BR112014019328A8 - Perfil de fenótipo de células progenitoras retinais humanas - Google Patents

Perfil de fenótipo de células progenitoras retinais humanas

Info

Publication number
BR112014019328A8
BR112014019328A8 BR112014019328A BR112014019328A BR112014019328A8 BR 112014019328 A8 BR112014019328 A8 BR 112014019328A8 BR 112014019328 A BR112014019328 A BR 112014019328A BR 112014019328 A BR112014019328 A BR 112014019328A BR 112014019328 A8 BR112014019328 A8 BR 112014019328A8
Authority
BR
Brazil
Prior art keywords
progenitor cells
retinal progenitor
human retinal
phenotype profile
human
Prior art date
Application number
BR112014019328A
Other languages
English (en)
Other versions
BR112014019328A2 (pt
Inventor
J Young Michael
Y Baranov Petr
Original Assignee
The Schepens Eye Res Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Schepens Eye Res Institute filed Critical The Schepens Eye Res Institute
Publication of BR112014019328A2 publication Critical patent/BR112014019328A2/pt
Publication of BR112014019328A8 publication Critical patent/BR112014019328A8/pt

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/062—Sensory transducers, e.g. photoreceptors; Sensory neurons, e.g. for hearing, taste, smell, pH, touch, temperature, pain
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0621—Eye cells, e.g. cornea, iris pigmented cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Acoustics & Sound (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Epidemiology (AREA)

Abstract

PERFIL DE FENÓTIPO DE CÉLULAS PROGENITORAS RETINAIS HUMANAS. A presente invenção refere-se a populações substancialmente homogêneas de células progenitoras retinais humanas tendo os seguintes marcadores de superfície positivos: SSEA4, CD73, PTK7 e PSA-NCAM. A invenção também se refere ao método para preparar tais populações de célula substancialmente homogêneas de tecido humano utilizando técnicas de classificação de célula.
BR112014019328A 2012-02-17 2013-02-15 Perfil de fenótipo de células progenitoras retinais humanas BR112014019328A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261600288P 2012-02-17 2012-02-17
PCT/US2013/026286 WO2013123292A1 (en) 2012-02-17 2013-02-15 Phenotype profile of human retinal progenitor cells

Publications (2)

Publication Number Publication Date
BR112014019328A2 BR112014019328A2 (pt) 2017-06-20
BR112014019328A8 true BR112014019328A8 (pt) 2017-07-11

Family

ID=48984730

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014019328A BR112014019328A8 (pt) 2012-02-17 2013-02-15 Perfil de fenótipo de células progenitoras retinais humanas

Country Status (10)

Country Link
US (2) US10758572B2 (pt)
EP (2) EP2814947B1 (pt)
JP (2) JP6468843B2 (pt)
KR (1) KR20140144680A (pt)
CN (2) CN104136601A (pt)
AU (3) AU2013221458B2 (pt)
BR (1) BR112014019328A8 (pt)
CA (1) CA2864818C (pt)
ES (1) ES2700980T3 (pt)
WO (1) WO2013123292A1 (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2700980T3 (es) 2012-02-17 2019-02-20 Schepens Eye Res Inst Perfil fenotípico de células progenitoras de retina humana
US10220117B2 (en) 2013-10-09 2019-03-05 The Regents Of The University Of California Methods of mammalian retinal stem cell production and applications
KR101690759B1 (ko) * 2015-02-25 2016-12-30 연세대학교 산학협력단 전능성 줄기세포로부터 중간엽 줄기세포를 수득하는 방법
CN106323845B (zh) * 2015-06-23 2019-11-19 何伟 鉴定具有治疗视网膜退行性病变功能的视网膜祖细胞的方法
WO2017044488A1 (en) * 2015-09-08 2017-03-16 Cellular Dynamics International, Inc. Macs-based purification of stem cell-derived retinal pigment epithelium
GB201615714D0 (en) * 2016-09-15 2016-11-02 Univ Of Sheffield The Otic progenitor identification and isolation
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US20230090462A1 (en) * 2019-03-15 2023-03-23 The Schepens Eye Research Institute, Inc. Isolation, enrichment and expansion of cone progenitor cells and uses thereof
WO2023215602A1 (en) * 2022-05-06 2023-11-09 The Schepens Eye Research Institute, Inc. Isolation, enrichment, and expansion of human rod progenitor cells and extracellular vesicles derived therefrom

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Also Published As

Publication number Publication date
BR112014019328A2 (pt) 2017-06-20
CA2864818A1 (en) 2013-08-22
CN104136601A (zh) 2014-11-05
US10758572B2 (en) 2020-09-01
ES2700980T3 (es) 2019-02-20
AU2021204404A1 (en) 2021-07-22
CN108588025A (zh) 2018-09-28
US20200345785A1 (en) 2020-11-05
JP2015508656A (ja) 2015-03-23
AU2018214122B2 (en) 2021-04-01
US20150017133A1 (en) 2015-01-15
WO2013123292A1 (en) 2013-08-22
KR20140144680A (ko) 2014-12-19
EP2814947B1 (en) 2018-11-21
JP6468843B2 (ja) 2019-02-13
US11957719B2 (en) 2024-04-16
AU2021204404B2 (en) 2024-05-02
EP2814947A4 (en) 2015-08-12
EP3492586A1 (en) 2019-06-05
EP3492586B1 (en) 2024-04-17
AU2018214122C1 (en) 2021-08-19
JP2019013243A (ja) 2019-01-31
AU2013221458A1 (en) 2014-08-07
AU2013221458B2 (en) 2018-08-30
EP2814947A1 (en) 2014-12-24
CA2864818C (en) 2022-05-03
WO2013123292A9 (en) 2015-01-08
AU2018214122A1 (en) 2018-08-30

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