TW201011755A (en) | 2008-09-10 | 2010-03-16 | Skymedi Corp | Flash memory system and its data recovery method |
| JP5420946B2 (ja) * | 2009-03-23 | 2014-02-19 | 富士フイルム株式会社 | 胆汁酸を含むミノキシジル水性組成物 |
| EP2645099A1 (en) | 2012-03-30 | 2013-10-02 | Phares Pharmaceutical Research N.V. | Biorelevant compositions |
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2011
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- 2011-08-23 UA UAA201400641A patent/UA113522C2/uk unknown
- 2011-08-23 WO PCT/US2011/048806 patent/WO2013028177A1/en active Application Filing
- 2011-08-23 EA EA201490175A patent/EA029305B1/ru unknown
- 2011-08-23 MY MYPI2014000197A patent/MY184277A/en unknown
- 2011-08-23 AU AU2011375432A patent/AU2011375432B2/en active Active
- 2011-08-23 KR KR1020177016779A patent/KR101919269B1/ko active IP Right Grant
- 2011-08-23 BR BR112014000547-8A patent/BR112014000547B1/pt active IP Right Grant
- 2011-08-23 KR KR1020197030233A patent/KR102073536B1/ko active IP Right Grant
- 2011-08-23 JP JP2014527128A patent/JP5919597B2/ja active Active
- 2011-08-23 NZ NZ620040A patent/NZ620040A/en not_active IP Right Cessation
- 2011-08-23 KR KR1020207002722A patent/KR20200013103A/ko not_active Application Discontinuation
- 2011-08-23 IN IN2188CHN2014 patent/IN2014CN02188A/en unknown
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Patent Citations (1)
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| CN1348360A (zh) * | 1998-07-24 | 2002-05-08 | 柳署弘 | 制备含有胆汁酸的澄清水溶液剂型 |
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| ADAM M.ROTUNDA等: "Randomized Double-Blind Clinical Trial of Subcutaneously Injected Deoxycholate Versus a Phosphatidylcholine-Deoxycholate Combination for the Reduction of Submental Fat", 《DERMATOL SURG》 * |
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