CN108578441A - A kind of composition, drug and the feed of the prevention and treatment bright red gill of crucian - Google Patents
A kind of composition, drug and the feed of the prevention and treatment bright red gill of crucian Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/10—Animal feeding-stuffs obtained by microbiological or biochemical processes
- A23K10/16—Addition of microorganisms or extracts thereof, e.g. single-cell proteins, to feeding-stuff compositions
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/20—Animal feeding-stuffs from material of animal origin
- A23K10/22—Animal feeding-stuffs from material of animal origin from fish
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
- A23K10/37—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms from waste material
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
- A23K20/147—Polymeric derivatives, e.g. peptides or proteins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
- A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
- A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
Abstract
The present invention provides a kind of composition, drug and the feeds of the prevention and treatment bright red gill of crucian, are related to veterinary drug technical field.The composition of the present invention includes the component of following parts by weight：Thermophilic aqueous 10~30 parts of aerogenesis sporangium bacteriophage, 5~15 parts of Bdellovibrio, 4~15 parts of lactobacillus acidophilus, 4~15 parts of vitamin C.The present invention utilizes microorganism principle, the composition is added in drug and feed, control and reduce harm of the bright red gill pathogenic microorganisms to cultured fishes, enhance the resisting stress and resistance of breed variety, the related property harm that stress reaction is brought is reduced, preferable prevention and treatment effect is played to the bright red gill disease of crucian.
Description
Technical field
The present invention relates to veterinary drug technical field, more particularly to a kind of composition that can prevent and treat the bright red gill of crucian.
Background technology
The bright red gill disease of crucian shows the gill portion oedema of disease fish, bleeding, is in cerise, therefore common people are referred to as " bright red
The gill ".The disease symptom of the bright red gill disease of crucian is：Sick fish rests on apart from 5~10 centimetres of depths of the water surface, does not move about, is struck with object
It fetches water face, fish can sink, but be returned to the original water surface after a while and do not move about.Sick fish fish body is black and thin, and fin ray point whitens, scale pine
Dynamic, gill portion mucus increases, oedema, bleeding, is in cerise.The sick fish of dissection find it is intraperitoneal have a weak yellow liquid, enteron aisle without food and
Redness, most apparent symptom are liver bleedings, serious with the internal organs bleeding such as kidney；Gollbladder dilation, darken or
In blackish green, bile is full, and some bile becomes brown；General cloacal aperture is without red and swollen phenomenon.
The bright red gill disease of crucian occurs mainly in be easiest to occur between plum rain season, especially 22 DEG C~26 DEG C of water temperature.
The disease belongs to the more typical and easy fish disease for distinguishing over other diseases in the breeding process of crucian.Disease morbidity is violent for this, it is fast to infect,
Lethality is high.Relevant aquaculture report has very much, but there is presently no the specific aim medication precedents of this kind of fish disease.
Conventional control or the method for treating the bright red gill disease of crucian are that liver and gall health (liver and gall Li Kang dissipates), dimension are added in feed
Raw element C etc. is to improve fish body autoimmunity ability.When treatment, sprinkled with red (main component is dithiocyano-methane) full pond is sterilized
It spills, is used in conjunction 2 days；Bacterium for oral administration vertical clear, intestines oxazepan, glucurolactone, multidimensional simultaneously, continuously feeds 5 days.Medication process is cumbersome, and uses
Drug variety it is more, application method is more complicated.What especially fungicide and antibiotics easily caused cultured fishes stress be anti-
It answers, cause to induce more fish diseases and causes serious explosive death, application risk is larger, and the use cost of multiclass drug
It is higher.
Invention content
The purpose of the present invention is to provide a kind of composition, drug and the feeds of the prevention and treatment bright red gill of crucian, utilize
Microorganism principle control and reduce harm of the bright red gill pathogenic microorganisms to cultured fishes, enhance breed variety resisting stress and
Resistance reduces the related property harm that stress reaction is brought.
Technical scheme is as follows：
The present invention provides a kind of compositions of the prevention and treatment bright red gill of crucian, include the component of following parts by weight：
Preferably, the composition of the prevention and treatment bright red gill of crucian, includes the component of following parts by weight：
Preferably, the composition of the prevention and treatment bright red gill of crucian, the thermophilic aqueous aerogenesis sporangium bacteriophage
A concentration of 100~20,000,000,000 pfu/g, a concentration of 200~30,000,000,000 pfu/g of Bdellovibrio bacteriophage, lactobacillus acidophilus it is a concentration of
50~20,000,000,000 cfu/g
The present invention also provides a kind of drugs of the prevention and treatment bright red gill of crucian, and the drug includes above-mentioned technical proposal
Composition, carrier described in any one and protective agent.
Preferably, 4~12% (quality) described compositions are contained in the drug.
Preferably, the carrier is DEXTROSE ANHYDROUS.
Preferably, the protective agent is sodium alginate and/or porous-starch.
The present invention also provides a kind of feed of the prevention and treatment bright red gill of crucian, contain above-mentioned technical side in the feed
Composition described in case any one or drug.
Preferably, in the feed containing 0.2~1.2% (quality) the drug or contain 0.0001~0.0006%
The composition of (quality).
The prior art is compared, and the present invention has the following advantages：
The present invention provides a kind of compositions of the prevention and treatment bright red gill of crucian, include the component of following parts by weight：It is thermophilic
Aqueous 10~30 parts of aerogenesis sporangium bacteriophage, 5~15 parts of Bdellovibrio bacteriophage, 4~15 parts of lactobacillus acidophilus, vitamin C 4
~15 parts.The composition of the present invention mainly controls and subtracts using thermophilic aqueous Aerononas punctata bacteriophage and Bdellovibrio bacteriophage
The pathogen Aeromonas hydrophila and vibrios entrained by crucian are cultivated less；Lactobacillus acidophilus contained in the present composition can divide
Antibiotin substance (acidolin, bacillus acidophilus's element, lactein) is secreted, there is antagonism, energy to pathogenic microorganisms
Colony balance is adjusted, the proliferation of undesirable microorganism is inhibited, reduces harm of the pathogenic microorganisms to cultured fishes；The present composition
Middle addition vitamin C can enhance the resisting stress and resistance of cultured fishes, participate in the metabolism of body tyrosine and adrenal gland skin
Matter hormone sensitive lipase gene promotes absorption of the enteron aisle to iron, is beneficial to hematopoiesis function, reduces the generation of bleeding.Therefore, the present invention carries
The above-mentioned composition of confession can play good preventive and therapeutic action to bright red gill pathogenic microorganisms.
Above-mentioned composition is prepared into drug or feed by the present invention, and for preventing and treating the bright red gill disease of crucian, utilization is micro-
Biological principle controls and reduces harm of the pathogenic microorganisms of the bright red gill disease of crucian to cultured fishes, enhances the anti-of breed variety and answers
Swash property and resistance, it is explosive dead caused by the outburst for the multiple fish disease of crucian that reduction stress reaction is brought and drug resisting stress
It dies.
Specific implementation mode
The present invention provides a kind of compositions of the prevention and treatment bright red gill of crucian, include the component of following parts by weight：It is thermophilic
Aqueous 10~30 parts of aerogenesis sporangium bacteriophage, 5~15 parts of Bdellovibrio bacteriophage, 4~15 parts of lactobacillus acidophilus, vitamin C 4
~15 parts.The present invention using the bright red gill disease main pathogens of crucian bacteriophage carry out BIOLOGICAL CONTROL, auxiliary lactobacillus acidophilus and
Vitamin C improves fish resistance, alleviates illness symptom, to achieve the effect that prevent and treat the bright red gill disease of crucian.
It is added to pathogen gas of the thermophilic aqueous aerogenesis sporangium bacteriophage to crucian bright red gill disease in the composition of the present invention
Monad is controlled.The additive amount of thermophilic aqueous aerogenesis sporangium bacteriophage of the present invention is preferably 15~25 parts by weight, more
Preferably 20 parts by weight.The present invention is not particularly limited the source of thermophilic aqueous aerogenesis sporangium bacteriophage, normal in this field
Thermophilic aqueous aerogenesis sporangium bacteriophage is advised, preferably thermophilic aqueous aerogenesis sporangium bacteriophage freeze-dried powder.The present invention is preferably thermophilic
The concentration of aqueous aerogenesis sporangium bacteriophage is preferably 100~20,000,000,000 pfu/g, more preferably 120~17,000,000,000 pfu/g.
It is added to Bdellovibrio bacteriophage in the composition of the present invention, the pathogen vibrios of crucian bright red gill disease is controlled
System.The additive amount of Bdellovibrio bacteriophage of the present invention is preferably 7~13 parts by weight, more preferably 12 parts by weight.The present invention couple
The source of Bdellovibrio bacteriophage is not particularly limited, and the conventional Bdellovibrio bacteriophage in this field, preferably Bdellovibrio bites
Thalline freeze-dried powder.The concentration of the preferred Bdellovibrio bacteriophage of the present invention is preferably 200~30,000,000,000 pfu/g, and more preferably 260~280
Hundred million pfu/g.
It is added to lactobacillus acidophilus in the composition of the present invention, there is antibiotin class in the metabolite of lactobacillus acidophilus
Substance has antagonism such as acidolin, bacillus acidophilus's element, lactein to the pathogenic microorganisms of crucian bright red gill disease,
Colony balance can be adjusted, the proliferation of undesirable microorganism is inhibited, reduces harm of the pathogenic microorganisms to cultured fishes.It is of the present invention
The additive amount of lactobacillus acidophilus is preferably 6~12 parts by weight, more preferably 10 parts by weight.The lactobacillus acidophilus of the present invention is ability
Conventional lactobacillus acidophilus in domain, preferably lactobacillus acidophilus freeze-drying powder.The concentration of lactobacillus acidophilus of the present invention is preferably 50~
20000000000 cfu/g, more preferably 100~15,000,000,000 cfu/g.
It is added to vitamin C in the composition of the present invention, vitamin C can enhance resisting stress and the resistance of cultured fishes
Power participates in the metabolism of body tyrosine and cortex hormone of aadrenaline synthesis, promotes absorption of the enteron aisle to iron, be beneficial to hematopoiesis function,
Reduce the generation of bright red gill disease bleeding.The ascorbic additive amount of the present invention is preferably 6~12 parts by weight, more preferably 10
Parts by weight.
Thermophilic aqueous aerogenesis sporangium bacteriophage, Bdellovibrio bacteriophage, lactobacillus acidophilus and vitamin C are mixed in proportion,
Obtain the composition of the present invention.The composition of the present invention belongs to microorganism formulation, has the bright red gill disease of crucian particularly for property,
Resistance of the fish to bright red gill pathogen can be improved, treatment and prevention effect is good, and not will produce irritability.
The present invention also provides a kind of drugs of the prevention and treatment bright red gill of crucian, and the drug includes above-mentioned technical proposal
The composition and carrier and protective agent.Mass percent of the composition in the drug is preferably 4~12%,
More preferably 5~8%.The carrier is preferably DEXTROSE ANHYDROUS, plays the role of dispersive composition.The carrier is in the medicine
Mass percent in object is preferably 85~95%, and more preferably 88~92%.The protective agent be preferably sodium alginate and/or
Porous-starch improves the activity of microorganism in composition.Mass percent of the protective agent in the drug be preferably 1~
5%, more preferably 2~4%.
The drug of the present invention is preferably pulvis or granule.Drug of the present invention is according to the routine side in this field
Prepared by method, this is not limited by the present invention.
The present invention also provides the feed of the prevention and treatment bright red gill of crucian, contain above-mentioned composition or medicine in the feed
Object.In the present invention, the above-mentioned composition of 0.0001~0.0006% (quality) is added in the preferably described feed, or directly addition is raised
Expect that quality 0.2~1.2%, more preferably 0.4~0.6% said medicine can play the bright red gill disease of crucian pre- well
Anti- and therapeutic effect.The preparation method of feed of the present invention is that above-mentioned composition or drug are added into fish day basestocks
In, obtain the fish meal that can prevent and treat the bright red gill of crucian.The fish day basestocks are the routine of this field Mesichthyes
Feeding feed stuff, such as fish meal, all kinds of albumen powders, wheat bran, Soybean Meal.
To make the objectives, technical solutions, and advantages of the present invention clearer, with reference to embodiment to the present invention into
Row detailed description, but they cannot be interpreted as limiting the scope of the present invention.
Embodiment 1
A kind of composition of the prevention and treatment bright red gill of crucian, includes the thermophilic aqueous aerogenesis sporangium phagocytosis of 20,000,000,000 pfu/g
Body 20g, 30,000,000,000 pfu/g Bdellovibrio freeze-dried powders 12g, 20,000,000,000 cfu/g lactobacillus acidophilus 10g, vitamin C 10g.By above-mentioned group
Divide mixing, obtains the composition of the prevention and treatment bright red gill of crucian.
Embodiment 2
A kind of composition of the prevention and treatment bright red gill of crucian, includes the thermophilic aqueous aerogenesis sporangium phagocytosis of 10,000,000,000 pfu/g
Body 12g, 20,000,000,000 pfu/g Bdellovibrio freeze-dried powders 15g, 5,000,000,000 cfu/g lactobacillus acidophilus 12g, vitamin C 5g.By said components
Mixing obtains the composition of the prevention and treatment bright red gill of crucian.
Embodiment 3
A kind of composition of the prevention and treatment bright red gill of crucian, includes the thermophilic aqueous aerogenesis sporangium phagocytosis of 15,000,000,000 pfu/g
Body 27g, 16,000,000,000 pfu/g Bdellovibrio freeze-dried powders 6g, 12,000,000,000 cfu/g lactobacillus acidophilus 5g, vitamin C 15g.By said components
Mixing obtains the composition of the prevention and treatment bright red gill of crucian.
Embodiment 4
A kind of drug of the prevention and treatment bright red gill of crucian, the composition containing 5g embodiments 1,900g DEXTROSE ANHYDROUSs,
40g sodium alginates and 55g porous-starch.Said components are mixed in proportion, obtain the drug of the prevention and treatment bright red gill of crucian.
Embodiment 5
A kind of drug of the prevention and treatment bright red gill of crucian, the composition containing 4g embodiments 1,950g DEXTROSE ANHYDROUSs,
46g sodium alginates.Said components are mixed in proportion, obtain the drug of the prevention and treatment bright red gill of crucian.
Embodiment 6
A kind of drug of the prevention and treatment bright red gill of crucian, the composition containing 7g embodiments 1,880g DEXTROSE ANHYDROUSs,
13g sodium alginates and 100g porous-starch.Said components are mixed in proportion, obtain the medicine of the prevention and treatment bright red gill of crucian
Object.
Embodiment 7
A kind of fish meal of the prevention and treatment bright red gill of crucian, includes the drug of fish day basestocks 100g and embodiment 4
0.2g, wherein fish days basestocks are white fish meal 20g, Soybean Meal 30g, shelled peanut cake 15g, wheat bran 5g, corn protein powder 25g,
Casein 5g.Said components are mixed in proportion, obtain the feed of the prevention and treatment bright red gill of crucian.
Embodiment 8
Early June, the fish pond of the Xinghua County industrial parks Bei He raiser started to go out daily with the rising of temperature
Dead fish phenomenon, daily dead fish quantity 10~40 are showed.3 fish ponds of the raiser to trip pool crucian beat respectively
Sample, dissection find fish gill swelling, and gill color is scarlet (being normally dark red), there is a few place blutpunktes.Fish body dissection finds that abdomen has on a small quantity
Faint yellow ponding, liver is red and swollen, and without food in enteron aisle, and fish tail side is slightly whitened.Sick fish body is thin and body colour is partially black, intolerant to temporarily foster.
Determine that the fish disease is the bright red gill of typical crucian.
June 12 started, and was added to the crucian carp of embodiment 4 according to 0.3% ratio in the fish meal normally fed daily
The bright red gill drug of fish, it may be found that the trip pool turn over tripe fish salvage clean up, avoid fish disease fast propagation spread.Record daily fish pond
Dead fish situation.
The dead fish in daily fish pond and trip pond fish quantity after the processing of table 1
June 23 started to be discontinued.June 24 drew a design again to the fish in fish pond, without finding disease in 9 crucians of sampling
Fish, and the stress ability of crucian is strong, temporarily supports power foot.
The bright red gill drug of crucian of the present invention prevents in the fish disease and has obtained effective verification in auxiliary treatment.Prove this
Invention controls and reduces harm of the bright red gill pathogenic microorganisms of crucian to cultured fishes using microorganism principle, enhances breed variety
Resisting stress and resistance validity.
Embodiment 9
There are a large amount of dead fish phenomenons daily in the crucian of mid-May, raiser Mr. Sun cultivation of Tianjin Xiqing District.Just
The morbidity crucian salvaged shows as abdomen swelling, and the gill filament is scarlet, and the gill filament is dimmed after temporarily supporting slightly whitens.The sick fish of dissection, abdomen have
Ponding flows out, and condenses quickly.Sick fish liver enlargement is in grey color, enteron aisle hyperemia swelling.By to trip pool disease fish it is temporary support with
Dissection confirms that the fish disease is the bright red gill of crucian.
May 24 started, and the feeding volume of fish meal halves, and was added to reality in 0.3% ratio in the feed fed
It applies the bright red gill drug of crucian of example 6, and continuous use 7-10 days, records daily dead fish situation, observe lower air port trip pond fish
Quantity changes.
The dead fish quantity record in daily fish pond after 2 medication of table
June 1 started to be discontinued, and increased feeding volume to feeding the 2/3 of standard originally.June 4 to the fish in fish pond again
It draws a design, without finding sick fish in 5 crucians of sampling, and leaves after temporarily foster water handles and pinch and hold and turn over a series of inspections such as gill cover observation
It places into still vigorous in water.From June 4, restore the normal feeding volume of feed.
This medication fully demonstrates the bright red gill drug of crucian of the present invention to the validity of this kind of disease, prevents the bright red gill
Large area outburst, reduce the loss of raiser.It utilizes the mechanism of action of microorganism, it is suppressed that harmful microorganism is to cultivation
The pathogenic effects of crucian provide the effect of prevention and auxiliary treatment to bright red gill disease for crucian cultivation, and effective reduce is supported
Risk is grown, cultivation survival rate is improved.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For member, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications are also answered
It is considered as protection scope of the present invention.
Claims (9)
1. a kind of composition of the prevention and treatment bright red gill of crucian, which is characterized in that include the component of following parts by weight：
2. preventing and treating the composition of the bright red gill of crucian according to claim 1, which is characterized in that including following parts by weight
Component：
3. the composition of the prevention and treatment bright red gill of crucian according to claim 1 or claim 2, which is characterized in that described thermophilic aqueous
A concentration of 100~20,000,000,000 pfu/g of aerogenesis sporangium bacteriophage, a concentration of 200~30,000,000,000 pfu/g of Bdellovibrio bacteriophage,
A concentration of 50~20,000,000,000 cfu/g of lactobacillus acidophilus.
4. a kind of drug of the prevention and treatment bright red gill of crucian, which is characterized in that the drug includes that claims 1 to 3 is arbitrary
Composition, carrier described in one and protective agent.
5. drug according to claim 4, which is characterized in that contain composition described in 4~12wt% in the drug.
6. drug according to claim 4 or 5, which is characterized in that the carrier is DEXTROSE ANHYDROUS.
7. drug according to claim 4 or 5, which is characterized in that the protective agent is sodium alginate and/or porous shallow lake
Powder.
8. a kind of feed of the prevention and treatment bright red gill of crucian, which is characterized in that appoint containing claims 1 to 3 in the feed
Composition described in meaning one or the drug described in claim 4~7 any one.
9. feed according to claim 8, which is characterized in that in the feed containing mass percentage be 0.2~
The composition that 1.2% drug or mass percentage is 0.0001~0.0006%.
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| CN109337838A (en) * | 2018-11-02 | 2019-02-15 | 中国药科大学 | A kind of aquatic products lactobacillus preparation and preparation method thereof |
| CN113383798A (en) * | 2020-07-04 | 2021-09-14 | 菲吉乐科(南京)生物科技有限公司 | Novel composite preparation and application thereof in bacterial diseases |
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