CN108535205A - 体外生物瓣抗钙化处理方法、钙化评价方法 - Google Patents
体外生物瓣抗钙化处理方法、钙化评价方法 Download PDFInfo
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- CN108535205A CN108535205A CN201810385139.0A CN201810385139A CN108535205A CN 108535205 A CN108535205 A CN 108535205A CN 201810385139 A CN201810385139 A CN 201810385139A CN 108535205 A CN108535205 A CN 108535205A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2427—Devices for manipulating or deploying heart valves during implantation
- A61F2/243—Deployment by mechanical expansion
- A61F2/2433—Deployment by mechanical expansion using balloon catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
- G01N1/4044—Concentrating samples by chemical techniques; Digestion; Chemical decomposition
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/44—Sample treatment involving radiation, e.g. heat
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/3103—Atomic absorption analysis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Botany (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Vascular Medicine (AREA)
- Mechanical Engineering (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims (10)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201810385139.0A CN108535205B (zh) | 2015-07-22 | 2015-07-22 | 体外生物瓣抗钙化处理方法、钙化评价方法 |
Applications Claiming Priority (2)
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CN201810385139.0A CN108535205B (zh) | 2015-07-22 | 2015-07-22 | 体外生物瓣抗钙化处理方法、钙化评价方法 |
CN201510434781.XA CN104990882B (zh) | 2015-07-22 | 2015-07-22 | 体外生物瓣钙化评价的方法及抗钙化因子溶液 |
Related Parent Applications (1)
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CN201510434781.XA Division CN104990882B (zh) | 2015-07-22 | 2015-07-22 | 体外生物瓣钙化评价的方法及抗钙化因子溶液 |
Publications (2)
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CN108535205A true CN108535205A (zh) | 2018-09-14 |
CN108535205B CN108535205B (zh) | 2021-06-22 |
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CN201510434781.XA Active CN104990882B (zh) | 2015-07-22 | 2015-07-22 | 体外生物瓣钙化评价的方法及抗钙化因子溶液 |
CN201810385139.0A Active CN108535205B (zh) | 2015-07-22 | 2015-07-22 | 体外生物瓣抗钙化处理方法、钙化评价方法 |
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CN201510434781.XA Active CN104990882B (zh) | 2015-07-22 | 2015-07-22 | 体外生物瓣钙化评价的方法及抗钙化因子溶液 |
Country Status (3)
Country | Link |
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US (1) | US10768099B2 (zh) |
CN (2) | CN104990882B (zh) |
WO (1) | WO2017012288A1 (zh) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104990882B (zh) * | 2015-07-22 | 2018-05-01 | 杭州启明医疗器械有限公司 | 体外生物瓣钙化评价的方法及抗钙化因子溶液 |
CN105363071B (zh) * | 2015-11-23 | 2018-10-09 | 金仕生物科技(常熟)有限公司 | 生物材料的抗钙化处理方法 |
CN105717053A (zh) * | 2016-01-28 | 2016-06-29 | 杭州启明医疗器械有限公司 | 一种基于疲劳试验台的体外生物瓣钙化评价方法 |
JP7138928B2 (ja) * | 2018-08-22 | 2022-09-20 | 株式会社サンメディカル技術研究所 | 大動脈弁評価補助具 |
CN110102190A (zh) * | 2019-04-30 | 2019-08-09 | 中国海洋石油集团有限公司 | 一种卤水体系下纳滤膜标准化测试方法及装置 |
CN111514375B (zh) * | 2020-05-28 | 2021-05-11 | 四川大学 | 一种抗钙化生物瓣膜材料及其制备方法 |
CN116593382B (zh) * | 2023-07-17 | 2023-10-27 | 上海汇禾医疗器械有限公司 | 一种钙化模拟液、体外生物瓣钙化评价方法及评价系统 |
Citations (8)
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WO1994001481A1 (en) * | 1992-07-09 | 1994-01-20 | University Of Michigan | Calcification-resistant synthetic biomaterials |
CN1136780A (zh) * | 1993-10-21 | 1996-11-27 | 密执安大学 | 制造抗钙化抗性生物修复组织的方法 |
CN1371750A (zh) * | 2002-02-28 | 2002-10-02 | 中南大学湘雅二医院 | 生物心脏瓣膜2,3-丁二醇防钙化改性的方法 |
US20030125813A1 (en) * | 2002-01-03 | 2003-07-03 | Carpentier Sophie M. | Treatment of bioprosthetic tissues to mitigate post implantation calcification |
CN101184516A (zh) * | 2005-03-25 | 2008-05-21 | 爱德华兹生命科学公司 | 对生物假体组织进行处理以缓解植入后钙化 |
CN102114270A (zh) * | 2011-02-22 | 2011-07-06 | 微创医疗器械(上海)有限公司 | 一种梯度交联及修饰型耐久性人工生物瓣及其制备方法 |
CN104023526A (zh) * | 2014-03-24 | 2014-09-03 | 金仕生物科技(常熟)有限公司 | 一种处理生物材料的方法及经该方法处理的生物材料 |
CN104990882A (zh) * | 2015-07-22 | 2015-10-21 | 杭州启明医疗器械有限公司 | 体外生物瓣钙化评价的方法及抗钙化因子溶液 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
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US4976733A (en) * | 1988-02-03 | 1990-12-11 | Biomedical Design, Inc. | Prevention of prosthesis calcification |
CN1052632C (zh) * | 1993-04-16 | 2000-05-24 | 成都科技大学 | 对胶原组织人工瓣膜材料缓钙化的方法 |
US5674298A (en) * | 1994-10-21 | 1997-10-07 | The Board Of Regents Of The University Of Michigan | Calcification-resistant bioprosthetic tissue and methods of making same |
US8357387B2 (en) * | 2007-12-21 | 2013-01-22 | Edwards Lifesciences Corporation | Capping bioprosthetic tissue to reduce calcification |
CN101947147A (zh) * | 2010-06-23 | 2011-01-19 | 乐普(北京)医疗器械股份有限公司 | 一种生物组织材料的化学处理方法 |
US9730609B2 (en) * | 2011-12-15 | 2017-08-15 | Siemens Healthcare Gmbh | Method and system for aortic valve calcification evaluation |
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2015
- 2015-07-22 CN CN201510434781.XA patent/CN104990882B/zh active Active
- 2015-07-22 CN CN201810385139.0A patent/CN108535205B/zh active Active
-
2016
- 2016-07-22 WO PCT/CN2016/000412 patent/WO2017012288A1/zh active Application Filing
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2018
- 2018-01-22 US US15/876,908 patent/US10768099B2/en active Active
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WO1994001481A1 (en) * | 1992-07-09 | 1994-01-20 | University Of Michigan | Calcification-resistant synthetic biomaterials |
CN1136780A (zh) * | 1993-10-21 | 1996-11-27 | 密执安大学 | 制造抗钙化抗性生物修复组织的方法 |
US20030125813A1 (en) * | 2002-01-03 | 2003-07-03 | Carpentier Sophie M. | Treatment of bioprosthetic tissues to mitigate post implantation calcification |
CN1371750A (zh) * | 2002-02-28 | 2002-10-02 | 中南大学湘雅二医院 | 生物心脏瓣膜2,3-丁二醇防钙化改性的方法 |
CN101184516A (zh) * | 2005-03-25 | 2008-05-21 | 爱德华兹生命科学公司 | 对生物假体组织进行处理以缓解植入后钙化 |
CN102114270A (zh) * | 2011-02-22 | 2011-07-06 | 微创医疗器械(上海)有限公司 | 一种梯度交联及修饰型耐久性人工生物瓣及其制备方法 |
CN104023526A (zh) * | 2014-03-24 | 2014-09-03 | 金仕生物科技(常熟)有限公司 | 一种处理生物材料的方法及经该方法处理的生物材料 |
CN104990882A (zh) * | 2015-07-22 | 2015-10-21 | 杭州启明医疗器械有限公司 | 体外生物瓣钙化评价的方法及抗钙化因子溶液 |
Non-Patent Citations (5)
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JIANYE ZHOU等: ""A Novel Anti-Calcification Strategy of Bovine Pericardium Using Sodium Bisulfite Modification"", 《THE JOURNAL OF HEART VALVE DISEASE》 * |
RACHIT OHRI 等: ""Hyaluronic acid grafting mitigates calcification of glutaraldehyde‐fixed bovine pericardium"", 《JOURNAL OF BIOMEDICAL MATERIALS RESEARCH》 * |
宋兵 等: ""心脏瓣膜修复材料钙化和抗钙化研究进展"", 《国家生物医学过程杂志》 * |
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魏旭峰: ""环氧氯丙烷处理生物瓣膜组织防钙化机制的进一步研究"", 《中国优秀博硕士学位论文全文数据库(博士)医药卫生科技辑》 * |
Also Published As
Publication number | Publication date |
---|---|
US20180149585A1 (en) | 2018-05-31 |
CN104990882B (zh) | 2018-05-01 |
CN108535205B (zh) | 2021-06-22 |
US10768099B2 (en) | 2020-09-08 |
WO2017012288A1 (zh) | 2017-01-26 |
CN104990882A (zh) | 2015-10-21 |
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Address after: 310052 Room 311, 3/F, Building 88, Jiangling Road, Binjiang District, Hangzhou City, Zhejiang Province Applicant after: Hangzhou Qiming Medical Devices Co., Ltd. Address before: 310052 Room 311, 3/F, Building 88, Jiangling Road, Binjiang District, Hangzhou City, Zhejiang Province Applicant before: Hangzhou Qiming Medical Device Co., Ltd. |
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Inventor after: Kuang Dajun Inventor after: Shao Nan Inventor after: Wu Yongjian Inventor after: Gao Runlin Inventor before: Kuang Dajun Inventor before: Shao Nan |
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