CN108513576A - 可调变体免疫球蛋白超家族结构域和工程改造的细胞治疗 - Google Patents

可调变体免疫球蛋白超家族结构域和工程改造的细胞治疗 Download PDF

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CN108513576A
CN108513576A CN201680066217.XA CN201680066217A CN108513576A CN 108513576 A CN108513576 A CN 108513576A CN 201680066217 A CN201680066217 A CN 201680066217A CN 108513576 A CN108513576 A CN 108513576A
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affinity
igsf
domain
cell
cross
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R·斯旺森
M·科纳克
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Alpine Immune Sciences Inc
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Alpine Immune Sciences Inc
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CN201680066217.XA 2015-09-14 2016-09-14 可调变体免疫球蛋白超家族结构域和工程改造的细胞治疗 Pending CN108513576A (zh)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US201562218531P 2015-09-14 2015-09-14
US62/218,531 2015-09-14
US201662323595P 2016-04-15 2016-04-15
US201662323608P 2016-04-15 2016-04-15
US62/323,595 2016-04-15
US62/323,608 2016-04-15
US201662367822P 2016-07-28 2016-07-28
US201662367819P 2016-07-28 2016-07-28
US62/367,819 2016-07-28
US62/367,822 2016-07-28
PCT/US2016/051786 WO2017048878A1 (en) 2015-09-14 2016-09-14 Tunable variant immunoglobulin superfamily domains and engineered cell therapy

Publications (1)

Publication Number Publication Date
CN108513576A true CN108513576A (zh) 2018-09-07

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CN201680066217.XA Pending CN108513576A (zh) 2015-09-14 2016-09-14 可调变体免疫球蛋白超家族结构域和工程改造的细胞治疗

Country Status (12)

Country Link
US (1) US20180256644A1 (https=)
EP (1) EP3350206A1 (https=)
JP (1) JP2018534245A (https=)
KR (1) KR20180054713A (https=)
CN (1) CN108513576A (https=)
AU (1) AU2016323069A1 (https=)
BR (1) BR112018004965A2 (https=)
CA (1) CA2997217A1 (https=)
EA (1) EA201890729A1 (https=)
IL (1) IL258102A (https=)
MX (1) MX2018003144A (https=)
WO (1) WO2017048878A1 (https=)

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WO2020132789A1 (zh) * 2018-12-24 2020-07-02 黄海东 突变的人2Ig-B7-H3蛋白编码基因、重组载体、包含其的宿主细胞、药物组合物及其应用
WO2021058038A1 (zh) * 2019-09-23 2021-04-01 中国药科大学 Cd200蛋白和cd200融合蛋白在制备治疗银屑病药物中的应用
CN113301954A (zh) * 2019-01-13 2021-08-24 耶路撒冷希伯来大学伊森姆研究发展有限公司 特异性针对人类连接蛋白-2的抗体
CN113795502A (zh) * 2019-04-26 2021-12-14 轩竹生物科技有限公司 Cd80变体蛋白及其应用
US12612457B2 (en) 2024-08-28 2026-04-28 Nectin Therapeutics Ltd. Humanized antibodies against Nectin-2 and drug conjugates thereof

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CA2904969C (en) 2013-03-13 2025-06-17 Imaginab, Inc. DIFFERENTIATION CLUSTER ANTIGEN-BINDING GENETIC CONSTRUCTIONS 8
EP3283508B1 (en) 2015-04-17 2021-03-17 Alpine Immune Sciences, Inc. Immunomodulatory proteins with tunable affinities
WO2017027325A1 (en) 2015-08-07 2017-02-16 Imaginab, Inc. Antigen binding constructs to target molecules
AU2016350701B2 (en) 2015-11-02 2021-08-19 Five Prime Therapeutics, Inc. CD80 extracellular domain polypeptides and their use in cancer treatment
IL262365B2 (en) * 2016-04-15 2024-11-01 Alpine Immune Sciences Inc Immunomodulatory proteins ICOS ligand variants and uses thereof
EP4706777A2 (en) 2016-04-15 2026-03-11 Alpine Immune Sciences, Inc. Cd80 variant immunomodulatory proteins and uses thereof
US11471488B2 (en) 2016-07-28 2022-10-18 Alpine Immune Sciences, Inc. CD155 variant immunomodulatory proteins and uses thereof
US11834490B2 (en) 2016-07-28 2023-12-05 Alpine Immune Sciences, Inc. CD112 variant immunomodulatory proteins and uses thereof
CA3040296A1 (en) * 2016-10-20 2018-04-26 Alpine Immune Sciences, Inc. Secretable variant immunomodulatory proteins and engineered cell therapy
JP2020511144A (ja) 2017-03-16 2020-04-16 アルパイン イミューン サイエンシズ インコーポレイテッド Ｐｄ−ｌ２バリアント免疫調節タンパク質及びその使用
EP3596114A2 (en) 2017-03-16 2020-01-22 Alpine Immune Sciences, Inc. Cd80 variant immunomodulatory proteins and uses thereof
WO2018201014A1 (en) 2017-04-28 2018-11-01 Five Prime Therapeutics, Inc. Methods of treatment with cd80 extracellular domain polypeptides
EP3672990A1 (en) 2017-08-25 2020-07-01 Five Prime Therapeutics, Inc. B7-h4 antibodies and methods of use thereof
KR102813968B1 (ko) 2017-10-10 2025-05-29 알파인 이뮨 사이언시즈, 인코포레이티드 Ctla-4 변이체 면역조절 단백질 및 이의 용도
SMT202600062T1 (it) * 2017-10-18 2026-03-09 Alpine Immune Sciences Inc Proteine immunomodulatrici del ligando di icos variante e composizioni e metodi correlati
SG11202006148UA (en) 2018-01-03 2020-07-29 Alpine Immune Sciences Inc Multi-domain immunomodulatory proteins and methods of use thereof
JP2021514379A (ja) 2018-02-21 2021-06-10 ファイブ プライム セラピューティクス， インコーポレイテッド Ｂ７−ｈ４抗体製剤
MA52416A (fr) 2018-03-02 2021-04-21 Five Prime Therapeutics Inc Anticorps b7-h4 et leurs procédés d'utilisation
US12065476B2 (en) 2018-06-15 2024-08-20 Alpine Immune Sciences, Inc. PD-1 variant immunomodulatory proteins and uses thereof
JP2021534196A (ja) 2018-08-23 2021-12-09 シージェン インコーポレイテッド 抗ｔｉｇｉｔ抗体
WO2020113141A2 (en) 2018-11-30 2020-06-04 Alpine Immune Sciences, Inc. Cd86 variant immunomodulatory proteins and uses thereof
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