CN108586406A - 一种3-砜基香豆素化合物的制备方法 - Google Patents
一种3-砜基香豆素化合物的制备方法 Download PDFInfo
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- CN108586406A CN108586406A CN201810339858.9A CN201810339858A CN108586406A CN 108586406 A CN108586406 A CN 108586406A CN 201810339858 A CN201810339858 A CN 201810339858A CN 108586406 A CN108586406 A CN 108586406A
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- 238000002360 preparation method Methods 0.000 title claims abstract description 26
- ZYGHJZDHTFUPRJ-UHFFFAOYSA-N benzo-alpha-pyrone Natural products C1=CC=C2OC(=O)C=CC2=C1 ZYGHJZDHTFUPRJ-UHFFFAOYSA-N 0.000 title claims abstract description 16
- 229960000956 coumarin Drugs 0.000 title claims abstract description 11
- 235000001671 coumarin Nutrition 0.000 title claims abstract description 11
- 238000006243 chemical reaction Methods 0.000 claims abstract description 82
- -1 sulfuryl coumarin compound Chemical class 0.000 claims abstract description 27
- RMVRSNDYEFQCLF-UHFFFAOYSA-N thiophenol Chemical compound SC1=CC=CC=C1 RMVRSNDYEFQCLF-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000007800 oxidant agent Substances 0.000 claims abstract description 16
- 150000001875 compounds Chemical class 0.000 claims abstract description 15
- 230000001590 oxidative effect Effects 0.000 claims abstract description 14
- 239000002994 raw material Substances 0.000 claims abstract description 12
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims abstract description 10
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 claims abstract description 10
- 229910052717 sulfur Inorganic materials 0.000 claims abstract description 10
- 239000011593 sulfur Substances 0.000 claims abstract description 10
- 230000003647 oxidation Effects 0.000 claims abstract description 8
- 238000007254 oxidation reaction Methods 0.000 claims abstract description 8
- 238000007363 ring formation reaction Methods 0.000 claims abstract description 7
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 claims abstract description 6
- LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 claims abstract description 5
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 63
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims description 37
- 239000012046 mixed solvent Substances 0.000 claims description 21
- 239000011734 sodium Substances 0.000 claims description 18
- 239000002904 solvent Substances 0.000 claims description 12
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 claims description 9
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 claims description 8
- 238000006467 substitution reaction Methods 0.000 claims description 7
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 6
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims description 6
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 6
- JRKICGRDRMAZLK-UHFFFAOYSA-L peroxydisulfate Chemical compound [O-]S(=O)(=O)OOS([O-])(=O)=O JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 claims description 5
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims description 4
- 125000003118 aryl group Chemical group 0.000 claims description 4
- 230000008859 change Effects 0.000 claims description 4
- USHAGKDGDHPEEY-UHFFFAOYSA-L potassium persulfate Chemical compound [K+].[K+].[O-]S(=O)(=O)OOS([O-])(=O)=O USHAGKDGDHPEEY-UHFFFAOYSA-L 0.000 claims description 4
- 235000019394 potassium persulphate Nutrition 0.000 claims description 4
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 3
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- 238000002156 mixing Methods 0.000 claims description 3
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims description 3
- XTHFKEDIFFGKHM-UHFFFAOYSA-N Dimethoxyethane Chemical class COCCOC XTHFKEDIFFGKHM-UHFFFAOYSA-N 0.000 claims description 2
- 229910001870 ammonium persulfate Inorganic materials 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- LSXWFXONGKSEMY-UHFFFAOYSA-N di-tert-butyl peroxide Chemical compound CC(C)(C)OOC(C)(C)C LSXWFXONGKSEMY-UHFFFAOYSA-N 0.000 claims description 2
- 229910052799 carbon Inorganic materials 0.000 claims 3
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 claims 1
- OTMSDBZUPAUEDD-UHFFFAOYSA-N Ethane Chemical compound CC OTMSDBZUPAUEDD-UHFFFAOYSA-N 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- 239000005864 Sulphur Substances 0.000 claims 1
- FNBBNRGOHBQXCM-UHFFFAOYSA-N [S].OC1=CC=CC=C1 Chemical compound [S].OC1=CC=CC=C1 FNBBNRGOHBQXCM-UHFFFAOYSA-N 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000004185 ester group Chemical group 0.000 claims 1
- 235000019441 ethanol Nutrition 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 150000004968 peroxymonosulfuric acids Chemical class 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 15
- 238000003786 synthesis reaction Methods 0.000 abstract description 7
- 239000000047 product Substances 0.000 description 57
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 46
- PQMOXTJVIYEOQL-UHFFFAOYSA-N Cumarin Natural products CC(C)=CCC1=C(O)C(C(=O)C(C)CC)=C(O)C2=C1OC(=O)C=C2CCC PQMOXTJVIYEOQL-UHFFFAOYSA-N 0.000 description 22
- FSOGIJPGPZWNGO-UHFFFAOYSA-N Meomammein Natural products CCC(C)C(=O)C1=C(O)C(CC=C(C)C)=C(O)C2=C1OC(=O)C=C2CCC FSOGIJPGPZWNGO-UHFFFAOYSA-N 0.000 description 22
- 239000003054 catalyst Substances 0.000 description 21
- 238000004809 thin layer chromatography Methods 0.000 description 20
- 238000001644 13C nuclear magnetic resonance spectroscopy Methods 0.000 description 19
- 238000005160 1H NMR spectroscopy Methods 0.000 description 19
- 229910002567 K2S2O8 Inorganic materials 0.000 description 19
- 239000012043 crude product Substances 0.000 description 19
- 239000003480 eluent Substances 0.000 description 19
- 239000000203 mixture Substances 0.000 description 19
- 239000003208 petroleum Substances 0.000 description 19
- 238000001228 spectrum Methods 0.000 description 19
- 238000004440 column chromatography Methods 0.000 description 18
- 239000002253 acid Substances 0.000 description 12
- LTYMSROWYAPPGB-UHFFFAOYSA-N diphenyl sulfide Chemical compound C=1C=CC=CC=1SC1=CC=CC=C1 LTYMSROWYAPPGB-UHFFFAOYSA-N 0.000 description 11
- 150000002148 esters Chemical class 0.000 description 11
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 10
- XNERWVPQCYSMLC-UHFFFAOYSA-N phenylpropiolic acid Chemical compound OC(=O)C#CC1=CC=CC=C1 XNERWVPQCYSMLC-UHFFFAOYSA-N 0.000 description 10
- 239000000741 silica gel Substances 0.000 description 10
- 229910002027 silica gel Inorganic materials 0.000 description 10
- 229960001866 silicon dioxide Drugs 0.000 description 10
- 239000000499 gel Substances 0.000 description 9
- 229920002379 silicone rubber Polymers 0.000 description 9
- GHUURDQYRGVEHX-UHFFFAOYSA-N prop-1-ynylbenzene Chemical compound CC#CC1=CC=CC=C1 GHUURDQYRGVEHX-UHFFFAOYSA-N 0.000 description 8
- 239000000463 material Substances 0.000 description 7
- 230000015572 biosynthetic process Effects 0.000 description 5
- 150000002978 peroxides Chemical class 0.000 description 5
- 238000004080 punching Methods 0.000 description 5
- HBGGXOJOCNVPFY-UHFFFAOYSA-N diisononyl phthalate Chemical compound CC(C)CCCCCCOC(=O)C1=CC=CC=C1C(=O)OCCCCCCC(C)C HBGGXOJOCNVPFY-UHFFFAOYSA-N 0.000 description 4
- 238000011031 large-scale manufacturing process Methods 0.000 description 4
- 229910001914 chlorine tetroxide Inorganic materials 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 150000003568 thioethers Chemical class 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- 230000001093 anti-cancer Effects 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- FHIVAFMUCKRCQO-UHFFFAOYSA-N diazinon Chemical compound CCOP(=S)(OCC)OC1=CC(C)=NC(C(C)C)=N1 FHIVAFMUCKRCQO-UHFFFAOYSA-N 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000003912 environmental pollution Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 229930014626 natural product Natural products 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- CHQMHPLRPQMAMX-UHFFFAOYSA-L sodium persulfate Chemical compound [Na+].[Na+].[O-]S(=O)(=O)OOS([O-])(=O)=O CHQMHPLRPQMAMX-UHFFFAOYSA-L 0.000 description 2
- BUUPQKDIAURBJP-UHFFFAOYSA-N sulfinic acid Chemical compound OS=O BUUPQKDIAURBJP-UHFFFAOYSA-N 0.000 description 2
- 230000002194 synthesizing effect Effects 0.000 description 2
- DPKBAXPHAYBPRL-UHFFFAOYSA-M tetrabutylazanium;iodide Chemical compound [I-].CCCC[N+](CCCC)(CCCC)CCCC DPKBAXPHAYBPRL-UHFFFAOYSA-M 0.000 description 2
- WSLDOOZREJYCGB-UHFFFAOYSA-N 1,2-Dichloroethane Chemical class ClCCCl WSLDOOZREJYCGB-UHFFFAOYSA-N 0.000 description 1
- ZFCFFNGBCVAUDE-UHFFFAOYSA-N 2-(benzenesulfonyl)acetonitrile Chemical compound N#CCS(=O)(=O)C1=CC=CC=C1 ZFCFFNGBCVAUDE-UHFFFAOYSA-N 0.000 description 1
- MEJAPGGFIJZHEJ-UHFFFAOYSA-N 5-acetamido-1,3,4-thiadiazole-2-sulfonyl chloride Chemical compound CC(=O)NC1=NN=C(S(Cl)(=O)=O)S1 MEJAPGGFIJZHEJ-UHFFFAOYSA-N 0.000 description 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 208000030507 AIDS Diseases 0.000 description 1
- 241000522215 Dipteryx odorata Species 0.000 description 1
- LEVWYRKDKASIDU-IMJSIDKUSA-N L-cystine Chemical compound [O-]C(=O)[C@@H]([NH3+])CSSC[C@H]([NH3+])C([O-])=O LEVWYRKDKASIDU-IMJSIDKUSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- QUHYUSAHBDACNG-UHFFFAOYSA-N acerogenin 3 Natural products C1=CC(O)=CC=C1CCCCC(=O)CCC1=CC=C(O)C=C1 QUHYUSAHBDACNG-UHFFFAOYSA-N 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000029936 alkylation Effects 0.000 description 1
- 238000005804 alkylation reaction Methods 0.000 description 1
- 238000005576 amination reaction Methods 0.000 description 1
- VAZSKTXWXKYQJF-UHFFFAOYSA-N ammonium persulfate Chemical compound [NH4+].[NH4+].[O-]S(=O)OOS([O-])=O VAZSKTXWXKYQJF-UHFFFAOYSA-N 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000003266 anti-allergic effect Effects 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000000078 anti-malarial effect Effects 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 230000010100 anticoagulation Effects 0.000 description 1
- 239000003430 antimalarial agent Substances 0.000 description 1
- 229940124976 antitubercular drug Drugs 0.000 description 1
- 239000000010 aprotic solvent Substances 0.000 description 1
- 150000007860 aryl ester derivatives Chemical class 0.000 description 1
- 125000005362 aryl sulfone group Chemical group 0.000 description 1
- 238000006254 arylation reaction Methods 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 235000010290 biphenyl Nutrition 0.000 description 1
- 239000004305 biphenyl Substances 0.000 description 1
- 125000006267 biphenyl group Chemical group 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Substances ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 125000000332 coumarinyl group Chemical group O1C(=O)C(=CC2=CC=CC=C12)* 0.000 description 1
- 229960003067 cystine Drugs 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- URLVCROWVOSNPT-QTTMQESMSA-N desacetyluvaricin Natural products O=C1C(CCCCCCCCCCCC[C@@H](O)[C@H]2O[C@@H]([C@@H]3O[C@@H]([C@@H](O)CCCCCCCCCC)CC3)CC2)=C[C@H](C)O1 URLVCROWVOSNPT-QTTMQESMSA-N 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000012973 diazabicyclooctane Substances 0.000 description 1
- VKFAUCPBMAGVRG-UHFFFAOYSA-N dipivefrin hydrochloride Chemical compound [Cl-].C[NH2+]CC(O)C1=CC=C(OC(=O)C(C)(C)C)C(OC(=O)C(C)(C)C)=C1 VKFAUCPBMAGVRG-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000006081 fluorescent whitening agent Substances 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 238000006206 glycosylation reaction Methods 0.000 description 1
- 230000026030 halogenation Effects 0.000 description 1
- 238000005658 halogenation reaction Methods 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- LAYLQVBQIBQVLL-UHFFFAOYSA-N iofendylate Chemical compound CCOC(=O)CCCCCCCCC(C)C1=CC=C(I)C=C1 LAYLQVBQIBQVLL-UHFFFAOYSA-N 0.000 description 1
- 239000000990 laser dye Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000000575 pesticide Substances 0.000 description 1
- QARVLSVVCXYDNA-UHFFFAOYSA-N phenyl bromide Natural products BrC1=CC=CC=C1 QARVLSVVCXYDNA-UHFFFAOYSA-N 0.000 description 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 1
- 238000005954 phosphonylation reaction Methods 0.000 description 1
- 230000001766 physiological effect Effects 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- UORVCLMRJXCDCP-UHFFFAOYSA-N propynoic acid Chemical compound OC(=O)C#C UORVCLMRJXCDCP-UHFFFAOYSA-N 0.000 description 1
- SBYHFKPVCBCYGV-UHFFFAOYSA-N quinuclidine Chemical compound C1CC2CCN1CC2 SBYHFKPVCBCYGV-UHFFFAOYSA-N 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- SMQUZDBALVYZAC-UHFFFAOYSA-N salicylaldehyde Chemical class OC1=CC=CC=C1C=O SMQUZDBALVYZAC-UHFFFAOYSA-N 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 125000004646 sulfenyl group Chemical group S(*)* 0.000 description 1
- 125000001174 sulfone group Chemical group 0.000 description 1
- 150000003457 sulfones Chemical class 0.000 description 1
- CIHOLLKRGTVIJN-UHFFFAOYSA-N tert‐butyl hydroperoxide Chemical compound CC(C)(C)OO CIHOLLKRGTVIJN-UHFFFAOYSA-N 0.000 description 1
- IMNIMPAHZVJRPE-UHFFFAOYSA-N triethylenediamine Chemical compound C1CN2CCN1CC2 IMNIMPAHZVJRPE-UHFFFAOYSA-N 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/06—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2
- C07D311/08—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring
- C07D311/12—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 2 not hydrogenated in the hetero ring substituted in position 3 and unsubstituted in position 7
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrane Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
本发明公开了一种3‑砜基香豆素化合物的制备方法及应用,涉及有机合成领域,以取代丙炔酸芳基酯和含硫化合物为原料,在氧化剂介导下进行氧化砜基化环合反应,得到3‑砜基香豆素化合物,所述含硫化合物为硫酚、硫醇或二硫醚。该方法与传统的制备方法相比,不仅原料经济易得、操作简便安全、反应条件绿色,并具有反应条件温和、成本低、产率高等优势。
Description
技术领域
本发明涉及有机合成领域,具体涉及一种3-砜基香豆素化合物的制备方法。
背景技术
香豆素是一类重要的有机杂环化合物,有明显的生物学活性,在医药、农药、工业等方面得到广泛的应用。研究表明,香豆素类化合物具有抗凝血、抗菌、抗炎、抗HIV和抗癌等生物活性[J.Med.Chem.,2003,46,5437;J.Heterocycl.Chem.,2004,14,141;J.CancerRes.Ther.,2007,3,86;Curr.Pharm.Des.,2013,19,3884]。而且,由于该类化合物在可见光范围内有很强的荧光性,因此可以用作为荧光增白剂、激光染料、荧光探针及非线性光学材料等[J.Med.Chem.2004,47,6349]。近年来,为了进一步提高香豆素的应用范围和价值,化学工作者对香豆素进行了多种功能化修饰,包括膦酰化[Tetrahedron 2015,71,8178,Org.Lett.2013,15,6266]、硝化[Synth.Commun.2001,31,301,8]、卤化[Tetrahedron2008,64,4999,10]、芳甲酰化[Tetrahedron 2015,71,630;RSC Adv.2015,5,88258;J.Org.Chem.2016,81,11982]、亚磺酰胺化[Chin.J.Org.Chem.2016,36,1653]、烷基化[Adv.Synth.Cat.2016,358,2422;J.Org.Chem.2015,80,7251]和芳基化[RSC Adv.2016,6,35936]等。
另一方面,砜基官能团在化学研究诸如药物化学、天然产物化学,及相关交叉领域包括农学与材料科学中,有着十分广泛的应用。砜结构单元通常是天然产物、生理活性分子和药物分子的关键结构骨架之一。研究表明,含有该结构片段的化合物具有广泛的生物学活性,如抗过敏、抗疟、抗癌、抗肿瘤、抗结核、抗艾滋等。将砜基官能团引入香豆素骨架中可以增强其化合物的合成应用以及生物活性,例如在香豆素中引入砜基团使其具有抗结核药理活性[J.Heterocycl.Chem.,1981,18,441]。
目前合成3‐砜基香豆素类化合物的主要方法包括:
(1)双氧水氧化3‐硫代香豆素合成3‐砜基香豆素的方法[J.Heterocycl.Chem.,1981,18,441,如式2)所示]。该方法缺点在于需要通过繁琐的程序预先制备3‐硫代香豆素,反应时间长,而且需要大量的双氧水作为氧化剂。
(2)邻羟基苯甲醛衍生物与苯磺酰乙腈[Synth.Commun.,2009,39,2954;Tetrahedron Lett.,2012,53,5235,如式3)所示]或苯磺酰基乙酸衍生物[TetrahedronLett.,2012,53,4422,如式4)所示]的环化反应合成3‐砜基香豆素。虽然该类反应不需要当量的氧化剂,但反应存在原料不易得、合成过程繁琐、条件苛刻及产率低的缺陷。
(3)以苯丙炔酸芳酯与磺酰肼的芳基磺酰化反应合成3‐砜基香豆素的方法。该方法以四丁基碘化铵TBAI(20mol%)为催化剂,过氧化叔丁醇TBHP(3当量)为氧化剂,在80℃反应温度下反应得到3‐砜基香豆素,如式5)所示。该反应原料简单,但反应需要大量的过氧化叔丁醇为氧化剂,放大反应进行产业化时,具有潜在危险性(Chem.Commun.,2015,51,768‐‐771)。
(4)室温下,利用可见光催化苯丙炔酸芳酯与亚磺酸的芳基砜基化反应,完成3‐砜基香豆素化合物的构建[Chem.Commun.,2015,51,7520,如式6)所示]。虽然该反应条件温和,但该反应仍存在一些缺点,例如反应中亚磺酸需要预先制备,仍需要当量级的过氧化叔丁醇等。
(5)无催化剂参与下苯丙炔酸芳酯与重氮盐和DABCO(SO2)2直接发生砜基化环合反应合成3‐砜基香豆素化合物的方法,如式7)所示。该方法反应条件温和,但原料重氮盐不稳定,难以储存,需要预先制备。此外,砜基化试剂DABCO(SO2)2价格昂贵,反应成本大,不利于工业化生产。
综上所述,目前发展的方法大都存在一些明显的限制,如原料不易得、成本高、过程繁琐、条件苛刻、产率低,使用大量过氧化合物等。所以发展一种高效合成3‐砜基香豆素化合物的方法仍是极其需要的。
发明内容
针对上述现有技术存在的问题,本发明的目的在于提供一种3-砜基香豆素化合物的制备方法,不仅原料经济易得、操作简便安全、反应条件绿色,具有反应条件温和、成本低、环境污染小、产率高等优势。
一种3-砜基香豆素化合物的制备方法,该方法以取代丙炔酸芳基酯和含硫化合物为原料,在氧化剂介导下进行氧化砜基化环合反应,得到3-砜基香豆素化合物,所述含硫化合物为硫酚、硫醇或二硫醚。。
在上述制备方法中,所述取代丙炔酸芳基酯如式I所示,硫酚、硫醇或二硫醚如式II所示,所述3-砜基香豆素化合物如式III所示,
该制备方法的反应方程式为:
优选的,在上述制备方法中,将所述取代丙炔酸芳基酯和所述含硫化合物溶解于溶剂中,在氧化剂存在下反应(10-15)h。
优选的,所述溶剂为非质子性溶剂或质子性溶剂中的一种或多种混合,非质子性溶剂为乙腈、二氯甲烷、乙酸乙酯、甲苯、氯仿、1,2-二氯乙烷、1,2-二甲氧基乙烷、四氢呋喃、1,4-二氧六环、二甲亚砜和N,N-二甲基甲酰胺中的至少一种,质子性溶剂为水、甲醇、乙醇、丙醇和异丙醇中的至少一种,
所述溶剂优选为乙腈和水混合溶剂,其中乙腈和水比例优选1:1。
优选的,所述氧化剂包括过硫酸盐、双氧水、过氧化叔丁醇、二叔丁基过氧化物的至少一种,过硫酸盐优选为过硫酸钾、过硫酸铵或过硫酸钠,更优选过硫酸钾。
所述取代丙炔酸芳基酯和所述含硫化合物的摩尔比为1:(1‐4):(1‐5),优选为1:1.5:3。反应温度优选为0‐120℃,更优选80℃。
一种采用上述制备方法制备在制备3‐砜基香豆素化合物中的应用,优选将过硫酸盐作为氧化剂应用于氧化砜基化环合反应中。
本发明的制备方法,各种物料的添加顺序以及具体反应步骤可由本领域技术人员自行调整,不仅适用于实验室小规模制备,也适合于化工厂的工业化大规模生产。在工业化大规模生产时,具体反应参数可由本领域技术人员通过实验确定。
本发明机理及所带来的综合效果如下:
传统的合成砜基香豆素化合物的方法往往需要难得的原料、大量过氧化物、苛刻的条件和繁多的反应步骤,本发明的制备方法通过取代炔酸芳酯与S-H基或双硫键为反应基础,并优选过硫化合物替代常规氧化剂,适合于合成各种3-砜基香豆素化合物及衍生物,具有较高的普适性且原料来源丰富易得。同时氧化剂也结构简单,造价便宜,可操作性好,并且避免了过氧化合物的使用,反应安全性高,适于产业化推广。该方法与传统的制备方法相比,具有反应条件温和、成本低、环境污染小、产率高等优势。
具体实施方式
本发明的以下实施例仅用来说明实现本发明的具体实施方式,这些实施方式不能理解为是对本发明的限制。其它的任何在未背离本发明的精神实质与原理下所做的改变、修饰、替代、组合、简化,均视为等效的置换方式,落在本发明的保护范围之内。
本发明的制备方法,各种物料的添加顺序以及具体反应步骤可由本领域技术人员自行调整,不仅适用于实验室小规模制备,也适合于化工厂的工业化大规模生产。在工业化大规模生产时,具体反应参数可由本领域技术人员通过实验确定。
本发明采用C≡H键的活化和含硫化合物氧化作为构建砜基有机分子的有效方法。尤其通过过硫氧化剂替代过氧化物氧化剂,原料更加经济且反应更加安全。在此,本发明通过具体实施例详细阐述本发明芳基砜类化合物构建的制备方法及其用途,该方法采用相对稳定的取代丙炔酸芳酯及简单易得的硫酚(醇)或二硫醚,以过硫化钾作为过氧化物氧化剂的替代物。
下述实施例中所用的实验方法如无特殊说明,均为常规方法。
下述实施例中所用的材料、试剂如无特殊说明,均可从商业途径得到或由商业途径所得原料合成。
实施例1
向装有磁力搅拌子的25毫升反应瓶中依次装入苯基丙炔酸苯酯(0.2mmol,44.4mg),二苯基硫醚(0.3mmol,65.4mg)和K2S2O8(0.6mmol,162mg),以CH3CN:H2O(1:1,v:v)为混合溶剂(2ml),混合,在80℃无催化剂条件下反应12h。通过TLC薄层色谱监测反应进度。反应完成后,将所得溶液经0.08Mpa真空减压浓缩至无溶剂,得到粗产物,然后用体积比为3:1的石油醚和乙酸乙酯的混合洗脱剂冲洗,硅胶柱快速柱层析,得到本实施例3‐砜基香豆素产物,55.0mg,收率76%。
产物结构式为:
所得产物核磁图谱数据为:
1H NMR(CDCl3,400MHz,ppm):δ8.03(t,J=8.7Hz,2H),7.66‐7.60(m,5H),7.53(t,J=8.0Hz,2H),7.39‐7.35(m,3H),7.22(t,J=8.7Hz,1H),7.05(dd,J1=1.4Hz,J2=8.1Hz,1H);
13C NMR(CDCl3,100MHz,ppm):δ159.5,155.6,153.9,140.3,134.7,133.7,132.6,130.0,129.3,129.2,128.6,128.2,127.5,125.9,124.8,120.3,116.8;
HRMS calc.for C21H14O4SNa(M+Na)+,385.0510;found,385.0513.
实施例2
在25ml反应瓶中,依次加入苯基丙炔酸对甲基苯酯(0.2mmol,47.2mg),二苯基硫醚(0.3mmol,65.4mg),K2S2O8(0.6mmol,162mg),CH3CN:H2O(1:1,v:v)为混合溶剂2ml,反应温度为80℃,在不使用催化剂条件下反应12h。用TLC检测至反应完成后,经真空(0.08Mpa)减压浓缩至无溶剂,得到粗产物,然后用体积比为3:1的石油醚和乙酸乙酯的混合洗脱剂冲洗,硅胶柱快速柱层析,得到本实施例3-砜基香豆素产物,57.2mg,收率79%。
产物结构式为:
所得产物核磁图谱数据为:
1H NMR(CDCl3,400MHz,ppm):δ8.02(d,J=7.4Hz,2H),7.63‐7.59(m,4H),7.52(t,J=7.9Hz,2H),7.37‐7.35(m,2H),7.17(s,1H),7.02(d,J=8.3Hz,1H),6.91(d,J=8.3Hz,1H),2.46(s,3H);
13C NMR(CDCl3,100MHz,ppm):δ159.6,155.8,154.1,146.8,140.4,133.6,132.8,129.7,129.2,129.1,128.6,128.1,127.5,126.2,124.7,117.9,116.9,21.9.
HRMS calc.for C22H16O4SNa(M+Na)+,399.0667;found,399.0665.
实施例3
在25ml反应瓶中,依次加入苯基丙炔酸对氟苯酯(0.2mmol,48mg),二苯基硫醚(0.3mmol,65.4mg),K2S2O8(0.6mmol,162mg)和CH3CN:H2O(1:1)为混合溶剂2ml,反应温度为80℃,在不使用催化剂条件下反应12h。用TLC检测至反应完成后,经真空(0.08Mpa)减压浓缩至无溶剂,得到粗产物,然后用体积比为2:1的石油醚和乙酸乙酯的混合洗脱剂冲洗,硅胶柱快速柱层析,得到本实施例3-砜基香豆素产物,61.6mg,收率81%。
产物结构式为:
所得产物核磁图谱数据为:
1H NMR(CDCl3,400MHz,ppm):δ8.01(d,J=7.6Hz,2H),7.64‐7.60(m,4H),7.52(t,J=7.8Hz,2H),7.36(t,J=3.4Hz,2H),7.09‐7.04(m,2H),6.97‐6.92(m,1H);
13C NMR(CDCl3,100MHz,ppm):δ166.1(d,J=258.1Hz),159.1,155.3,155.2(d,J=13.4Hz),140.1,133.8,132.4,132.3,129.5,129.2,128.7,128.3,127.4,124.9,117.0(d,J=2.6Hz),113.3(d,J=22.5Hz),104.2(d,J=25.5Hz).
HRMS calc.for C21H13FO4SNa(M+Na)+,403.0416;found,403.0413.
实施例4
在25ml反应瓶中,依次加入苯基丙炔酸对氯苯酯(0.2mmol,51.2mg),二苯基硫醚(0.3mmol,65.4mg),K2S2O8(0.6mmol,162mg)和CH3CN:H2O(1:1)为混合溶剂2ml,反应温度为80℃,在不使用催化剂条件下反应12h。用TLC检测至反应完成后,经真空(0.08Mpa)减压浓缩至无溶剂,得到粗产物,然后用体积比为2:1的石油醚和乙酸乙酯的混合洗脱剂冲洗,硅胶柱快速柱层析,得到本实施例3-砜基香豆素产物,63.4mg,收率80%。
产物结构式为:
所得产物核磁图谱数据为:
1H NMR(CDCl3,400MHz,ppm):δ8.02(d,J=7.5Hz,2H),7.64‐7.61(m,4H),7.54(t,J=7.9Hz,2H),7.38‐7.34(m,3H),7.18(dd,J1=2.0Hz,J2=8.7Hz,1H),6.97(d,J=8.7Hz,1H);
13C NMR(CDCl3,100MHz,ppm):δ158.8,155.0,154.1,141.1,140.1,133.8,132.2,130.9,129.5,129.2,128.7,128.3,127.4,125.9,125.6,118.9,117.0;
HRMS calc.for C21H13ClO4SNa(M+Na)+,419.0121;found,419.0126.
实施例5
在25ml反应瓶中,依次加入苯基丙炔酸对溴苯酯(0.2mmol,60mg),二苯基硫醚(0.3mmol,65.4mg),K2S2O8(0.6mmol,162mg)和CH3CN:H2O(1:1)为混合溶剂2ml,反应温度为80℃,在不使用催化剂条件下反应12h。用TLC检测至反应完成后,经真空(0.08Mpa)减压浓缩至无溶剂,得到粗产物,然后用体积比为2:1的石油醚和乙酸乙酯的混合洗脱剂冲洗,硅胶柱快速柱层析,得到本实施例3-砜基香豆素产物,73.9mg,收率84%。
产物结构式为:
所得产物核磁图谱数据为:
1H NMR(CDCl3,400MHz,ppm):δ8.01(d,J=7.4Hz,2H),7.63‐7.61(m,4H),7.57‐7.52(m,3H),7.36‐7.32(m,3H),6.89(d,J=8.7Hz,1H);
13C NMR(CDCl3,100MHz,ppm):δ158.9,154.9,153.9,140.0,133.8,132.1,130.9,129.5,129.4,129.2,128.7,128.4,128.3,127.4,126.1,120.1,119.3;
HRMS calc.for C21H14BrO4S(M+H)+,440.9800;found,440.9797.
实施例6
在25ml反应瓶中,依次加入苯基丙炔酸对碘苯酯(0.2mmol,69.6mg),二苯基硫醚(0.3mmol,65.4mg),K2S2O8(0.6mmol,162mg)和CH3CN:H2O(1:1)为混合溶剂2ml,反应温度为80℃,在不使用催化剂条件下反应12h。用TLC检测至反应完成后,经真空(0.08Mpa)减压浓缩至无溶剂,得到粗产物,然后用体积比为2:1的石油醚和乙酸乙酯的混合洗脱剂冲洗,硅胶柱快速柱层析,得到本实施例3-砜基香豆素产物,76.1mg,收率78%。
产物结构式为:
所得产物核磁图谱数据为:
1H NMR(CDCl3,400MHz,ppm):δ8.01(d,J=7.6Hz,2H),7.75(s,1H),7.63‐7.60(m,4H),7.53(t,J=8.0Hz,3H),7.36‐7.34(m,2H),6.71(d,J=8.6Hz,1H);
13C NMR(CDCl3,100MHz,ppm):δ159.0,154.8,153.4,140.0,134.3,133.8,132.1,130.6,129.5,129.2,128.7,128.3,127.4,126.3,126.0,119.8,101.6;
HRMS calc.for C21H13IO4SNa(M+Na)+,510.9477;found,510.9478.
实施例7
在25ml反应瓶中,依次加入苯基丙炔酸对三氟甲基苯酯(0.2mmol,58mg),二苯基硫醚(0.3mmol,65.4mg),K2S2O8(0.6mmol,162mg)和CH3CN:H2O(1:1)为混合溶剂2ml,反应温度为80℃,在不使用催化剂条件下反应12h。用TLC检测至反应完成后,经真空(0.08Mpa)减压浓缩至无溶剂,得到粗产物,然后用体积比为2:1的石油醚和乙酸乙酯的混合洗脱剂冲洗,硅胶柱快速柱层析,得到本
实施例3-砜基香豆素产物,73.1mg,收率85%。
产物结构式为:
所得产物核磁图谱数据为:
1H NMR(CDCl3,400MHz,ppm):δ8.02(d,J=7.3Hz,2H),7.65‐7.62(m,5H),7.55(t,J=8.0Hz,2H),7.44(d,J=8.5Hz,1H),7.38‐7.36(m,2H),7.19(d,J=8.4Hz,1H);
13C NMR(CDCl3,100MHz,ppm):δ158.2,154.7,153.5,139.7,135.8(d,J=33.7Hz),134.0,131.8,130.9,129.7,129.0,128.8,128.5,127.4,124.1,122.9,121.2(d,J=3.6Hz),114.2(d,J=4.0Hz);
HRMS calc.for C22H13F3O4SNa(M+Na)+,453.0384;found,453.0393.
实施例8
在25ml反应瓶中,依次加入苯基丙炔酸对苯基苯酯(0.2mmol,59.6mg),二苯基硫醚(0.3mmol,65.4mg),K2S2O8(0.6mmol,162mg)和CH3CN:H2O(1:1)为混合溶剂2ml,反应温度为80℃,在不使用催化剂条件下反应12h。用TLC检测至反应完成后,经真空(0.08Mpa)减压浓缩至无溶剂,得到粗产物,然后用体积比为3:1的石油醚和乙酸乙酯的混合洗脱剂冲洗,硅胶柱快速柱层析,得到本
实施例3-砜基香豆素产物,73.6mg,收率84%。
产物结构式为:
所得产物核磁图谱数据为:
1H NMR(CDCl3,400MHz,ppm):δ8.05(d,J=7.4Hz,2H),7.65‐7.61(m,5H),7.58‐7.40(m,10H),7.10(d,J=8.4Hz,1H);
13C NMR(CDCl3,100MHz,ppm):δ159.4,155.7,154.4,147.9,140.4,138.3,133.6,132.7,131.5,130.9,130.3,129.3,129.2,128.6,128.2,127.5,127.3,125.3,123.6,119.1,114.7;
HRMS calc.for C27H18O4SNa(M+Na)+,461.0823;found,461.0822.
实施例9
在25ml反应瓶中,依次加入4-甲基苯基丙炔酸苯酯(0.2mmol,47.2mg),二苯基硫醚(0.3mmol,65.4mg),K2S2O8(0.6mmol,162mg)和CH3CN:H2O(1:1)为混合溶剂2ml,反应温度为80℃,在不使用催化剂条件下反应12h。用TLC检测至反应完成后,经真空(0.08Mpa)减压浓缩至无溶剂,得到粗产物,然后用体积比为3:1的石油醚和乙酸乙酯的混合洗脱剂冲洗,硅胶柱快速柱层析,得到本
实施例3-砜基香豆素产物,64.6mg,收率86%。
产物结构式为:
所得产物核磁图谱数据为:
1H NMR(CDCl3,400MHz,ppm):δ8.03(d,J=7.6Hz,2H),7.64‐7.60(m,2H),7.52(t,J=7.8Hz,2H),7.41(d,J=7.7Hz,2H),7.38‐7.34(m,1H),7.29‐7.25(m,2H),7.21(t,J=7.7Hz,1H),7.11(t,J=6.6Hz,1H),2.52(s,3H);
13C NMR(CDCl3,100MHz,ppm):δ160.0,155.6,153.9,140.4,139.3,134.6,133.6,130.0,129.5,129.1,128.9,128.6,127.5,125.9,124.8,120.4,116.8,21.6;
HRMS calc.for C22H17O4S(M+H)+,377.0848;found,377.0849.
实施例10
在25ml反应瓶中,依次加入4-甲氧基苯基丙炔酸苯酯(0.2mmol,50.4mg),二苯基硫醚(0.3mmol,65.4mg),K2S2O8(0.6mmol,162mg)和CH3CN:H2O(1:1)为混合溶剂2ml,反应温度为80℃,在不使用催化剂条件下反应12h。用TLC检测至反应完成后,经真空(0.08Mpa)减压浓缩至无溶剂,得到粗产物,然后用体积比为3:1的石油醚和乙酸乙酯的混合洗脱剂冲洗,硅胶柱快速柱层析,得到本
实施例3-砜基香豆素产物,61.9mg,收率79%。
产物结构式为:
所得产物核磁图谱数据为:
1H NMR(CDCl3,400MHz,ppm):δ8.01(d,J=7.4Hz,2H),7.65‐7.59(m,2H),7.52(t,J=8.0Hz,2H),7.37‐7.35(m,1H),7.31‐7.29(m,2H),7.22(t,J=8.0Hz,1H),7.17‐7.11(m,3H),3.95(s,3H);
13C NMR(CDCl3,100MHz,ppm):δ160.5,159.7,155.7,153.9,140.5,134.5,133.6,130.9,130.0,129.2,129.1,128.6,124.8,124.3,120.5,116.8,113.7,55.4;
HRMS calc.for C22H16O5SNa(M+Na)+,415.0616;found,415.0615.
实施例11
在25ml反应瓶中,依次加入4-氯苯基丙炔酸苯酯(0.2mmol,51.2mg),二苯基硫醚(0.3mmol,65.4mg),K2S2O8(0.6mmol,162mg)和CH3CN:H2O(1:1)为混合溶剂2ml,反应温度为80℃,在不使用催化剂条件下反应12h。用TLC检测至反应完成后,经真空(0.08Mpa)减压浓缩至无溶剂,得到粗产物,然后用体积比为3:1的石油醚和乙酸乙酯的混合洗脱剂冲洗,硅胶柱快速柱层析,得到本实施例3-砜基香豆素产物,66.5mg,收率84%。
产物结构式为:
所得产物核磁图谱数据为:
1H NMR(CDCl3,400MHz,ppm):δ8.02(d,J=7.4Hz,2H),7.68‐7.58(m,4H),7.54(t,J=7.9Hz,2H),7.37(d,J=7.8Hz,1H),7.32(d,J=8.4Hz,2H),7.24(t,J=8.2Hz,1H),7.04(dd,J1=1.4Hz,J2=8.1Hz,1H);
13C NMR(CDCl3,100MHz,ppm):δ158.3,155.3,153.9,140.0,135.6,134.9,133.8,130.9,129.6,129.2,128.9,128.7,128.6,126.3,125.0,119.9,117.0;
HRMS calc.for C21H13ClO4SNa(M+Na)+,419.0121;found,419.0123.
实施例12
在25ml反应瓶中,依次加入2-丁基炔酸苯酯(0.2mmol,32mg),二苯基硫醚(0.3mmol,65.4mg),K2S2O8(0.6mmol,162mg)和CH3CN:H2O(1:1)为混合溶剂2ml,反应温度为80℃,在不使用催化剂条件下反应12h。用TLC检测至反应完成后,经真空(0.08Mpa)减压浓缩至无溶剂,得到粗产物,然后用体积比为3:1的石油醚和乙酸乙酯的混合洗脱剂冲洗,硅胶柱快速柱层析,得到本实施例3-砜基香豆素产物,43.2mg,收率72%。
产物结构式为:
所得产物核磁图谱数据为:
1H NMR(CDCl3,400MHz,ppm):δ8.13(d,J=7.3Hz,2H),7.93(dd,J1=1.3Hz,J2=8.2Hz,1H),7.69‐7.62(m,2H),7.56(t,J=7.9Hz,2H),7.43‐7.39(m,1H),7.32(dd,J1=0.9Hz,J2=8.3Hz,1H),3.19(s,3H);
13C NMR(CDCl3,100MHz,ppm):δ158.3,155.3,153.4,140.8,134.6,133.7,128.7,128.6,126.6,125.0,119.7,117.3,15.3;
HRMS calc.for C16H12O4SNa(M+Na)+,323.0354;found,323.0357.
实施例13
在25ml反应瓶中,依次加入苯基丙炔酸苯酯(0.2mmol,44.2mg),二-4-甲基苯基硫醚(0.3mmol,73.8mg),K2S2O8(0.6mmol,162mg)和CH3CN:H2O(1:1)为混合溶剂2ml,反应温度为80℃,在不使用催化剂条件下反应12h。用TLC检测至反应完成后,经真空(0.08Mpa)减压浓缩至无溶剂,得到粗产物,然后用体积比为3:1的石油醚和乙酸乙酯的混合洗脱剂冲洗,硅胶柱快速柱层析,得到本
实施例3-砜基香豆素产物,59.4mg,收率79%。
产物结构式为:
所得产物核磁图谱数据为:
1H NMR(CDCl3,400MHz,ppm):δ7.91(d,J=8.3Hz,2H),7.65‐7.59(m,4H),7.38‐7.35(m,3H),7.32(d,J=8.0Hz,2H),7.23‐7.19(m,1H),7.04(dd,J1=1.4Hz,J2=8.1Hz,1H),2.44(s,3H);
13C NMR(CDCl3,100MHz,ppm):δ159.2,155.6,153.9,144.8,137.3,134.6,132.7,129.9,129.3,129.2,128.2,127.5,126.2,124.7,120.3,116.8,21.7;
HRMS calc.for C22H15BrO4SNa(M+Na)+,476.9772;found,476.9776.
实施例14
在25ml反应瓶中,依次加入苯基丙炔酸苯酯(0.2mmol,44.4mg),二-4-氟苯基硫醚(0.3mmol,76.2mg),K2S2O8(0.6mmol,162mg)和CH3CN:H2O(1:1)为混合溶剂2ml,反应温度为80℃,在不使用催化剂条件下反应12h。用TLC检测至反应完成后,经真空(0.08Mpa)减压浓缩至无溶剂,得到粗产物,然后用体积比为3:1的石油醚和乙酸乙酯的混合洗脱剂冲洗,硅胶柱快速柱层析,得到本实施例3-砜基香豆素产物,60.8mg,收率80%。
产物结构式为:
所得产物核磁图谱数据为:
1H NMR(CDCl3,400MHz,ppm):δ8.07‐8.04(m,2H),7.67‐7.59(m,4H),7.23‐7.17(m,3H),7.25‐7.17(m,3H),7.06(dd,J1=1.4Hz,J2=8.2Hz,1H);
13C NMR(CDCl3,100MHz,ppm):δ165.9(d,J=254.9Hz),159.6,155.6,153.9,136.2(d,J=3.1Hz),134.8,132.5,132.3,132.2,129.7(d,J=62.4Hz),128.2,127.4,125.8,124.9,120.2,116.9,115.9(d,J=22.6Hz);
HRMS calc.for C21H13FO4SNa(M+Na)+,403.0416;found,403.0419.
实施例15
在25ml反应瓶中,依次加入苯基丙炔酸苯酯(0.2mmol,44.4mg),二-4-氯苯基硫醚(0.3mmol,85.6mg),K2S2O8(0.6mmol,162mg)和CH3CN:H2O(1:1)为混合溶剂2ml,反应温度为80℃,在不使用催化剂条件下反应12h。用TLC检测至反应完成后,经真空(0.08Mpa)减压浓缩至无溶剂,得到粗产物,然后用体积比为3:1的石油醚和乙酸乙酯的混合洗脱剂冲洗,硅胶柱快速柱层析,得到本实施例3-砜基香豆素产物,61.8mg,收率78%。
产物结构式为:
所得产物核磁图谱数据为:
1H NMR(CDCl3,400MHz,ppm):δ7.96(d,J=8.7Hz,2H),7.66‐7.60(m,4H),7.49(d,J=8.7Hz,2H),7.39‐7.35(m,3H),7.25‐7.21(m,1H)7.06(dd,J1=1.4Hz,J2=8.2Hz,1H);
13C NMR(CDCl3,100MHz,ppm):δ159.9,155.6,153.9,140.5,138.7,134.9,132.4,130.8,130.0,129.4,129.0,128.3,127.4,125.6,125.0,120.2,116.9;
HRMS calc.for C21H13ClO4SNa(M+Na)+,419.0121;found,419.0123.
实施例16
在25ml反应瓶中,依次加入苯基丙炔酸苯酯(0.2mmol,32mg),二-4-溴苯基硫醚(0.3mmol,112.4mg),K2S2O8(0.6mmol,162mg)和CH3CN:H2O(1:1)为混合溶剂2ml,反应温度为80℃,在不使用催化剂条件下反应12h。用TLC检测至反应完成后,经真空(0.08Mpa)减压浓缩至无溶剂,得到粗产物,然后用体积比为3:1的石油醚和乙酸乙酯的混合洗脱剂冲洗,硅胶柱快速柱层析,得到本实施例3-砜基香豆素产物,66.9mg,收率76%。
产物结构式为:
所得产物核磁图谱数据为:
1H NMR(CDCl3,400MHz,ppm):δ7.89(d,J=8.7Hz,2H),7.68‐7.60(m,6H),7.39‐7.35(m,3H),7.25‐7.21(m,1H),7.06(dd,J1=1.5Hz,J2=8.2Hz,1H);
13C NMR(CDCl3,100MHz,ppm):δ159.9,155.6,153.9,139.2,134.9,132.4,132.0,130.8,130.0,129.4,129.2,128.3,127.4,125.6,125.0,120.2,116.9;
HRMS calc.for C21H13BrO4SNa(M+Na)+,462.9616;found,462.9619.
实施例17
在25ml反应瓶中,依次加入苯基丙炔酸苯酯(0.2mmol,44.4mg),二-2-三氟甲基苯基硫醚(0.3mmol,106.2mg),K2S2O8(0.6mmol,162mg)和CH3CN:H2O(1:1)为混合溶剂2ml,反应温度为80℃,在不使用催化剂条件下反应12h。用TLC检测至反应完成后,经真空(0.08Mpa)减压浓缩至无溶剂,得到粗产物,然后用体积比为3:1的石油醚和乙酸乙酯的混合洗脱剂冲洗,硅胶柱快速柱层析,得到本实施例3-砜基香豆素产物,72.3mg,收率81%。
产物结构式为:
所得产物核磁图谱数据为:
1H NMR(CDCl3,400MHz,ppm):δ8.54(d,J=8.0Hz,1H),7.82‐7.79(m,2H),7.72(t,J=7.0Hz,1H),7.69‐7.64(m,1H),7.60‐7.58(m,3H),7.47‐7.45(m,2H),7.39(dd,J1=0.8Hz,J2=8.3Hz,1H),7.29‐7.25(m,1H),7.19(dd,J1=1.6Hz,J2=8.2Hz,1H);
13C NMR(CDCl3,100MHz,ppm):δ158.8,155.7,153.8,139.8,134.6,133.4,133.2,132.1,131.6,129.7(d,J=4.2Hz),128.2,128.1,127.7(q,J=6.4Hz),127.5,126.4,125.0,123.0(d,J=285Hz),120.0,117.0;
HRMS calc.for C22H13F3O4SNa(M+Na)+,453.0384;found,453.0385.
实施例18
在25ml反应瓶中,依次加入苯基丙炔酸苯酯(0.2mmol,44.4mg),二-2-三氟甲基苯基硫醚(0.3mmol,95.4mg),K2S2O8(0.6mmol,162mg)和CH3CN:H2O(1:1)为混合溶剂2ml,反应温度为80℃,在不使用催化剂条件下反应12h。用TLC检测至反应完成后,经真空(0.08Mpa)减压浓缩至无溶剂,得到粗产物,然后用体积比为3:1的石油醚和乙酸乙酯的混合洗脱剂冲洗,硅胶柱快速柱层析,得到本实施例3-砜基香豆素产物,67.2mg,收率82%。
产物结构式为:
所得产物核磁图谱数据为:
1H NMR(CDCl3,400MHz,ppm):δ8.63(s,1H),8.01(d,J=7.9Hz,1H),7.95(s,2H),7.91(d,J=8.1Hz,1H),7.68‐7.60(m,6H),7.43‐7.40(m,2H),7.35(d,J=8.2Hz,1H),7.22(t,J=8.0Hz,1H),7.07(d,J=8.1Hz,1H);
13C NMR(CDCl3,100MHz,ppm):δ159.5,155.6,153.9,137.1,135.4,134.7,132.6,132.0,131.4,129.9,129.7,129.4,129.3,128.7,128.2,127.9,127.6,127.4,126.1,124.8,123.6,120.3,116.8;
HRMS calc.for C25H16O4SNa(M+Na)+,435.0667;found,435.0669.
实施例19
在25ml反应瓶中,依次加入苯基丙炔酸苯酯(0.2mmol,44.4mg),苯硫酚(0.3mmol,33mg),K2S2O8(0.6mmol,162mg)和CH3CN:H2O(1:1)为混合溶剂2ml,反应温度为80℃,在不使用催化剂条件下反应12h。用TLC检测至反应完成后,经真空(0.08Mpa)减压浓缩至无溶剂,得到粗产物,然后用体积比为3:1的石油醚和乙酸乙酯的混合洗脱剂冲洗,硅胶柱快速柱层析,得到本实施例3-砜基香豆素产物,44.2mg,收率61%。
产物结构式为:
所得产物核磁图谱数据为:
1H NMR(CDCl3,400MHz,ppm):δ8.04(t,J=8.7Hz,2H),7.66‐7.61(m,5H),7.54(t,J=8.0Hz,2H),7.39‐7.34(m,3H),7.23(t,J=8.7Hz,1H),7.04(dd,J1=1.4Hz,J2=8.1Hz,1H);
13C NMR(CDCl3,100MHz,ppm):δ159.5,155.6,153.9,140.3,134.7,133.7,132.6,130.0,129.3,129.2,128.6,128.2,127.5,125.9,124.8,120.3,116.9;
HRMS calc.for C21H14O4SNa(M+Na)+,385.0510;found,385.0514.
虽然本发明已作了详细描述,但对本领域技术人员来说,在本发明精神和范围内的修改将是显而易见的。此外,应当理解的是,本发明记载的各方面、不同具体实施方式的各部分、和列举的各种特征可被组合或全部或部分互换。在上述的各个具体实施方式中,那些参考另一个具体实施方式的实施方式可适当地与其它实施方式组合,这是将由本领域技术人员所能理解的。此外,本领域技术人员将会理解,前面的描述仅是示例的方式,并不旨在限制本发明。
Claims (10)
1.一种3-砜基香豆素化合物的制备方法,其特征在于,以取代丙炔酸芳基酯和含硫化合物为原料,在氧化剂介导下进行氧化砜基化环合反应,得到3-砜基香豆素化合物,所述含硫化合物为硫酚、硫醇或二硫醚。
2.根据权利要求1所述的制备方法,其特征在于,所述取代丙炔酸芳基酯如式I所示,硫酚、硫醇或二硫醚如式II所示,所述3-砜基香豆素化合物如式III所示,
其中,R1为任意取代的卤素、芳基、1-7碳烷基、烷氧基、酯基、氰基或硝基;R2为任意取代的芳基、杂芳基、或1-8碳烷基;R3为芳基、杂芳基、或1-8碳烷基。
3.根据权利要求2所述的制备方法,其特征在于,该制备方法的反应方程式为:
4.根据权利要求2所述的制备方法,其特征在于,将所述取代丙炔酸芳基酯和所述含硫化合物溶解于溶剂中,在氧化剂存在下反应(10-15)h。
5.根据权利要求4所述的制备方法,其特征在于,所述溶剂为非质子性溶剂或质子性溶剂中的一种或多种混合,非质子性溶剂为乙腈、二氯甲烷、乙酸乙酯、甲苯、氯仿、1,2-二氯乙烷、1,2-二甲氧基乙烷、四氢呋喃、1,4-二氧六环、二甲亚砜和N,N-二甲基甲酰胺中的至少一种,质子性溶剂为水、甲醇、乙醇、丙醇和异丙醇中的至少一种,
所述溶剂优选为乙腈和水混合溶剂,其中乙腈和水比例优选1:1。
6.根据权利要求4所述的制备方法,其特征在于,所述氧化剂包括过硫酸盐、双氧水、过氧化叔丁醇、二叔丁基过氧化物的至少一种,过硫酸盐优选为过硫酸钾、过硫酸铵或过硫酸钠,更优选过硫酸钾。
7.根据权利要求4所述的制备方法,其特征在于,所述取代丙炔酸芳基酯和所述含硫化合物的摩尔比为1:(1-4):(1-5),优选为1:1.5:3。
8.根据权利要求4所述的制备方法,其特征在于,反应温度为0-120℃,优选80℃。
9.一种如权利要求1-8中任一项所述制备方法在制备3-砜基香豆素化合物中的应用。
10.根据权利要求9所述的应用,其特征在于,将过硫酸盐作为氧化剂应用于氧化砜基化环合反应中。
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