CN110141599A - A kind of dedicated ointment of chronic catarrhal conjuntivitis and preparation method thereof - Google Patents

A kind of dedicated ointment of chronic catarrhal conjuntivitis and preparation method thereof Download PDF

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Publication number
CN110141599A
CN110141599A CN201810138383.7A CN201810138383A CN110141599A CN 110141599 A CN110141599 A CN 110141599A CN 201810138383 A CN201810138383 A CN 201810138383A CN 110141599 A CN110141599 A CN 110141599A
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ointment
conjuntivitis
dedicated
chronic catarrhal
chronic
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陈光武
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/074—Ganoderma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/489—Sophora, e.g. necklacepod or mamani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Alternative & Traditional Medicine (AREA)
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  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention provides a kind of dedicated ointment of chronic catarrhal conjuntivitis, are made of ganoderma spove powder 8g, Roselle 3g, honeysuckle 5g, borneol 2g and sophora bud 3g, the ganoderma spove powder, polyoses content 0.2-3%, triterpene content is 2.5-3%, and ash content≤6%, sulfur content is lower than 5ppm；The present invention also provides a kind of preparation method, including ultrasound wave irradiation, powder processed, homogeneous and cream processed, the ultrasound wave irradiation, supersonic frequency 18kHz, ultrasonic power 300W, ultrasonic time 250min；The dedicated ointment of a kind of chronic catarrhal conjuntivitis of the invention, synergistic effect is generated between each ingredient, and effect is greater than the sum of the effect of separate constituent, achieve the purpose that cold-evil is dispelled in collaboration, treating both manifestation and root cause of disease simultaneously, it is uneasy to recur, it does not develop drug resistance, total effective rate is high, up to 96%, short treating period can fully recover total effective rate for 7-10 days, without toxin, achieve the effect that rapid healing.

Description

A kind of dedicated ointment of chronic catarrhal conjuntivitis and preparation method thereof
Technical field
The invention belongs to pharmaceutical technology fields, are related to a kind of dedicated ointment of chronic catarrhal conjuntivitis, and in particular to a kind of Dedicated ointment of chronic catarrhal conjuntivitis and preparation method thereof.
Background technique
Chronic catarrhal conjuntivitis is the conjunctiva chronic inflammation as caused by many reasons, more bilateral morbidities.According to the cause of disease Difference, subjective symptoms and eye manifestation are different, chronic inflammation long-time stimulus person, then it is congested, plump, newborn to show as papebral conjunctiva Head hyperplasia is in velvet sample, there is mucus or mucus purulent secretion, if suffer from margo palpebrae while being involved, deplumation occurs, falls The performance such as eyelash, lid inflammation, then prompt infection of staphylococcus aureus, the exotoxin of staphylococcus aureus can produce non-specific Membranous conjunctivitis or superficial punctate keratitis, its main feature is that flexible often generation symptom when from lower section, patient's morning of corneal epithelial diseases adds Weight, foreign body sensation is obvious, there is glutinous purulent secretion.Chronic conjunctivitis caused by Moraxella often has apparent conjunctival follicle, therefore can The inflammatory damage of eyelid and corner of the eyes portion skin can be caused by the proteolytic enzyme that Moraxella generates, it might even be possible to as the main of the disease Clinical manifestation.
There are following major defects: existing ointment (1) therapeutic process for the ointment of existing treatment chronic catarrhal conjuntivitis Slowly, the course for the treatment of is long, need to adhere to that treating a very long time even several Nian Caihui takes effect, general effect is undesirable；It is (2) efficient low, It is also easy to produce detoxifying function, symptom mitigates during medication, once symptom of discontinuing medication recurs, is easy to produce drug resistance.
Summary of the invention
Against the above deficiency, technical problem to be solved by the invention is to provide a kind of chronic catarrhal conjuntivitis by the present invention Dedicated ointment and preparation method thereof.Following goal of the invention may be implemented in the present invention:
(1) using the ointment for the treatment of chronic catarrhal conjuntivitis of the invention, each ingredient cooperateed with mutually, reach jointly dispel it is cold Heresy, clearing heat and detoxicating purpose, can toxin expelling sterilization, treating both manifestation and root cause of disease achievees the effect that rapid healing.
(2) using the ointment for the treatment of chronic catarrhal conjuntivitis of the invention, total effective rate is high, short treating period, and no toxin is made With, it is uneasy to recur, it does not develop drug resistance.
In order to solve the above technical problems, using following technical scheme:
A kind of dedicated ointment of chronic catarrhal conjuntivitis, which is characterized in that the dedicated ointment of chronic catarrhal conjuntivitis, by with The bulk pharmaceutical chemicals of lower weight form: ganoderma spove powder, Roselle, honeysuckle, borneol and the sophora bud.
As currently preferred technical solution, the dedicated ointment of chronic catarrhal conjuntivitis, by the original of following weight Expect medicine composition: ganoderma spove powder 8g, Roselle 3g, honeysuckle 5g, borneol 2g and sophora bud 3g.
As currently preferred technical solution, the ganoderma spove powder, polyoses content 0.2-3%, triterpene content is 2.5-3%, ash content≤6%, sulfur content are lower than 5ppm.
As currently preferred technical solution, the sophora bud, vitamin P4 > 2%, Quercetin > 0.8%, sulfur content is low In 5ppm.
As currently preferred technical solution, the Roselle, procyanidine > 0.2%, sulfur content is lower than 5ppm, bacterium Fall sum≤99cfu/g.
A kind of preparation method of the dedicated ointment of chronic catarrhal conjuntivitis characterized by comprising ultrasound wave irradiation, powder processed, Homogeneous and cream processed.
As currently preferred technical solution, the ultrasound wave irradiation, supersonic frequency 18kHz, ultrasonic power is 300W。
As currently preferred technical solution, the cream processed, mild and heavy respiration alternately tanning 3 times, mild fire, intense fire are alternately boiled 3 times, each 15min.
As currently preferred technical solution, the ultrasound wave irradiation, ultrasonic time 250min.
As currently preferred technical solution, 125 ± 3 DEG C of the mild fire, 185 ± 3 DEG C of the intense fire.
The invention adopts the above technical scheme, compared with prior art, has the advantage that
(1) using the ointment for the treatment of chronic catarrhal conjuntivitis of the invention, each ingredient cooperateed with mutually, reach jointly dispel it is cold Heresy, clearing heat and detoxicating purpose, can toxin expelling sterilization, treating both manifestation and root cause of disease achievees the effect that rapid healing.
(2) using the ointment for the treatment of chronic catarrhal conjuntivitis of the invention, total effective rate height, total effective rate up to 96%, Short treating period, can fully recover for 7-10 days, and no detoxifying function is uneasy to recur, not develop drug resistance.
Specific embodiment
1 dedicated ointment of a kind of chronic catarrhal conjuntivitis of embodiment and preparation method thereof
A kind of dedicated ointment of chronic catarrhal conjuntivitis, is made of the bulk pharmaceutical chemicals of following weight: ganoderma spove powder 8g, Lip river mind Flower 3g, honeysuckle 5g, borneol 2g and sophora bud 3g；
Ganoderma spove powder, polyoses content 0.2-3%, triterpene content are 2.5-3%, and ash content≤6%, sulfur content is lower than 5ppm；
Roselle, procyanidine > 0.2%, sulfur content are lower than 5ppm, total plate count≤99cfu/g, and water content is lower than 3%；
The sophora bud, citrin4> 2%, Quercetin > 0.8%, sulfur content are lower than 5ppm.
The preparation method of the above-mentioned dedicated ointment of chronic catarrhal conjuntivitis of the present invention, comprising the following steps:
1, it sterilizes: above-mentioned raw material is removed into surface impurity, put sterilization processing 15min under ultraviolet light, ultraviolet wavelength uses 400nm；Ganoderma spove powder, Roselle, honeysuckle, borneol and the sophora bud of corresponding weight: wall-breaking lucidum are weighed according to formula Conidia powder 8g, Roselle 3g, honeysuckle 5g, borneol 2g and sophora bud 3g.
2, ultrasound wave irradiation: carrying out ultrasound wave irradiation for above-mentioned raw materials, is 18kHz, ultrasonic power 300W in supersonic frequency Under conditions of ultrasound wave irradiation, ultrasonic time 250min.
3, powder processed: above-mentioned honeysuckle, Roselle, borneol and the sophora bud are mixed, 200 mesh is ground to, obtains powder.
4, homogeneous: ganoderma spove powder 8g and 35ml yellow rice wine is sequentially added into powder, is heated to 40 DEG C, homogeneous.
5, cream processed: 125 ± 3 DEG C of mild fire, military by above-mentioned after mixing evenly with mild and heavy respiration alternately tanning 3 times, each 15min 185 ± 3 DEG C of fire, when naturally cooling to 40 DEG C, is added appropriate vaseline, stirs evenly, until at paste.
It is the single factor analysis done to the formula of the embodiment of the present invention 1 below, the weight of formula is as shown in table 1, preparation side Method is the same as embodiment 1.(unit: g)
Table 1: the distribution of weight being respectively formulated
Clinical treatment is carried out to the case for clinically suffering from chronic catarrhal conjuntivitis:
(1) test setting I group, II group, III group, IV group, V group, VI group, VII group, VIII group and Ⅸ group of case use embodiment respectively The ointment in ointment, comparative example 1- comparative example 8 in 1；Case in-Ⅸ group of I group suffers from chronic catarrhal conjuntivitis, and each Group case gender, age (21-59 years old), the course of disease (1-3) etc. are comparable through statistical analysis.
(2) clinical to work out the standard of curative effect evaluation:
Effective: the foreign body sensation of clinical manifestation friction sense, sensation of dryness, is itched, the elimination of shouting pain and asthenopia；Stickiness point in conjunctival sac Secretion completely disappears, and papebral conjunctiva redness disappears, and surface is smooth, transparent, and blood vessel is clear；Teat tissue under slit lamp biomicroscope Layer of structure is clearly demarcated, no hyperplasia phenomenon.
It is effective: clinic have chronic catarrhal conjuntivitis symptom, such as foreign body sensation, friction sense, it is dry and astringent, itch, tingling sensation it is bright Aobvious to mitigate, asthenopia sense is restored, and nipple layer of structure is more clear under slit lamp biomicroscope, mild hyperplasia phenomenon.
Invalid: symptom and sign and auxiliary examination of the clinic with chronic catarrhal conjuntivitis are without change.
Wherein, (effective+effectively)/sum × 100%=total effective rate.
(3) treatment method: washing one's face with warm water before smearing, and ointment is applied along Jingming acupoint through Tongzi point to temple clockwise It smears, is rubbed 10-12 times clockwise after smearing, obtaining slightly pain is degree；One day 2-3 times, general one day can antalgesic-antipruritic, 7-10 days It can fully recover, daytime can be used at night.
(4) therapeutic effect: in clinical trial, being counted using the therapeutic effect of ointment of the present invention and comparative example 1-8, Treatment effectiveness evaluation the results are shown in Table 2.
Table 2: treatment effectiveness evaluation result
As seen from the above table, the 100 chronic catarrhal conjuntivitis patients treated using prescription of the present invention, using the standard of curative effect evaluation Progress treatment effectiveness evaluation: effective 82, effective 14, invalid 4, total effective rate 96%.
As it can be seen that a kind of dedicated ointment of chronic catarrhal conjuntivitis of the embodiment of the present invention 1, using ganoderma spove powder 8g, Roselle 3g, honeysuckle 5g, borneol 2g and sophora bud 3g, synergistic effect is generated between above each ingredient, and effect is greater than independent The sum of effect of ingredient achievees the purpose that cold-evil, while treating both manifestation and root cause of disease are dispelled in collaboration, uneasy to recur, does not develop drug resistance, always has High-efficient, total effective rate is up to 96%, and short treating period can fully recover for 7-10 days, and no detoxifying function achievees the effect that rapid healing.
In addition, the setting of comparative example 9: comparative example 9 is using formula, weight and preparation method described in embodiment 1, with reality The difference for applying example 1 is to lack ultrasound wave irradiation step, obtains ointment；The ointment that X group case is obtained using comparative example 9, X group are set Case in case and above-mentioned-Ⅸ group of I group suffers from chronic catarrhal conjuntivitis, and each group case gender, age (21-59 Year), the course of disease (1-3) etc. through statistical analysis, be comparable.Clinical treatment, treatment effectiveness evaluation knot are carried out to it Fruit is: effective 41, effective 38, and invalid 21, total effective rate 79%.
Unless otherwise indicated, percentage of the present invention is weight percent, and ratio of the present invention is Mass ratio.
Finally, it should be noted that the foregoing is only a preferred embodiment of the present invention, it is not intended to restrict the invention, It, for those skilled in the art, still can be with although describing the invention in detail with reference to the foregoing embodiments It modifies the technical solutions described in the foregoing embodiments or equivalent replacement of some of the technical features.It is all Within the spirit and principles in the present invention, any modification, equivalent replacement, improvement and so on should be included in guarantor of the invention Within the scope of shield.

Claims (10)

1. a kind of dedicated ointment of chronic catarrhal conjuntivitis, which is characterized in that the dedicated ointment of chronic catarrhal conjuntivitis, by The bulk pharmaceutical chemicals of following weight form: ganoderma spove powder, Roselle, honeysuckle, borneol and the sophora bud.
2. the dedicated ointment of a kind of chronic catarrhal conjuntivitis according to claim 1, which is characterized in that the chronic catarrh The dedicated ointment of membranous conjunctivitis, is made of the bulk pharmaceutical chemicals of following weight: ganoderma spove powder 8g, Roselle 3g, honeysuckle 5g, Borneol 2g and sophora bud 3g.
3. the dedicated ointment of a kind of chronic catarrhal conjuntivitis according to claim 1, which is characterized in that the wall-breaking lucidum Conidia powder, polyoses content 0.2-3%, triterpene content are 2.5-3%, and ash content≤6%, sulfur content is lower than 5ppm.
4. the dedicated ointment of a kind of chronic catarrhal conjuntivitis according to claim 1, which is characterized in that the sophora bud, dimension Raw element P4> 2%, Quercetin > 0.8%, sulfur content are lower than 5ppm.
5. the dedicated ointment of a kind of chronic catarrhal conjuntivitis according to claim 1, which is characterized in that the Roselle, Procyanidine > 0.2%, sulfur content are lower than 5ppm, total plate count≤99cfu/g.
6. a kind of preparation method of the dedicated ointment of chronic catarrhal conjuntivitis characterized by comprising ultrasound wave irradiation, powder processed, Matter and cream processed.
7. a kind of preparation method of the dedicated ointment of chronic catarrhal conjuntivitis according to claim 6, which is characterized in that institute State ultrasound wave irradiation, supersonic frequency 18kHz, ultrasonic power 300W.
8. a kind of preparation method of the dedicated ointment of chronic catarrhal conjuntivitis according to claim 6, which is characterized in that institute State cream processed, mild and heavy respiration alternately tanning 3 times, alternately tanning 3 times of mild fire, intense fire, each 15min.
9. a kind of preparation method of the dedicated ointment of chronic catarrhal conjuntivitis according to claim 6, which is characterized in that institute State ultrasound wave irradiation, ultrasonic time 250min.
10. a kind of preparation method of the dedicated ointment of chronic catarrhal conjuntivitis according to claim 6, which is characterized in that 125 ± 3 DEG C of the mild fire, 185 ± 3 DEG C of the intense fire.
CN201810138383.7A 2018-02-10 2018-02-10 A kind of dedicated ointment of chronic catarrhal conjuntivitis and preparation method thereof Withdrawn CN110141599A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT202200002108A1 (en) 2022-02-07 2023-08-07 Indena Spa QUERCETIN-BASED COMPOSITIONS FOR THE TREATMENT AND PREVENTION OF EYE DISEASES

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT202200002108A1 (en) 2022-02-07 2023-08-07 Indena Spa QUERCETIN-BASED COMPOSITIONS FOR THE TREATMENT AND PREVENTION OF EYE DISEASES

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