CN108543031A - 一种治疗牛皮癣的药物及其制备方法 - Google Patents

一种治疗牛皮癣的药物及其制备方法 Download PDF

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CN108543031A
CN108543031A CN201810854812.0A CN201810854812A CN108543031A CN 108543031 A CN108543031 A CN 108543031A CN 201810854812 A CN201810854812 A CN 201810854812A CN 108543031 A CN108543031 A CN 108543031A
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radix
impurity
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李少伦
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李少伦
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Abstract

本发明公开了一种治疗牛皮癣的药物及其制备方法,其主要是由银线草、苦参、蛇床子、鸡血藤、水牛角、雪莲花、虎杖、紫草、地肤子、板蓝根、槐花、白鲜皮、北豆根、甘草、丹参、三七、三棱、泽泻按一定重量配比制备而成,本发明药物具有祛风燥湿、清热解毒、活血舒筋、益卫固表、托毒生肌、补中益的功能,用于治疗牛皮癣见效快、疗效好,不复发。

Description

一种治疗牛皮癣的药物及其制备方法
技术领域
[0001 ]本发明涉及一种治疗牛皮癣的药物及其制备方法,属中药领域。 技术背景
[0002] 牛皮癣是一种常见的具有特征性皮损的慢性易于复发的炎症性皮肤病,特征性损 害为红色丘疹或斑块上覆有多层银白色鳞肩。中医则认为牛皮癣与血热内蕴、血虚风燥、气 血瘀滞、湿毒蕴阻、火毒炽盛有关。由于西药治疗副作用大,因此人们对有效治疗牛皮癣的 中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
[0003] 本发明人在祖传医方的基础上,又经过临床试验的反复验证,终于找到了有效治 疗牛皮癣的药物,从而完成了本发明。
[0004] 本发明的目的就是提供一种有效治疗牛皮癣的中药组合药物。
[0005] 本发明的另一目的就是提供了该中药组合药物的制备方法。
[0006] 本发明是选择银线草、苦参、蛇床子、鸡血藤、水牛角、雪莲花、虎杖、紫草、地肤子、 板蓝根、槐花、白鲜皮、北豆根、甘草、丹参、三七、三棱、泽泻、白术、黄芪、侧柏叶药物进行组 合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗牛皮癣。其 中,选用银线草是因为其性味辛苦,温,有毒,有散寒,祛风,行瘀,解毒的功能,治风寒咳嗽, 妇女经闭,风痒,跌打,痈肿疮疖。选用苦参是因为其性味苦,寒,入肝、肾、大肠、小肠经,有 清热,燥湿,杀虫的功能,治热毒血痢,肠风下血,黄疸,赤白带下,小儿肺炎,疳积,急性扁桃 体炎,痔漏,脱肛,皮肤瘙痒,阴疮湿痒,瘰疬,烫伤。选用蛇床子是因为其性味辛苦,温,入 肾、脾经,有温肾助阳,祛风,燥湿,杀虫的功能,治男子阳痿,阴囊湿痒,女子带下阴痒,子宫 寒冷不孕,风湿痹痛,疥癣湿疮。选用鸡血藤是因为其性味苦甘,温,入心、脾二经,有活血、 舒筋的功能,治腰膝酸痛,麻木瘫痪,月经不调。选用水牛角是因为其性味苦咸,寒,有清热、 凉血、解毒的功能,治热病头痛,壮热神昏,斑疹,吐衄,小儿惊风,喉痹咽肿。选用雪莲花是 因为其性味甘苦,温,入肝、脾、肾三经,有除寒,壮阳,调经,止血的功能,治阳萎,腰膝软弱, 妇女崩漏,月经不调,风湿性关节炎,外伤出血。选用虎杖是因为其性味苦,平,有祛风,利 湿,破瘀,通经的功能,治风湿筋骨疼痛,湿热黄疸,淋浊带下,妇女经闭,产后恶露不下,癥 瘕积聚,痔漏下血,跌扑损伤,烫伤,恶疮癣疾。选用紫草是因为其性味苦苦,寒,入心包络、 肝经,有凉血,活血,清热解毒的功能,治温热斑疹,湿热黄疸,紫癜,吐、衄、尿血,淋浊,血 痢,热结便秘,烧伤,湿疹,丹毒,痈疡。选用地肤子是因为其性味甘苦,寒,入肾、膀胱经,有 利小便,清湿热的功能,治小便不利,淋病,带下,疝气,风疹,疮毒,疥癣,阴部湿痒。选用板 蓝根是因为其性味苦,寒,入肝、胃血分,有清热,解毒,凉血的功能,治流感,流脑,乙脑,肺 炎,丹毒,热毒发斑,神昏吐衄,咽肿,痄腮,火眼,疮疹。选用槐花是因为其性味苦,凉,入肝、 大肠经,有清热,凉血,止血的功能,治肠风便血,痔血,尿血,血淋,崩漏,衄血,赤白痢下,风 热目赤,痈疽疮毒,并用于预防中风。选用白鲜皮是因为其性味苦,咸,寒,入脾、胃经,有祛 风,燥湿,清热,解毒的功能,治风热疮毒,疥癣,皮肤痒疹,风湿痹痛,黄疸。选用北豆根是因 为其性味苦,寒,有小毒,归脾、胃、大肠经,有清热解毒,祛风止痛的功能,治咽喉肿痛,泄泻 痢疾,风湿痹痛。选用甘草是因为其性味甘平,入脾、胃、肺经,有和中缓急,润肺,解毒,调和 诸药的功能,炙用治脾胃虚弱,食少,腹痛便溏,劳倦发热,肺痿咳嗽,心悸,惊痈,生用治咽 喉肿痛,消化性溃疡,痈疽疮疡,解药毒及食物中毒。选用丹参是因为其性味苦,微温,入心、 肝经,有活血去瘀,安神宁心,排脓,止痛的功能,治心绞痛,月经不调,痛经,以闭,血崩带 下,癥瘕,积聚,瘀血腹痛,骨节疼痛,惊悸不眠,恶疮肿毒。选用三七是因为其性味甘微苦, 温,入肝、胃、大肠经,有止血,散瘀,消肿,定痛的功能,治吐血,咳血,衄血,便血,血痢,崩 漏,癥瘕,产后血晕,恶露不下,跌扑瘀血,外伤出血,痈肿疼痛。选用三棱是因为其性味苦 辛,平,入肝、脾经,有破血,行气,消积,止痛的功能,治癥瘕积聚,气血凝带,心腹疼痛,胁下 胀疼,经闭,产后瘀血腹痛,跌打损伤,疮肿坚硬。选用泽泻是因为其性味甘,寒,入膀胱经, 有利水,渗湿,泄热的功能,治小便不利,水肿肛满,呕吐,泻痢,痰饮,脚气,淋病,尿血。选用 白术是因为其性味苦甘,温,入脾、胃经,有补脾,益胃,燥湿,和中的功能,治脾胃气弱,不思 饮食,倦怠少气,虚胀,泄泻,痰饮,水肿,黄疸,湿痹,小便不利,头晕,自汗,胎气不安。选用 黄芪是因为其性味甘,微温,入肺、脾经,生用有益卫固表,利水消肿,托毒,生肌的功能,治 自汗,盗汗,血痹,浮肿,痈疽不溃或溃久敛;炙用有补中益的功能,治内伤劳倦,脾虚泄泻, 脱肛,气虚血脱,崩带及一切气衰血虚之症。选用侧柏叶是因为其性味苦涩,寒,入心、肝、大 肠经,有凉血,止血,祛风湿,散肿毒的功能,治吐血,衄血,尿血,血痢,肠风,崩漏,风湿痹 痛,细菌性痢疾,高血压,咳嗽,丹毒,痄腮,烫伤。
[0007] 本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下 述重量范围内都具有较好的疗效: 银线草15-25克、苦参10-15克、蛇床子5-15克、鸡血藤25-35克、水牛角25-35克、雪莲花 10-15克、虎杖7-12克、紫草10-20克、地肤子5-15克、板蓝根25-35克、槐花25-35克、白鲜皮 5-15克、北豆根7-12克、甘草3-7克、丹参25-35克、三七25-35克、三棱10-20克、泽泻7-12克、 白术7-12克、黄芪15-25克、侧柏叶10-15克。
[0008] 优选为 银线草20克、苦参12克、蛇床子10克、鸡血藤30克、水牛角30克、雪莲花13克、虎杖9克、 紫草15克、地肤子10克、板蓝根30克、槐花30克、白鲜皮10克、北豆根9克、甘草5克、丹参30 克、三七30克、三棱15克、泽泻9克、白术9克、黄芪20克、侧柏叶12克。
[0009] 本发明药物的制备方法如下 一、备料 1、 银线草:春、夏间采,洗净,阴干; 2、 苦参:拣净杂质,除去残茎,洗净泥土,用水浸泡,捞出,润透,切片,晒干; 3、 蛇床子:拣去杂质,筛去泥砂,洗净,晒干; 4、 鸡血藤:用水润透,切片,或蒸软后趁热切片,晒干; 5、 水牛角:劈开,用热水浸泡,捞出,镑片,晒干; 6、 雪莲花:6-7月间开花时采收,拔起全株,除去泥沙,晾干; 7、 虎杖:取原药材,除去杂质,洗净,干燥,劈碎; 8、 紫草:洗净,润透,切片,晒干; 9、 地肤子:取原药材,除去杂质,筛去碎肩; 10、 板蓝根:拣净杂质,洗净,润透,切片,晒干; 11、 槐花:取原药材,除去梗、叶及杂质,筛去灰肩; 12、 白鲜皮:拣净杂质,除去粗皮,洗净,稍润,切片,晒干; 13、 北豆根:除去残茎、杂质,大小分档,浸泡至六七成透时,取出,润透,切厚片,干燥, 筛去碎肩; 14、 甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,晾干; 15、 丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干; 16、 三七:拣净杂质,捣碎,研末或润透后切片晒干; 17、 三棱:拣净杂质,用水浸泡,捞出润透,切片,晒干; 18、 泽泻:拣去杂质,大小分档,用水浸泡至八成透,捞出,晒凉,闷润至内外湿度均匀, 切片,晒干; 19、 白术:拣净杂质,用水浸泡,泡后捞出,润透,切片,晒干; 20、 黄芪:拣净杂质,除去残留的根头和空心较大的根,用水浸泡,捞出,润透后及时切 片,晒干; 21、 侧柏叶:拣净杂质,揉碎去梗,筛净灰肩。
[0010] 二、制备 1、 将所述重量的银线草、苦参、蛇床子、鸡血藤、水牛角、雪莲花、虎杖、紫草、地肤子、板 蓝根、槐花、白鲜皮、北豆根、甘草、丹参、三七、三棱、泽泻、白术、黄苗、侧柏叶放人煎药容器 内,加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮 液,将第一次煎煮液倒入容器内; 2、 将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液; 3、 将两次煎煮液混合搅拌均匀,分为3剂服用。
[0011] 组方中银线草散寒,祛风,行瘀,解毒,苦参有清热,燥湿,杀虫的功能二者为君药; 蛇床子温肾助阳,祛风,燥湿,杀虫,鸡血藤有活血、舒筋的功能,与水牛角、雪莲花为臣药, 与君药共同发挥行瘀解毒、清热燥湿、祛风、活血舒筋、杀虫的作用,治疗牛皮癣效力全面, 且以行瘀解毒、清热燥湿、祛风、活血舒筋为主,可治本;白鲜皮有祛风,燥湿,清热,解毒的 功能与北豆根、甘草、丹参、三七为佐药;黄芪有益卫固表,利水消肿,托毒,生肌,补中益的 功能与余下诸药为使药,是治标。
[0012] 本发明药物具有祛风燥湿、清热解毒、活血舒筋、益卫固表、托毒生肌、补中益的功 能,用于治疗牛皮癣,疗程短、见效快、治愈后不复发。
具体实施方式
[0013] 以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发 明药物的动物毒性试验报告和临床疗效观察资料。
[0014] [试验例1]本发明药物的动物毒性试验报告: 取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验 组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给 药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良 毒副作用。
[0015] [试验例2]本发明药物的临床疗效观察 1、一般资料 收治牛皮癣门诊患者共32例。
[0016] 2、诊断标准 典型症状为:皮肤表层有鳞肩、全身弥漫性潮红、脓疱、丘疹、关节疼痛等。
[0017] 3、治疗方法 选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,30天为一个疗程,连续 服用2个疗程。
[0018] 4、疗效评定标准 显效:牛皮癣症状消失,皮肤恢复正常,随访一年未复发; 好转:患者皮肤表层有鳞肩、全身弥漫性潮红、脓疱、丘疹、关节疼痛的现象减轻,牛皮 癣症状明显好转,体质逐步恢复; 无效:达不到好转标准者。
[0019] 5、治疗结果(见下表)
Figure CN108543031AD00071
在上述治疗中,用本发明药物治疗牛皮癣患者32例,结果显效27例,显效率为84.38%, 好转4例,好转率为12.5%,无效1例,总有效率为96.88%。

Claims (3)

1. 一种治疗牛皮癣的药物,其特征在于:它是由下列重量范围内的原料药制成: 银线草15-25克、苦参10-15克、蛇床子5-15克、鸡血藤25-35克、水牛角25-35克、雪莲花 10-15克、虎杖7-12克、紫草10-20克、地肤子5-15克、板蓝根25-35克、槐花25-35克、白鲜皮 5-15克、北豆根7-12克、甘草3-7克、丹参25-35克、三七25-35克、三棱10-20克、泽泻7-12克、 白术7-12克、黄芪15-25克、侧柏叶10-15克。
2. 根据权利要求1所述的药物,其中各原料药的用量为: 银线草20克、苦参12克、蛇床子10克、鸡血藤30克、水牛角30克、雪莲花13克、虎杖9克、 紫草15克、地肤子10克、板蓝根30克、槐花30克、白鲜皮10克、北豆根9克、甘草5克、丹参30 克、三七30克、三棱15克、泽泻9克、白术9克、黄芪20克、侧柏叶12克。
3. 根据权利要求1或2所述药物的制备方法,它包括下列步骤: (一) 备料 ⑴银线草:春、夏间采,洗净,阴干; (2) 苦参:拣净杂质,除去残茎,洗净泥土,用水浸泡,捞出,润透,切片,晒干; (3) 蛇床子:拣去杂质,筛去泥砂,洗净,晒干; (4) 鸡血藤:用水润透,切片,或蒸软后趁热切片,晒干; (5) 水牛角:劈开,用热水浸泡,捞出,镑片,晒干; (6) 雪莲花:6-7月间开花时采收,拔起全株,除去泥沙,晾干; (7) 虎杖:取原药材,除去杂质,洗净,干燥,劈碎; (8) 紫草:洗净,润透,切片,晒干; (9) 地肤子:取原药材,除去杂质,筛去碎肩; (10) 板蓝根:拣净杂质,洗净,润透,切片,晒干; (11) 槐花:取原药材,除去梗、叶及杂质,筛去灰肩; (12) 白鲜皮:拣净杂质,除去粗皮,洗净,稍润,切片,晒干; (13) 北豆根:除去残茎、杂质,大小分档,浸泡至六七成透时,取出,润透,切厚片,干燥, 筛去碎肩; (14) 甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,晾干; (15) 丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,瞭干; (16) 三七:拣净杂质,捣碎,研末或润透后切片晒干; (17) 三棱:拣净杂质,用水浸泡,捞出润透,切片,晒干; (18) 泽泻:拣去杂质,大小分档,用水浸泡至八成透,捞出,晒凉,闷润至内外湿度均匀, 切片,晒干; (19) 白术:拣净杂质,用水浸泡,泡后捞出,润透,切片,晒干; (20) 黄芪:拣净杂质,除去残留的根头和空心较大的根,用水浸泡,捞出,润透后及时切 片,晒干; (21) 侧柏叶:拣净杂质,揉碎去梗,筛净灰肩; (二) 制备 (1)将所述重量的银线草、苦参、蛇床子、鸡血藤、水牛角、雪莲花、虎杖、紫草、地肤子、 板蓝根、槐花、白鲜皮、北豆根、甘草、丹参、三七、三棱、泽泻、白术、黄芪、侧柏叶放人煎药容 器内,加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮 液,将第一次煎煮液倒入容器内; (2) 将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液; (3) 将两次煎煮液混合搅拌均匀,分为3剂服用。
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