CN108542945A - It is a kind of to be used to treat external use liquid dressing of skin diseases and preparation method thereof and application method - Google Patents
It is a kind of to be used to treat external use liquid dressing of skin diseases and preparation method thereof and application method Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P17/00—Drugs for dermatological disorders
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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Abstract
External use liquid dressing that the present invention relates to a kind of for treating skin diseases and preparation method thereof and application method, belong to pharmaceutical technology field.The liquid dressing of the present invention is that high mountain flower of Sorbaria or high mountain flower of Sorbaria are spent seed, first uses water 20~60min of bored profit, then adds 5~15 times to measure water, and slow fire decocts 2 times, decocts 2~4h for the first time, and second of 1~3h of decoction finally filters decoction liquor and can be prepared by.The external use liquid dressing Easy dosing for treating skin diseases of the present invention, only with the flower or flower seed of high mountain flower of Sorbaria as raw material, and preparation method and application method are simple and convenient.In addition, raw material sources of the present invention are extensive, cheap, the technological process of production is simple, and throughput rate is fast, can mass production.And the liquid dressing of the present invention is easy to use, clinical application is safe and free of toxic and side effects.It takes effect within general 3~5 days, basic healing in 30 days or so has a good application prospect.
Description
Technical field
The invention belongs to pharmaceutical technology fields, and in particular to it is a kind of for treat skin diseases external use liquid dressing and
Preparation method and application method.
Background technology
Psoriasis is a kind of common chronic inflammatory dermatoses for being easy to recurrence with characteristic skin lesion.From the beginning of for
For inflammatory red papules, about grain grain to mung bean size, being gradually expanded or merge later becomes brownish red patch, clear border, surrounding
There is inflammatory blush, substrate infiltration is apparent, and surface covers the canescence or the silvery white scales of skin that peel off of multilayer drying.Gently scraper surface squama
One layer of shinny semitransparent thin film of pale red is gradually exposed in bits, claims film phenomenon.Film is struck off again, then small blutpunkte occurs, is claimed
Petechial hemorrhage phenomenon.The white scales of skin that peel off, shinny film and petechial hemorrhage are the important feature for diagnosing psoriasis, referred to as three signs.It seeks
Normal psoriasis pustulosa skin lesion is broadly divided into three periods from occurring to subside to the end：Into the departure date, resting stage, catagen.
Psoriasis is a kind of refractory skin for being difficult to cure, and doctor trained in Western medicine is mainly to take Western medicine, external application steroids ointment orally
Based on, on the one hand western medical treatment cannot effect a radical cure, be on the other hand that side effect is big.It is mainly clearing heat and detoxicating cool blood for Chinese medicine synthesis
Based on, mostly short, curative effect unobvious are easy recurrence though this disease does not jeopardize patients ' lives but Relapse rate, and delay is difficult
More, the huge uncomfortable and stress thus brought to patient, the also serious burden of economic aspect.
In addition, in the prior art for other skin diseases, such as neurodermatitis, eczema, bleb, fash, women
It (includes mainly direct current electrotherapy and medicine-inductiveness, low-frequency pulse electrotherapy, ultrasound that leukoplakia vulvae etc., which generally uses physiotherapy,
Therapy, acupuncture, light therapy etc.), drug therapy (mainly include non-steroidal antiinflammatory drugs NSAIDs, glucocorticoid Gs, improve disease
Feelings act on antirheumatic DMARDs, autonomic drug, biological agent etc. slowly), immune i.e. biological therapy is (such as cell factor
Target molecule treatment, plasma exchange, immunologic purging, immunologic reconstitution, mesenchymal stem cell transplantation etc.), (main includes closing for surgical intervention
Save chamber puncture, synovectomy, joint replacement, joint be orthopedic, joint fusion) etc., but above-mentioned various methods can only be alleviated, subtract
Gently, improve and delay progression of disease, and high cost, it cannot be guaranteed that As the medicine took effect, the symptoms lessened, and surgical intervention make patient body by
Damage is still tormented by disease, is decocted for a long time, and the healing that cannot be completely cured.
Based on the above reasons, special to propose the application.
Invention content
The technical problem to be solved by the present invention is to：There is provided it is a kind of for treat skin diseases external use liquid dressing and
Preparation method and application method.The liquid dressing of the present invention is mainly with natural plants high mountain flower of Sorbaria or high mountain flower of Sorbaria
Flower seed be raw material through bored profit, decoct, filtering is made, it is raw materials used it is cheap and easy to get, preparation method is simple, easy to use, clinical answers
With safe and free of toxic and side effects.
In order to solve the above technical problems, it is an object of the present invention to provide a kind of external applications for treating skin diseases
Liquid dressing, the liquid dressing are that raw material is made through bored profit, decoction, filtering by the flower or flower seed of natural plants high mountain flower of Sorbaria
.
Second object of the present invention is to provide the external use liquid dressing for treating skin diseases described above
Preparation method, the method specifically comprises the following steps：
High mountain flower of Sorbaria or high mountain flower of Sorbaria are spent into seed, first use water 20~60min of bored profit, then adds 5~15 times of amount water,
Slow fire decocts 2 times, decocts 2~4h for the first time, and second of 1~3h of decoction finally filters decoction liquor and can be prepared by the liquid
Dressing.
Further, the high mountain flower of Sorbaria described in above-mentioned technical proposal step or high mountain flower of Sorbaria flower seed and bored profit
It is 100g with the proportioning of water：100~200ml.
Further, the bored profit time described in above-mentioned technical proposal step is preferably 30min.
Further, the first time decocting time described in above-mentioned technical proposal step is preferably 3h, when decocting for the second time
Between preferably 2h.
Third object of the present invention is to provide the external use liquid dressing for treating skin diseases described above
Application method：The liquid dressing specifically is applied directly to affected part, daily 1~3 time, adhere to using 3~30 days by external application
.
Further, the skin diseases described in above-mentioned technical proposal include outside psoriasis, neurodermatitis and women
Cloudy hickie.
Further, the skin diseases described in above-mentioned technical proposal are preferably psoriasis.
The pharmacology of the above-mentioned high mountain flower of Sorbaria of the present invention or high mountain flower of Sorbaria flower seed component is as follows：
False spiraea also known as mountain sorghum, Yagi spark gap item are rosaceous plant, spend to have a variety of harmful bacterias and kill or inhibit
Effect.
Beneficial effects of the present invention：
(1) of the invention for treating the external use liquid dressing Easy dosing of skin diseases, only with high mountain false spiraea
Colored flower or flower seed is as raw material, and preparation method and application method are simple and convenient.In addition, the liquid dressing of the present invention has
Good effect, cure rate are high, recurrence rate is low, have no adverse reaction, the advantages that expense is low, general patient can receive.
(2) the external use liquid dressing raw material sources for the treatment of skin diseases of the invention are extensive, cheap, production technology
Flow is simple, and throughput rate is fast, can mass production.
(3) the external use liquid dressing for the treatment of skin diseases of the invention is easy to use, clinical application is safe and nontoxic secondary makees
With.It takes effect within general 3~5 days, basic healing in 30 days or so：It is total to over nearly 2 years and cures psoriatic 256, cure rate 100%,
Therefore, liquid dressing of the invention has a good application prospect.
Specific implementation mode
It elaborates below to the case study on implementation of the present invention.The implementation case under the premise of technical solution of the present invention into
Row is implemented, and gives detailed embodiment and specific operating process, but protection scope of the present invention is not limited to following realities
Apply case.
The information for including according to the application, to those skilled in the art can be easily to the essence of the present invention
Really description carries out various changes, without departing from spirit and scope of the appended claims.It should be understood that the scope of the present invention is not
Process, property or component defined by being confined to, because these embodiments and other descriptions are just for the sake of schematic
Illustrate certain aspects of the present disclosure.In fact, this field or those skilled in the relevant art obviously can be to embodiment party of the present invention
The various changes that formula is made all cover within the scope of the appended claims.
For a better understanding of the present invention rather than limit the scope of the invention, expression dosage used in this application,
All numbers of percentage and other numerical value, are understood to " about " be modified with word in all cases.Therefore,
Unless stated otherwise, otherwise digital parameters listed in specification and appended book are all approximations, may
It can be changed according to the difference for the desirable properties for attempting to obtain.Each digital parameters at least should be considered as according to being reported
Effective digital and by it is conventional round up method by obtain.
Embodiment 1
A kind of external use liquid dressing for treating skin diseases of the present embodiment, the liquid dressing is by natural plants
The flower or flower seed of high mountain flower of Sorbaria are that raw material is made through bored profit, decoction, filtering.
External use liquid dressing for treating skin diseases described above is prepared with the following method, the side
Method specifically comprises the following steps：
100g high mountains flower of Sorbaria or high mountain flower of Sorbaria are spent into seed, first use the bored profit 30min of 200ml water, then adds 10 times of amounts
Water, slow fire decoction 2 times, first time decoct 3h, second of decoction 2h, and finally it is deposited to can be prepared by the liquid for filtering decoction liquor
Material.
Embodiment 2
A kind of external use liquid dressing for treating skin diseases of the present embodiment, the liquid dressing is by natural plants
The flower or flower seed of high mountain flower of Sorbaria are that raw material is made through bored profit, decoction, filtering.
External use liquid dressing for treating skin diseases described above is prepared with the following method, the side
Method specifically comprises the following steps：
100g high mountains flower of Sorbaria or high mountain flower of Sorbaria are spent into seed, first use the bored profit 60min of 100ml water, then adds 5 times of amounts
Water, slow fire decoction 2 times, first time decoct 4h, second of decoction 1h, and finally it is deposited to can be prepared by the liquid for filtering decoction liquor
Material.
Embodiment 3
A kind of external use liquid dressing for treating skin diseases of the present embodiment, the liquid dressing is by natural plants
The flower or flower seed of high mountain flower of Sorbaria are that raw material is made through bored profit, decoction, filtering.
External use liquid dressing for treating skin diseases described above is prepared with the following method, the side
Method specifically comprises the following steps：
100g high mountains flower of Sorbaria or high mountain flower of Sorbaria are spent into seed, first use the bored profit 20min of 150ml water, then adds 15 times of amounts
Water, slow fire decoction 2 times, first time decoct 2h, second of decoction 3h, and finally it is deposited to can be prepared by the liquid for filtering decoction liquor
Material.
To verify the validity of product, spy passes through test of many times, inquires into the liquid dressing of the present invention to treating Cutaneous disease
The clinical therapeutic efficacy of disease.
One, psoriasis is common one of skin diseases, and different types of psoriasis has different diagnostic criteria.It is clinical
On be generally divided into homeliness type, erythrodermic, pustule type, four kinds of joint type.
Two, psoriasic doctor trained in Western medicine diagnosis basis
1, there can be family history.
2, any age can fall ill, but based on person between twenty and fifty.
3, chronic process, alleviation are alternately present with breaking-out, normal lasting for years.There are certain seasonality, general weight summer in winter light.
4, have certain predilection site, be followed successively by scalp, ancon, knee, friction part, also can general hair whole body, including mucous membrane
Position and refer to (toe) first.
Three, psoriasic Western medicine diagnostic criteria
1, homeliness type：According to three phases of the course of disease point.
(1) catagen or convalescence：Inflammation subsides substantially, and fash diminution flattens, and tinge around occurs, and tinge expands,
Deflorescence.
(2) into the departure date：Skin lesion infiltration is apparent, and the scales of skin that peel off is thicker, skin lesions circumferece blush, scratching perverse by mechanical stimulation such as needle
Or with excitatory stronger external used medicine, new skin lesion is often caused in irritated portion, claims isomorphic effect, also known as Koebher signs.
(3) stationary phase or resting stage：Stable disease, pause only develop, and inflammation mitigates, and no new fash occurs.
2, erythrodermic：Often by it is inappropriate treatment and the stronger drug of external application irritation and cause, skin lesion in diffuse sexflush,
It is purplish red, in addition swollen infiltration, a large amount of furfurs, the constitutional symptoms such as the heat that often occurs together, shiver with cold.
3, pustule type：Common to slap foot plantar, the general hair whole body of severe one, fash is that occur syringe needle on the basis of erythema big to maize
Pimple or recurrent exerbation, often occur together heat, arthralgia etc., and blister liquid Bacteria Culture is negative.
4, joint type：In addition to having homeliness type typical case's skin lesion, with arthralgia, big Minor articulus can be involved, and can cause destruction of bone,
Minority occurs together the constitutional symptoms such as heat.
Efficacy evaluation：
Reference《Disease of tcm Standardization of diagnosis and curative effect》Evaluate curative effect.Recovery from illness：Bleb all subsides, and itch, pain disappear；It is aobvious
Effect：Bleb recession 70%, itch, pain, furfur, heating paresthesia disappear substantially；Effectively：Bleb recession 30~69%, itch, pain
Bitterly, furfur, heating paresthesia mitigate；In vain：Bleb recession≤30%, itch, pain, furfur, heating paresthesia do not mitigate.Treatment is total
Efficient=(recovery from illness number of cases+effective number of cases+effective number of cases)/total number of cases × 100%.
Method：Using the method for completely random, 200 study subjects are assigned to treatment group (100) and control group 100
Example).Wherein treatment group man 70, female 30,25~75 years old age.The course of disease 5~180 months.100 men 80 of control group, female 20
Example, age 23~76, the course of disease 6~180 months.Two groups of patients are comparable in gender, age, severity extent etc..It controls
Using liquid dressing made from the embodiment of the present invention 1, control group is disappeared spray treatment group using the rare earth silver of the auspicious safe eye research and development in Beijing.
| Group | Number of cases | It cures | It is effective | Effectively | In vain | It is total effective |
| Treatment group | 100 | 78 | 19 | 3 | 0 | 100 |
| Control group | 100 | 60 | 20 | 15 | 5 | 90 |
Interpretation of result：The liquid dressing of the present invention has curative for effect to treatment skin diseases, has no toxic side effect.
Application Example 1
By liquid dressing made from the above embodiment of the present invention for treating psoriasis, about 0.2~0.3ml is directly applied every time
It smears in affected part, daily 2~3 times.It takes effect within general 3~5 days, basic healing in 30 days or so：It is total to over nearly 2 years and cures psoriatic
256, cure rate 100%.
Clinical case is as follows：
Case one, Mr. Liu, 35 years old, Gansu people from Minxian County, with Niu Pi Xian 3 years, Niu Pi Xian was used after ear and posterior neck position
A lot of kinds of ox skin Xian ointment are crossed, some ointment have been used first-class and recurred, and some effect unobvious, some does not work.Use this
High mountain flower of Sorbaria liquid dressing made from inventive embodiments 1 treats a course for the treatment of (4 weeks), has cured the intractable ox of patient
Psoriasis does not recur more than 1 year so far.
Case two, Mrs Wei, 48 years old, Gansu people from Minxian County more than 6 years, was mainly distributed on four with serious grain grain shape ox skin Xian
Limb, it is invalid to seek medical advice everywhere, and money has been spent much, has used high mountain flower of Sorbaria liquid dressing 2 made from the embodiment of the present invention 1 later
Wheat harvesting period, psoriasis symptoms disappear, and skin restores normal.So far it is not recurred more than 1 year.
Case three, Mr. Li, 53 years old, Gansu people from west of Gansu Province, with psoriasis more than 4 years, psoriasis symptoms interspersed among head, very
Itch unbearably, multi-treatment is ineffective, hangs in the balance, and does not effect a radical cure, through using high mountain flower of Sorbaria liquid made from embodiment 2 to apply
Material, has positive effect in one month, and when being continuing with to 2 wheat harvesting period, skin has appeared fine hair, and skin restores normal skin tone.So far 1
Nian Duowei recurs.
Case four, Mr. Liu, 72 years old, Baiyin people, leg suffered from ox-hide moss 30 years or so, and hilllock starts a fritter,
It is big that the rim of a bowl is gradually diffused to later, is in brownish red patch, and surface covers the canescence shape scales of skin that peel off of multilayer drying, very itches sometimes not
Than itch scratches skin often, has used a lot of dermatologics, palliative, only temporarily antipruritic, fails from basic
Upper releasing is ailing, and increasingly severe.Using high mountain flower of Sorbaria liquid dressing made from embodiment 3, effect at 7 days is used
Feel that the skin surface canescence shape scales of skin that peel off is also few, also less itches it is obvious that skin gradually has improvement.Adhere to using 1
When wheat harvesting period, skin has appeared fine hair, and skin colour is also normal, is not recurred more than half a year so far.High mountain flower of Sorbaria liquid applies
Expect that effect is really good.My ox-hide moss for many years not more is eradicated.
Case five, Miss Wu, 43 years old, Gansu people from Minxian County, there is the small water of erythematous papules on the outside of both hands in unknown cause before 1 year
Itch is not cured blister repeatedly, is now developed to both hands inside and thigh, shank, elbow joint, vulva etc..After diagnosing, the patient symptom
Belong to typical neurodermatitis.Using high mountain flower of Sorbaria liquid dressing made from embodiment 1, it is used continuously one week, it is daily to apply
Smear affected part 2 times, effect feels, it is obvious that skin gradually has improvement, do not occur itch situation, and blister is also gradually subsiding, hard
It holds using after 4 weeks, skin returns to normal.
Claims (8)
1. a kind of external use liquid dressing for treating skin diseases, it is characterised in that：The liquid dressing is by natural plants
The flower or flower seed of high mountain flower of Sorbaria are that raw material is made through bored profit, decoction, filtering.
2. the preparation method described in claim 1 for treating the external use liquid dressing of skin diseases, it is characterised in that：Institute
The method of stating specifically comprises the following steps：
High mountain flower of Sorbaria or high mountain flower of Sorbaria are spent into seed, first use water 20~60min of bored profit, then adds 5~15 times of amount water, slow fire
It decocts 2 times, decocts 2~4h for the first time, second of 1~3h of decoction finally filters decoction liquor and can be prepared by the liquid dressing.
3. the preparation method according to claim 2 for treating the external use liquid dressing of skin diseases, feature exists
In：The high mountain flower of Sorbaria or high mountain flower of Sorbaria flower seed and the proportioning of bored profit water are 100g：100~200ml.
4. the preparation method according to claim 2 for treating the external use liquid dressing of skin diseases, feature exists
In：The bored profit time is 30min.
5. the preparation method according to claim 2 for treating the external use liquid dressing of skin diseases, feature exists
In：The first time decocting time is 3h, and second of decocting time is 2h.
6. the application method of liquid dressing made from claim 2~5 the method, it is characterised in that：The liquid dressing is
The liquid dressing specifically is applied directly to affected part, daily 1~3 time, adhere to using 3~30 days by external application.
7. the application method of liquid dressing according to claim 6, it is characterised in that：The skin diseases include ox
Psoriasis, neurodermatitis and female vulva hickie.
8. the application method of liquid dressing according to claim 7, it is characterised in that：The skin diseases are ox-hide
Tinea.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103251847A (en) * | 2013-06-05 | 2013-08-21 | 高忠青 | Traditional Chinese medicine for treating leucoderma |
| CN107802645A (en) * | 2017-12-11 | 2018-03-16 | 武汉左点科技有限公司 | Rare earth element spray |
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2018
- 2018-07-24 CN CN201810819756.7A patent/CN108542945A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103251847A (en) * | 2013-06-05 | 2013-08-21 | 高忠青 | Traditional Chinese medicine for treating leucoderma |
| CN107802645A (en) * | 2017-12-11 | 2018-03-16 | 武汉左点科技有限公司 | Rare earth element spray |
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| Title |
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| 谭支绍: "《中医天灸疗法》", 31 December 1991, 南宁：广西科学技术出版社 * |
| 陈爱国等: "珍珠梅花膏剂联合阿昔洛韦治疗带状疱疹的疗效观察", 《内科》 * |
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Application publication date: 20180918 |