CN104288250A - Liquid vitamin premixed feed preparation for resisting piglet isospora as well as preparation method and application of liquid vitamin premixed feed preparation - Google Patents
Liquid vitamin premixed feed preparation for resisting piglet isospora as well as preparation method and application of liquid vitamin premixed feed preparation Download PDFInfo
- Publication number
- CN104288250A CN104288250A CN201410581666.0A CN201410581666A CN104288250A CN 104288250 A CN104288250 A CN 104288250A CN 201410581666 A CN201410581666 A CN 201410581666A CN 104288250 A CN104288250 A CN 104288250A
- Authority
- CN
- China
- Prior art keywords
- preparation
- piglet
- premixed feed
- liquid
- isospora
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/222—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having aromatic groups, e.g. dipivefrine, ibopamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/13—Coniferophyta (gymnosperms)
- A61K36/14—Cupressaceae (Cypress family), e.g. juniper or cypress
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/282—Artemisia, e.g. wormwood or sagebrush
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Dispersion Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a liquid vitamin premixed feed preparation for resisting piglet isospora. The liquid vitamin premixed feed preparation is characterized in that every 1000 weight parts of the liquid vitamin premixed feed preparation comprises active components, 13.5-27 parts of an emulsifier and 2-5 parts of a co-emulsifier, wherein the active components comprises the following components in parts by weight: 3-7 parts of vitamin, 10-25 parts of sodium butyrate and 935-972 parts of Chinese medicine extraction. The invention aims to provide the liquid vitamin premixed feed preparation for resisting the piglet isospora with the special effects of eliminating dampness, astringing, resisting isospora, nourishing intestinal villi, repairing damaged intestinal mucosa, promoting digestive organ development and maintaining intestinal health condition, and also aims to provide a preparation method for the liquid vitamin premixed feed preparation for resisting the piglet isospora as well as application of the liquid vitamin premixed feed preparation in suckling piglet feeding.
Description
Technical field
The present invention relates to animal feed additive field, particularly a kind of liquid vitamin premixed feed preparation of anti-piglet isospora, and preparation method thereof and suckling pig raise in application.
Background technology
Isospora suis mainly encroaches on suckling pig enterocyte; make small intestinal generation serious change; cause epithelial cell shedding and Villus atrophy (intestinal villus shortens, merge); intestinal mucosa epithelial layer is caused to suffer extensive damage; digestive and absorptive functions is had a strong impact on; more seriously the invasion of Secondary cases pathogen (antibacterial, virus) can be conducive to because the defencive function of intestinal mucosa is badly damaged; cause serious digestive system disease, indirectly cause great economic loss.Find according to the investigation of authoritative research institution, south China area Intensive Farm of Pig Raising piglet coccidium infection rate up to 68.7%, and has the trend increased year by year; This disease is worldwide distribution, and the more advanced foreign pig farm coccidium infection rate of intensive culture is higher, and Germany is up to 100%, and Belgium reaches 80%, and Holland reaches 72%, and Spain reaches 85%, and Italy reaches 68%, and Mexico reaches 70%, and Brazil reaches 45%.
The most effectual way of current control Isospora suis disease is piglet special " Baycox " suspension (5%) of oral Bayer Bitterfeld GmbH production in 3-6 days after suckling pig birth, uses and once can kill Isospora suis, and can produce semelincident immunization.This product is the patent of invention product of Bayer A.G, due to intellectual property protection reason, the domestic manufacturing enterprise of veterinary drug without permission all must not produce this like product, and this product use cost is high, the 100ml/ bottle market price is up to 150-180 unit, and the use cost of every piglet is close to 2 yuan; Not by drinking water administration, every piglet by only gavaging, operation easier is large, and labor intensity is high, and product alkalescence is comparatively strong, and palatability is poor, has vomiting phenomenon, have impact on result of use after part piglet gavages; Based on above reason, add that China raiser is generally not enough to the serious harm understanding of Isospora suis, the specification of preventing and treating constraining Isospora suis disease is carried out, and makes Isospora suis disease stealthily, indirectly deprive the deserved cultivation interests of major part of raiser.
Summary of the invention
The present invention aims to provide a kind of dampness, convergence, anticoccidial, nutrition intestinal villi, repairs damaged intestinal mucosa, facilitating digestion allelotaxis, maintains the liquid vitamin premixed feed preparation of the anti-piglet isospora of the special efficacy of intestinal health state, another object of the present invention is the preparation method of the liquid vitamin premixed feed preparation providing this anti-piglet isospora, and its suckling pig raise in application.
The scheme of the liquid vitamin premixed feed preparation of a kind of anti-piglet isospora of the present invention is: it is characterized in that, the liquid vitamin premixed feed preparation of every 1000 weight portions comprises active component, 13.5 ~ 27 parts of emulsifying agents, 2 ~ 5 parts of co-emulsifier, described active component comprises following parts by weight of component: 3 ~ 7 parts of vitamin, 10 ~ 25 parts of sodium butyrates and 935 ~ 972 parts of Chinese medicine extraction liquid, wherein, 935 ~ 972 parts of described Chinese medicine extraction liquid are by 350 ~ 450 portions of Radix Dichroaes, 550 ~ 650 portions of Herba Artemisiae Annuaes, 550 ~ 650 portions of Radix Pulsatillaes, 550 ~ 650 portions of Semen Torreyaes, 350 ~ 450 portions of Cacumen Platycladis, 350 ~ 450 parts of Radix Sophorae Flavescentiss, 150 ~ 250 portions of Radix Glycyrrhizaes are through extracting, the mixture obtained after concentrated.
As a further improvement on the present invention, the liquid vitamin premixed feed preparation of every 1000 weight portions comprises active component, 15 ~ 25 parts of emulsifying agents, 3 ~ 4 parts of co-emulsifier, described active component comprises following parts by weight of component: 4 ~ 6 parts of vitamin, 15 ~ 20 parts of sodium butyrates and 940 ~ 965 parts of Chinese medicine extraction liquid, wherein, 940 ~ 965 parts of described Chinese medicine extraction liquid are by 380 ~ 420 portions of Radix Dichroaes, 580 ~ 620 portions of Herba Artemisiae Annuaes, 580 ~ 620 portions of Radix Pulsatillaes, 580 ~ 620 portions of Semen Torreyaes, 380 ~ 420 portions of Cacumen Platycladis, 380 ~ 420 parts of Radix Sophorae Flavescentiss, 180 ~ 220 portions of Radix Glycyrrhizaes are through extracting, the mixture obtained after concentrated.
In the liquid vitamin premixed feed preparation of above-mentioned anti-piglet isospora, described vitamin is by 1 ~ 3 part by weight of vitamin A acetas, 0.5 ~ 1 part by weight of vitamin D
3, 1.5 ~ 3 weight portion DL-ɑ-tocopherol acetas composition.
Preferably, described vitamin is by 1.5 ~ 2.5 part by weight of vitamin A acetass, 0.7 ~ 0.9 part by weight of vitamin D
3, 1.8 ~ 2.5 weight portion DL-ɑ-tocopherol acetas composition, wherein, described vitamin D
3specification be that concentration is not less than 1,000,000 IU/g oil preparationes, the specification of retinyl acetate is that concentration is not less than 1,000,000 IU/g oil preparationes, and the specification of DL-ɑ-tocopherol acetas is the oil preparation that concentration is not less than 92.0%.
In the liquid vitamin premixed feed preparation of above-mentioned anti-piglet isospora, it is characterized in that, also comprise 0.15 ~ 0.3 weight portion antioxidant BHT.
In the liquid vitamin premixed feed preparation of above-mentioned anti-piglet isospora, it is characterized in that, also comprise 0.1 ~ 0.3 weight portion antiseptic Ethyl Hydroxybenzoate.
In the liquid vitamin premixed feed preparation of above-mentioned anti-piglet isospora, described emulsifying agent comprises 6 ~ 12 parts by weight of polyoxyethylene 20 sorbitan mono-oleic acid esters, 6 ~ 12 weight portion PEG400s, 1.5 ~ 3 parts by weight of fatty polyoxyethylenated alcohol.
Preferably, described emulsifying agent comprises 8 ~ 11 parts by weight of polyoxyethylene 20 sorbitan mono-oleic acid esters, 8 ~ 11 weight portion PEG400s, 1.8 ~ 2.5 parts by weight of fatty polyoxyethylenated alcohol.
In the liquid vitamin premixed feed preparation of above-mentioned anti-piglet isospora, described co-emulsifier is ethanol, and the consumption of described co-emulsifier is 2 ~ 5 weight portions.
Preferably, the consumption of described co-emulsifier is 3 ~ 4.5 weight portions.
The invention also discloses the preparation method of the liquid vitamin premixed feed preparation of above-mentioned anti-piglet isospora, comprise the following steps:
Step 1: take vitamin, emulsifying agent, co-emulsifier and antioxidant and mix homogeneously, obtain oil phase;
Step 2: take Chinese medicine extraction liquid, antiseptic and sodium butyrate and mix homogeneously, obtain aqueous phase;
Step 3: aqueous phase is joined in oil phase and carry out vacuum emulsification and high pressure homogenize operation, obtain nanometer micro-emulsion;
In the preparation method of the liquid vitamin premixed feed preparation of above-mentioned anti-piglet isospora, described Chinese medicine extraction liquid extracts concentrated obtaining by percolation.
In the preparation method of the liquid vitamin premixed feed preparation of above-mentioned anti-piglet isospora, the step being obtained Chinese medicine extraction liquid by percolation is comprised:
Step 1: the decoction pieces taking the Radix Dichroae of certain part by weight, Herba Artemisiae Annuae, the Radix Pulsatillae, Semen Torreyae, Cacumen Platycladi, Radix Sophorae Flavescentis, Radix Glycyrrhizae, and be crushed into 20 ~ 24 object coarse powder;
Step 2: be equivalent to 1 ~ 4 times of the gross weight of the above-mentioned prepared slices of Chinese crude drugs 70% ~ 75% alcoholic solution for the above-mentioned coarse powder of solvent soaking;
Step 3: the ethanol with 70% ~ 75% is that solvent processes the coarse powder after immersion with percolation, obtains percolate;
Step 4: become Chinese medicine extraction liquid by concentrated for percolate.
In the preparation method of the liquid vitamin premixed feed preparation of above-mentioned anti-piglet isospora, the mixture that described Chinese medicine extraction liquid is 350 ~ 450 portions of Radix Dichroaes, 550 ~ 650 portions of Herba Artemisiae Annuaes, 550 ~ 650 portions of Radix Pulsatillaes, 550 ~ 650 portions of Semen Torreyaes, 350 ~ 450 portions of Cacumen Platycladis, 350 ~ 450 portions of Radix Sophorae Flavescentiss, 150 ~ 250 portions of Radix Glycyrrhizaes obtain after extracting, concentrating, described Chinese medicine extraction liquid is 935 ~ 972 weight portions.
Preferably, the mixture that described Chinese medicine extraction liquid is obtained after extracting, concentrating by 380 ~ 420 portions of Radix Dichroaes, 580 ~ 620 portions of Herba Artemisiae Annuaes, 580 ~ 620 portions of Radix Pulsatillaes, 580 ~ 620 portions of Semen Torreyaes, 380 ~ 420 portions of Cacumen Platycladis, 380 ~ 420 portions of Radix Sophorae Flavescentiss, 180 ~ 220 portions of Radix Glycyrrhizaes, described Chinese medicine extraction liquid is 940 ~ 965 parts.
In the preparation method of the liquid vitamin premixed feed preparation of above-mentioned anti-piglet isospora, described vitamin is by 1 ~ 3 part by weight of vitamin A acetas, 0.5 ~ 1 part by weight of vitamin D
3, 1.5 ~ 3 weight portion DL-ɑ-tocopherol acetas composition, wherein, described vitamin D
3specification be the oil preparation that concentration is not less than 1,000,000 IU/g, the specification of retinyl acetate is the oil preparation that concentration is not less than 1,000,000 IU/g, and the specification of DL-ɑ-tocopherol acetas is the oil preparation that concentration is not less than 92.0%.
In the preparation method of the liquid vitamin premixed feed preparation of above-mentioned anti-piglet isospora, described antioxidant is 0.15 ~ 0.3 weight portion BHT.
In the preparation method of the liquid vitamin premixed feed preparation of above-mentioned anti-piglet isospora, described antiseptic is 0.1 ~ 0.3 weight portion ethyl hydroxybenzoate.
In the preparation method of the liquid vitamin premixed feed preparation of above-mentioned anti-piglet isospora, described emulsifying agent comprises 6 ~ 12 parts by weight of polyoxyethylene 20 sorbitan mono-oleic acid esters, 6 ~ 12 weight portion PEG400s, 1.5 ~ 3 parts by weight of fatty polyoxyethylenated alcohol.
Preferably, described emulsifying agent comprises 8 ~ 11 parts by weight of polyoxyethylene 20 sorbitan mono-oleic acid esters, 8 ~ 11 weight portion PEG400s, 1.8 ~ 2.5 parts by weight of fatty polyoxyethylenated alcohol.
In the preparation method of the liquid vitamin premixed feed preparation of above-mentioned anti-piglet isospora, described co-emulsifier is ethanol, and the consumption of described co-emulsifier is 2 ~ 5 weight portions.
Preferably, the consumption of described co-emulsifier is 3 ~ 4.5 weight portions.
In the preparation method of the liquid vitamin premixed feed preparation of above-mentioned anti-piglet isospora, described step 3 specifically comprises following sub-step:
Sub-step 1: joined in emulsion tank by oil phase, and constant temperature 35 ~ 40 DEG C, start vacuum emulsifying machine and keep the rotating speed of 4000 ~ 8000 revs/min, slowly being joined in emulsion tank by aqueous phase and carry out vacuum emulsification;
Sub-step 2: emulsion after emulsifying is imported in high pressure homogenizer and carries out backflow high pressure homogenize, operating pressure is 80-100 MPa;
Sub-step 3: the high pressure emulsion after homogenizing imported in emulsion tank, obtain transparency emulsion, reduce the vacuum of emulsion tank gradually, obtains nanometer micro-emulsion after transparency emulsion being carried out cooling and filter.
The present invention also provides the application of liquid vitamin premixed feed preparation in suckling pig is raised of above-mentioned anti-piglet isospora, the liquid vitamin premixed feed preparation of described anti-piglet isospora rises after piglet birth on the 3rd day, take feed by the draught animals or after being watered, put into suckling pig Special drinking fountain and allow and freely drink, use amount is every suckling pig this product 1ml/ every day, is used in conjunction 3 days.
Because the allelotaxis that digests and assimilates of suckling pig goes back imperfection, its intestinal is easily subject to nutrition stress there is multiple anaphylaxis with the impact of growing environment, and then the function causing piglet to digest causes confusion unordered phenomenon, meeting more very causes diarrhoea, and this is the extremely incident symptom of suckling pig.The invention provides the vitamin of compound, this vitamin maintains the healthy and trace nutrient needed for normal growth growth of piglet stage piglet, and being piglet stage indispensable a kind of nutrient thing, is a kind of Nutrition and Metabolism that coenzyme participates in body.The shortage of vitamin A, can cause suckling pig dyspepsia, causes diarrhoea and dysentery; The shortage of vitamin D, can cause the alcium and phosphor metabolization of suckling pig to get muddled phenomenon, affect piglet to the absorption of other mineral and discharge, and skeleton calcification stops, and grows up very slow; The shortage of vitamin E, can cause suckling pig to repel and suck the breast, occur diarrhoea, and fur slightly disorderly.Be piglet vitimin supplement scientifically and rationally, not only can piglet be effectively prevented to occur avitaminosis, effectively can also improve the nonspecific immunity systemic-function of piglet, strengthen the antiviral of piglet and the ability of anti-stress, be conducive to wean in the future, turn group and weightening finish.
The present invention is directed to above-mentioned reason, in conjunction with " nutrition immune " and Chinese medicine " preventive treatment of disease " theory, selected fat-soluble A, D, E, intestinal villi nutrient-sodium butyrate, parasite killing is dispelled long-pending Radix Dichroae, Herba Artemisiae Annuae, the Radix Pulsatillae, Semen Torreyae, Cacumen Platycladi, Radix Sophorae Flavescentis, the high-quality Chinese crude drugs such as Radix Glycyrrhizae, adopt low temperature alcohol extraction, concentrating under reduced pressure, high pressure homogenize, the technology such as vacuum nano microemulsified and hyperfiltration, making both can by the administration of drinking-water colony, also the oral solution formulation of administration can individual be gavaged, specific killing action is had to Isospora suis ovum, strengthen the toleration that Isospora suis is corroded, and palatability is fabulous.One of main component in the present invention sodium butyrate is a kind of energy source of quick noble cells, stimulates impaired chorial reparation by upgrading intermediate cell, provides quick and be easy to the energy source of absorption for animal body and histiocyte thereof; Can promote that intestinal mucosa is grown, repair mucosal epithelial cells, activated lymphocyte; Promote propagation and the maturation of gastrointestinal tract cell, promote non-specific immune systems and specific immune system function, adjustment micro ecology of gastrointestinal tract balance, promotes probiotics growth, suppresses harmful bacteria growth, safeguards intestinal health, make gastrointestinal tract ecology be in positive balance; Promote the absorption of calcium, stimulate the secretion of pancreas and intestinal endoenzyme, the special odor of Yoghourt has very strong attractant to young pig, and palatability is splendid.Radix Dichroae bitter in the mouth in Chinese prescription of the present invention, cold in nature, poisonous, the antipyretic malaria of effect; Herba Artemisiae Annuae bitter in the mouth, pungent, cold in nature, effect clearing away summer-heat, antibacterial, preventing the attack (or recurrence) of malaria, parasiticide is monarch drug with Radix Dichroae altogether; Radix Pulsatillae bitter in the mouth, cold in nature, effect heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery, removing dampness and killing parasites; Radix Sophorae Flavescentis bitter in the mouth, cold in nature, effect heat clearing and damp drying, wind dispelling insecticide; Semen Torreyae sweet in the mouth, property are flat, effect killing insect and eliminating accumulation, and moistening dryness for relaxing bowels is ministerial drug with the Radix Pulsatillae, Radix Sophorae Flavescentis altogether; Side Cacumen Platycladi (Cacumen Biotae) bitter and puckery flavor, cold in nature, effect removing heat from blood, hemostasis, dysentery relieving is adjuvant drug; Radix Glycyrrhizae sweet in the mouth, property are flat, effect invigorating the spleen and replenishing QI, and coordinating the actions of various ingredients in a prescription, for making medicine; All medicines share, and gather effect of parasite killing, dampness, convergence, dysentery relieving altogether.
The present invention chooses high-quality fatsoluble vitamin, intestinal villus sources of cellular energy, convergence parasite killing Chinese medicinal herb essence composition, by nano micro-emulsification technology, nutrition, energy source, health care three are organically combined, mutual synergism, complementary not enough, there is dampness, convergence, anticoccidial, nutrition intestinal villi, repair damaged intestinal mucosa, facilitating digestion allelotaxis, maintain the special efficacy of intestinal health state, continuous use can reach the effect killing piglet isospora, promoting digestion and invigorating the stomach, astringing to arrest diarrhea 2-3 time, and produces the effect of lifetime immunity to coccidiosis.Easy to use, good palatability, use cost low (being only 1/2nd of Baycox), Clinical practice effect meets or exceeds " Baycox " suspension (5%) of Bayer A.G, and have no drug resistance, and can piglet growth be promoted, the antibiotic use of piglet stage can be greatly reduced, there is great popularizing application prospect, good economic benefit and social benefit can be produced.
Detailed description of the invention
Below in conjunction with detailed description of the invention, technical scheme of the present invention is described in further detail, but does not form any limitation of the invention.
Embodiment 1
1, the preparation of Chinese medicine extraction liquid:
Step 1.1: take Radix Dichroae 400kg, Herba Artemisiae Annuae 600kg, Radix Pulsatillae 600kg, Semen Torreyae 600kg, Cacumen Platycladi 400kg, Radix Sophorae Flavescentis 400kg, Radix Glycyrrhizae 200kg;
Step 1.2: the 7 taste pulverizing medicinal materials such as Radix Dichroae step 1.1 taken, Herba Artemisiae Annuae become 20 ~ 24 object coarse powder, add in percolate pot, adding concentration is that 70-75% alcoholic solution (about 3500kg) is to soaking full medical material, soak 7 days, percolation is carried out with the speed of 500ml per minute by percolation 70% ethanol as solvent, percolation is thin out to medicinal liquid color, drains medicinal residues, collects filtrate and is about 9000kg;
Step 1.3: step 1.2 gained filtrate is reclaimed ethanol through concentrating under reduced pressure, obtains alcohol extraction concentrated solution and is about 2700kg;
Step 1.4: step 1.3 gained alcohol extraction concentrated solution is put into concentration pan and concentrates, thickening temperature is 100 ± 5 DEG C, be concentrated into medicinal liquid and be about 945.5kg, (Ethyl Hydroxybenzoate 0.2kg is dissolved in 2kg95% ethanol slowly to add 5% Ethyl Hydroxybenzoate alcoholic solution 4kg, slowly add deionized water to 4kg), be stirred to dissolve, obtain about 949.5kg sepia Chinese medicine extraction liquid, cool for subsequent use;
2. the preparation of oil phase:
Take 10kg Tween 80,10kg PEG400,2.5kg fatty alcohol-polyoxyethylene ether, join in material-compound tank and carry out heated and stirred, until be dissolved to clear; Add DL-ɑ-tocopherol acetas oil preparation 2.5kg that concentration is 92% while stirring, concentration is not less than the retinyl acetate oil preparation 2kg of 1,000,000 IU/g, and concentration is not less than the vitamin D of 1,000,000 IU/g
3oil preparation 0.8kg, Butylated hydroxyanisole 0.2kg, abundant stirring and dissolving, adds ethanol 2.5kg, fully stirs, until form the oil phase of uniform and stable clear.
3. the preparation of aqueous phase:
In aqueous phase material-compound tank, inject 1 the concentrated liquid of tradition Chinese medicine 949.5kg, add sodium butyrate 20kg while stirring, fully stir, if dissolve not exclusively, can heat slightly, until form the sepia aqueous phase of uniform and stable clarification;
4. emulsifying:
2 oil phases are injected emulsion tank, emulsion tank temperature arranges 35-40 DEG C, start high-speed shearing emulsion machine (4000-8000 rev/min), slowly add solution in aqueous phase, and start high pressure homogenizer (operating pressure is adjusted to 80-100 MPa), emulsion through preliminary emulsification pretreatment is carried out high pressure homogenize, reflux back after homogenizing emulsion tank, until formation sepia, clarification, transparent microemulsion, after about 30 minutes, the mixing speed of continuous reduction vacuum emulsifying machine, until speed is 0, stop homogenizer, start delivery pump and the microemulsion through Over emulsfication and homogenizing is injected storage tank through plate filter and heat exchange cooler, wherein, plate filter uses microporous filter membrane aperture, the microporous filter membrane aperture of hyperfiltration is 0.22-0.43um, obtain about 1000kg sepia, clarification, transparent nanometer micro-emulsion.
5. check:
4 gained nanometer micro-emulsions are carried out the detections such as sanitary index, discriminating, content by quality criteria requirements, after qualified, obtains sample 1.
Quality standard:
1. sanitary index: GB 13078 requirement should be met, wherein total arsenic (in As)≤10mg/kg; Plumbous (in Pb)≤30mg/kg, fluorine (in F)≤1000mg/kg;
2. differentiate: in the chromatogram that (1) records under DL-ɑ-tocopherol acetas assay item, the retention time at test sample peak should consistent with the retention time at DL-ɑ-tocopherol acetas reference substance peak (GB/T 17812).
3. assay: retinyl acetate 100 ~ 3,000,000 IU/L (GB/T 17817), DL-ɑ-tocopherol acetas>=2g/L (GB/T 17812), vitamin D
350 ~ 1,000,000 IU/L (GB/T 17818).
Embodiment 2:
Concrete formula is substantially identical with embodiment 1 with step, and different places is,
In the preparation process of Chinese medicine extraction liquid, the weight of each taste Chinese medicine is as follows: Radix Dichroae 380kg, Herba Artemisiae Annuae 580kg, Radix Pulsatillae 620kg, Semen Torreyae 620kg, Cacumen Platycladi 385kg, Radix Sophorae Flavescentis 410kg, Radix Glycyrrhizae 190kg.
Embodiment 3:
Concrete formula is substantially identical with embodiment 1 with step, and different places is,
In the preparation process of Chinese medicine extraction liquid, the weight of each taste Chinese medicine is as follows: Radix Dichroae 430kg, Herba Artemisiae Annuae 625kg, Radix Pulsatillae 560kg, Semen Torreyae 570kg, Cacumen Platycladi 425kg, Radix Sophorae Flavescentis 370kg, Radix Glycyrrhizae 160kg.
Embodiment 4:
Concrete formula is substantially identical with embodiment 1 with step, and different places is,
In the preparation process of Chinese medicine extraction liquid, the weight of each taste Chinese medicine is as follows: Radix Dichroae 390kg, Herba Artemisiae Annuae 590kg, Radix Pulsatillae 618kg, Semen Torreyae 592kg, Cacumen Platycladi 418kg, Radix Sophorae Flavescentis 415kg, Radix Glycyrrhizae 190kg.
Embodiment 5:
Concrete formula is substantially identical with embodiment 1 with step, and different places is,
Vitamin is by 1.9 kg retinyl acetate oil preparationes, 0.85 kg vitamin D
3oil preparation, 2.2 kgDL-ɑ-tocopherol acetas composition, retinyl acetate is the oil preparation that concentration is not less than 1,000,000 IU/g, vitamin D
3for concentration is not less than 1,000,000 IU/g oil preparationes, the concentration of DL-ɑ-tocopherol acetas oil preparation is 92%.
Comparative example 1
The preparation of contrast sample 1
1. the preparation of oil phase:
Take 10kg Tween 80,10kg PEG400,2.5kg fatty alcohol-polyoxyethylene ether, join in material-compound tank and carry out heated and stirred, until be dissolved to clear; Add DL-ɑ-tocopherol acetas oil preparation 2.5kg that concentration is 92% while stirring, concentration is not less than the retinyl acetate oil preparation 2kg of 1,000,000 IU/g, and concentration is not less than the vitamin D of 1,000,000 IU/g
3oil preparation 0.8kg, Butylated hydroxyanisole 0.2kg, abundant stirring and dissolving, adds ethanol 2.5kg, fully stirs, until form the oil phase of uniform and stable clear.
2. the preparation of aqueous phase:
Deionized water 945.5kg is injected in aqueous phase material-compound tank, add sodium butyrate 20kg while stirring, abundant stirring, if dissolve not exclusively, can heat slightly, (Ethyl Hydroxybenzoate 0.2kg is dissolved in 2kg95% ethanol slowly to add 5% Ethyl Hydroxybenzoate alcoholic solution 4kg, slowly add deionized water to 4kg), until form the aqueous phase of uniform and stable clarification;
3. emulsifying:
1 oil phase is injected emulsion tank, emulsion tank temperature arranges 35-40 DEG C, start high-speed shearing emulsion machine (4000-8000 rev/min), slowly add solution in aqueous phase, and start high pressure homogenizer (operating pressure is adjusted to 80-100 MPa), emulsion through preliminary emulsification pretreatment is carried out high pressure homogenize, reflux back after homogenizing emulsion tank, until formation sepia, clarification, transparent microemulsion, after about 30 minutes, the mixing speed of continuous reduction vacuum emulsifying machine, until speed is 0, stop homogenizer, start delivery pump and the microemulsion through Over emulsfication and homogenizing is injected storage tank through plate filter and heat exchange cooler, obtain the micro-yellow of about 1000kg, clarification, transparent nanometer micro-emulsion.
4. check:
3 gained nanometer micro-emulsions are carried out the detections such as sanitary index, discriminating, content by quality criteria requirements, obtains after qualified contrasting sample 1.
Quality standard:
1. sanitary index: GB 13078 requirement should be met, wherein total arsenic (in As)≤10mg/kg; Plumbous (in Pb)≤30mg/kg, fluorine (in F)≤1000mg/kg;
2. differentiate: in the chromatogram that (1) records under DL-ɑ-tocopherol acetas assay item, the retention time at test sample peak should consistent with the retention time at DL-ɑ-tocopherol acetas reference substance peak (GB/T 17812).
3. assay: retinyl acetate 100 ~ 3,000,000 IU/L (GB/T 17817), DL-ɑ-tocopherol acetas>=2g/L (GB/T 17812), vitamin D
350 ~ 1,000,000 IU/L (GB/T 17818).
Comparative example 2
The preparation of comparative sample 2
1. the preparation of Chinese medicine extraction liquid:
Step 1.1: take Radix Dichroae 500kg, Herba Artemisiae Annuae 700kg, Radix Pulsatillae 700kg, Semen Torreyae 700kg, Cacumen Platycladi 500kg, Radix Sophorae Flavescentis 500kg, Radix Glycyrrhizae 250kg;
Step 1.2: the 7 taste pulverizing medicinal materials such as Radix Dichroae step 1.1 taken, Herba Artemisiae Annuae become 20 ~ 24 object coarse powder, add in percolate pot, adding concentration is that 70-75% alcoholic solution (about 4500kg) is to soaking full medical material, soak 7 days, percolation is carried out with the speed of 500ml per minute by percolation 70% ethanol as solvent, percolation is thin out to medicinal liquid color, drains medicinal residues, collects filtrate and is about 11000kg;
Step 1.3: step 1.2 gained filtrate is reclaimed ethanol through concentrating under reduced pressure, obtains alcohol extraction concentrated solution and is about 3300kg;
Step 1.4: step 1.3 gained alcohol extraction concentrated solution is put into concentration pan and concentrates, thickening temperature is 100 ± 5 DEG C, be concentrated into medicinal liquid and be about 965.5kg, (Ethyl Hydroxybenzoate 0.2kg is dissolved in 2kg95% ethanol slowly to add 5% Ethyl Hydroxybenzoate alcoholic solution 4kg, slowly add deionized water to 4kg), be stirred to dissolve, obtain about 969.5kg sepia Chinese medicine extraction liquid, cool for subsequent use;
2. the preparation of oil phase:
Take 10kg Tween 80,10kg PEG400,2.5kg fatty alcohol-polyoxyethylene ether, join in material-compound tank and carry out heated and stirred, until be dissolved to clear; Add DL-ɑ-tocopherol acetas oil preparation 2.5kg that concentration is 92% while stirring, concentration is not less than the retinyl acetate oil preparation 2kg of 1,000,000 IU/g, and concentration is not less than the vitamin D of 1,000,000 IU/g
3oil preparation 0.8kg, Butylated hydroxyanisole 0.2kg, abundant stirring and dissolving, adds ethanol 2.5kg, fully stirs, until form the oil phase of uniform and stable clear.
3. the preparation of aqueous phase:
1 the concentrated liquid of tradition Chinese medicine 969.5kg is injected in aqueous phase material-compound tank;
4. emulsifying:
2 oil phases are injected emulsion tank, emulsion tank temperature arranges 35-40 DEG C, start high-speed shearing emulsion machine (4000-8000 rev/min), slowly add solution in aqueous phase, and start high pressure homogenizer (operating pressure is adjusted to 80-100 MPa), emulsion through preliminary emulsification pretreatment is carried out high pressure homogenize, reflux back after homogenizing emulsion tank, until formation sepia, clarification, transparent microemulsion, after about 30 minutes, the mixing speed of continuous reduction vacuum emulsifying machine, until speed is 0, stop homogenizer, start delivery pump and the microemulsion through Over emulsfication and homogenizing is injected storage tank through plate filter and heat exchange cooler, obtain about 1000kg sepia, clarification, transparent nanometer micro-emulsion.
6. check:
4 gained nanometer micro-emulsions are carried out the detections such as sanitary index, discriminating, content by quality criteria requirements, after qualified, obtains comparative sample 2.
Animal feeding embodiment 1
" Baycox " suspension (5%) that sample 1 and contrast sample 1 are produced with, contrast sample 2 and Bayer (Sichuan) animal health company limited is to the immunocompetence comparative test of suckling pig isosporiasis.
1, materials and methods
(1) material
Get the test material of contrast sample 2 as the present embodiment of the sample 1 of above-described embodiment 1 and the contrast sample 1 of comparative example 1 and comparative example 2.
(2) conceptual design
Subjects chooses piglet isospora to infect positive pig farm, source is consistent, same parity, the farrowing time is close, and litter size is identical, sex ratio is close, the Du great Chang ternary 3 age in days suckling pig that birth weight is close, is divided into experiment I group by paired experiment principle, tests II group, tests III group, tests IV group and blank group totally 5 groups, often organizes 3 repetitions, each repetition 20, totally 300.Test I group of initial head counterpoise (1.65 ± 0.15) kg, test II group of initial head counterpoise (1.62 ± 0.11) kg, test III group of initial head counterpoise (1.58 ± 0.12) kg, test IV group of initial head counterpoise (1.60 ± 0.11) kg, blank group initial head counterpoise (1.68 ± 0.15) kg.Test I group of sample 1 of feeding, the 3rd age in days is to the 5th age in days, and feed every day every 1ml, connects and feeds 3 days; Test II group of contrast sample the 1,3rd age in days of feeding to the 5th age in days, feed every day every 1ml, connects and feed 3 days; Test III group of contrast sample the 2,3rd age in days of feeding to the 5th age in days, feed every day every 1ml, connects and feed 3 days; Test IV group of feed " Baycox " 5% suspension, the every draught animals of the 5th age in days takes feed 1ml; Blank group does not additionally add any medicated premix; Fed breast milk by sow completely before 7 days, within the 7th day, play feed piglets material gradually, 21-25 age in days weans, and feeding cycle is 25 days.Period regularly cleans pig house, and vaccine program vaccinate.The concrete formula of piglets material is Semen Maydis 34.8%, popcorn 25.0%, bean cake 24.0%, fermented bean cake 5.0%, whey powder 5.0%, high-quality fish meal 3%, calcium hydrogen phosphate 1.3%, stone powder 0.2%, salt 0.2%, lysine 0.2%, citric acid 0.1%, premix material 1.2%.
Period notices the piglet that diarrhoea occurs, there is the feces of latter 2 days in picking diarrhoea, for sick dead pig, the intestinal mucosa of directly scraping jejunum or ileum can carry out floating microexamination inspection, 12 age in days picking fresh excretas are unified in for normal piglet and carry out floating microexamination inspection.Adopt saturated saline floatation, get diseased region intestinal contents or fresh excreta about 10 ~ 20 grams, add in 50 milliliters of saturated aqueous common salts, leave standstill 10 minutes after stirring, get supernatant and drop on microscope slide, observe under 100 power microscopes, the coccidian oocyst of many circles can be seen, the egg capsule size of isospora is 20 ~ 23 × 17 ~ 19 (average 21.1 × 17.9) micron, and do not have micropore, isospora infects to have this feature to be judged to be.
The diarrhoea frequency of matched group and experimental group, mortality rate, Isospora suis infection rate, weanling weight is recorded in 25 days.
2, result and data
Table three:
Result of the test shows:
Find out that the Incidence of Diarrhea of each experimental group, mortality rate, Isospora suis infection rate are all starkly lower than blank group by table three, daily gain is also apparently higher than blank group; Wherein feeding, to organize effect the most obvious and close for inventive samples 1 group and feed " Baycox ", and also very remarkable with the difference of other experimental grouies.Feed inventive samples 1 group at experimental session, only has a piglet generation mild diarrhea, feces does not find Isospora suis ovum through floating microexamination inspection, fully recovers after 2 days, and all the other piglets carry out floating microexamination inspection at 12 ages in days to feces and all do not find Isospora suis ovum; Because inventive samples 1 pair of Isospora suis ovum has specific killing effect, and piglet can be made to produce semelincident immunization, so small intestinal intestinal wall does not destroy by coccidiosis, intestinal health is kept to grow, and there is promoting digestion and invigorating the stomach, astringing to arrest diarrhea, nutrition intestinal villi, repair damaged intestinal mucosa, facilitating digestion allelotaxis, maintain the special efficacy of intestinal health state, therefore this group piglet survival ratio, daily gain, weanling weight are the highest, and body weight is very even, the red hair of skin is bright, vivaciously active.Blank group piglet is due to 80% all infected pigs's isospora, small bowel destroys impaired, impact digesting and assimilating nutrient substance, more easily causes other bacterial viruses to invade, therefore in the diarrhoea that 7-15 age in days all occurs in various degree, use Multiple Classes of Antibiotics treatment all to no effect, so this group piglet diarrhea incidence rate and mortality rate the highest, weanling weight and daily gain minimum, and size weight is very uneven, uneven, staple length shades.Therefore, the liquid vitamin premixed feed preparation of a kind of anti-piglet isospora of the present invention has promoting digestion and invigorating the stomach clearly, astringing to arrest diarrhea, kills the effect of Isospora suis, and energy significantly nutrition intestinal villi, promote the growth of suckling pig digestive system, the immunity of enhancing body, the generation of remarkable minimizing intestine of young pigs disease, and use cost is low, easy to use, good palatability, have no drug resistance, cost performance is the highest, and Clinical practice effect meets or exceeds " Baycox " suspension (5%) of Beyer Co., Ltd.
Above-describedly be only preferred embodiment of the present invention, all do within the scope of the spirit and principles in the present invention any amendment, equivalently to replace and improvement etc., all should be included within protection scope of the present invention.
Claims (18)
1. the liquid vitamin premixed feed preparation of an anti-piglet isospora, it is characterized in that, the liquid vitamin premixed feed preparation of every 1000 weight portions comprises active component, 13.5 ~ 27 parts of emulsifying agents, 2 ~ 5 parts of co-emulsifier, described active component comprises following parts by weight of component: 3 ~ 7 parts of vitamin, 10 ~ 25 parts of sodium butyrates and 935 ~ 972 parts of Chinese medicine extraction liquid, described Chinese medicine extraction liquid is by 350 ~ 450 portions of Radix Dichroaes, 550 ~ 650 portions of Herba Artemisiae Annuaes, 550 ~ 650 portions of Radix Pulsatillaes, 550 ~ 650 portions of Semen Torreyaes, 350 ~ 450 portions of Cacumen Platycladis, 350 ~ 450 parts of Radix Sophorae Flavescentiss, 150 ~ 250 portions of Radix Glycyrrhizaes are through extracting, the mixture obtained after concentrated.
2. the liquid vitamin premixed feed preparation of anti-piglet isospora according to claim 1, is characterized in that, described vitamin is by 1 ~ 3 part by weight of vitamin A acetas, 0.5 ~ 1 part by weight of vitamin D
3, 1.5 ~ 3 weight portion DL-ɑ-tocopherol acetas composition, wherein, described vitamin D
3specification be the oil preparation that concentration is not less than 1,000,000 IU/g, the specification of retinyl acetate is the oil preparation that concentration is not less than 1,000,000 IU/g, and the specification of DL-ɑ-tocopherol acetas is the oil preparation that concentration is not less than 92.0%.
3. the liquid vitamin premixed feed preparation of anti-piglet isospora according to claim 1, is characterized in that, also comprises 0.15 ~ 0.3 weight portion antioxidant BHT.
4. the liquid vitamin premixed feed preparation of anti-piglet isospora according to claim 1, is characterized in that, also comprises 0.1 ~ 0.3 weight portion antiseptic Ethyl Hydroxybenzoate.
5. the liquid vitamin premixed feed preparation of anti-piglet isospora according to claim 1, it is characterized in that, described emulsifying agent comprises 6 ~ 12 parts by weight of polyoxyethylene 20 sorbitan mono-oleic acid esters, 6 ~ 12 weight portion PEG400s, 1.5 ~ 3 parts by weight of fatty polyoxyethylenated alcohol.
6. the liquid vitamin premixed feed preparation of anti-piglet isospora according to claim 6, is characterized in that, described co-emulsifier is ethanol.
7. a preparation method for the liquid vitamin premixed feed preparation of anti-piglet isospora as claimed in claim 1, is characterized in that, comprise the following steps:
Step 1: take vitamin, emulsifying agent, co-emulsifier and antioxidant and mix homogeneously, obtain oil phase;
Step 2: take Chinese medicine extraction liquid, antiseptic and sodium butyrate and mix homogeneously, obtain aqueous phase;
Step 3: aqueous phase is joined in oil phase and carry out vacuum emulsification and high pressure homogenize operation, obtain nanometer micro-emulsion.
8. the preparation method of the liquid vitamin premixed feed preparation of anti-piglet isospora according to claim 7, is characterized in that, described Chinese medicine extraction liquid extracts concentrated obtaining by percolation.
9. the preparation method of the liquid vitamin premixed feed preparation of anti-piglet isospora according to claim 8, it is characterized in that, the step being obtained Chinese medicine extraction liquid by percolation is comprised:
Step 1: the decoction pieces taking the Radix Dichroae of certain part by weight, Herba Artemisiae Annuae, the Radix Pulsatillae, Semen Torreyae, Cacumen Platycladi, Radix Sophorae Flavescentis, Radix Glycyrrhizae, and be crushed into 20 ~ 24 object coarse powder;
Step 2: be equivalent to 1 ~ 4 times of the gross weight of the above-mentioned prepared slices of Chinese crude drugs 70% ~ 75% alcoholic solution for the above-mentioned coarse powder of solvent soaking;
Step 3: the ethanol with 70% ~ 75% is that solvent processes the coarse powder after immersion with percolation, obtains percolate;
Step 4: by percolate decompression recycling ethanol, concentrates and becomes Chinese medicine extraction liquid.
10. the preparation method of the liquid vitamin premixed feed preparation of anti-piglet isospora according to claim 8, it is characterized in that, the mixture that described Chinese medicine extraction liquid is 350 ~ 450 portions of Radix Dichroaes, 550 ~ 650 portions of Herba Artemisiae Annuaes, 550 ~ 650 portions of Radix Pulsatillaes, 550 ~ 650 portions of Semen Torreyaes, 350 ~ 450 portions of Cacumen Platycladis, 350 ~ 450 portions of Radix Sophorae Flavescentiss, 150 ~ 250 portions of Radix Glycyrrhizaes obtain after extracting, concentrating, described Chinese medicine extraction liquid is 935 ~ 972 weight portions.
The preparation method of the liquid vitamin premixed feed preparation of 11. anti-piglet isosporas according to claim 8, is characterized in that, described vitamin is by 1 ~ 3 part by weight of vitamin A acetas, 0.5 ~ 1 part by weight of vitamin D
3, 1.5 ~ 3 weight portion DL-ɑ-tocopherol acetas composition, wherein, described vitamin D
3specification be the oil preparation that concentration is not less than 1,000,000 IU/g, the specification of retinyl acetate is the oil preparation that concentration is not less than 1,000,000 IU/g, and the specification of DL-ɑ-tocopherol acetas is the oil preparation that concentration is not less than 92.0%.
The preparation method of the liquid vitamin premixed feed preparation of 12. anti-piglet isosporas according to claim 8, is characterized in that, described antioxidant is 0.15 ~ 0.3 weight portion BHT.
The preparation method of the liquid vitamin premixed feed preparation of 13. anti-piglet isosporas according to claim 8, is characterized in that, described antiseptic is 0.1 ~ 0.3 weight portion ethyl hydroxybenzoate.
The preparation method of the liquid vitamin premixed feed preparation of 14. anti-piglet isosporas according to claim 8, it is characterized in that, described emulsifying agent comprises 6 ~ 12 parts by weight of polyoxyethylene 20 sorbitan mono-oleic acid esters, 6 ~ 12 weight portion PEG400s, 1.5 ~ 3 parts by weight of fatty polyoxyethylenated alcohol.
The preparation method of the liquid vitamin premixed feed preparation of 15. anti-piglet isosporas according to claim 14, it is characterized in that, described co-emulsifier is ethanol, and the consumption of described co-emulsifier is 2 ~ 5 weight portions.
The preparation method of the liquid vitamin premixed feed preparation of 16. anti-piglet isosporas according to claim 8, it is characterized in that, described step 3 specifically comprises following sub-step:
Sub-step 1: joined in emulsion tank by oil phase, and constant temperature 35 ~ 40 DEG C, start vacuum emulsifying machine and keep the rotating speed of 4000 ~ 8000 revs/min, slowly being joined in emulsion tank by aqueous phase and carry out vacuum emulsification;
Sub-step 2: emulsion after emulsifying is imported in high pressure homogenizer and carries out backflow high pressure homogenize, operating pressure is 80 ~ 100 MPas;
Sub-step 3: the high pressure emulsion after homogenizing imported in emulsion tank, obtain transparency emulsion, reduce the vacuum of emulsion tank gradually, obtains nanometer micro-emulsion after transparency emulsion being carried out cooling and filter.
The preparation method of the liquid vitamin premixed feed preparation of 17. anti-piglet isosporas according to claim 16, it is characterized in that, be filtered through microporous filter membrane in described sub-step 3 and carry out hyperfiltration, described microporous filter membrane aperture is 0.22 ~ 0.43um.
The application of liquid vitamin premixed feed preparation in suckling pig is raised of 18. 1 kinds of anti-piglet isosporas as claimed in claim 1, it is characterized in that, the liquid vitamin premixed feed preparation of described anti-piglet isospora is used within the 3rd day, rising after piglet birth, take feed by the draught animals or after being watered, put into suckling pig Special drinking fountain and allow and freely drink, use amount is every suckling pig this product 1ml/ every day, is used in conjunction 3 days.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410581666.0A CN104288250B (en) | 2014-10-27 | 2014-10-27 | A kind of liquid vitamin premixed feed preparation of anti-piglet isospora and its preparation method and application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410581666.0A CN104288250B (en) | 2014-10-27 | 2014-10-27 | A kind of liquid vitamin premixed feed preparation of anti-piglet isospora and its preparation method and application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104288250A true CN104288250A (en) | 2015-01-21 |
| CN104288250B CN104288250B (en) | 2017-07-11 |
Family
ID=52308362
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410581666.0A Active CN104288250B (en) | 2014-10-27 | 2014-10-27 | A kind of liquid vitamin premixed feed preparation of anti-piglet isospora and its preparation method and application |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104288250B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104664068A (en) * | 2015-03-18 | 2015-06-03 | 广东迈科特生物科技有限公司 | Special multivitamin immunopolysaccharide microemulsion preparation for waterfowl and preparation method and application thereof |
| CN104664168A (en) * | 2015-03-16 | 2015-06-03 | 广州益牲宝动物药业有限公司 | Multivitamin micro-emulsion preparation special for piglets, as well as preparation method and application of multivitamin micro-emulsion preparation |
| CN105901363A (en) * | 2016-04-21 | 2016-08-31 | 武汉家家乐饲料股份有限公司 | Quickly-growing-type piglet later period premixed feed and feeding method thereof |
| CN107050114A (en) * | 2017-04-28 | 2017-08-18 | 防城港市动物疫病预防控制中心 | A kind of anthelmintic for animals and preparation method thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002128619A (en) * | 2000-10-25 | 2002-05-09 | Dai Ichi Seiyaku Co Ltd | Anti-coccidium agent |
| CN101007126A (en) * | 2007-01-23 | 2007-08-01 | 天津生机集团有限公司 | Drug for preventing or treating parasites of avian and its preparation method |
| CN101040924A (en) * | 2007-04-27 | 2007-09-26 | 天津生机集团有限公司 | Chinese traditional medicine for treating fowl coccidiosis and the preparing method thereof |
| CN101129673A (en) * | 2007-08-17 | 2008-02-27 | 李培英 | Pure traditional Chinese medicine formulated product for preventing and treating coccidiosis |
| CN101209330A (en) * | 2006-12-25 | 2008-07-02 | 天津市润拓生物技术有限公司 | Compound Chinese medicinal granule with heat-clearing and detoxication, worm-expelling and liver-protecting efficacy |
| CN102846781A (en) * | 2011-06-29 | 2013-01-02 | 王洪涛 | Veterinary drug containing Chinese medicines for treating coccidiosis in poultry |
| CN104068219A (en) * | 2014-06-18 | 2014-10-01 | 广东金品动物营养有限公司 | Composite vitamin immunopolysaccharide nano micro-emulsion for livestock and poultry as well as preparation method and application of micro-emulsion |
-
2014
- 2014-10-27 CN CN201410581666.0A patent/CN104288250B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002128619A (en) * | 2000-10-25 | 2002-05-09 | Dai Ichi Seiyaku Co Ltd | Anti-coccidium agent |
| CN101209330A (en) * | 2006-12-25 | 2008-07-02 | 天津市润拓生物技术有限公司 | Compound Chinese medicinal granule with heat-clearing and detoxication, worm-expelling and liver-protecting efficacy |
| CN101007126A (en) * | 2007-01-23 | 2007-08-01 | 天津生机集团有限公司 | Drug for preventing or treating parasites of avian and its preparation method |
| CN101040924A (en) * | 2007-04-27 | 2007-09-26 | 天津生机集团有限公司 | Chinese traditional medicine for treating fowl coccidiosis and the preparing method thereof |
| CN101129673A (en) * | 2007-08-17 | 2008-02-27 | 李培英 | Pure traditional Chinese medicine formulated product for preventing and treating coccidiosis |
| CN102846781A (en) * | 2011-06-29 | 2013-01-02 | 王洪涛 | Veterinary drug containing Chinese medicines for treating coccidiosis in poultry |
| CN104068219A (en) * | 2014-06-18 | 2014-10-01 | 广东金品动物营养有限公司 | Composite vitamin immunopolysaccharide nano micro-emulsion for livestock and poultry as well as preparation method and application of micro-emulsion |
Non-Patent Citations (1)
| Title |
|---|
| 秦枫，等: "防治球虫病的常用中草药研究进展", 《中国医药导报》 * |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104664168A (en) * | 2015-03-16 | 2015-06-03 | 广州益牲宝动物药业有限公司 | Multivitamin micro-emulsion preparation special for piglets, as well as preparation method and application of multivitamin micro-emulsion preparation |
| CN104664168B (en) * | 2015-03-16 | 2018-02-16 | 广州益牲宝动物药业有限公司 | A kind of piglet specific complex vitamin microemulsion preparation and its preparation method and application |
| CN104664068A (en) * | 2015-03-18 | 2015-06-03 | 广东迈科特生物科技有限公司 | Special multivitamin immunopolysaccharide microemulsion preparation for waterfowl and preparation method and application thereof |
| CN105901363A (en) * | 2016-04-21 | 2016-08-31 | 武汉家家乐饲料股份有限公司 | Quickly-growing-type piglet later period premixed feed and feeding method thereof |
| CN107050114A (en) * | 2017-04-28 | 2017-08-18 | 防城港市动物疫病预防控制中心 | A kind of anthelmintic for animals and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104288250B (en) | 2017-07-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN102835609B (en) | Pig feed capable of preventing piglets from diarrhea and traditional Chinese medicine composition | |
| CN103734519B (en) | Method and product for producing forage immune enhancer by adopting soybean curb residue and orange peel | |
| CN101664421B (en) | Traditional Chinese biological preparation for preventing and treating livestock diarrhea and preparation method and feedstuff thereof | |
| CN111513211A (en) | Water-soluble nutrient essential oil for livestock and poultry and aquaculture and preparation method and application thereof | |
| CN104054973B (en) | Feed used for improving immune function of carp | |
| CN104054972A (en) | Feed for raising river crab | |
| CN103598405B (en) | For improving the feed of laying hen Egg Quality | |
| CN104187091B (en) | A kind of common eel compound Chinese herbal medicine additive of disease-resistant growth-promoting | |
| CN104288250B (en) | A kind of liquid vitamin premixed feed preparation of anti-piglet isospora and its preparation method and application | |
| CN104304679B (en) | A kind of B B-complex C, E immune polysaccharide microemulsion preparation and its preparation method and application | |
| CN110200151A (en) | A kind of yak feed addictive and preparation method thereof that yak survival rate can be improved | |
| CN105853454A (en) | Broad-spectrum antiparasitic drug nano-emulsion and preparation method thereof | |
| Zhang et al. | A review-biology, aquaculture and medical use of seahorse, Hippocampus spp | |
| CN101139554B (en) | Solid-state fermentation preparing method for Chinese herbal medicine yeast selenium | |
| CN103598437B (en) | For improving the feed of Layer Production Performance | |
| US10500236B2 (en) | Bioactive animal feed | |
| CN107373023A (en) | A kind of young quail fermented type Chinese herbal feed additive and preparation method thereof | |
| CN107233428A (en) | A kind of fishes and shrimps enteritis pesticide control and preparation method thereof | |
| CN104435069B (en) | It is a kind of improve pig immune function animal medicinal composition, using and preparation method thereof | |
| CN110089639A (en) | A kind of feed addictive improving child care pig growth performance and its preparation and application | |
| CN106260523A (en) | A kind of feeding composite plant quintessence oil additive and feedstuff | |
| CN104664168B (en) | A kind of piglet specific complex vitamin microemulsion preparation and its preparation method and application | |
| CN107095061A (en) | Improve the fermented feed preparation method and applications of growing and fattening pigs gut barrier function | |
| CN106421275A (en) | Traditional Chinese medicine compound preparation for treating fish sporidiosis and preparation method thereof | |
| CN105104715A (en) | Feed preventing vibrio infection of xenocypris davidi and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A liquid vitamin premixed feed formulation for resisting piglet isospora and its preparation method and application Effective date of registration: 20230911 Granted publication date: 20170711 Pledgee: Bank of China Limited Guangzhou Development Zone Branch Pledgor: GUANGDONG GINPIN ANIMAL NUTRITION CO.,LTD. Registration number: Y2023980056223 |
|
| PE01 | Entry into force of the registration of the contract for pledge of patent right |