CN108601760A - 艾日布林的合成中的中间体及相关的合成方法 - Google Patents

艾日布林的合成中的中间体及相关的合成方法 Download PDF

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Publication number
CN108601760A
CN108601760A CN201780010903.XA CN201780010903A CN108601760A CN 108601760 A CN108601760 A CN 108601760A CN 201780010903 A CN201780010903 A CN 201780010903A CN 108601760 A CN108601760 A CN 108601760A
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CN
China
Prior art keywords
formula
compound
salt
eribulin
aldehyde
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CN201780010903.XA
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English (en)
Chinese (zh)
Inventor
P.S.巴兰
C.E.蔡斯
F.G.方
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Sanitary Material R&d Management Co ltd
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Sanitary Material R&d Management Co ltd
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Publication of CN108601760A publication Critical patent/CN108601760A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/22—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Materials For Photolithography (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
CN201780010903.XA 2016-02-12 2017-02-10 艾日布林的合成中的中间体及相关的合成方法 Pending CN108601760A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662294538P 2016-02-12 2016-02-12
US62/294538 2016-02-12
PCT/US2017/017501 WO2017139664A1 (en) 2016-02-12 2017-02-10 Intermediates in the synthesis of eribulin and related methods of synthesis

Publications (1)

Publication Number Publication Date
CN108601760A true CN108601760A (zh) 2018-09-28

Family

ID=59563582

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201780010903.XA Pending CN108601760A (zh) 2016-02-12 2017-02-10 艾日布林的合成中的中间体及相关的合成方法

Country Status (10)

Country Link
US (1) US10676481B2 (https=)
EP (1) EP3413887B1 (https=)
JP (1) JP6786610B2 (https=)
KR (1) KR20180107243A (https=)
CN (1) CN108601760A (https=)
IL (1) IL260717B (https=)
MX (1) MX377663B (https=)
RU (1) RU2732575C2 (https=)
SG (1) SG11201806133UA (https=)
WO (1) WO2017139664A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110568121A (zh) * 2019-07-11 2019-12-13 山东省药学科学院 一种艾日布林及含艾日布林的制剂中有关物质的检测方法
CN115551866A (zh) * 2020-05-11 2022-12-30 研成精密化学株式会社 艾瑞布林的结晶盐

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BR112016009452B1 (pt) 2013-11-04 2022-06-07 Eisai R&D Management Co., Ltd Métodos de preparar intermediários na síntese de eribulina, métodos de preparar eribulina e mesilato de eribulina, e compostos intermediários
EP3077399B1 (en) 2013-12-06 2019-02-20 Eisai R&D Management Co., Ltd. Methods useful in the synthesis of halichondrin b analogs
MX392296B (es) 2015-05-07 2025-03-24 Eisai R&D Man Co Ltd Reacciones de macrociclizacion e intermediarios y otros fragmentos utiles en la sintesis de macrolidos de halicondrina.
KR102404629B1 (ko) 2016-06-30 2022-06-02 에자이 알앤드디 매니지먼트 가부시키가이샤 할리콘드린 마크롤리드 및 그의 유사체의 합성에 유용한 프린스 반응 및 중간체
IL275729B2 (en) 2018-01-03 2023-09-01 Eisai R&D Man Co Ltd Prins reaction and compounds useful in the synthesis of helicondrin macrolides and their analogs

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KR102404629B1 (ko) 2016-06-30 2022-06-02 에자이 알앤드디 매니지먼트 가부시키가이샤 할리콘드린 마크롤리드 및 그의 유사체의 합성에 유용한 프린스 반응 및 중간체
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110568121A (zh) * 2019-07-11 2019-12-13 山东省药学科学院 一种艾日布林及含艾日布林的制剂中有关物质的检测方法
CN115551866A (zh) * 2020-05-11 2022-12-30 研成精密化学株式会社 艾瑞布林的结晶盐

Also Published As

Publication number Publication date
EP3413887A1 (en) 2018-12-19
JP2019504839A (ja) 2019-02-21
EP3413887A4 (en) 2019-08-14
US20190300542A1 (en) 2019-10-03
RU2018132264A3 (https=) 2020-04-15
RU2018132264A (ru) 2020-03-12
KR20180107243A (ko) 2018-10-01
JP6786610B2 (ja) 2020-11-18
SG11201806133UA (en) 2018-08-30
RU2732575C2 (ru) 2020-09-21
EP3413887B1 (en) 2021-04-07
IL260717B (en) 2020-10-29
MX2018009794A (es) 2018-12-17
WO2017139664A8 (en) 2018-07-26
MX377663B (es) 2025-03-11
WO2017139664A1 (en) 2017-08-17
US10676481B2 (en) 2020-06-09

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