CN108588025A - 人视网膜祖细胞的表型谱 - Google Patents

人视网膜祖细胞的表型谱 Download PDF

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Publication number
CN108588025A
CN108588025A CN201810203142.6A CN201810203142A CN108588025A CN 108588025 A CN108588025 A CN 108588025A CN 201810203142 A CN201810203142 A CN 201810203142A CN 108588025 A CN108588025 A CN 108588025A
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cells
human
progenitor cells
retinal progenitor
cell population
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Pending
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CN201810203142.6A
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Chinese (zh)
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迈克尔·J·杨
彼得·Y·巴拉诺夫
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Schepens Eye Research Institute Inc
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Schepens Eye Research Institute Inc
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/062—Sensory transducers, e.g. photoreceptors; Sensory neurons, e.g. for hearing, taste, smell, pH, touch, temperature, pain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Developmental Biology & Embryology (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Hematology (AREA)
  • Acoustics & Sound (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
CN201810203142.6A 2012-02-17 2013-02-15 人视网膜祖细胞的表型谱 Pending CN108588025A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261600288P 2012-02-17 2012-02-17
US61/600,288 2012-02-17
CN201380007641.3A CN104136601A (zh) 2012-02-17 2013-02-15 人视网膜祖细胞的表型谱

Related Parent Applications (1)

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CN201380007641.3A Division CN104136601A (zh) 2012-02-17 2013-02-15 人视网膜祖细胞的表型谱

Publications (1)

Publication Number Publication Date
CN108588025A true CN108588025A (zh) 2018-09-28

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CN201810203142.6A Pending CN108588025A (zh) 2012-02-17 2013-02-15 人视网膜祖细胞的表型谱
CN201380007641.3A Pending CN104136601A (zh) 2012-02-17 2013-02-15 人视网膜祖细胞的表型谱

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US (3) US10758572B2 (https=)
EP (2) EP2814947B1 (https=)
JP (2) JP6468843B2 (https=)
KR (1) KR20140144680A (https=)
CN (2) CN108588025A (https=)
AU (3) AU2013221458B2 (https=)
BR (1) BR112014019328A8 (https=)
CA (1) CA2864818C (https=)
ES (1) ES2700980T3 (https=)
WO (1) WO2013123292A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108588025A (zh) 2012-02-17 2018-09-28 斯格本斯眼科研究所 人视网膜祖细胞的表型谱
EP3047017B1 (en) 2013-10-09 2025-09-10 The Regents of the University of California Methods of mammalian retinal stem cell production and applications
KR101690759B1 (ko) * 2015-02-25 2016-12-30 연세대학교 산학협력단 전능성 줄기세포로부터 중간엽 줄기세포를 수득하는 방법
CN106323845B (zh) * 2015-06-23 2019-11-19 何伟 鉴定具有治疗视网膜退行性病变功能的视网膜祖细胞的方法
KR20260003355A (ko) * 2015-09-08 2026-01-06 후지필름 셀룰러 다이내믹스, 인코포레이티드 줄기 세포에서 유래된 망막색소상피의 macs 기반 정제
GB201615714D0 (en) * 2016-09-15 2016-11-02 Univ Of Sheffield The Otic progenitor identification and isolation
GB201703058D0 (en) 2017-02-24 2017-04-12 Ucl Business Plc Biomarkers
WO2020190848A1 (en) * 2019-03-15 2020-09-24 The Schepens Eye Research Institute, Inc. Isolation, enrichment and expansion of cone progenitor cells and uses thereof
JP2025516357A (ja) * 2022-05-06 2025-05-27 ザ スケペンス アイ リサーチ インスティテュート，インコーポレイテッド ヒト杆体前駆細胞およびそれら由来の細胞外ベシクルの単離、濃縮および拡大培養

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001058460A1 (en) * 2000-02-11 2001-08-16 The Schepens Eye Research Institute, Inc. Isolation and transplantation of retinal stem cells
WO2003031656A1 (en) * 2001-10-05 2003-04-17 United States Environmental Protection Agency Genetic testing for male factor infertility
CN1761749A (zh) * 2003-03-10 2006-04-19 独立行政法人科学技术振兴机构 检测间充质干细胞的标记和采用该标记识别间充质干细胞的方法
CN1968608A (zh) * 2004-01-23 2007-05-23 先进细胞技术公司 用于治疗视网膜变性病的改良模式
WO2009132156A1 (en) * 2008-04-22 2009-10-29 Regenerative Research Foundation Retinal pigment epithelial stem cells
CN101952415A (zh) * 2007-07-31 2011-01-19 生命扫描有限公司 人胚胎干细胞的分化
US20110064701A1 (en) * 1999-09-24 2011-03-17 Abt Holding Company Pluripotent embryonic-like stem cells, compositions, methods and uses thereof

Family Cites Families (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
FR2636968B1 (fr) 1988-09-27 1992-01-03 Inst Nat Sante Rech Med Acide nucleique codant pour l'enzyme de conversion de l'angiotensine (eca) humaine, et ses applications, notamment pour le diagnostic in vitro de l'hypertension arterielle
DE69123241T2 (de) 1990-12-14 1997-04-17 Cell Genesys Inc Chimärische ketten zur transduktion von rezeptorverbundenen signalwegen
US5851832A (en) 1991-07-08 1998-12-22 Neurospheres, Ltd. In vitro growth and proliferation of multipotent neural stem cells and their progeny
US5750376A (en) 1991-07-08 1998-05-12 Neurospheres Holdings Ltd. In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny
US6071889A (en) 1991-07-08 2000-06-06 Neurospheres Holdings Ltd. In vivo genetic modification of growth factor-responsive neural precursor cells
US5980885A (en) 1991-07-08 1999-11-09 Neurospheres Holdings Ltd. Growth factor-induced proliferation of neural precursor cells in vivo
US5981165A (en) 1991-07-08 1999-11-09 Neurospheres Holdings Ltd. In vitro induction of dopaminergic cells
US5849553A (en) 1992-07-27 1998-12-15 California Institute Of Technology Mammalian multipotent neural stem cells
JPH08500245A (ja) 1992-07-27 1996-01-16 カリフォルニア インスティテュート オブ テクノロジー 哺乳動物の多能性神経幹細胞
US5654183A (en) 1992-07-27 1997-08-05 California Institute Of Technology Genetically engineered mammalian neural crest stem cells
US5928947A (en) 1992-07-27 1999-07-27 California Institute Of Technology Mammalian multipotent neural stem cells
AU683023B2 (en) 1992-10-16 1997-10-30 Neurospheres Holdings Ltd Remyelination using neural stem cells
EP0669973B9 (en) 1992-10-28 2007-10-10 NeuroSpheres Holdings Ltd. Biological factors and neural stem cells
FR2699191B1 (fr) 1992-12-16 1995-02-10 Univ Paris Curie Nouveaux vecteurs rétroviraux, lignées cellulaires les contenant, et leur utilisation dans le traitement des tumeurs.
ATE262912T1 (de) 1993-01-29 2004-04-15 Neurospheres Holdings Ltd Genetische modifikation von neuralen stammzellen
US6033906A (en) 1993-07-26 2000-03-07 California Institute Of Technology Methods for differentiating neural stem cells to glial cells using neuregulins
CA2175992C (en) 1993-11-09 2008-04-01 Samuel Weiss In situ modification and manipulation of stem cells of the central nervous system
PT733103E (pt) 1993-11-09 2004-07-30 Targeted Genetics Corp Criacao de elevados titulos de vectores de aav recombinantes
US6001654A (en) 1994-01-28 1999-12-14 California Institute Of Technology Methods for differentiating neural stem cells to neurons or smooth muscle cells using TGT-β super family growth factors
US5935849A (en) 1994-07-20 1999-08-10 Cytotherapeutics, Inc. Methods and compositions of growth control for cells encapsulated within bioartificial organs
US5840576A (en) 1994-07-20 1998-11-24 Cytotherapeutics, Inc. Methods and compositions of growth control for cells encapsulated within bioartificial organs
DE69523771T2 (de) 1994-09-23 2002-08-01 Neurospheres Holding Ltd., Calgary In vitro-modelle für cns-funktion und-dysfunktion
FI971956L (fi) 1994-11-14 1997-07-04 Neurospheres Holdings Ltd Hermosolujen lisääntymisen säännöstely
US5861283A (en) 1995-03-31 1999-01-19 The University Of Medicine And Dentistry Of New Jersey DNA encoding a limbic system-associated membrane protein
WO1997035605A1 (en) 1996-03-26 1997-10-02 Neurospheres Holdings Ltd. Manipulation of mitotically active cells of the hippocampal region of the brain
US5753506A (en) 1996-05-23 1998-05-19 Cns Stem Cell Technology, Inc. Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals
CA2216439A1 (en) 1996-09-25 1998-03-25 Derek Van Der Kooy Pharmaceuticals containing retinal stem cells
US6908763B1 (en) 1997-08-22 2005-06-21 The Board Of Trustees Of The Leland Stanford Junior University Mammalian common lymphoid progenitor cell
US5968829A (en) 1997-09-05 1999-10-19 Cytotherapeutics, Inc. Human CNS neural stem cells
US6093531A (en) 1997-09-29 2000-07-25 Neurospheres Holdings Ltd. Generation of hematopoietic cells from multipotent neural stem cells
US6165783A (en) 1997-10-24 2000-12-26 Neuro Spheres Holdings Ltd. Erythropoietin-mediated neurogenesis
US6171610B1 (en) 1998-04-24 2001-01-09 University Of Massachusetts Guided development and support of hydrogel-cell compositions
WO1999055838A1 (en) 1998-04-24 1999-11-04 University Of Nebraska Board Of Regents Compositions and methods for the characterization and transplantation of mammalian retinal stem cells
US5958767A (en) 1998-08-14 1999-09-28 The Children's Medical Center Corp. Engraftable human neural stem cells
US6184035B1 (en) 1998-11-18 2001-02-06 California Institute Of Technology Methods for isolation and activation of, and control of differentiation from, skeletal muscle stem or progenitor cells
WO2000047718A1 (en) 1999-02-11 2000-08-17 The Salk Institute For Biological Studies Isolation of stem cells and methods of use thereof
US6468794B1 (en) 1999-02-12 2002-10-22 Stemcells, Inc. Enriched central nervous system stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for such populations
US7015037B1 (en) 1999-08-05 2006-03-21 Regents Of The University Of Minnesota Multiponent adult stem cells and methods for isolation
US6638369B1 (en) 2002-05-07 2003-10-28 The United States Of America As Represented By The Secretary Of The Navy Non-chromate conversion coatings
WO2005123909A2 (en) 2004-06-09 2005-12-29 The Board Of Trustees Of The Leland Stanford Junior University Isolation and characterization of muscle regenerating cells
CA2589041C (en) 2004-12-23 2019-08-20 DePuy Synthes Products, Inc. Postpartum cells derived from umbilical cord tissue, and methods of making and using the same
US9061017B2 (en) 2006-05-03 2015-06-23 The Schepens Eye Research Institute, Inc. Isolation and therapeutic application of adult retinal stem cells collected from extra-retinal tissues
US7781179B2 (en) 2006-12-07 2010-08-24 The Board Of Trustees Of The Leland Stanford Junior University Identification and isolation of transitional cell carcinoma stem cells
US20100318193A1 (en) 2007-03-08 2010-12-16 Desai Tejal A Topographically engineered structures and methods for using the same in regenerative medicine applications
WO2009042209A2 (en) * 2007-09-25 2009-04-02 The Board Of Trustees Of The Leland Stanford Junior University Identification of thymically derived cd4 t cells by protein tyrosine kinase 7 expression
US8368588B2 (en) 2007-11-26 2013-02-05 Mediatek Inc. Method and apparatus for updating transformation information parameters used in global navigation satellite system
US20090306772A1 (en) 2008-04-18 2009-12-10 The Regents Of The University Of California Ocular Scaffolds and Methods for Subretinal Repair of Bruch's Membrane
US20110004304A1 (en) 2009-03-20 2011-01-06 Tao Sarah L Culturing retinal cells and tissues
WO2011028524A1 (en) 2009-08-24 2011-03-10 Wisconsin Alumni Research Foundation Substantially pure human retinal progenitor, forebrain progenitor, and retinal pigment epithelium cell cultures and methods of making the same
EP2383333B1 (en) 2010-04-28 2015-05-27 Technische Universität Dresden Method for producing polarized retinal progenitor cells from pluripotent stem cells and their differentiation into retinal pigment epithelium cells
EP3636286A1 (en) * 2011-05-18 2020-04-15 The Regents of The University of California Compositions and methods for treating retinal diseases
US8563304B2 (en) 2011-06-14 2013-10-22 The Schepens Eye Research Institute Low oxygen culture conditions for maintaining retinal progenitor cell multipotency
WO2012177968A1 (en) 2011-06-22 2012-12-27 The Schepens Eye Research Institute, Inc. A scaffold for subretinal cell transplantation and drug delivery
US20130189341A1 (en) * 2012-01-23 2013-07-25 Caio Regatieri Generation of photoreceptors from human retinal progenitor cells using polycaprolactone substrates
CN108588025A (zh) 2012-02-17 2018-09-28 斯格本斯眼科研究所 人视网膜祖细胞的表型谱

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110064701A1 (en) * 1999-09-24 2011-03-17 Abt Holding Company Pluripotent embryonic-like stem cells, compositions, methods and uses thereof
WO2001058460A1 (en) * 2000-02-11 2001-08-16 The Schepens Eye Research Institute, Inc. Isolation and transplantation of retinal stem cells
WO2003031656A1 (en) * 2001-10-05 2003-04-17 United States Environmental Protection Agency Genetic testing for male factor infertility
CN1761749A (zh) * 2003-03-10 2006-04-19 独立行政法人科学技术振兴机构 检测间充质干细胞的标记和采用该标记识别间充质干细胞的方法
CN1968608A (zh) * 2004-01-23 2007-05-23 先进细胞技术公司 用于治疗视网膜变性病的改良模式
CN102204930A (zh) * 2004-01-23 2011-10-05 先进细胞技术公司 用于治疗视网膜变性病的改良模式
CN101952415A (zh) * 2007-07-31 2011-01-19 生命扫描有限公司 人胚胎干细胞的分化
WO2009132156A1 (en) * 2008-04-22 2009-10-29 Regenerative Research Foundation Retinal pigment epithelial stem cells

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
HENRY KLASSEN等: "Isolation of retinal progenitor cells from post-moterm human tissue and comparison with autologous brain progenitors", 《J NEUROSCI RES》 *
JAN PRUSZAK等: "Markers and methods for cell sorting of human embryonic stem cell-derived neural cell populations", 《STEM CELLS》 *
PETR BARANOV等: "Human retinal progenitor cells as a tool for retinal: establishing cell lines for clinical study", 《INVESTIGATIVE OPHTHALMOLOGY ＆ VISUAL SCIENCE》 *
PETR Y等: "Characterization of human retinal progenitor cells", 《INVESTIGATIVE OPHTHALMOLOGY ＆ VISUAL SCIENCE》 *
吴军兵等: "胶质细胞的神经干细胞/祖细胞特性 ", 《细胞生物学杂志》 *

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Publication number Publication date
JP6468843B2 (ja) 2019-02-13
BR112014019328A8 (pt) 2017-07-11
JP2019013243A (ja) 2019-01-31
CA2864818C (en) 2022-05-03
BR112014019328A2 (https=) 2017-06-20
US11957719B2 (en) 2024-04-16
CN104136601A (zh) 2014-11-05
AU2018214122B2 (en) 2021-04-01
WO2013123292A9 (en) 2015-01-08
ES2700980T3 (es) 2019-02-20
AU2013221458A1 (en) 2014-08-07
WO2013123292A1 (en) 2013-08-22
EP3492586A1 (en) 2019-06-05
CA2864818A1 (en) 2013-08-22
US20200345785A1 (en) 2020-11-05
EP2814947B1 (en) 2018-11-21
AU2018214122A1 (en) 2018-08-30
EP3492586B1 (en) 2024-04-17
EP2814947A1 (en) 2014-12-24
EP2814947A4 (en) 2015-08-12
AU2021204404B2 (en) 2024-05-02
KR20140144680A (ko) 2014-12-19
AU2018214122C1 (en) 2021-08-19
AU2013221458B2 (en) 2018-08-30
US10758572B2 (en) 2020-09-01
JP2015508656A (ja) 2015-03-23
AU2021204404A1 (en) 2021-07-22
US20150017133A1 (en) 2015-01-15
US20250161366A1 (en) 2025-05-22

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